We describe an application of machine learning to the problem of predicting preterm birth. We conduct a secondary analysis on a clinical trial dataset collected by the National In- stitute of Child Health and Human Development (NICHD) while focusing our attention on predicting different classes of preterm birth. We com…
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48 results for “preterm birth”
Preterm births occur at an alarming rate of 10-15%. Preemies have a higher risk of infant mortality, developmental retardation and long-term disabilities. Predicting preterm birth is difficult, even for the most experienced clinicians. The most well-designed clinical study thus far reaches a modest sensitivity of 18.2-…
Preterm birth is the most common cause of neonatal death. Current diagnostic methods that assess the risk of preterm birth involve the collection of maternal characteristics and transvaginal ultrasound imaging conducted in the first and second trimester of pregnancy. Analysis of the ultrasound data is based on visual i…
Study shows over-sampling biases prediction results on imbalanced datasets.
problem Over-optimistic prediction results on imbalanced data.
method Applying over-sampling before partitioning training and testing sets.
result Over-sampling causes biased results and reduces predictive performance.
In this paper we are interested in the prediction of preterm birth based on diagnosis codes from longitudinal EHR. We formulate the prediction problem as a supervised classification with noisy labels. Our base classifier is a Recurrent Neural Network with an attention mechanism. We assume the availability of a data sub…
A Semi-Markov Chain Approach to Modeling Respiratory Patterns Prior to Extubation in Preterm Infantseess.SP
After birth, extremely preterm infants often require specialized respiratory management in the form of invasive mechanical ventilation (IMV). Protracted IMV is associated with detrimental outcomes and morbidities. Premature extubation, on the other hand, would necessitate reintubation which is risky, technically challe…
Extremely preterm infants commonly require intubation and invasive mechanical ventilation after birth. While the duration of mechanical ventilation should be minimized in order to avoid complications, extubation failure is associated with increases in morbidities and mortality. As part of a prospective observational st…
Improved preterm prediction using synthetic EHG signals.
problem Prediction bias towards term labor in preterm EHG data.
method Quantifying synthetic samples' effect, optimizing feature weights, and combining activation functions.
result Substantial improvement in prediction precision.
New methods estimate causal effects through mediators, handling confounding without strict assumptions.
problem Estimating causal effects through mediators while accounting for unmeasured confounding.
method Developed four nonparametric identification strategies using proximal confounding bridge functions, efficient influence function, and quadruply robust estimator. Proposed proximal debiased machine learning approach for high-dimensional nuisance parameters.
result Achieved -consistency and asymptotic normality for path-specific effect estimation.
Study introduces a new method to estimate causal mediation with multiple mediators.
problem Estimating causal effects with multiple mediators and confounders.
method Simulates potential outcomes using parametric and nonparametric models.
result General approach to estimating various causal mediation quantities.
Recent works have shown that applying Machine Learning to Electronic Health Records (EHR) can strongly accelerate precision medicine. This requires developing models based on diverse EHR sources. Federated Learning (FL) has enabled predictive modeling using distributed training which lifted the need of sharing data and…
Extremely preterm infants often require endotracheal intubation and mechanical ventilation during the first days of life. Due to the detrimental effects of prolonged invasive mechanical ventilation (IMV), clinicians aim to extubate infants as soon as they deem them ready. Unfortunately, existing strategies for predicti…
We propose a general method to obtain approximation of the first passage time distribution for the birth-death processes. We rely on the general properties of birth-death processes, Keilson's theorem and the concept of Riemann sum to obtain closed-form expressions. We apply the method to the three selected birth-death …
Preterm newborns undergo various stresses that may materialize as learning problems at school-age. Sleep staging of the Electroencephalogram (EEG), followed by prediction of their brain-age from these sleep states can quantify deviations from normal brain development early (when compared to the known age). Current auto…
Study birth-death dynamics for sampling Gibbs measures with nonconvex potentials.
problem Sampling Gibbs measures with nonconvex potentials.
method Birth-death dynamics, Kullback-Leibler divergence, divergence, kernel-based approximations, -convergence of gradient flows.
result Probability density converges exponentially fast to Gibbs equilibrium measure with a universal rate.
