Prognostic scores improve logistic regression analysis in RCTs with binary outcomes.
problem Non-collapsibility in logistic regression analysis of RCTs with binary endpoints.
method Prognostic score adjustment using AI predictions to address non-collapsibility.
result Prognostic score adjustment increases power or reduces sample size for estimating conditional odds ratios.
Bayesian method improves clinical trial efficiency.
problem Increase treatment effect estimates in clinical trials.
method Combines prognostic covariate adjustment with a Bayesian framework.
result Substantial increase in statistical power with controlled type I error.
A new VAE model identifies and estimates treatment effects with limited overlap.
problem Identifying and estimating treatment effects when subjects with certain features belong to a single treatment group.
method Developed a latent variable model to estimate a prognostic score, which is sufficient for treatment effects. The model is a new type of VAE called β-Intact-VAE.
result The model identifies individualized treatment effects and provides TE error bounds.
Improves trial efficiency by adjusting for historical prognostic scores.
problem Reducing statistical uncertainty in randomized trial estimates.
method Linear covariate adjustment using a prognostic model trained on historical data.
result Prognostic covariate adjustment achieves minimum variance and reduces mean-squared error.
Deconfounding scores improve causal effect estimation with weak overlap.
problem Challenges in causal treatment effect estimation due to weak overlap in high-dimensional data.
method Propose deconfounding scores to preserve identification and target estimation while improving overlap.
result Prognostic scores are overlap-optimal under a broad family of generalized linear models with Gaussian features.
Current prognostic risk scores in cardiac surgery are based on statistics and do not yet benefit from machine learning. Statistical predictors are not robust enough to correctly identify patients who would benefit from Transcatheter Aortic Valve Implantation (TAVI). This research aims to create a machine learning model…
MEC-Cox: A Machine-Learning-Assisted Generalized Entropy Calibration Method for Estimating ATT Marginal Hazard-Ratio
problem Estimating ATT marginal hazard-ratio in externally controlled survival trials
method Machine-learning-assisted generalized entropy calibration for IPW Cox regression
result Reduces bias, increases efficiency, and improves coverage
Method predicts ODX scores for breast cancer patients based on clinical data.
problem Predicting ODX scores for breast cancer patients to aid decision-making.
method Distributional random forest approach using 9 clinico-pathological characteristics.
result Correctly predicted 92% of low risk and 40.2% of high risk patients.
Enhances PHM solutions by augmenting scarce multivariate time series data.
problem Data scarcity in failure prognostics.
method Extends autoregressive models for data augmentation.
result Significantly improves PHM solution performance.
A federated model predicts failures using multi-stream incomplete data.
problem Insufficient data for reliable prognostic models in multi-stream applications.
method Federated data fusion, multivariate functional principal component analysis, (log)-location-scale regression model, federated algorithm.
result Performance is as good as classic non-federated models and better than individual models.
Deep learning model forecasts PV power production with high accuracy.
problem Accurate forecasting of photovoltaic power production is needed for electricity infrastructure.
method Sequence to sequence model with attention mechanism using weather predictions and historical data.
result The model outperforms existing methods in forecast skill score.
A federated learning framework improves RUL prognosis for aircraft engines without sharing data.
problem Limited run-to-failure data samples for accurate RUL prognosis.
method Federated learning framework, decentralized validation, and robust aggregation methods.
result The federated learning framework leads to more accurate RUL prognosis for five out of six airlines.
New method interprets deep learning for causal effects, separating prognostic and moderating covariates.
problem Estimating individual causal/treatment effects under confounders.
method Deep counterfactual learning architecture for estimating CATE with interpretable score functions.
result Demonstrated improved interpretability and quantification of uncertainty in CATE estimation.
Paper proposes a tensor data model for incomplete imaging data.
problem Prognostics models for incomplete imaging data.
method Supervised tensor dimension reduction with TTF supervision and optimization.
result Model effectively extracts low-dimensional features from incomplete data.
CBMs improve interpretability in RUL prediction for aircraft engines.
problem Lack of interpretability in deep learning models for asset prognostics.
method Concept Bottleneck Models (CBMs) for RUL prediction.
result CBMs achieve comparable or superior performance to black-box models while being more interpretable.
Proposes a federated learning approach for industrial asset failure prediction.
problem Lack of data and privacy concerns in industrial prognostics.
method Two-stage federated learning: dimension reduction and parameter estimation.
result Validated the approach using simulated and real data.
