In treatment allocation problems the individuals to be treated often arrive sequentially. We study a problem in which the policy maker is not only interested in the expected cumulative welfare but is also concerned about the uncertainty/risk of the treatment outcomes. At the outset, the total number of treatment assign…
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48 results for “sequential treatment”
New method estimates treatment effects over time with unobserved confounders.
problem Estimating treatment effects from observational data with unobserved confounders.
method Sequential Deconfounder using Gaussian process latent variable model.
result Unbiased estimates of individualized treatment responses over time.
The paper develops methods to estimate optimal treatment sequences under policy constraints.
problem Estimating the best sequence of treatments over multiple stages for individuals.
method Empirical welfare maximization approach, solving treatment assignment sequentially or simultaneously.
result Established convergence rates and upper bounds for estimation methods.
Proposes methods for learning optimal dynamic treatment regimes robust to unconfoundedness violations.
problem Estimating optimal dynamic treatment regimes using historical observational data when unconfoundedness is violated.
method Utilizes proximal causal inference framework to propose three nonparametric identification methods, a (K+1)-robust method, and establish a semiparametric efficiency bound.
result Establishes the (K+1)-robust method for learning optimal dynamic treatment regimes, validating its efficiency and multiple robustness through numerical experiments.
The paper addresses estimating long-term treatment effects with monotone missing data.
problem Estimating long-term treatment effects with missing data, especially monotone missing.
method The paper introduces the sequential missingness assumption for identification and proposes three novel estimation methods: inverse probability weighting, sequential regression imputation, and SeqMSM. It also introduces a balancing-enhanced approach, BalanceNet, to improve estimation accuracy.
result The proposed methods, including BalanceNet, effectively estimate long-term treatment effects with monotone missing data.
The paper addresses treatment recommendation problems by optimizing distributional characteristics.
problem Optimizing treatment recommendations based on distributional targets.
method Characterizes the problem's difficulty and proposes near-optimal policies.
result Characterizes the difficulty of the problem and proposes near-regret optimal policies.
Dynamic covariate balancing: estimating treatment effects over time with potential local projectionsecon.EM
Dynamic treatment effects estimated over time using covariate balancing.
problem Estimating treatment effects in panel data with dynamic treatments.
method Dynamic covariate balancing with potential local projections.
result Established inferential guarantees for the proposed method.
Variable selection for optimal treatment regime in a clinical trial or an observational study is getting more attention. Most existing variable selection techniques focused on selecting variables that are important for prediction, therefore some variables that are poor in prediction but are critical for decision-making…
We study how to efficiently estimate average treatment effects (ATEs) using adaptive experiments. In adaptive experiments, experimenters sequentially assign treatments to experimental units while updating treatment assignment probabilities based on past data. We start by defining the efficient treatment-assignment prob…
Optimal tests developed for sequential experiments with asymptotic properties.
problem Performing hypothesis tests after sequential experiments without prior design.
method Analyze asymptotic properties of sequential experiments; develop tests for Gaussian process observations.
result Asymptotic power function of any test can be matched by a specific test in a limit experiment.
Study designs for estimating treatment effects in adaptive experiments.
problem Estimating treatment effects under adaptive treatment assignment.
method Propose and analyze IPW and AIPW estimators, establish CLTs under design stability.
result Central limit theorems for IPW and AIPW estimators under design stability.
Proposes DSW for unbiased ITE estimation with dynamic confounders.
problem Estimating ITE from dynamic observational data with time-varying confounders.
method Deep Sequential Weighting (DSW) infers hidden confounders using current treatment assignments and historical information.
result DSW generates unbiased and accurate treatment effects.
The paper tackles long-term treatment effects with persistent confounders using sequential short-term outcomes.
problem Estimating long-term treatment effects with persistent unmeasured confounders.
method Exploiting the sequential structure of short-term outcomes, the paper develops three novel identification strategies and corresponding estimators.
result The proposed methods outperform existing approaches in handling persistent confounders.
G-Net uses deep learning for complex counterfactual outcome prediction.
problem Estimating counterfactual outcomes under dynamic treatment strategies.
method G-Net is a sequential deep learning framework for G-computation.
result G-Net can handle complex temporal data and provide accurate treatment effects.
New method for estimating counterfactual means in adaptive experiments.
problem Inference for counterfactual means in sequentially designed experiments with adaptive treatment policies.
method Latent factor model and nearest neighbors method for estimation.
result Asymptotically valid confidence intervals for counterfactual means established.
Deep Bayesian models estimate causal effects for dynamic treatment regimes over long follow-up times.
problem Challenges in causal effect estimation for dynamic treatment regimes with long follow-up times.
method Combining outcome regression models with deep Bayesian models for high-dimensional features.
result Stable and accurate dynamic causal effect estimation from observational data, especially with long-term follow-up.
