Maintaining good cardiac function for as long as possible is a major concern for healthcare systems worldwide and there is much interest in learning more about the impact of different risk factors on cardiac health. The aim of this study is to analyze the impact of systolic blood pressure (SBP) on cardiac function whil…
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48 results for “preserved cardiac function”
Causal Analysis of the TOPCAT Trial: Spironolactone for Preserved Cardiac Function Heart Failurestat.ML
Causal analysis reveals regional discrepancies in TOPCAT trial results.
problem Inconclusive results in TOPCAT trial for heart failure treatment.
method Causal discovery methods with domain knowledge integration.
result Significant causal effects shown for some subgroups globally.
The exploitation of large-scale population data has the potential to improve healthcare by discovering and understanding patterns and trends within this data. To enable high throughput analysis of cardiac imaging data automatically, a pipeline should comprise quality monitoring of the input images, segmentation of the …
We propose a hybrid controllable image generation method to synthesize anatomically meaningful 3D+t labeled Cardiac Magnetic Resonance (CMR) images. Our hybrid method takes the mechanistic 4D eXtended CArdiac Torso (XCAT) heart model as the anatomical ground truth and synthesizes CMR images via a data-driven Generative…
Cardiac motion modeling using LDDMM and shape splines.
problem Difficulties in probing cardiac function due to shape and deformation interactions.
method LDDMM framework, parallel transport, normalization, shape splines.
result Significant differences in model parameters between pathologies, revealing insights into disease dynamics.
Study finds AI can predict diverse cardiac and non-cardiac diagnoses from a single ECG.
problem Narrow focus of ECG analysis models for diverse medical conditions.
method Exploratory study using a single AI model to predict multiple ICD codes.
result Model achieved AUROC scores > 0.8 for 253 cardiac and 172 non-cardiac diagnoses.
CardiacGen generates realistic ECG signals for training deep learning models.
problem Creating realistic synthetic ECG signals for training deep learning models.
method Hierarchical deep generative model with multi-objective loss functions.
result Synthetic ECG signals from CardiacGen can be used for data augmentation and improve classifier performance.
Method identifies cardiac ectopic activity sites from 12-lead ECG.
problem Locate dangerous ectopic activation sites in the heart.
method Bayesian optimization on cardiac model and ECG data.
result Method converges to minimum after 11.7-3.5 iterations.
Radiomics identifies subtle cardiac changes in hypertension.
problem Subtle cardiac alterations in hypertension not captured by conventional imaging.
method Combines feature selection and machine learning for identifying structural and tissue changes.
result Radiomics model detects changes beyond conventional imaging.
Background: Cardiac MRI derived biventricular mass and function parameters, such as end-systolic volume (ESV), end-diastolic volume (EDV), ejection fraction (EF), stroke volume (SV), and ventricular mass (VM) are clinically well established. Image segmentation can be challenging and time-consuming, due to the complex a…
In this work, a novel approach is proposed for joint analysis of high dimensional time-resolved cardiac motion features obtained from segmented cardiac MRI and low dimensional clinical risk factors to improve survival prediction in heart failure. Different methods are evaluated to find the optimal way to insert convent…
Large prospective epidemiological studies acquire cardiovascular magnetic resonance (CMR) images for pre-symptomatic populations and follow these over time. To support this approach, fully automatic large-scale 3D analysis is essential. In this work, we propose a novel deep neural network using both CMR images and pati…
Novel framework monitors cardiac image segmentation models in real-time.
problem Ensuring continuous high model performance and segmentation results in clinics.
method Formulated as anomaly detection, the framework derives surrogate quality measures for segmentation.
result Demonstrated accurate, fast, and scalable quality control monitoring.
We propose a method to classify cardiac pathology based on a novel approach to extract image derived features to characterize the shape and motion of the heart. An original semi-supervised learning procedure, which makes efficient use of a large amount of non-segmented images and a small amount of images segmented manu…
hyperSBINN improves drug cardiosafety assessment by efficiently modeling cardiac action potentials.
problem Complexity and limited data in modeling cardiac effects of drugs.
method Combining meta-learning with SBINNs to solve parameterized cardiac action potential models.
result hyperSBINN outperforms traditional solvers in speed and accuracy for predicting APD90 values.
The segmentation of the left ventricle (LV) from CINE MRI images is essential to infer important clinical parameters. Typically, machine learning algorithms for automated LV segmentation use annotated contours from only two cardiac phases, diastole, and systole. In this work, we present an analysis work-flow for fully-…
SoQal uses selective oracle questioning to improve active learning of cardiac signals.
problem Active learning of cardiac signals is challenging due to limited labelled data and high annotation costs.
method Proposes a framework combining selective oracle questioning and Bayesian active learning by consistency.
result SoQal outperforms baseline methods in active learning of cardiac signals, even with noisy oracles.