Bessel-like birth-death processphysics.soc-ph
We consider models of the population or opinion dynamics which result in the non-linear stochastic differential equations (SDEs) exhibiting the spurious long-range memory. In this context, the correspondence between the description of the birth-death processes as the continuous-time Markov chains and the continuous SDE…
Study estimates personalized effects of maternal PM2.5 exposure on birth weight.
problem Identify critical windows and heterogeneity in maternal PM2.5 exposure effects on birth weight.
method Heterogeneous Distributed Lag Models and Bayesian Additive Regression Trees.
result Evidence of heterogeneity in PM2.5-birth weight relationship, with some dyads showing 3x larger decrease.
Near a birth-death critical point in a one-parameter family of gradient flows, there are precisely two Morse critical points of index difference one on the birth side. This paper gives a self-contained proof of the folklore theorem that these two critical points are joined by a unique gradient trajectory up to time-shi…
A fundamental problem in Bayesian inference and statistical machine learning is to efficiently sample from multimodal distributions. Due to metastability, multimodal distributions are difficult to sample using standard Markov chain Monte Carlo methods. We propose a new sampling algorithm based on a birth-death mechanis…
New method uses birth-death process and exploration component to accelerate sampling from multimodal distributions.
problem Sampling from multimodal probability distributions efficiently.
method Combines birth-death process and exploration component to accelerate sampling.
result Proves exponential asymptotic convergence under mild assumptions.
Bayesian networks (BNs) are graphical models that are useful for representing high-dimensional probability distributions. There has been a great deal of interest in recent years in the NP-hard problem of learning the structure of a BN from observed data. Typically, one assigns a score to various structures and the sear…
FS&P uses birth-death process to ensure global convergence of stochastic conic particle gradient descent.
problem Global optimization of non-convex objective functions over measure space.
method Introduces Fast Spawn\&Prune (FS\&P) combining CPGD with birth-death process.
result First theoretical guarantee of global convergence for discrete-time stochastic algorithms.
Fair quantile regressionmath.ST
Quantile regression is a tool for learning conditional distributions. In this paper we study quantile regression in the setting where a protected attribute is unavailable when fitting the model. This can lead to "unfair'' quantile estimators for which the effective quantiles are very different for the subpopulations de…
Reinforcement Learning in a Birth and Death Process: Breaking the Dependence on the State Spacecs.LG
New RL algorithm reduces regret in birth-death queueing problems.
problem Efficiency of reinforcement learning in MDPs with large state spaces.
method Modified Ucrl2 algorithm exploiting birth-death structure.
result Regret bound of independent of state space size.
We consider probabilistic programming for birth-death models of evolution and introduce a new widely-applicable inference method that combines an extension of the alive particle filter (APF) with automatic Rao-Blackwellization via delayed sampling. Birth-death models of evolution are an important family of phylogenetic…
Classifies and analyzes the stability of black hole event horizon birth points using contact geometry.
problem Classifying and understanding the structural possibilities of black hole crease sets.
method Contact geometry approach, focusing on BigFronts and their Legendrian projections.
result Refined stability discussion of the event horizon birth component and identification of additional components.
Every year, 3 million newborns die within the first month of life. Birth asphyxia and other breathing-related conditions are a leading cause of mortality during the neonatal phase. Current diagnostic methods are too sophisticated in terms of equipment, required expertise, and general logistics. Consequently, early dete…
Decision trees are flexible models that are well suited for many statistical regression problems. In a Bayesian framework for regression trees, Markov Chain Monte Carlo (MCMC) search algorithms are required to generate samples of tree models according to their posterior probabilities. The critical component of such an …
Paper disproves conjecture about log-Sobolev constants.
problem Log-Sobolev constants and curvature bounds.
method Counterexample on birth-death chains.
result Conjecture about Ollivier curvature is incorrect.
Paper uses AI to improve medical diagnosis accuracy.
problem Improving accuracy of medical diagnoses.
method Heuristic frequentist and Bayesian approaches applied to a nationwide dataset.
result Algorithm outperforms human doctors in detecting abnormal births.
New metrics and coordinates for barcode space using group theory.
problem Describing and measuring the space of barcodes.
method Geometric group theory applied to barcodes.
result Stratification of barcode space into regions with similar statistical properties.