New method uses few instruments to estimate complex causal effects.
problem Estimating causal effects with limited instruments in high-dimensional settings.
method Sequentially selects and combines instruments to estimate the treatment effect.
result Can reliably recover the treatment effect's projection onto the instrumented subspace.
New method uses online learning to improve AIPW estimators for adaptively collected data.
problem Estimating treatment effects with adaptively collected data.
method Online learning to minimize sequentially weighted estimation error.
result Local minimax lower bound shows optimality of AIPW estimator.
A new RL framework evaluates dynamic mediation effects over time.
problem Dynamic mediation effects in sequentially assigned treatments.
method Reinforcement Learning framework for decomposition and estimation of causal effects.
result Superior performance demonstrated through numerical studies and real data analysis.
DeepBlip estimates treatment effects over time using neural networks.
problem Estimating treatment effects over time with interpretable blip effects.
method DeepBlip uses a novel double optimization trick to enable simultaneous learning of blip functions with sequential neural networks.
result DeepBlip achieves state-of-the-art performance across various clinical datasets.
We consider a multi-armed bandit problem with covariates. Given a realization of the covariate vector, instead of targeting the treatment with highest conditional expectation, the decision maker targets the treatment which maximizes a general functional of the conditional potential outcome distribution, e.g., a conditi…
This study optimizes covariate density and propensity score for efficient ATE estimation.
problem Efficiently estimating average treatment effects (ATEs) with minimal variance.
method Adaptive experiment optimizing both covariate density and propensity score.
result Proposed method minimizes the semiparametric efficiency bound for ATE estimation.
New method improves treatment effect estimation in adaptive experiments with noncompliance.
problem Estimating average treatment effect in adaptive experiments with binary instrumental variable.
method AMRIV estimator that balances outcome noise and compliance variability.
result AMRIV achieves semiparametric efficiency bound and is robust to noncompliance.
Many applied decision-making problems have a dynamic component: The policymaker needs not only to choose whom to treat, but also when to start which treatment. For example, a medical doctor may choose between postponing treatment (watchful waiting) and prescribing one of several available treatments during the many vis…
Bridges uplift modeling and sequential decision-making with online budget allocation.
problem Treatment allocation under budget constraints in digital advertising.
method Budget-Constrained Causal Bandits (BCCB) integrates learning, exploration, and budget pacing.
result Data-efficiency crossover: BCCB operates effectively from the first user, 3-5x lower performance variance.
Method learns optimal treatment sequences from observational data.
problem Optimal dynamic treatment regimes for public policies and medical interventions.
method Doubly robust classification-based approach via backward induction.
result Achieves optimal convergence rate of n^(-1/2) for welfare regret.
Experimenting, Fast and Slow: Bayesian Optimization of Long-term Outcomes with Online Experimentscs.LG
Bayesian optimization for long-term outcomes using fast and slow experiments.
problem Optimizing long-term system effects with short-term misleading results.
method Combining fast and slow experiments for Bayesian optimization.
result Sequential optimization over large action spaces in a short time.
Proposes estimators for complex dose-response curves using kernel methods.
problem Estimating complex dose-response curves with continuous treatments, mediators, and covariates.
method Kernel ridge regression with sequential kernel embedding technique.
result Simple estimators for mediated and time-varying dose response curves with nonasymptotic uniform rates.
TV-SurvCaus improves causal inference for dynamic treatments in survival analysis.
problem Estimating causal effects of time-varying treatments on survival outcomes.
method Representation balancing techniques extended to time-varying treatment regimes with survival outcomes.
result TV-SurvCaus outperforms existing methods in estimating individualized treatment effects with time-varying covariates and treatments.
Efficient inference method for adaptive experiments with tighter confidence sequences.
problem Efficient inference of Average Treatment Effect in a changing policy sequential experiment.
method Semiparametric efficient inference using Adaptive Augmented Inverse-Probability Weighted estimator and asymptotic confidence sequences.
result Derives tighter confidence sequences for adaptive experiments under data-dependent stopping times.
Efficient RL method uses SSL for small labeled data in health outcomes.
problem Lack of precise health outcome data for reinforcement learning.
method Semi-supervised learning approach for Q-learning and value estimation.
result Method efficiently estimates Q-function and value function, robust to mis-specification.
A new method generates counterfactual treatment outcomes for time-varying treatments.
problem Estimating counterfactual outcomes for time-varying treatments with high-dimensional outcomes.
method Conditional generative framework with inverse probability re-weighting.
result Our method outperforms state-of-the-art baselines in generating high-quality counterfactual samples.