Novel method embeds generative model into Bayesian optimization for HD cardiac model parameter estimation.
problem High-dimensional optimization of patient-specific cardiac model parameters with limited data.
method Embeds a generative variational auto-encoder into the objective function of Bayesian optimization.
result Improves accuracy of parameter estimation with more than 10x gain in efficiency.
Researchers use operator learning to predict cardiac activation and repolarization times.
problem Computational demands and need for clear, interpretable information in cardiac electrophysiology.
method Exploiting Fourier Neural Operators (FNO) and Kernel Operator Learning (KOL) to learn operator mappings.
result Both FNO and KOL approaches are computationally efficient and robust to hyperparameters.
Model-based free-breathing cardiac MRI reconstruction using deep learned \& STORM priors: MoDL-STORMcs.LG
We introduce a model-based reconstruction framework with deep learned (DL) and smoothness regularization on manifolds (STORM) priors to recover free breathing and ungated (FBU) cardiac MRI from highly undersampled measurements. The DL priors enable us to exploit the local correlations, while the STORM prior enables us …
We train an enhanced deep convolutional neural network in order to identify eight cardiac abnormalities from the standard 12-lead electrocardiograms (ECGs) using the dataset of 14000 ECGs. Instead of straightforwardly applying an end-to-end deep learning approach, we find that deep convolutional neural networks enhance…
CardiacNET: Segmentation of Left Atrium and Proximal Pulmonary Veins from MRI Using Multi-View CNNcs.CV
Anatomical and biophysical modeling of left atrium (LA) and proximal pulmonary veins (PPVs) is important for clinical management of several cardiac diseases. Magnetic resonance imaging (MRI) allows qualitative assessment of LA and PPVs through visualization. However, there is a strong need for an advanced image segment…
This study benchmarks algorithms for automatic segmentation of LGE-MRI images of the left atrium.
problem Challenging segmentation of LGE-MRI images due to low contrast.
method Organized a large-scale benchmarking challenge with 154 3D LGE-MRIs and 27 teams.
result Top method achieved 93.2% dice score and 0.7 mm mean surface to surface distance.
This study benchmarks changepoint detection algorithms on cardiac time series data.
problem Identifying state changes in cardiac time series for disease classification.
method Comparison of 8 changepoint detection algorithms on artificial and real cardiac time series data.
result RMDM algorithm achieved highest true positive rate and cross validated accuracy for classification.
Echocardiography (echo) is a common means of evaluating cardiac conditions. Due to the label scarcity, semi-supervised paradigms in automated echo analysis are getting traction. One of the most sought-after problems in echo is the segmentation of cardiac structures (e.g. chambers). Accordingly, we propose an echocardio…
Performing inference over simulators is generally intractable as their runtime means we cannot compute a marginal likelihood. We develop a likelihood-free inference method to infer parameters for a cardiac simulator, which replicates electrical flow through the heart to the body surface. We improve the fit of a state-o…
We review some of the latest approaches to analysing cardiac electrophysiology data using machine learning and predictive modelling. Cardiac arrhythmias, particularly atrial fibrillation, are a major global healthcare challenge. Treatment is often through catheter ablation, which involves the targeted localized destruc…
CLOCS uses contrastive learning to improve cardiac signal representations.
problem Lack of labelled data in cardiac signal analysis.
method Contrastive learning across space, time, and patients.
result CLOCS outperforms state-of-the-art methods and achieves strong generalization.
Cardiac Arrhythmia Detection from ECG Combining Convolutional and Long Short-Term Memory Networkseess.SP
Objectives: Atrial fibrillation (AF) is a common heart rhythm disorder associated with deadly and debilitating consequences including heart failure, stroke, poor mental health, reduced quality of life and death. Having an automatic system that diagnoses various types of cardiac arrhythmias would assist cardiologists to…
Recent introduction of wearable single-lead ECG devices of diverse configurations has caught the intrigue of the medical community. While these devices provide a highly affordable support tool for the caregivers for continuous monitoring and to detect acute conditions, such as arrhythmia, their utility for cardiac diag…
Framework for imputing missing heart data to simulate brain-heart interactions.
problem Lack of multi-modal patient data representing heart and brain processes.
method Probabilistic framework for joint cardiac data imputation and mechanistic model personalization.
result Accurate imputation of missing cardiac features in incomplete datasets.
