A novel machine learning optimization process coined Restrictive Federated Model Selection (RFMS) is proposed under the scenario, for example, when data from healthcare units can not leave the site it is situated on and it is forbidden to carry out training algorithms on remote data sites due to either technical or pri…
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FONT clusters patients across health systems with privacy and efficiency.
Improves SVGP methods for faster and more accurate Gaussian process inference.
Estimates users' preference for a site over others using engagement data.
Learning from the crowd has become increasingly popular in the Web and social media. There is a wide variety of crowdlearning sites in which, on the one hand, users learn from the knowledge that other users contribute to the site, and, on the other hand, knowledge is reviewed and curated by the same users using assessm…
Site-specific recombination is an enzymatic process where two sites of precise sequence and orientation along a circle come together, are cleaved, and the ends are recombined. Site-specific recombination on a knotted substrate produces another knot or a two-component link depending on the relative orientation of the si…
Paper tackles robust decision-making from multiple sites with shared structure.
Clinical AI models fail to transfer between sites due to site-specific practices.
A novel framework synthesizes treatment data across sites using optimal transport.
Meta-analysis improves personalized treatment rules across multiple sites.
Tree-based model averaging improves CATE estimation from diverse sites.
A new method estimates protein evolutionary fields and couplings from alignments.
A rational knot or link can be put into a standard alternating format which has horizontal and vertical twist sites (double helices). The number and type of these twist sites are determined by terms of next-to-highest -degree in Kauffman's regular isotopy invariant . In particular, for a knot or link with $c…
We consider the problem of designing a sparse Gaussian process classifier (SGPC) that generalizes well. Viewing SGPC design as constructing an additive model like in boosting, we present an efficient and effective SGPC design method to perform a stage-wise optimization of a predictive loss function. We introduce new me…
The study explores how different Grothendieck topologies and functors between categories preserve locality.
The research reported in this paper identifies the epigenetic biomarker (methylation beta pattern) of breast cancer. Many cancers are triggered by abnormal gene expression levels caused by aberrant methylation of CpG sites in the DNA. In order to develop early diagnostics of cancer-causing methylations and to develop a…
Paper tackles online facility location with user requests and provides a quasi-linear time algorithm.
New federated method preserves privacy and estimates treatment effects.
Method improves robustness and generalizability of CATE estimation.
A site-specific Gordian distance between two spatial embeddings of an abstract graph is the minimal number of crossing changes from one to another where each crossing change is performed between two previously specified abstract edges of the graph. It is infinite in some cases. We determine the site-specific Gordian di…
Owners of a web-site are often interested in analysis of groups of users of their site. Information on these groups can help optimizing the structure and contents of the site. In this paper we use an approach based on formal concepts for constructing taxonomies of user groups. For decreasing the huge amount of concepts…
Paper proves model structures equal for smooth manifolds and Cartesian spaces.
Site-specific recombination on supercoiled circular DNA molecules can yield a variety of knots and catenanes. Twist knots are some of the most common conformations of these products and they can act as substrates for further rounds of site-specific recombination. They are also one of the simplest families of knots and …
Connectivity studies using resting-state functional magnetic resonance imaging are increasingly pooling data acquired at multiple sites. While this may allow investigators to speed up recruitment or increase sample size, multisite studies also potentially introduce systematic biases in connectivity measures across site…
Study predicts coastal water quality using machine learning, identifying salinity as key factor.
RNA-binding proteins (RBPs) play crucial roles in many biological processes, e.g. gene regulation. Computational identification of RBP binding sites on RNAs are urgently needed. In particular, RBPs bind to RNAs by recognizing sequence motifs. Thus, fast locating those motifs on RNA sequences is crucial and time-efficie…
Desingularizes singular spaces using sheaves and groupoids.
PLOT uses optimal transport to find neural site handles for causal abstraction.
HBR improves normative modeling of neuroimaging data across multiple sites.
Paper proposes federated offline RL for personalized medicine.
A cased-based reasoning method predicts rare events on strategic sites using satellite imagery.
Masked LARk prevents cross-site tracking while training models.
Sparse Markovian Gaussian processes improve probabilistic model inference for large datasets.
Collecting the large datasets needed to train deep neural networks can be very difficult, particularly for the many applications for which sharing and pooling data is complicated by practical, ethical, or legal concerns. However, it may be the case that derivative datasets or predictive models developed within individu…
We associate to any integrable Poisson manifold a stack, i.e. a category fibered in groupoids over a site. The site in question has objects Dirac manifolds and morphisms pairs consisting of a smooth map and a closed 2-form. We show that two Poisson manifolds are symplectically Morita equivalent if and only if their ass…
Computational approaches to transcription factor binding site identification have been actively researched for the past decade. Negative examples have long been utilized in de novo motif discovery and have been shown useful in transcription factor binding site search as well. However, understanding of the roles of nega…
Many studies in biomedical and health sciences involve small sample sizes due to logistic or financial constraints. Often, identifying weak (but scientifically interesting) associations between a set of predictors and a response necessitates pooling datasets from multiple diverse labs or groups. While there is a rich l…
In this study, the wind data series from five locations in Aegean Sea islands, the most active `hotspots' in terms of refugee influx during the Oct/2015 - Jan/2016 period, are investigated. The analysis of the three-per-site data series includes standard statistical analysis and parametric distributions, auto-correlati…
This thesis is divided into four chapters. The first chapter discusses the relationship between stacks on a site and groupoids internal to the site. It includes a rigorous proof of the folklore result that there is an equivalence between the bicategory of internal groupoids and the bicategory of geometric stacks. The s…
GOPSA optimizes EEG data for cross-site age prediction, improving performance on multiple metrics.
A theory of dg schemes is developed so that it becomes a homotopy site, and the corresponding infinity category of stacks is equivalent to the infinity category of stacks, as constructed by Toen and Vezzosi, on the site of dg algebras whose cohomologies have finitely many generators in each degree. Stacks represented b…
We develop a topological model of site-specific recombination that applies to substrates which are the connected sum of two torus links of the form . Then we use our model to prove that all knots and links that can be produced by site-specific recombination on such substrates are contained in one of two…
Resting-state functional Magnetic Resonance Imaging (R-fMRI) holds the promise to reveal functional biomarkers of neuropsychiatric disorders. However, extracting such biomarkers is challenging for complex multi-faceted neuropatholo-gies, such as autism spectrum disorders. Large multi-site datasets increase sample sizes…
Modeling infection hotspots to quantify effects of contact tracing and testing.
Bayesian models forecast COVID-19 hospitalizations at single sites.
New method detects RNA modifications without prior training, revealing novel sites.
Many applications in data analysis begin with a set of points in a Euclidean space that is partitioned into clusters. Common tasks then are to devise a classifier deciding which of the clusters a new point is associated to, finding outliers with respect to the clusters, or identifying the type of clustering used for th…
Purpose: In the present work we describe the correction of diffusion-weighted MRI for site and scanner biases using a novel method based on invariant representation. Theory and Methods: Pooled imaging data from multiple sources are subject to variation between the sources. Correcting for these biases has become very im…