The Infant Mortality Rate (IMR) is the number of infants per 1000 that do not survive until their first birthday. It is an important metric providing information about infant health but it also measures the society's general health status. Despite the high level of prosperity in the U.S.A., the country's IMR is higher …
Paper proposes scalable method for analyzing multi-omic data.
problem Integrating high-dimensional multi-omic data for cancer subtyping.
method Mixed graphical model approach using Birth-Death MCMC algorithm.
result Our method outperforms LASSO and standard BDMCMC in computational efficiency and model selection accuracy.
Neural networks with a large number of parameters admit a mean-field description, which has recently served as a theoretical explanation for the favorable training properties of "overparameterized" models. In this regime, gradient descent obeys a deterministic partial differential equation (PDE) that converges to a glo…
In this paper, we study curvature dimension conditions on birth-death processes which correspond to linear graphs, i.e., weighted graphs supported on the infinite line or the half line. We give a combinatorial characterization of Bakry and Émery's condition for linear graphs and prove the triviality of edge w…
Recent advances in Reinforcement Learning, grounded on combining classical theoretical results with Deep Learning paradigm, led to breakthroughs in many artificial intelligence tasks and gave birth to Deep Reinforcement Learning (DRL) as a field of research. In this work latest DRL algorithms are reviewed with a focus …
Paper introduces a Bayesian nonparametric approach for tracking multiple objects with spawning events.
problem Tracking multiple objects with birth and death events (spawning).
method Bayesian nonparametric approach with MCMC sampling for unknown number of objects.
result Advantages of nonparametric modeling for scenarios with spawning events.
Topic models have proven to be a useful tool for discovering latent structures in document collections. However, most document collections often come as temporal streams and thus several aspects of the latent structure such as the number of topics, the topics' distribution and popularity are time-evolving. Several mode…
Thirty years after the birth of foliations in the 1950's, André Haefliger has introduced a special property satisfied by holonomy pseudogroups of foliations on compact manifolds, called compact generation. Up to now, this is the only general property known about holonomy on compact manifolds. In this article, we give a…
Enhances early risk assessments for pediatric outcomes using contrastive learning.
problem Improving risk assessments in early stages of pediatric development.
method Contrastive multi-modal framework that treats each time window as a distinct modality, training on all available data.
result Consistent improvements in early-stage risk assessments validated on real-world tasks.
Explains the history and challenges of minimal surfaces.
problem Understanding the regularity of minimal surfaces.
method Historical overview and technical analysis.
result Outlines the evolution and current state of minimal surfaces.
Kernel methods identify treatment effects with unobserved confounding using negative controls.
problem Learning causal relationships with unmeasured confounding.
method Kernel ridge regression algorithms for nonparametric treatment effects.
result Uniform consistency and finite sample rates of convergence proved.
This is a survey article on recent progress of comparison geometry and geometric analysis on Finsler manifolds of weighted Ricci curvature bounded below. Our purpose is two-fold: Give a concise and geometric review on the birth of weighted Ricci curvature and its applications; Explain recent results from a nonlinear an…
Flow Matching for Count Datastat.ML
Flow Matching for count data improves sample quality and efficiency.
problem Mapping between count distributions across batches or time points in high-dimensional count data.
method count-FM, a flow-matching framework based on a continuous-time birth-death process with local unit jumps.
result count-FM achieves better sample quality than representative baselines while using fewer parameters.
Bayesian method estimates QTEs from observational data.
problem Estimating nuanced characteristics of counterfactual distributions.
method Bayesian semiparametric conditional distribution regression model with double balancing score.
result Proposed method provides more accurate QTE estimates than other methods.
The surgery technique of Gromov and Lawson may be used to construct families of positive scalar curvature metrics which are parameterised by Morse functions. This has played an important role in the study of the space of metrics of positive scalar curvature on a smooth manifold and its corresponding moduli spaces. In t…
We propose a new Bayesian tracking and parameter learning algorithm for non-linear non-Gaussian multiple target tracking (MTT) models. We design a Markov chain Monte Carlo (MCMC) algorithm to sample from the posterior distribution of the target states, birth and death times, and association of observations to targets, …
Understanding human fetal neurodevelopment is of great clinical importance as abnormal development is linked to adverse neuropsychiatric outcomes after birth. Recent advances in functional Magnetic Resonance Imaging (fMRI) have provided new insight into development of the human brain before birth, but these studies hav…