POSL predicts dynamic convection volumes in hemodiafiltration patients.
problem Continuous, personalised predictions in personalised medicine.
method Adapted POSL to dynamically predict convection volumes using combinations of parametric regressions and machine learning.
result POSL outperformed candidate learners in predicting convection volumes with lower errors and better calibration.
Users of a personalised recommendation system face a dilemma: recommendations can be improved by learning from data, but only if the other users are willing to share their private information. Good personalised predictions are vitally important in precision medicine, but genomic information on which the predictions are…
Causal ML methods failed to validate their personalized treatment effects in two large trials.
problem Validating causal machine learning methods for personalized treatment effects in precision medicine.
method Assessed 17 mainstream causal heterogeneity ML methods using two large randomized controlled trials.
result None of the ML methods reliably validated their performance, internal or external, showing significant discrepancies between training and test data.
Paper tackles federated learning with personalised bandit algorithms.
problem Optimizing local and global objectives in a heterogeneous environment.
method Surrogate objective function combining client preferences and global knowledge; phase-based elimination algorithm.
result Achieves sublinear regret with logarithmic communication overhead.
Antibodies are a critical part of the immune system, having the function of directly neutralising or tagging undesirable objects (the antigens) for future destruction. Being able to predict which amino acids belong to the paratope, the region on the antibody which binds to the antigen, can facilitate antibody design an…
Proposes FedPop for personalised federated learning with uncertainty quantification.
problem Uncertainty quantification and client drift in personalised federated learning.
method FedPop recasts FL into population modeling with Markov chain Monte Carlo methods.
result Non-asymptotic convergence guarantees for uncertainty quantification.
Personalized stress model using transfer learning from 20 participants.
problem Limited generalizability of machine learning models due to individual physiological differences.
method Transfer learning from a base model trained on 20 participants' physiological data collected in real-time.
result Improved model personalization and cross-domain performance.
Study proposes BFEL framework for privacy-preserving FL in personalized healthcare.
problem Privacy and security concerns in traditional cloud-centric ML, especially in wearable devices.
method Develops a blockchain-enhanced federated edge learning (BFEL) framework based on FedCurv, incorporating fisher information matrix and public key encryption.
result Significant reduction in communication cost and high efficiency for federated training on non-iid and heterogeneous data.
The distribution of absorbed dose in radionuclide therapy with Lu177 can be approximated by convolving an image of the time-integrated activity distribution with a dose voxel kernel representing different tissue types. This fast but inaccurate approximation is unsuitable for personalised dosimetry because it negle…
EduQG generates better educational questions by pre-training on scientific text.
problem Improving the quality of educational questions for scalable self-assessment.
method Adapting a large language model for educational question generation, pre-trained on scientific text.
result EduQG produces superior educational questions compared to baseline models.
In personalised decision making, evidence is required to determine whether an action (treatment) is suitable for an individual. Such evidence can be obtained by modelling treatment effect heterogeneity in subgroups. The existing interpretable modelling methods take a top-down approach to search for subgroups with heter…
MTFL improves UA and speeds convergence in personalised DNNs on edge devices.
problem Non-IID user data harms FL convergence and global UA is not always the goal.
method Introduces non-federated BN layers into federated DNNs for personalised training.
result MTFL reduces UA rounds by up to 5x and convergence time by up to 3x.
Today, despite decades of developments in medicine and the growing interest in precision healthcare, vast majority of diagnoses happen once patients begin to show noticeable signs of illness. Early indication and detection of diseases, however, can provide patients and carers with the chance of early intervention, bett…
Study reduces complexity and uncertainty in human atrial cell models.
problem Uncertainty in parameter estimates from gating kinetics models.
method Approximate Bayesian computation to re-calibrate models, investigate two approaches: more complete datasets and less complex formulations.
result Less complex model with fewer parameters gives better fit and lower uncertainty.
In this paper, we describe a solution to tackle a common set of challenges in e-commerce, which arise from the fact that new products are continually being added to the catalogue. The challenges involve properly personalising the customer experience, forecasting demand and planning the product range. We argue that the …
A framework for causal classification using uplift and causal heterogeneity methods.
problem Predicting the effect of interventions on different individuals from data.
method Causal classification framework using off-the-shelf supervised methods.
result Framework works for causal classification and uplift modelling, competitive with other methods.
