Enhances early risk assessments for pediatric outcomes using contrastive learning.
problem Improving risk assessments in early stages of pediatric development.
method Contrastive multi-modal framework that treats each time window as a distinct modality, training on all available data.
result Consistent improvements in early-stage risk assessments validated on real-world tasks.
Our work focuses on the problem of predicting the transfer of pediatric patients from the general ward of a hospital to the pediatric intensive care unit. Using data collected over 5.5 years from the electronic health records of two medical facilities, we develop classifiers based on adaptive boosting and gradient tree…
Background: While machine learning (ML) models are rapidly emerging as promising screening tools in critical care medicine, the identification of homogeneous subphenotypes within populations with heterogeneous conditions such as pediatric sepsis may facilitate attainment of high-predictive performance of these prognost…
Survey of techniques for diagnosing pediatric sleep apnea from inexpensive data.
problem Diagnosing pediatric sleep apnea from limited and variable data.
method Exploratory data analysis using correlation networks, Mapper, SVD; supervised and unsupervised learning techniques.
result Analysis of various learning techniques applied to pediatric sleep apnea data.
New CNN architecture improves pediatric image segmentation by homogenizing pose and size.
problem Challenges in segmenting pediatric images due to pose and size heterogeneity.
method Spatial Transformer Network (STN) for pose and scale invariance, combined with UNet for segmentation.
result Improved pediatric segmentation, especially renal tumor delineation, with accelerated processing.
New method phenotypes sleep apnea patients using time series analysis.
problem Traditional diagnosis of sleep apnea is insufficient for capturing its multi-faceted outcomes.
method Fuzzy clustering in time and frequency domains, and persistent homology for topological analysis.
result Phenotyping patients improves understanding of sleep apnea.
Machine Learning (ML) is proving extremely beneficial in many healthcare applications. In pediatric oncology, retrospective studies that investigate the relationship between treatment and late adverse effects still rely on simple heuristics. To assess the effects of radiation therapy, treatment plans are typically simu…
Pediatric asthma is the most prevalent chronic childhood illness, afflicting about 6.2 million children in the United States. However, asthma could be better managed by identifying and avoiding triggers, educating about medications and proper disease management strategies. This research utilizes deep learning methodolo…
Viewing the trajectory of a patient as a dynamical system, a recurrent neural network was developed to learn the course of patient encounters in the Pediatric Intensive Care Unit (PICU) of a major tertiary care center. Data extracted from Electronic Medical Records (EMR) of about 12000 patients who were admitted to the…
Obstructive sleep apnea is a serious condition causing a litany of health problems especially in the pediatric population. However, this chronic condition can be treated if diagnosis is possible. The gold standard for diagnosis is an overnight sleep study, which is often unobtainable by many potentially suffering from …
The paper tackles distribution-free prediction intervals for multi-source data.
problem Challenges in achieving valid inferences due to distribution shifts and privacy concerns.
method Derives efficient influence functions, incorporates machine learning, and proposes data-adaptive strategies.
result Achieves parametric rates of convergence to nominal coverage probabilities for prediction intervals.
Bayesian model estimates ACT impact on pediatric AML survival.
problem Estimating ACT impact on survival in AML patients with treatment timing issues.
method Generative Bayesian semi-parametric model with Gamma Process priors.
result Posterior inference for ACT efficacy under dynamic rules.
Objective: Predict patient-specific vitals deemed medically acceptable for discharge from a pediatric intensive care unit (ICU). Design: The means of each patient's hr, sbp and dbp measurements between their medical and physical discharge from the ICU were computed as a proxy for their physiologically acceptable state …
A ML-based method reconstructs 3D organ doses from 2D radiographs for pediatric abdominal radiotherapy.
problem Reconstructing detailed 3D dose distributions for childhood cancer survivors using limited 2D radiographs.
method Surrogate-free ML approach using 142 abdominal planning CTs, 300 artificial plans, and evolutionary algorithm.
result Accurate 3D dose reconstructions with MAEs ≤ 1.7 Gy for edge organs, validated on independent dataset.
Objective: Predict individual septic children's personalized physiologic responses to vasoactive titrations by training a Recurrent Neural Network (RNN) using EMR data. Materials and Methods: This study retrospectively analyzed EMR of patients admitted to a pediatric ICU from 2009 to 2017. Data included charted time se…
HOLMES improves real-time model serving for ICU patients, balancing accuracy and speed.
problem Real-time model serving is crucial in ICU due to urgency and cost.
method Online model ensemble serving framework for healthcare applications.
result HOLMES achieves high accuracy and sub-second latency for model ensemble serving.
