Detects physiological patterns to hemodynamic stress using unsupervised deep learning.
problem Identify and characterize physiological responses to hemorrhage in raw vital sign data.
method Transform vital sign time series into latent space using unsupervised deep learning, identify clusters, and evaluate latent embeddings.
result Clusters in latent embeddings correspond to physiological response patterns matching physicians' intuition.
Motivation: Cell-biological processes are regulated through a complex network of interactions between genes and their products. The processes, their activating conditions, and the associated transcriptional responses are often unknown. Organism-wide modeling of network activation can reveal unique and shared mechanisms…
Objective: Predict individual septic children's personalized physiologic responses to vasoactive titrations by training a Recurrent Neural Network (RNN) using EMR data. Materials and Methods: This study retrospectively analyzed EMR of patients admitted to a pediatric ICU from 2009 to 2017. Data included charted time se…
Multi-output Gaussian processes (GPs) are a flexible Bayesian nonparametric framework that has proven useful in jointly modeling the physiological states of patients in medical time series data. However, capturing the short-term effects of drugs and therapeutic interventions on patient physiological state remains chall…
In this paper, we present an experimental study for the classification of perceived human stress using non-invasive physiological signals. These include electroencephalography (EEG), galvanic skin response (GSR), and photoplethysmography (PPG). We conducted experiments consisting of steps including data acquisition, fe…
Characterizing the dynamic interactive patterns of complex systems helps gain in-depth understanding of how components interrelate with each other while performing certain functions as a whole. In this study, we present a novel multimodal data fusion approach to construct a complex network, which models the interaction…
The relation between performance and stress is described by the Yerkes-Dodson Law but varies significantly between individuals. This paper describes a method for determining the individual optimal performance as a function of physiological signals. The method is based on attention and reasoning tests of increasing comp…
Bayesian model detects internal bleeding in ICU patients.
problem Late detection of internal bleeding in ICU patients.
method Bayesian regime switching model analyzing vitals and labs.
result Probabilistic assessment of patient's physiological state.
Affective states have a critical role in driving performance and safety. They can degrade driver situation awareness and negatively impact cognitive processes, severely diminishing road safety. Therefore, detecting and assessing drivers' affective states is crucial in order to help improve the driving experience, and i…
Time series models such as dynamical systems are frequently fitted to a cohort of data, ignoring variation between individual entities such as patients. In this paper we show how these models can be personalised to an individual level while retaining statistical power, via use of multi-task learning (MTL). To our knowl…
The measurement and analysis of Electrodermal Activity (EDA) offers applications in diverse areas ranging from market research, to seizure detection, to human stress analysis. Unfortunately, the analysis of EDA signals is made difficult by the superposition of numerous components which can obscure the signal informatio…
New method estimates effects of multiple nutrients on blood glucose.
problem Estimating physiological response to multiple nutrient treatments.
method Convolution-based multi-output Gaussian process model.
result Improved prediction accuracy and better interpretation of individual nutrient effects.
Advances of modern sensing and sequencing technologies generate a deluge of high dimensional space-temporal physiological and next-generation sequencing (NGS) data. Physiological traits are observed either as continuous random functions, or on a dense grid and referred to as function-valued traits. Both physiological a…
Late fusion of clinical notes and physiological data improves ICU mortality prediction.
problem Improving ICU mortality prediction using multimodal data.
method Late fusion of clinical notes and physiological time series data with a deep learning architecture.
result Late fusion approach provides statistically significant improvement in mortality prediction performance.
Model improves emotion recognition using multiple physiological signals.
problem Single physiological signal is insufficient for accurate emotion recognition.
method Fused multiple modal physiological signals (EEG, EMG, EOG) for emotion classification.
result Best classification accuracy of 94.42% on arousal and 94.02% on valence in two-class tasks.
Paper models treatment effects by clustering patients with distinct survival characteristics.
problem Estimating treatment efficacy in clinical settings with censored outcomes.
method Latent variable approach to model heterogeneous treatment effects.
result The latent structure can mediate base survival rates and reveal actionable phenotypes.
Model explains optical illusions using geometric sub-Riemannian geodesics.
problem Understanding and explaining geometrical optical illusions.
method Neuro-mathematical model based on sub-Riemannian geodesics in the Roto-Translation Group.
result Illusory contours are described as geodesics in a new metric.
