System predicts respiratory failure up to 8 hours early.
problem Early detection of respiratory failure in ICU patients.
method Machine learning on ICU patient monitoring data.
result System outperforms traditional clinical decision-making.
On-device research index
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48 results for “patient failure”
Enhances patient failure prediction using dynamic survival models.
problem Lack of precise individual level prediction in conventional models.
method Developed counterfactual dynamic survival model (CDSM).
result Inflection point of estimated survival curves predicts patient failure time.
Survival Prediction of Heart Failure Patients using Stacked Ensemble Machine Learning Algorithmcs.LG
Study predicts heart failure patient survival using stacked ensemble ML.
problem Predicting survival of heart failure patients.
method Collect and analyze patient data, apply SMOTE, use K-Means, Fuzzy C-Means clustering, Random Forest, XGBoost, Decision Tree, and propose a stacked ensemble model.
result Supervised ML algorithms outperform unsupervised models, achieving high accuracy and F1 score.
Intensive care clinicians are presented with large quantities of patient information and measurements from a multitude of monitoring systems. The limited ability of humans to process such complex information hinders physicians to readily recognize and act on early signs of patient deterioration. We used machine learnin…
Cardiotoxicity related to cancer therapies has become a serious issue, diminishing cancer treatment outcomes and quality of life. Early detection of cancer patients at risk for cardiotoxicity before cardiotoxic treatments and providing preventive measures are potential solutions to improve cancer patients's quality of …
Proposes a framework for personalized treatment recommendations using observational data.
problem Estimating patient-level treatment effects from observational data.
method Integrates existing methods for learning patient-level causal models.
result Improves patient outcomes in heart failure patients with acute kidney injury.
Machine learning models fail due to concept and data drift during pandemic.
problem Machine learning models trained before the pandemic are unreliable during the pandemic.
method Detect and diagnose concept and data drift in models.
result Model resilience and robustness are crucial for future predictions.
Random shuffle method boosts HF dataset size 10-21 times.
problem Narrow dataset cardinality in HF clinical studies.
method Random shuffle method to enhance dataset size.
result Enhanced HF dataset size 10-21 times.
In this paper we present a Recurrent neural networks (RNN) based architecture that achieves an AUCROC of 0.9147 for predicting the onset of Congestive Heart Failure (CHF) 15 months in advance using a 12-month observation window on a large cohort of 216,394 patients. We believe this to be the largest study in CHF onset …
Bayesian model identifies health disparities in disease progression.
problem Health disparities bias disease progression models.
method Interpretable Bayesian model accounting for three disparities.
result Model identifies and corrects for health disparities.
Medical practitioners use survival models to explore and understand the relationships between patients' covariates (e.g. clinical and genetic features) and the effectiveness of various treatment options. Standard survival models like the linear Cox proportional hazards model require extensive feature engineering or pri…
Although timely sepsis diagnosis and prompt interventions in Intensive Care Unit (ICU) patients are associated with reduced mortality, early clinical recognition is frequently impeded by non-specific signs of infection and failure to detect signs of sepsis-induced organ dysfunction in a constellation of dynamically cha…
Phenotyping electronic health records (EHR) focuses on defining meaningful patient groups (e.g., heart failure group and diabetes group) and identifying the temporal evolution of patients in those groups. Tensor factorization has been an effective tool for phenotyping. Most of the existing works assume either a static …
Predicting MRI coil failures using time series classification.
problem Early detection of MRI hardware failures to prevent downtime.
method Training a statistical model on sequential image data features over time.
result LSTMs achieved an F-score of 86.43% and 98.33% accuracy in predicting coil damage.