We demonstrate a simple strategy to cope with missing data in sequential inputs, addressing the task of multilabel classification of diagnoses given clinical time series. Collected from the pediatric intensive care unit (PICU) at Children's Hospital Los Angeles, our data consists of multivariate time series of observat…
Physical activity levels are an important predictor of cardiovascular health and increasingly being measured by sensors, like accelerometers. Accelerometers produce rich multivariate data that can inform important clinical decisions related to individual patients and public health. The CHAMPION study, a study of youth …
There is growing interest in applying machine learning methods to Electronic Medical Records (EMR). Across different institutions, however, EMR quality can vary widely. This work investigated the impact of this disparity on the performance of three advanced machine learning algorithms: logistic regression, multilayer p…
Kidney function evaluation using dynamic contrast-enhanced MRI (DCE-MRI) images could help in diagnosis and treatment of kidney diseases of children. Automatic segmentation of renal parenchyma is an important step in this process. In this paper, we propose a time and memory efficient fully automated segmentation method…
Paper simplifies balancing weights by relaxing outcome assumptions.
problem Estimating missing outcomes in a target population.
method Relaxes outcome assumptions to simplify balancing weights.
result Balancing weights can be simplified with convex loss and minimum worst-case bias.
Human brain development is rapid during infancy and early childhood. Many disease processes impair this development. Therefore, brain developmental age estimation (BDAE) is essential for all diseases affecting cognitive development. Brain magnetic resonance imaging (MRI) of infants shows brain growth and morphologic pa…
A method corrects bias in estimating a high-dimensional classification rule using auxiliary outcomes.
problem Bias in estimating a high-dimensional classification rule using only one outcome.
method Robust transfer learning approach combining MTL and calibration steps.
result Final estimator achieves lower error than using only the target outcome.
Proposes dynamic borrowing method for historical data in clinical trials.
problem Insufficient statistical power in rare and pediatric disease clinical trials.
method Dynamic borrowing method based on frequentist approach using similarity measures.
result Demonstrates usefulness of dynamic borrowing in reanalyzing clinical trial data.
Extends HMM to topological spaces for modeling complex data.
problem Modeling complex, continuous data in infinite-dimensional spaces.
method Use of Onsager-Machlup functional and Cameron-Martin space.
result Demonstrates versatility in identifying sleep states and snowfall patterns.
PO-Flow models potential and counterfactual outcomes for personalized treatment decisions.
problem Predicting individualized treatment effects from observational data.
method Continuous normalizing flow (CNF) framework for causal inference.
result Unified approach to potential outcome prediction, treatment effect estimation, and counterfactual prediction.
Fuses ITRs for primary and secondary outcomes to minimize harm.
problem Learn an ITR maximizing primary outcome while minimizing harm to secondary outcomes.
method Introduces fusion penalty to encourage similar recommendations for different outcomes. Two algorithms estimate the ITR using surrogate loss functions.
result Agreement rate between primary and secondary optimal ITRs converges faster than ignoring secondary outcomes.
Firms delay write-downs for adverse macroeconomic and industry outcomes but not for firm-specific issues.
problem Timeliness of write-downs for adverse macroeconomic and industry outcomes versus firm-specific issues.
method Comparative analysis of write-downs driven by macroeconomic and industry outcomes versus firm-specific outcomes.
result Firms delay write-downs for adverse macroeconomic and industry outcomes but not for firm-specific issues.
Reduces variance in noisy social outcomes to improve policy evaluation and optimization.
problem Improving access to opportunity through personalized treatment decisions.
method Data-driven dimensionality-reduction using reduced rank regression to denoise multiple outcomes.
result Improves estimation error in policy evaluation and optimization, including on real-world data.
The paper introduces metrics to rank potential outcomes for better decision-making.
problem Optimal action selection in uncertain situations using causal reasoning.
method Introducing two new metrics: probabilities of potential outcome ranking (PoR) and probability of achieving the best potential outcome (PoB). Establishing identification theorems and deriving bounds for these metrics, and presenting estimation methods.
result The estimators' finite-sample properties and their application to a real-world dataset are demonstrated.
Proposes a deep learning framework for estimating counterfactual outcomes.
problem Challenges in estimating individual outcomes under different treatments.
method Deep variational Bayesian framework integrating factual and similar subjects' outcomes.
result Rigorously integrates individual features and similar subjects' responses for counterfactual outcomes.
The study uses transfer learning to compare surgical outcomes across racial/ethnic subgroups.
problem Difficulty in comparing surgical outcomes due to racial/ethnic and geographic differences.
method Causal inference framework and transfer learning to incorporate data from multiple populations.
result Racial and ethnic differences in surgical outcomes are found, with non-Hispanic Black patients experiencing wide variability.