Due to physiological variation, patients diagnosed with the same condition may exhibit divergent, but related, responses to the same treatments. Hidden Parameter Markov Decision Processes (HiP-MDPs) tackle this transfer-learning problem by embedding these tasks into a low-dimensional space. However, the original formul…
PULSE learns representations from physiological time series.
problem Lack of effective pretraining objectives for physiological time series.
method Proposes a pretraining framework exploiting dynamical systems generative model.
result PULSE learns representations that distinguish semantic classes and improve transfer learning.
Hybrid Amortized Inference improves PPG model interpretability.
problem Tension between PPG biomarker accuracy and clinical interpretability.
method Introduces PPGen for biophysical PPG signal-physiological parameter relation, and HAI for fast, robust estimation.
result Hybrid Amortized Inference accurately infers physiological parameters from PPG signals.
Adversarial transfer learning improves stress assessment across users.
problem Transfer learning challenges in physiological biosignals.
method Disentangled nuisance-robust representations using adversarial networks.
result Adversarial framework enhances cross-subjects stress assessment.
PHASE predicts surgical complications from physiological signals.
problem Predicting adverse surgical outcomes from physiological signals.
method Self-supervised transfer learning for physiological signals.
result PHASE outperforms other approaches in predicting five surgical complications.
This paper addresses the problem of emotion recognition from physiological signals. Features are extracted and ranked based on their effect on classification accuracy. Different classifiers are compared. The inter-subject variability and the personalization effect are thoroughly investigated, through trial-based and su…
CLOPS improves deep learning for continuous physiological data.
problem Deep learning struggles with streaming, multi-sensor clinical data.
method CLOPS is a replay-based continual learning strategy.
result CLOPS outperforms state-of-the-art methods in continual learning scenarios.
Proposes a framework for extracting consistent physiological features across users.
problem Variability of biosignals across different users and tasks.
method Adversarial feature extractor for disentangled universal representations.
result Up to 8.8% improvement in average accuracy of classification.
Sepsis is a poorly understood and potentially life-threatening complication that can occur as a result of infection. Early detection and treatment improves patient outcomes, and as such it poses an important challenge in medicine. In this work, we develop a flexible classifier that leverages streaming lab results, vita…
UNHaP removes noise from physiological events using Hawkes processes.
problem Challenges in identifying true events from spurious ones in physiological signal analysis.
method UNHaP uses marked Hawkes processes to distinguish and unmix true events from noise.
result UNHaP significantly reduces false detection rates and enhances event understanding.
PerCDL learns personalized dictionaries for physiological signals combining global and local structures.
problem Representing datasets with both global and local structures in human physiological signals.
method Personalized Convolutional Dictionary Learning (PerCDL) that combines a global and personalized local dictionary.
result PerCDL effectively learns interpretable representations for human locomotion data.
Computational analysis on physiological signals would provide immense impact for enabling automated clinical analytics. However, the class imbalance issue where negative or minority class instances are rare in number impairs the robustness of the practical solution. The key idea of our approach is intelligent augmentat…
Plants sense their environment by producing electrical signals which in essence represent changes in underlying physiological processes. These electrical signals, when monitored, show both stochastic and deterministic dynamics. In this paper, we compute 11 statistical features from the raw non-stationary plant electric…
We developed a new approach for the analysis of physiological time series. An iterative convolution filter is used to decompose the time series into various components. Statistics of these components are extracted as features to characterize the mechanisms underlying the time series. Motivated by the studies that show …
Plants monitor their surrounding environment and control their physiological functions by producing an electrical response. We recorded electrical signals from different plants by exposing them to Sodium Chloride (NaCl), Ozone (O3) and Sulfuric Acid (H2SO4) under laboratory conditions. After applying pre-processing tec…
Noninvasive reconstruction of cardiac transmembrane potential (TMP) from surface electrocardiograms (ECG) involves an ill-posed inverse problem. Model-constrained regularization is powerful for incorporating rich physiological knowledge about spatiotemporal TMP dynamics. These models are controlled by high-dimensional …
Aim: To review how machine learning (ML) is applied to imaging biomarkers in neuro-oncology, in particular for diagnosis, prognosis, and treatment response monitoring. Materials and Methods: The PubMed and MEDLINE databases were searched for articles published before September 2018 using relevant search terms. The sear…
CardiacGen generates realistic ECG signals for training deep learning models.
problem Creating realistic synthetic ECG signals for training deep learning models.
method Hierarchical deep generative model with multi-objective loss functions.
result Synthetic ECG signals from CardiacGen can be used for data augmentation and improve classifier performance.
