Machine learning predicts patient recruitment for clinical trials.
problem Improving patient recruitment prediction for clinical trials.
method Machine learning methods applied to historical clinical trial data.
result Reduced prediction error compared to current industry standards.
Randomized Controlled Trials (RCTs) are the gold standard for comparing the effectiveness of a new treatment to the current one (the control). Most RCTs allocate the patients to the treatment group and the control group by uniform randomization. We show that this procedure can be highly sub-optimal (in terms of learnin…
Doctor2Vec learns doctor representations from EHRs for better clinical trial recruitment.
problem Identifying the right doctors for clinical trials based on EHR data and trial descriptions.
method Dynamic Memory Network with attention mechanism to learn doctor and trial representations.
result Improved performance by up to 8.7% in PR-AUC on real-world trials and EHR data.
C3T-Budget optimizes drug efficacy in dose-finding trials with budget and safety constraints.
problem Heterogeneous patient populations and budget constraints make dose-finding clinical trials challenging.
method Contextual constrained clinical trial algorithm that maximizes drug efficacy while learning subgroup responses.
result Demonstrates efficient budget usage and balanced learning-treatment trade-off in simulated trials.
Study automates detection of visitation disruptions in ICU patients.
problem Difficulty in detecting frequent visitation disruptions in ICU patients.
method Used DensePose R-CNN model to count people in video frames, analyzed disruptions and patient outcomes.
result Automated method detects visitation disruptions, impacts on pain and length of stay examined.
Syntax designs adaptive trials for subpopulations with potential benefits.
problem Identifying subpopulations with positive treatment effects in diverse patient populations.
method Adaptive patient recruitment and synthetic control estimation.
result Syntax outperforms conventional trial designs in identifying beneficial subpopulations.
SDF-Bayes finds safe drug combinations safely, balancing optimism and caution.
problem Finding safe drug combinations in clinical trials with multiple drugs and patient heterogeneity.
method SDF-Bayes uses Bayesian statistics to choose the most likely MTD while ensuring safety constraints.
result SDF-Bayes outperforms existing methods in both accuracy and safety for drug combination trials.
Background: Fluctuating hearing loss is characteristic of Meniere's Disease (MD) during acute episodes. However, no reliable audiometric hallmarks are available for counselling the hearing recovery possibility. Aims/Objectives: To find parameters for predicting MD hearing outcomes. Material and Methods: We applied mach…
Random shuffle method boosts HF dataset size 10-21 times.
problem Narrow dataset cardinality in HF clinical studies.
method Random shuffle method to enhance dataset size.
result Enhanced HF dataset size 10-21 times.
Turtle Score analyzes developer similarity to match high-performing candidates.
problem Finding suitable candidates for IT companies based on cultural fit.
method Examines employee performance data, applies machine learning for similarity analysis.
result Develops a model for recruiters to identify high-performing candidates.
Early prognosis of Alzheimer's dementia is hard. Mild cognitive impairment (MCI) typically precedes Alzheimer's dementia, yet only a fraction of MCI individuals will progress to dementia, even when screened using biomarkers. We propose here to identify a subset of individuals who share a common brain signature highly p…
Talent search and recommendation systems at LinkedIn strive to match the potential candidates to the hiring needs of a recruiter or a hiring manager expressed in terms of a search query or a job posting. Recent work in this domain has mainly focused on linear models, which do not take complex relationships between feat…
Test for quasi-independence in ordered time data.
problem Determining dependence beyond temporal ordering.
method Nonparametric statistical test considering infinite alternatives.
result Better power and computational efficiency compared to existing methods.
Ant colonies and boosting algorithms both reduce bias and variance through adaptive mechanisms.
problem Understanding the mathematical principles behind ensemble learning and ant colony behavior.
method Developed a formal mapping between AdaBoost's adaptive reweighting and ant recruitment dynamics.
result Proved that the fundamental theorem of weak learnability has a direct analog in colony decision-making.
Imagine a large firm with multiple departments that plans a large recruitment. Candidates arrive one-by-one, and for each candidate the firm decides, based on her data (CV, skills, experience, etc), whether to summon her for an interview. The firm wants to recruit the best candidates while minimizing the number of inte…
New private algorithm for sequential hypothesis testing with privacy and error rate guarantees.
problem Privacy protection in sequential hypothesis testing for sensitive data.
method Renyi differential privacy, Wald's Sequential Probability Ratio Test (SPRT).
result Private algorithm with strong privacy guarantees and theoretical performance analysis.
