Paper develops a framework to discover bioprocessing regulatory mechanisms using symbolic and statistical learning.
problem Challenges in modeling complex intracellular regulation, stochastic system behavior, and limited experimental data.
method Symbolic and statistical learning framework based on stochastic differential equations and Bayesian learning.
result Improved sample efficiency and robust model selection compared to state-of-the-art approaches.
Efficiently infers gene regulatory networks from spatial data.
problem Inferring spatially-varying gene regulatory networks.
method Proposed an efficient optimization problem for SV-GMRFs.
result Solves large-scale SV-GMRF problems in minutes.
Study efficient auditing of ML fairness models.
problem Scalability of auditing ML models for fairness.
method Query-based auditing algorithms for estimating demographic parity.
result Optimal deterministic and practical randomized algorithms for fairness estimation.
Gene regulatory networks play a crucial role in controlling an organism's biological processes, which is why there is significant interest in developing computational methods that are able to extract their structure from high-throughput genetic data. Many of these computational methods are designed to infer individual …
Survey examines agentic AI in finance, highlighting its autonomy and challenges.
problem Autonomous AI systems in finance and their implications.
method Systematic review of research, technical architectures, market applications, and governance frameworks.
result Agentic AI offers enhanced market efficiency but introduces new risks.
Gene regulatory networks play a crucial role in controlling an organism's biological processes, which is why there is significant interest in developing computational methods that are able to extract their structure from high-throughput genetic data. A typical approach consists of a series of conditional independence t…
New framework for adaptive clinical trials to address real-world challenges.
problem Real-world challenges in post-regulatory clinical trials.
method RFAN framework integrating regulatory constraints and treatment policy value.
result Empirical evaluation of RFAN's performance.
SHARC explains machine learning risk models for regulatory capital, linking outputs to scenarios.
problem Inability to explain machine learning model outputs to regulatory bodies.
method SHAP-based explainability framework for Hybrid GPR-HS architecture and SVaR stress-testing.
result SHARC links SVaR outputs to scenario inputs, providing auditable traceability.
New method infers causal factors from large-scale data without full graph reconstruction.
problem Inferring causal variables from large-scale systems without full causal graph reconstruction.
method Supervised learning on simulated data using a neural network and subsampled-ensemble inference.
result Efficiently identifies causal relationships in large-scale gene regulatory networks.
Over the last 23 years, the U.S. Securities and Exchange Commission has required over 34,000 companies to file over 165,000 annual reports. These reports, the so-called "Form 10-Ks," contain a characterization of a company's financial performance and its risks, including the regulatory environment in which a company op…
Facing the FRTB, banks need to allocate their capital to each business units or risk positions to evaluate the capital efficiency of their strategies. This paper proposes two computationally efficient allocation methods which are weighted according to liquidity horizon. Both methods provide more stable and less negativ…
This paper examines market misconduct in DeFi and proposes regulatory solutions.
problem Novel forms of market misconduct in DeFi.
method Comprehensive analysis, comparative study, empirical measurements, and tailored regulatory framework investigation.
result Identification of key areas for regulatory enhancement in DeFi.
The paper develops a scalable method to infer GRNs from sparse data.
problem Inferring complex gene regulatory networks from limited and temporally sparse data.
method Bayesian optimization and kernel-based methods to construct a Gaussian Process (GP) model.
result The method efficiently searches for the topology with the highest likelihood value.
Paper introduces RiskEmbed, a finetuned model for financial risk management.
problem Improving retrieval accuracy in financial question-answering systems.
method Curated dataset and finetuned BERT model for financial domain.
result RiskEmbed significantly outperforms general-purpose and financial embedding models.
regvis.net offers a visual survey of regulatory visualization.
problem Lack of a comprehensive resource for regulatory visualization.
method Collection and manual tagging of 80+ publications, creation of a searchable webpage.
result First publication set tailored for regulatory visualization.
Optimizes insurance profits under regulatory constraints.
problem Maximizing profits while adhering to regulatory and risk policies.
method Developed a formalism for in-force business profit optimisation.
result Identified optimal asset allocation and annual opportunity cost.
ZICO learns DAGs from zero-inflated count data efficiently.
problem Learning network structures from zero-inflated count data.
method ZICO uses node-wise likelihoods with canonical links and a differentiable surrogate constraint for acyclicity.
result ZICO achieves superior performance and faster runtimes on simulated data.