Consider the case that one observes a single time-series, where at each time t one observes a data record O(t) involving treatment nodes A(t), possible covariates L(t) and an outcome node Y(t). The data record at time t carries information for an (potentially causal) effect of the treatment A(t) on the outcome Y(t), in…
A new method for analyzing adaptive experiments using kernel treatment effects.
problem Efficiently analyzing adaptive experiments that adjust treatment assignments based on outcomes.
method Kernel Treatment Effects (KTE) framework combining RKHS scores and witness functions.
result Effective for both mean shifts and higher-moment differences, outperforming adaptive baselines.
Adaptive designs achieve strong Neyman regret guarantees for ATE estimation.
problem Estimating unbiased average treatment effect in sequential experiments.
method Proposed adaptive designs with Neyman regret under boundedness assumptions and multigroup Neyman regret in covariate-based settings.
result Adaptive designs outperform non-adaptive designs in terms of Neyman regret, especially in covariate-based settings.
A treatment regime is a function that maps individual patient information to a recommended treatment, hence explicitly incorporating the heterogeneity in need for treatment across individuals. Patient responses are dichotomous and can be predicted through an unknown relationship that depends on the patient information …
A new algorithm learns optimal personalized treatment plans online with low regret.
problem Learning optimal dynamic treatment regimes in an online setting.
method Developed a novel algorithm balancing exploration and exploitation for rate-optimal regret.
result Guaranteed rate-optimal regret for linear transition and reward models.
This paper proposes a new AED framework for multi-metric experiments with fixed budget.
problem Statistical power challenges in testing multiple metrics simultaneously.
method Two-phase structure: adaptive exploration followed by validation. SHRVar algorithm with relative-variance-based sampling.
result Achieves provable error probability that decreases exponentially.
Dynamic treatment regimes are of growing interest across the clinical sciences as these regimes provide one way to operationalize and thus inform sequential personalized clinical decision making. A dynamic treatment regime is a sequence of decision rules, with a decision rule per stage of clinical intervention; each de…
Unified framework for robust A/B testing under model misspecification.
problem Improving sample efficiency in A/B testing with model misspecification.
method Unified framework for contextual bandit and dynamic settings, proving worst-case mean squared error bounds.
result Empirically validated approach using synthetic and real-world datasets.
Develops methods to learn optimal treatment regimes using causal tree methods.
problem Lack of methods for estimating treatment effects and handling complex patient data.
method Causal tree and causal forest methods for estimating heterogeneous treatment effects.
result Outperforms state-of-the-art baselines in cumulative regret and percentage of optimal decisions.
We study the problem of estimating the continuous response over time to interventions using observational time series---a retrospective dataset where the policy by which the data are generated is unknown to the learner. We are motivated by applications where response varies by individuals and therefore, estimating resp…
Q-learning adapted to find near-equivalent treatment strategies.
problem Finding optimal treatment sequences in dynamic treatment regimes.
method Introducing a worst-value tolerance criterion to find sets of near-equivalent policies.
result Constructs families of near-equivalent treatment strategies.
Study identifies and estimates treatment effect heterogeneity within principal stratification subpopulations.
problem Causal inference with intermediate outcomes and treatment effect heterogeneity.
method Proposes a novel doubly cross-fit doubly robust machine learner to efficiently learn conditional principal causal effects under principal ignorability.
result Demonstrates informative patterns of treatment effect heterogeneity within the always-survivor subpopulation in an acute lung injury trial.
IntelligentPooling improves treatment decisions in mHealth.
problem Optimizing treatment decisions in mobile health with limited data and non-stationary responses.
method Generalized Thompson-Sampling bandit algorithms to IntelligentPooling, addressing differential response, limited data, and non-stationary responses.
result IntelligentPooling achieves 26% lower regret compared to state-of-the-art methods.
Proposes a deep spectral Q-learning for mobile health data.
problem Personalized treatment assignment for patients with time-varying covariates.
method Integrates PCA with deep Q-learning for mixed frequency data.
result Mean return converges to optimal under estimated optimal policy.
Bayesian model estimates ACT impact on pediatric AML survival.
problem Estimating ACT impact on survival in AML patients with treatment timing issues.
method Generative Bayesian semi-parametric model with Gamma Process priors.
result Posterior inference for ACT efficacy under dynamic rules.
Proposes new method to handle hidden confounders in causal mediation analysis.
problem Break down total effect of treatment on outcome through different causal pathways.
method Combines proxy strategies and deep learning to uncover latent variables and estimate causal effects.
result Validated effectiveness of the proposed method for causal fairness analysis.