DEBIAS learns causal effects from psychiatric longitudinal data by optimizing outcome weights.
problem Causal inference challenges in psychiatric longitudinal data due to symptom heterogeneity and latent confounding.
method DEBIAS algorithm that optimizes outcome weights to maximize durable treatment effects and minimize confounding.
result DEBIAS consistently outperforms state-of-the-art methods in recovering causal effects for clinically interpretable composite outcomes.
New approach tackles decision-making under predictions that shape outcomes.
problem Challenges in learning optimal decision rules when predictions influence outcomes.
method Introduces performative omniprediction, a predictor that encodes optimal decision rules for multiple objectives.
result Efficient performative omnipredictors exist under a natural restriction of outcome performativity.
New method identifies proxies for causal effects on multiple outcomes.
problem Estimating causal effects in scenarios with multiple outcomes and treatments.
method Causal discovery method leveraging multiple outcomes as proxies for each treatment effect.
result Parallel studies of multiple outcomes can assist in causal identification.
Study uses surrogate data to improve treatment effect estimation with scarce outcome data.
problem Limited outcome data hinders estimating treatment effects.
method Uses abundant surrogate data to estimate treatment effects without stringent assumptions.
result Improves precision of treatment effect estimation.
The paper targets optimal interventions for long-term outcomes using imputed data and policy learning.
problem Maximizing long-term outcomes observed only in the future.
method Imputing missing long-term outcomes and using a doubly-robust approach for policy evaluation and optimization.
result The approach outperforms simple short-term proxies and achieves significant revenue impact over three years.
Bayesian optimization learns DM preferences for multi-outcome experiments.
problem Optimizing expensive experiments with unknown utility functions and multiple outcomes.
method Alternates preference learning and Bayesian optimization, using pairwise comparisons.
result Preference exploration strategies improve Bayesian optimization performance.
New method provides reliable probabilistic bounds for VUR detection.
problem Detect VUR in children without radiation exposure.
method Machine learning with probabilistic bounds for conditional probability.
result Guaranteed bounds contain well-calibrated probabilities.
There is tremendous interest in precision medicine as a means to improve patient outcomes by tailoring treatment to individual characteristics. An individualized treatment rule formalizes precision medicine as a map from patient information to a recommended treatment. A treatment rule is defined to be optimal if it max…
Discusses handling intercurrent events in clinical trials with time-to-event outcomes.
problem Handling intercurrent events in clinical trials with time-to-event outcomes.
method Defines estimands and six ICE handling strategies, including new competing-risk strategy.
result Novel methods for handling intercurrent events in clinical trials with time-to-event outcomes.
We study notions of fairness in decision-making systems when individuals have diverse preferences over the possible outcomes of the decisions. Our starting point is the seminal work of Dwork et al. which introduced a notion of individual fairness (IF): given a task-specific similarity metric, every pair of individuals …
Flow IV uses IVs to infer counterfactuals in complex models.
problem Identifying causal effects and counterfactual reasoning in nonseparable outcome models.
method Utilizes instrumental variables and normalizing flows to estimate and infer counterfactual outcomes.
result Identifies a method to make causal inferences from observed data in nonseparable models.
Study uses remotely sensed data to infer economic outcomes in experiments and quasi-experiments.
problem Imperfect measurement of economic outcomes by remotely sensed variables.
method Combines experimental and observational data to identify causal parameters, using satellite imagery and mobile phone activity.
result Developed a robust method for n^{-1/2} inference that does not restrict remotely sensed variable processing algorithms.
Two new estimators reduce costs and improve accuracy for EHR outcome prediction.
problem Sparse estimate distributions, high computational cost, and high sampling variance in EHR outcome prediction.
method Proposed SCOPE and REACH estimators that leverage next-token probability distributions.
result SCOPE and REACH match Monte Carlo accuracy with token reductions of 2.5-3.4 times and variance guarantees.
New method combines multiple data sources for optimal decision-making with limited outcomes.
problem Optimal decision-making with limited outcome data from multiple heterogeneous sources.
method Calibrated optimal decision-making method leveraging common intermediate outcomes.
result Proposed estimator of conditional mean outcome is asymptotically normal and more efficient.
Paper proposes a method to estimate counterfactual outcomes without a known SCM.
problem Estimating counterfactual outcomes without a known structural causal model.
method Introduces rank preservation assumption and a novel ideal loss for unbiased learning of counterfactual outcomes.
result The proposed method is effective and unbiased, as shown by theoretical analysis and experiments.
A new method removes biases in data integration by using surrogate control outcomes.
problem Data integration methods can be biased due to data-dependent processes.
method Post-integrated inference method using surrogate control outcomes to account for latent heterogeneity.
result The method provides consistent and efficient estimators under minimal assumptions and potential misspecifications.