Within the Own Risk and Solvency Assessment framework, the Solvency II directive introduces the need for insurance undertakings to have efficient tools enabling the companies to assess the continuous compliance with regulatory solvency requirements. Because of the great operational complexity resulting from each comple…
TNDE quantifies dynamic gene drivers from single-cell snapshots.
problem Reconstructing time-resolved regulatory effects in biological processes.
method Time-varying Network Driver Estimation (TNDE) using shared graph attention encoder and partial optimal transport.
result TNDE identifies stage-specific driver genes in mouse erythropoiesis.
In a market system, regulations are designed to prevent or rectify market failures that inhibit fair exchange, such as monopoly or transactions with hidden costs. Because regulations reduce profits to those possessing unfair advantage, these advantaged corporations (whether individuals, companies, or other collective o…
RegTech improves compliance and risk management through tech solutions.
problem Increasing regulatory costs and reliance on tech for crisis management.
method Examining RegTech solutions and their benefits.
result RegTech will be a promising market due to rising compliance costs and tech reliance.
Paper constructs a CRRIX index to assess cryptocurrency market risks from regulatory changes.
problem Lack of indices quantifying regulatory risks in cryptocurrencies.
method CRRIX index based on news coverage frequency, using Latent Dirichlet Allocation and Hellinger distance.
result CRRIX successfully captures major policy-changing moments and synchronizes with market volatility.
InfoSEM infers gene regulatory networks without GT labels, improving performance.
problem Inferring GRNs from gene expression data with high accuracy and avoiding biases.
method InfoSEM uses deep generative models with informative priors (textual gene embeddings).
result InfoSEM outperforms existing models by 38.5% across four datasets.
Healthcare companies must submit pharmaceutical drugs or medical devices to regulatory bodies before marketing new technology. Regulatory bodies frequently require transparent and interpretable computational modelling to justify a new healthcare technology, but researchers may have several competing models for a biolog…
New method constructs confidence bands for ODE models with unknown regulatory effects.
problem Building confidence bands for ODE models with unknown regulatory relations is challenging.
method Localized kernel learning approach combined with de-biasing method.
result The constructed confidence band has the desired asymptotic coverage probability and accurately recovers the regulatory network.
Proposes a new method for determining LGD discount rates based on cost of capital.
problem Determining an appropriate discount rate for LGD estimation.
method Market-consistent pricing of defaulted loan portfolios to infer discount rates.
result Discount rates reflect both undiversifiable risk and time value of money.
GO-CBED optimizes experiments for specific causal queries, improving efficiency.
problem Efficiently infer causal relationships with limited resources.
method Goal-oriented Bayesian framework that maximizes expected information gain on user-specified causal quantities.
result GO-CBED outperforms existing methods in various causal tasks, especially with limited budgets.
Funding is a cost to trading desks that they see as an input. Current FVA-related literature reflects this by also taking funding costs as an input, usually constant, and always risk-neutral. However, this funding curve is the output from a Treasury point of view. Treasury must consider Regulatory-required liquidity bu…
Simple method calculates WWR for regulatory and accounting purposes.
problem Estimating WWR for regulatory and accounting capital requirements.
method Model-independent approach using integral expressions and component calibration.
result WWR effects for FVA are significantly more material than for CVA.
DASH simplifies neural networks for gene regulatory dynamics using domain knowledge.
problem Pruning neural networks for gene regulatory dynamics lacks biologically meaningful structure learning.
method DASH uses domain-specific structural information to guide network pruning, leading to sparser, better interpretable models.
result DASH outperforms general pruning methods in gene regulatory network inference, yielding deeper insights.
Cryptocurrency markets show similar returns but different volatility responses to infrastructure and regulatory shocks.
problem Understanding how cryptocurrency markets differentiate between infrastructure and regulatory shocks.
method Event-level block bootstrap inference on 31 cryptocurrency events across Bitcoin, Ethereum, Solana, and Cardano (2019-2025).
result No statistically significant difference in cumulative abnormal returns between infrastructure failures and regulatory enforcement.
Robust machine learning models improve DNA regulatory sequence prediction under various shifts.
problem Real-world applications of DNA regulatory sequence prediction involve shifts not captured by standard i.i.d. assumptions.
method Introduces a robustness framework combining simulation benchmarks and real data analysis.
result Models remain accurate and calibrated under mild shifts but show higher error and miscalibration under strong shifts.