Bayesian networks learn sub-population differences from data.
problem Inference from a single network structure can be misleading when data populations are heterogeneous.
method A mixture of Bayesian networks where component probabilities depend on individual characteristics.
result Identifies both network structures and demographic predictors of sub-population membership.
Aims to integrate AI and modelling for patient health forecasting.
problem Personalized, precise treatment plans for patients.
method Graph neural network (GNNs) and generative adversarial network (GANs) for probabilistic simulations.
result Demonstrated integration of molecular data for predicting physiological state evolution.
A framework for federated learning with heterogeneous data.
problem Federated learning with data from clients using different data representations.
method FLIC framework that maps client data into a common feature space via local embedding functions, learned federally using Wasserstein barycenters and trained locally via distribution alignment.
result FLIC outperforms FL benchmarks with heterogeneous input feature spaces.
Personalized medicine has become an important part of medicine, for instance predicting individual drug responses based on genomic information. However, many current statistical methods are not tailored to this task, because they overlook the individual heterogeneity of patients. In this paper, we look at personalized …
Bandit algorithms optimize treatment decisions for precision medicine.
problem Optimizing treatment decisions for individual patients based on genetic or molecular profiling.
method Contextual bandit algorithms that consider patient characteristics.
result Bandit algorithms are useful for mobile health and digital phenotyping.
Framework for imputing missing heart data to simulate brain-heart interactions.
problem Lack of multi-modal patient data representing heart and brain processes.
method Probabilistic framework for joint cardiac data imputation and mechanistic model personalization.
result Accurate imputation of missing cardiac features in incomplete datasets.
This paper reviews random forest methods for analyzing longitudinal data in precision medicine.
problem Analyzing longitudinal data for precision medicine.
method Extensions of random forest for longitudinal data analysis.
result Categorization of random forest methods for different data structures and repeated measurements.
Study improves engagement prediction in educational videos.
problem Addressing cold-start problem in educational recommenders.
method Introduced VLE dataset with content and engagement features, conducted experiments.
result VLE dataset leads to better engagement prediction models.
This paper considers the use of Machine Learning (ML) in medicine by focusing on the main problem that this computational approach has been aimed at solving or at least minimizing: uncertainty. To this aim, we point out how uncertainty is so ingrained in medicine that it biases also the representation of clinical pheno…
PTOPOFL uses topological descriptors to protect privacy in federated learning.
problem Privacy and data reconstruction attacks in federated learning.
method PTOPOFL replaces gradient communication with persistent homology feature vectors for privacy and topology-guided aggregation.
result PTOPOFL achieves higher AUC and reduces reconstruction risk compared to gradient sharing.
Time series models such as dynamical systems are frequently fitted to a cohort of data, ignoring variation between individual entities such as patients. In this paper we show how these models can be personalised to an individual level while retaining statistical power, via use of multi-task learning (MTL). To our knowl…
There is tremendous interest in precision medicine as a means to improve patient outcomes by tailoring treatment to individual characteristics. An individualized treatment rule formalizes precision medicine as a map from patient information to a recommended treatment. A treatment rule is defined to be optimal if it max…
Expands statistical background for knee osteoarthritis treatment models.
problem Developing optimal exercise and weight loss treatments for knee osteoarthritis.
method Precision medicine models and jackknife cross-validation method.
result Jackknife estimator provides consistent value function estimation.
AI-enabled precision medicine promises a transformational improvement in healthcare outcomes by enabling data-driven personalized diagnosis, prognosis, and treatment. However, the well-known "curse of dimensionality" and the clustered structure of biomedical data together interact to present a joint challenge in the hi…
Traditional medicine typically applies one-size-fits-all treatment for the entire patient population whereas precision medicine develops tailored treatment schemes for different patient subgroups. The fact that some factors may be more significant for a specific patient subgroup motivates clinicians and medical researc…
The paper advocates for interpretable, accountable, reproducible machine learning in medicine.
problem Black box models in medicine lack transparency and regulatory approval.
method Intrinsically interpretable modeling approaches and collaborative learning paradigms.
result Interpretable machine learning models can support clinical decisions and gain regulatory approval.