Proposes a framework for fairness in two-sided marketplaces.
problem Achieving fairness in two-sided marketplaces.
method Developed an end-to-end framework for fairness constraints from both sides of the marketplace, including dynamic aspects.
result Efficacy of the proposed framework demonstrated through simulations.
ADRL improves participant selection in MCS systems.
problem Designing a participant selection algorithm for different MCS systems with multiple goals.
method Auxiliary-task based deep reinforcement learning (ADRL) using transformers and pointer networks.
result ADRL outperforms other baselines in various MCS settings.
A new framework for adaptive behavior using reusable value profiles.
problem Adaptive behavior in changing environments requires switching among value-control regimes, but maintaining separate parameters for each situation is impractical.
method Introduces value profiles: reusable bundles of parameters assigned to hidden states, allowing for state-conditional strategy recruitment without independent parameters for each context.
result Profile-based models outperform simpler alternatives in probabilistic reversal learning, suggesting belief-dependent control of adaptive behavior.
Improved forecasting of suicide attempts using LSGPs for patients with little data.
problem Challenges in predicting suicide attempts due to their rarity and patient heterogeneity.
method Introduced Latent Similarity Gaussian Processes (LSGPs) to capture patient heterogeneity.
result LSGPs outperform baseline models, even without kernel-design, and offer new insights into patient similarity.
Efficiently fine-tunes patient-independent seizure detection models with tensor kernel machine.
problem Improving seizure detection accuracy for wearable devices.
method Transfer learning with tensor kernel machine using canonical polyadic decomposition.
result Patient fine-tuned model achieves high performance with smaller model size.
Personalized models explain TB treatment outcomes considering patient context.
problem Heterogeneity in TB treatment outcomes due to co-morbidities.
method Multi-task learning approach encoding patient context into personalized models.
result Identifies anemia, age of onset, and HIV as influential for treatment efficacy.
Simulates patient pathways to detect delayed rare disease diagnoses.
problem Delayed rare disease diagnoses in France, causing health system and patient harm.
method Probabilistic modelling of patient pathways to create an alert system.
result Alert system detects and refers wandering patients to CRMRs.
Bluetooth data predicts depression severity, showing 18.8% extra variance.
problem Predicting depressive symptom severity using Bluetooth data.
method Extracted 49 Bluetooth features from NBDC data, used linear mixed-effect and hierarchical Bayesian linear regression models.
result Hierarchical Bayesian model achieved best prediction metrics (R2=0.526, RMSE=3.891).
Model predicts wound and episode-level readmission risk and time to re-admit.
problem Identify patients at high risk of re-admission to prevent wound recurrences and reduce healthcare costs.
method Data-driven analysis of wound care and episode-level patient data.
result Model achieves high recall and precision for predicting re-admission risk and time.
Currently, approximately 30% of epileptic patients treated with antiepileptic drugs (AEDs) remain resistant to treatment (known as refractory patients). This project seeks to understand the underlying similarities in refractory patients vs. other epileptic patients, identify features contributing to drug resistance acr…
Over the past two decades, the notion of implicit bias has come to serve as an important component in our understanding of discrimination in activities such as hiring, promotion, and school admissions. Research on implicit bias posits that when people evaluate others -- for example, in a hiring context -- their unconsc…
Cluster analysis aims at separating patients into phenotypically heterogenous groups and defining therapeutically homogeneous patient subclasses. It is an important approach in data-driven disease classification and subtyping. Acute coronary syndrome (ACS) is a syndrome due to sudden decrease of coronary artery blood f…
The health outcomes of high-need patients can be substantially influenced by the degree of patient engagement in their own care. The role of care managers includes that of enrolling patients into care programs and keeping them sufficiently engaged in the program, so that patients can attain various goals. The attainmen…
System detects multiple patients' behaviors in real-time using mmWave radar and CNN.
problem Real-time patient behavior monitoring in hospitals.
method Used mmWave radar for tracking and collecting Doppler patterns. Created a three-layer CNN model for behavior classification.
result System achieved very good inference accuracy in predicting patient behaviors in real-time.