Develops probabilistic models for gene regulatory network inference.
problem Challenges in reconstructing gene regulatory networks from genome-wide data.
method Two complementary frameworks: PMF-GRN and GLM-Prior.
result Probabilistic inference refines regulatory estimates with quantified uncertainty.
Study examines how business units can benefit from group cohesion under regulatory constraints.
problem Regulatory constraints limit business units' ability to form a single cohesive group.
method Defined and analyzed cohesive risk measures to minimize capital costs.
result Cohesive risk measures allow groups to achieve minimal capital costs without altering individual liabilities.
The DAO Report led to a significant shift of ICO activity to Europe.
problem The impact of U.S. regulatory changes on global ICO activity.
method Analysis of a global dataset of ICOs from 2014 to 2021, focusing on the DAO Report's effects.
result A substantial and persistent reallocation of ICO activity to Europe following the DAO Report.
This study examines the execution phase of corporate share buy-backs, highlighting inefficiencies and costs.
problem Lack of research on share buy-back execution practices and associated costs.
method Comparative analysis of execution practices and fees charged to corporations and investors.
result Uncovered inefficiencies and frictional costs in share buy-back executions, advocating for transparency and fairness.
Optimizes bank capital structure under Basel III constraints, simplifying complex dynamics.
problem Optimizing risky investments, dividends, and capital structure under Basel III constraints.
method Formulated as a stochastic control problem, reducing dynamics to a one-dimensional process in leverage ratio.
result Simple policy: pay dividends at an upper barrier and recapitalize at the distress boundary.
Study identifies a Strategic Gap in market efficiency due to AI-driven timing and complexity in disclosure.
problem Market inefficiency due to structural influence of disclosure timing and complexity.
method Introduces Autonomous Disclosure Regulator, a multi-node AI framework to audit disclosure complexity and unpredictability.
result Companies use confusing language and unpredictable timing to slow down market learning, creating a 60% Structural Gap.
This paper tackles post-trade allocation inefficiencies and presents a uniform return allocation method.
problem Return divergence among accounts after trade allocation.
method Systematic treatment of trade allocation risk, presenting a uniform return allocation method.
result Uniform allocation of returns irrespective of the number of accounts and trade sizes.
Constructing gene regulatory networks is a critical step in revealing disease mechanisms from transcriptomic data. In this work, we present NO-BEARS, a novel algorithm for estimating gene regulatory networks. The NO-BEARS algorithm is built on the basis of the NOTEARS algorithm with two improvements. First, we propose …
Reconstructing transcriptional regulatory networks is an important task in functional genomics. Data obtained from experiments that perturb genes by knockouts or RNA interference contain useful information for addressing this reconstruction problem. However, such data can be limited in size and/or are expensive to acqu…
Model predicts trade volume changes from financial filings.
problem Improving financial market understanding through machine learning.
method Hierarchical Reformer model trained on SEDAR filings.
result Model can predict trade volume changes without explicit training.
Regulations impose idiosyncratic capital and funding costs for holding derivatives. Capital requirements are costly because derivatives desks are risky businesses; funding is costly in part because regulations increase the minimum funding tenor. Idiosyncratic costs mean no single measure makes derivatives martingales f…
We present a Bayesian hierarchical multi-view mixture model termed Symphony that simultaneously learns clusters of cells representing cell types and their underlying gene regulatory networks by integrating data from two views: single-cell gene expression data and paired epigenetic data, which is informative of gene-gen…
FinDiff generates synthetic financial data for regulatory tasks.
problem Sharing microdata for research due to privacy regulations.
method Diffusion model using embedding encodings for mixed modality financial data.
result FinDiff excels in generating high-fidelity, privacy-preserving synthetic financial data.
New framework makes ML methods compliant with regulations.
problem Ensuring ML methods meet regulatory standards.
method InfoGram and Admissible Machine Learning framework.
result Redesigns ML methods for regulatory compliance.
In 1999 Robert Fernholz observed an inconsistency between the normative assumption of existence of an equivalent martingale measure (EMM) and the empirical reality of diversity in equity markets. We explore a method of imposing diversity on market models by a type of antitrust regulation that is compatible with EMMs. T…
Regulatory compliance is an organization's adherence to laws, regulations, guidelines and specifications relevant to its business. Compliance officers responsible for maintaining adherence constantly struggle to keep up with the large amount of changes in regulatory requirements. Keeping up with the changes entail two …