Private RL algorithm with privacy guarantees for personalized medicine decisions.
problem Privacy-preserving reinforcement learning for personalized medicine decisions.
method Developed a private optimism-based RL algorithm using joint differential privacy (JDP).
result Achieved strong PAC and regret bounds with a privacy guarantee.
Interactive explanations improve machine learning transparency.
problem Transparency of machine learning predictions for diverse stakeholders.
method Personalized counterfactual explanations and follow-up questions.
result Improved understanding of black-box systems through interactive explanations.
Recent exploration of optimal individualized decision rules (IDRs) for patients in precision medicine has attracted a lot of attention due to the heterogeneous responses of patients to different treatments. In the existing literature of precision medicine, an optimal IDR is defined as a decision function mapping from t…
Develops methods to learn optimal treatment regimes using causal tree methods.
problem Lack of methods for estimating treatment effects and handling complex patient data.
method Causal tree and causal forest methods for estimating heterogeneous treatment effects.
result Outperforms state-of-the-art baselines in cumulative regret and percentage of optimal decisions.
Proposes a federated transfer learning method to improve precision medicine models for underrepresented populations.
problem Underrepresentation of minorities in precision medicine research leads to underperforming risk prediction models.
method Two-way federated transfer learning strategy integrating diverse populations and healthcare institutions.
result Improves risk prediction models for underrepresented populations, reducing performance gaps.
AI could democratize education but risks inequality.
problem AI risks creating educational inequality.
method Speculation and posing questions on AI in education.
result AI could exacerbate educational inequality.
In this paper we present an early Apprenticeship Learning approach to mimic the behaviour of different players in a short adaption of the interactive fiction Anchorhead. Our motivation is the need to understand and simulate player behaviour to create systems to aid the design and personalisation of Interactive Narrativ…
AI enhances personalized drug development and decision-making in pharma.
problem Traditional drug development lacks personalized treatment plans.
method Application of AI in drug discovery, clinical trials, and post-marketing assessment.
result AI improves personalized medicine, optimizing health outcomes.
CAPITAL algorithm identifies optimal patient subgroups for better treatment.
problem Identify maximum number of patients benefiting from better treatment.
method Constrained Policy Tree Search (CAPITAL) algorithm to find optimal subgroup selection rule (SSR).
result Maximizes the number of patients with enhanced treatment effects.
Bayesian model clusters diverse 'omics data for disease subtyping.
problem Clustering diverse 'omics datasets conflates multiple structures.
method Multi-view Bayesian mixture model with semi-supervised learning.
result Identifies distinct clusters of patients for stratified medicine.
In medicine, visualizing chromosomes is important for medical diagnostics, drug development, and biomedical research. Unfortunately, chromosomes often overlap and it is necessary to identify and distinguish between the overlapping chromosomes. A segmentation solution that is fast and automated will enable scaling of co…
PDX studies help personalize cancer treatment.
problem Precision medicine in cancer treatment.
method Machine learning methods for estimating optimal ITRs from PDX data.
result Superlearner approach combining multiple ITRs improves personalized treatment recommendations.
The use of computational methods to evaluate aesthetics in photography has gained interest in recent years due to the popularization of convolutional neural networks and the availability of new annotated datasets. Most studies in this area have focused on designing models that do not take into account individual prefer…
ManifoldMind uses adaptive-curvature probabilistic spheres for trustworthy recommendations in semantic hierarchies.
problem Sparse and abstract recommendation domains where users explore diverse conceptual paths.
method Adaptive-curvature probabilistic spheres, soft multi-hop inference, and curvature-aware semantic kernel.
result Superior NDCG, calibration, and diversity compared to baselines on public benchmarks.
Study uses LLMs to create personalized treatment plans for rare gynecological tumors.
problem Suboptimal management and poor prognosis due to low incidence and heterogeneity of rare gynecological tumors.
method Developed a digital twin system using LLMs to integrate clinical and biomarker data.
result LLM-enabled digital twins efficiently model individual patient trajectories and identify potential treatment options.
In this paper, we propose a new deep feature selection method based on deep architecture. Our method uses stacked auto-encoders for feature representation in higher-level abstraction. We developed and applied a novel feature learning approach to a specific precision medicine problem, which focuses on assessing and prio…