Deep learning model creates patient representations for scalable EHR-based stratification.
problem Challenges in summarizing and representing patient data from EHRs prevent scalable stratification analysis.
method Unsupervised framework based on deep learning (ConvAE) using word embeddings, CNNs, and autoencoders.
result ConvAE significantly outperformed baselines in clustering diverse patient cohorts, identifying clinically relevant subtypes.
Characterizing a patient's progression through stages of sepsis is critical for enabling risk stratification and adaptive, personalized treatment. However, commonly used sepsis diagnostic criteria fail to account for significant underlying heterogeneity, both between patients as well as over time in a single patient. W…
We develop a personalized real time risk scoring algorithm that provides timely and granular assessments for the clinical acuity of ward patients based on their (temporal) lab tests and vital signs. Heterogeneity of the patients population is captured via a hierarchical latent class model. The proposed algorithm aims t…
Longitudinal patient data has the potential to improve clinical risk stratification models for disease. However, chronic diseases that progress slowly over time are often heterogeneous in their clinical presentation. Patients may progress through disease stages at varying rates. This leads to pathophysiological misalig…
Over the last few decades, the player recruitment process in professional football has evolved into a multi-billion industry and has thus become of vital importance. To gain insights into the general level of their candidate reinforcements, many professional football clubs have access to extensive video footage and adv…
Bayesian methods improve group testing for identifying infected patients.
problem Identifying infected patients from group testing results with false positives.
method Bayesian inference and belief propagation algorithm, combined with expectation-maximization method.
result True-positive rate improved by considering credible intervals.
Paper predicts IVF pregnancy rates from basic patient info.
problem Predicting IVF pregnancy rates from patient characteristics.
method Clustering patients into groups, then SVM models for each group.
result Support vector machine models achieve best overall performance.
Model identifies key problems in HIV patients' records.
problem Complex and time-consuming task of identifying patient problems from electronic health records.
method Unsupervised phenotyping approach that jointly learns phenotypes from structured and unstructured data.
result Learned phenotypes and their relatedness are clinically valid and surpass existing methods.
Evaluating the clinical similarities between pairwise patients is a fundamental problem in healthcare informatics. A proper patient similarity measure enables various downstream applications, such as cohort study and treatment comparative effectiveness research. One major carrier for conducting patient similarity resea…
Study develops electronic phenotypes of ICU patient acuity.
problem Limited time for patient acuity assessments and imprecise clinical trajectory prediction.
method Developed electronic phenotypes using automated variable retrieval in electronic health records.
result Identified three phenotypes: persistently stable, persistently unstable, and transitioning from unstable to stable.
Deep learning clusters patient time-series data for better prognosis.
problem Clustering time-series data for patient phenotyping and prognosis.
method Deep predictive clustering with novel loss functions for future outcome distribution.
result Model achieves superior clustering performance and identifies meaningful patient subgroups.
Multi-output Gaussian processes (GPs) are a flexible Bayesian nonparametric framework that has proven useful in jointly modeling the physiological states of patients in medical time series data. However, capturing the short-term effects of drugs and therapeutic interventions on patient physiological state remains chall…
Over the past decades, both critical care and cancer care have improved substantially. Due to increased cancer-specific survival, we hypothesized that both the number of cancer patients admitted to the ICU and overall survival have increased since the millennium change. MIMIC-III, a freely accessible critical care data…
Machine learning detects NASH patients from medical claims data.
problem Detecting undiagnosed NASH patients for screening and management.
method Gradient-boosted decision trees trained on administrative medical claims data.
result Model precision for NASH detection is significantly higher than NASH incidence.
Many computational models were proposed to extract temporal patterns from clinical time series for each patient and among patient group for predictive healthcare. However, the common relations among patients (e.g., share the same doctor) were rarely considered. In this paper, we represent patients and clinicians relati…
The paper tracks patient recovery using graphs of joint movement data.
problem Tracking individual patient recovery trajectories in physical therapy.
method Bayesian learning of Random Geometric Graphs from joint movement data.
result Optimal exercise routines can be recommended based on patient recovery data.
Model predicts HU response for sickle cell patients.
problem Predicting which sickle cell patients will respond to Hydroxyurea.
method Developed Deep Artificial Neural Network models.
result 92.6% accuracy in predicting HbF response.
Enhances understanding of patient healthcare journeys using self-attention.
problem Capturing hidden dependencies in multi-level patient journey data.
method Proposes a multi-level self-attention network (MusaNet) for encoding patient journeys.
result MusaNet produces higher-quality representations than state-of-the-art methods.