This paper is an attempt to separate cardiac and respiratory signals from an electrical bio-impedance (EBI) dataset. For this two well-known algorithms, namely Principal Component Analysis (PCA) and Independent Component Analysis (ICA), were used to accomplish the task. The ability of the PCA and the ICA methods first …
The FitzHugh-Nagumo equation provides a simple mathematical model of cardiac tissue as an excitable medium hosting spiral wave vortices. Here we present extensive numerical simulations studying long-term dynamics of knotted vortex string solutions for all torus knots up to crossing number 11. We demonstrate that FitzHu…
Cardiovascular disease (CVD) is the global leading cause of death. A strong risk factor for CVD events is the amount of coronary artery calcium (CAC). To meet demands of the increasing interest in quantification of CAC, i.e. coronary calcium scoring, especially as an unrequested finding for screening and research, auto…
In cardiac magnetic resonance imaging, fully-automatic segmentation of the heart enables precise structural and functional measurements to be taken, e.g. from short-axis MR images of the left-ventricle. In this work we propose a recurrent fully-convolutional network (RFCN) that learns image representations from the ful…
DRUM transfers cardiac arrest models across registries with missing covariates.
problem Clinical prediction models fail when key training covariates are unavailable at deployment.
method DRUM transfers models to target populations with structurally missing covariates, optimizing worst-case predictive performance over unknown target distributions.
result DRUM yields better-calibrated predictions and improved clinical classification performance across sites.
LU-Net improves cardiac segmentation accuracy and robustness.
problem Robustness and accuracy of deep learning cardiac segmentation.
method Multi-task end-to-end network designed to improve cardiac segmentation.
result Outperforms current best deep learning solution, reducing outliers and improving clinical indices.
Planning the optimal time of intervention for pulmonary valve replacement surgery in patients with the congenital heart disease Tetralogy of Fallot (TOF) is mainly based on ventricular volume and function according to current guidelines. Both of these two biomarkers are most reliably assessed by segmentation of 3D card…
In vivo diffusion tensor imaging (DTI) is a promising technique to investigate noninvasively the fiber structures of the in vivo human heart. However, signal loss due to motions remains a persistent problem in in vivo cardiac DTI. We propose a novel motion-compensation method for investigating in vivo myocardium struct…
This paper improves parameter estimation in cardiac models using Gaussian process-based MH sampling.
problem Uncertainty in estimating patient-specific model parameters from sparse and noisy clinical data.
method Integrates surrogate modeling into Metropolis-Hastings sampling to improve computational efficiency and accuracy.
result Significant gain in computational efficiency without compromising accuracy, and insights into tissue heterogeneity.
Intricating cardiac complexities are the primary factor associated with healthcare costs and the highest cause of death rate in the world. However, preventive measures like the early detection of cardiac anomalies can prevent severe cardiovascular arrests of varying complexities and can impose a substantial impact on h…
Manual segmentation of the Left Ventricle (LV) is a tedious and meticulous task that can vary depending on the patient, the Magnetic Resonance Images (MRI) cuts and the experts. Still today, we consider manual delineation done by experts as being the ground truth for cardiac diagnosticians. Thus, we are reviewing the p…
Study creates a multimodal learning framework for CVD risk prediction.
problem Predicting cardiovascular disease risk in diverse populations.
method Combines cross modal transformers, graph neural networks, and causal representation learning.
result Model predicts personalized CVD risk with causal invariance across subpopulations.
Compact neural network for ECG classification reduces resource needs.
problem Current reliance on deep learning for ECG analysis requires extensive resources and large datasets.
method Simple ANN architecture with advanced feature engineering.
result Achieved 97.36% accuracy in classifying 4 types of arrhythmias.
Personalization of cardiac models involves the optimization of organ tissue properties that vary spatially over the non-Euclidean geometry model of the heart. To represent the high-dimensional (HD) unknown of tissue properties, most existing works rely on a low-dimensional (LD) partitioning of the geometrical model. Wh…
Recent years have witnessed widespread adoption of machine learning (ML)/deep learning (DL) techniques due to their superior performance for a variety of healthcare applications ranging from the prediction of cardiac arrest from one-dimensional heart signals to computer-aided diagnosis (CADx) using multi-dimensional me…
Motion analysis is used in computer vision to understand the behaviour of moving objects in sequences of images. Optimising the interpretation of dynamic biological systems requires accurate and precise motion tracking as well as efficient representations of high-dimensional motion trajectories so that these can be use…
Online Graph Topology Learning via Time-Vertex Adaptive Filters: From Theory to Cardiac Fibrillationeess.SP
AdaCGP learns dynamic graph topology from time series data, improving over existing methods.
problem Learning dynamic graph topology from time-varying signals, especially in real-time applications.
method AdaCGP is a sparsity-aware adaptive algorithm that recursively estimates the Graph Shift Operator (GSO) through variable splitting.
result AdaCGP outperforms state-of-the-art methods in GSO estimation, achieving improvements exceeding 83%.