This paper improves federated learning for industrial predictive analytics by accommodating client heterogeneity.
problem Traditional federated models assume homogeneity in degradation processes, which doesn't apply to industrial settings.
method Personalized federated prognostic model using proximal gradient descent algorithm for joint parameter estimation.
result The proposed model enhances performance and provides comprehensive failure time distributions.
Bayesian PROCOVA uses AI to adjust for covariates in RCTs.
problem Unbiased and precise treatment effect inferences from RCTs.
method Generative AI constructs digital twins for covariate adjustment, using an additive mixture prior.
result Efficiency gains in smaller RCTs compared to frequentist methods.
Prognostics or early detection of incipient faults is an important industrial challenge for condition-based and preventive maintenance. Physics-based approaches to modeling fault progression are infeasible due to multiple interacting components, uncontrolled environmental factors and observability constraints. Moreover…
Proposes a new VAE model to estimate treatment effects from confounded data.
problem Estimating treatment effects in the presence of confounding variables.
method Intact-VAE, a variant of variational autoencoder (VAE), using a latent variable for confounders.
result Proves identification of treatment effects under unconfoundedness and shows state-of-the-art performance.
Self-supervised learning improves RUL prediction with limited data in fatigue damage prognosis.
problem Limited labelled data for RUL prediction in fatigue damage prognosis.
method Pre-training deep learning models on unlabelled sensor data using self-supervised learning.
result Self-supervised pre-trained models significantly outperform non-pre-trained models in RUL prediction with scarce labelled data.
We study information theoretic methods for ranking biomarkers. In clinical trials there are two, closely related, types of biomarkers: predictive and prognostic, and disentangling them is a key challenge. Our first step is to phrase biomarker ranking in terms of optimizing an information theoretic quantity. This formal…
Proposes FMPCA for federated tensor data dimensionality reduction.
problem Integration of MPCA into federated learning.
method Federated Multilinear Principal Component Analysis (FMPCA).
result FMPCA preserves performance of traditional MPCA in federated learning.
Paper proposes ARPHMM for fault detection and prognosis in aero-engines.
problem Fault detection and prognosis in aero-engines using sensor data.
method Autoregressive Partially-hidden Markov Model (ARPHMM) with prior knowledge integration.
result Model estimates remaining useful life and degradation level.
Deep learning models (aka Deep Neural Networks) have revolutionized many fields including computer vision, natural language processing, speech recognition, and is being increasingly used in clinical healthcare applications. However, few works exist which have benchmarked the performance of the deep learning models with…
We investigate the effect of the proportional hazards assumption on prognostic and predictive models of the survival time of patients suffering from amyotrophic lateral sclerosis (ALS). We theoretically compare the underlying model formulations of several variants of survival forests and implementations thereof, includ…
Transfer learning improves machine learning models for equipment diagnostics.
problem Limited model performance due to training data mismatch.
method Transfer learning to reuse knowledge from similar tasks.
result Transfer learning enhances model applicability in PHM.
Deep learning predicts AMD progression from longitudinal fundus images.
problem Predicting future stages of age-related macular degeneration (AMD).
method InceptionV3 feature vectors, interval scaling, Recurrent Neural Network.
result 0.878 sensitivity, 0.887 specificity, 0.950 AUC.
In this paper we propose network methodology to infer prognostic cancer biomarkers based on the epigenetic pattern DNA methylation. Epigenetic processes such as DNA methylation reflect environmental risk factors, and are increasingly recognised for their fundamental role in diseases such as cancer. DNA methylation is a…
This paper studies an intelligent ultimate technique for health-monitoring and prognostic of common rotary machine components, particularly bearings. During a run-to-failure experiment, rich unsupervised features from vibration sensory data are extracted by a trained sparse auto-encoder. Then, the correlation of the ex…
Paper presents a data preprocessing method for PHM models.
problem Lack of consistent data preprocessing for PHM applications.
method Comprehensive pipeline for sensor data preprocessing.
result Creation of clean data sets for training machinery health state classifiers.
This research improves asset life prediction by integrating deep learning with mixture distributions.
problem Predicting residual useful life for assets with multiple failure modes.
method Integrates mixture (log)-location-scale distribution with deep learning.
result Proposed models outperform existing methods in predicting residual useful life.