Algorithm selects optimal segment for physiological signal analysis.
problem Physiological signals are often corrupted by noise, requiring selective analysis.
method Combines deep neural networks for signal analysis and combinatorial optimization for segment selection.
result Significant improvement in system performance, e.g. 2.4% increase in sensitivity for heart sound segmentation.
UniPhyNet improves cognitive load classification accuracy using EEG, ECG, and EDA signals.
problem Classifying cognitive load using multimodal physiological data.
method Unified network architecture integrating multiscale parallel convolutional blocks, ResNet-type blocks, and channel block attention module. Uses bidirectional gated recurrent unit for temporal dependencies.
result Improves raw signal classification accuracy from 70% to 80% (binary) and 62% to 74% (ternary) on CL-Drive dataset.
New model predicts blood glucose in diabetics with improved accuracy.
problem Forecasting blood glucose in type 1 diabetics with high accuracy.
method Integrates machine learning with existing biomedical model to capture time-varying dynamics.
result Improved long-term forecasting of blood glucose up to 6 hours.
This paper investigates the use of distributed processing on the problem of emotion recognition from physiological sensors using a popular machine learning library on distributed mode. Specifically, we run a random forests classifier on the biosignal-data, which have been pre-processed to form exclusive groups in an un…
PhysioMTL learns personalized HRV rhythms from wearable data, improving prediction and counterfactual analysis.
problem Challenges in interpreting HRV measurements due to variability and stressors.
method PhysioMTL combines Optimal Transport and MTL to learn personalized diurnal rhythms from heterogeneous data.
result PhysioMTL outperforms other methods in predicting unseen subjects and generating counterfactual effects.
Study explores DNNs' reliance on existing vs. new features in physiological signals.
problem Understanding how deep neural networks discover new features in physiological signals.
method Proposes a method to remove hand-engineered features and force DNNs to learn new representations.
result DNNs often rediscover known features, but can also learn new ones.
Falls prevention, especially in older people, becomes an increasingly important topic in the times of aging societies. In this work, we present Gated Recurrent Unit-based neural networks models designed for predicting falls (syncope). The cardiovascular systems signals used in the study come from Gravitational Physiolo…
Functional brain networks exhibit dynamics on the sub-second temporal scale and are often assumed to embody the physiological substrate of cognitive processes. Here we analyse the temporal and spatial dynamics of these states, as measured by EEG, with a hidden Markov model and compare this approach to classical EEG mic…
Paper identifies resting positions using EGG, ECG, respiration rate, and SpO2.
problem Identifying the resting position for health monitoring.
method Hybrid stacked ensemble machine learning model combining Decision tree, Random Forest, and Xgboost.
result 100% accurate prediction of resting positions.
A neuron is a basic physiological and computational unit of the brain. While much is known about the physiological properties of a neuron, its computational role is poorly understood. Here we propose to view a neuron as a signal processing device that represents the incoming streaming data matrix as a sparse vector of …
Personalized stress model using transfer learning from 20 participants.
problem Limited generalizability of machine learning models due to individual physiological differences.
method Transfer learning from a base model trained on 20 participants' physiological data collected in real-time.
result Improved model personalization and cross-domain performance.
DecompKAN improves time series forecasting accuracy and transparency.
problem Accurate and transparent time series forecasting in scientific domains.
method Combines decomposition, patching, normalization, and B-spline KAN edge functions.
result Achieves best or tied-best MSE on 20 of 36 comparisons across 9 datasets.
Energy consumption is an important issue in continuous wireless telemonitoring of physiological signals. Compressed sensing (CS) is a promising framework to address it, due to its energy-efficient data compression procedure. However, most CS algorithms have difficulty in data recovery due to non-sparsity characteristic…