Machine learning improves trial analysis precision by adjusting for prognostic variables.
problem Improving precision in randomized trial analyses using covariate adjustment.
method Targeted machine learning estimation (TMLE) with adaptive pre-specification.
result Maximized empirical efficiency through cross-validated variance minimization.
The health state assessment and remaining useful life (RUL) estimation play very important roles in prognostics and health management (PHM), owing to their abilities to reduce the maintenance and improve the safety of machines or equipment. However, they generally suffer from this problem of lacking prior knowledge to …
We analyse an issue when comparing survival curves between two subgroups. We show that there is a direct relationship between estimates of subgroups' survival at a time point and positive and negative predictive values in the binary classification settings. Our findings present a case where current methods of comparing…
Clinical prognostic models derived from largescale healthcare data can inform critical diagnostic and therapeutic decisions. To enable off-theshelf usage of machine learning (ML) in prognostic research, we developed AUTOPROGNOSIS: a system for automating the design of predictive modeling pipelines tailored for clinical…
DARTS optimizes covariate selection in trials with limited data.
problem Limited budget for high-dimensional pretreatment data.
method Dynamic Adaptive Rerandomization via Thompson Sampling (DARTS).
result DARTS efficiently concentrates budget on informative features.
Data-driven fault diagnostics and prognostics suffers from class-imbalance problem in industrial systems and it raises challenges to common machine learning algorithms as it becomes difficult to learn the features of the minority class samples. Synthetic oversampling methods are commonly used to tackle these problems b…
Intact-VAE estimates treatment effects with latent confounders.
problem Estimating treatment effects under unobserved confounding.
method Intact-VAE, a VAE variant, models latent confounders to identify treatment effects.
result Intact-VAE is a consistent estimator of treatment effects under certain settings.
A framework uses preprocessing to improve psychiatric questionnaire predictions while maintaining interpretability.
problem Weak predictive accuracy and limited interpretability of psychiatric questionnaires.
method Two-stage method: stable preprocessing followed by a linear mapping.
result REFINE outperforms other interpretable approaches in psychiatric and non-psychiatric prediction tasks.
Framework predicts remaining useful life of DSH subsystems under unknown failure modes.
problem Predicting remaining useful life of DSH subsystems with unknown failure modes.
method Unsupervised framework using mixture of Gaussian regressions and Expectation-Maximization algorithm.
result Improved prediction accuracy and interpretability of RUL.
Deep object detection improves mitotic nucleus detection in breast cancer biopsies.
problem Challenges in automated mitotic nucleus detection in breast cancer histopathological images.
method Adapted Mask R-CNN for deep object detection, initially selects candidate regions with maximum recall, refines them with multi-object loss function.
result Improved discrimination ability (F-score of 0.86) and significant precision (0.86) for mitotic nuclei compared to two-stage models.
Performance metrics (error measures) are vital components of the evaluation frameworks in various fields. The intention of this study was to overview of a variety of performance metrics and approaches to their classification. The main goal of the study was to develop a typology that will help to improve our knowledge a…
Study identifies biomarkers for lung cancer in female non-smokers.
problem Identifying prognostic biomarkers for stage III NSCLC in non-smoking females.
method Gene expression profiling and XGBoost machine learning algorithm.
result Top biomarkers validated in literature, with AUC score of 0.835.
Study developed phenotypes for ICU patients' brain dysfunction states.
problem Underdiagnosis of acute brain dysfunction in ICU patients.
method Created algorithms to quantify and cluster brain dysfunction states.
result Developed three phenotypes of ICU patients' brain dysfunction states.
Prognostics or Remaining Useful Life (RUL) Estimation from multi-sensor time series data is useful to enable condition-based maintenance and ensure high operational availability of equipment. We propose a novel deep learning based approach for Prognostics with Uncertainty Quantification that is useful in scenarios wher…
This study evaluates uncertainty quantification methods for deep learning in predictive maintenance.
problem Uncertainty quantification for reliable decision-making in predictive maintenance.
method State-of-the-art variational inference algorithms for Bayesian neural networks (BNN), Monte Carlo Dropout (MCD), deep ensembles (DE), and heteroscedastic neural networks (HNN) were tested.
result No method clearly outperforms others in all situations, but DE and MCD provide more conservative uncertainty estimates.
Deep learning has shown remarkable results for image analysis and is expected to aid individual treatment decisions in health care. To achieve this, deep learning methods need to be promoted from the level of mere associations to being able to answer causal questions. We present a scenario with real-world medical image…