Alzheimer's disease (AD) is the most common neurodegenerative disease in older people. Despite considerable efforts to find a cure for AD, there is a 99.6% failure rate of clinical trials for AD drugs, likely because AD patients cannot easily be identified at early stages. This project investigated machine learning app…
As machine learning (ML) models, trained on real-world datasets, become common practice, it is critical to measure and quantify their potential biases. In this paper, we focus on renal failure and compare a commonly used traditional risk score, Tangri, with a more powerful machine learning model, which has access to a …
Digital Adherence Technologies (DATs) are an increasingly popular method for verifying patient adherence to many medications. We analyze data from one city served by 99DOTS, a phone-call-based DAT deployed for Tuberculosis (TB) treatment in India where nearly 3 million people are afflicted with the disease each year. T…
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by a rapid motor decline, leading to respiratory failure and subsequently to death. In this context, researchers have sought for models to automatically predict disease progression to assisted ventilation in ALS patients. However, the clin…
Deep Survival Analysisstat.ML
The electronic health record (EHR) provides an unprecedented opportunity to build actionable tools to support physicians at the point of care. In this paper, we investigate survival analysis in the context of EHR data. We introduce deep survival analysis, a hierarchical generative approach to survival analysis. It depa…
Electronic health records (EHR) are increasingly being used for constructing disease risk prediction models. Feature engineering in EHR data however is challenging due to their highly dimensional and heterogeneous nature. Low-dimensional representations of EHR data can potentially mitigate these challenges. In this pap…
Febrile neutropenia (FN) has been associated with high mortality, especially among adults with cancer. Understanding the patient and provider level heterogeneity in FN hospital admissions has potential to inform personalized interventions focused on increasing survival of individuals with FN. We leverage machine learni…
An accurate model of a patient's individual survival distribution can help determine the appropriate treatment for terminal patients. Unfortunately, risk scores (e.g., from Cox Proportional Hazard models) do not provide survival probabilities, single-time probability models (e.g., the Gail model, predicting 5 year prob…
Schizophrenia, a mental disorder that is characterized by abnormal social behavior and failure to distinguish one's own thoughts and ideas from reality, has been associated with structural abnormalities in the architecture of functional brain networks. Using various methods from network analysis, we examine the effect …
Deep learning predicts heart failure readmission from clinical notes.
problem Predicting and preventing heart failure readmission.
method Convolutional Neural Networks (CNN) trained on clinical notes.
result Deep learning models outperform traditional machine learning methods in readmission prediction.
Traditional methods for assessing illness severity and predicting in-hospital mortality among critically ill patients require time-consuming, error-prone calculations using static variable thresholds. These methods do not capitalize on the emerging availability of streaming electronic health record data or capture time…
A new method boosts survival analysis by stratifying patients and removing noise covariates.
problem Weak detection of treatment differences in randomized clinical trials due to patient heterogeneity.
method 5-Step Stratified Testing and Amalgamation Routine (5-STAR) using elastic net Cox regression and conditional inference trees.
result The 5-STAR routine significantly improves power in detecting treatment effects compared to traditional methods.
Causal Explainability of Machine Learning in Heart Failure Prediction from Electronic Health Recordsstat.ML
The paper investigates causal relationships in heart failure prediction using machine learning.
problem Understanding the causal relationships between clinical variables and heart failure.
method Proposes a new computational framework for causal structure discovery (CSD) of mixed-type clinical variables for binary disease outcomes.
result Feature importance from nonlinear classifiers strongly correlates with causal strength of variables, but not differentiating cause and effect.
Characterization of a patient clinical phenotype is central to biomedical informatics. ICD codes, assigned to inpatient encounters by coders, is important for population health and cohort discovery when clinical information is limited. While ICD codes are assigned to patients by professionals trained and certified in c…
Many in-hospital mortality risk prediction scores dichotomize predictive variables to simplify the score calculation. However, hard thresholding in these additive stepwise scores of the form "add x points if variable v is above/below threshold t" may lead to critical failures. In this paper, we seek to develop risk pre…
Heart failure (HF) is one of the leading causes of hospital admissions in the US. Readmission within 30 days after a HF hospitalization is both a recognized indicator for disease progression and a source of considerable financial burden to the healthcare system. Consequently, the identification of patients at risk for …
New method uses probabilistic independence to discover disease signatures from medical records.
problem Insufficiently precise diagnosis of clinical disease leading to treatment failures.
method Unsupervised machine learning using probabilistic independence to disentangle disease patterns.
result Inferred 2000 clinical disease signatures from medical records, improving cancer prediction.
Machine learning improves kidney transplant outcomes prediction.
problem Improving prediction of kidney transplant success.
method Random forest machine learning model trained on kidney donor risk index data.
result Random forest predicted 2,148 more successful transplants than the risk index.
Generating datasets that "look like" given real ones is an interesting tasks for healthcare applications of ML and many other fields of science and engineering. In this paper we propose a new method of general application to binary datasets based on a method for learning the parameters of a latent variable moment that …
New method for discrete-time survival analysis with competing risks.
problem Discrete failure time data in survival analysis.
method Proposes a new estimation procedure for discrete-time survival analysis with competing events.
result Offers advantages over existing procedures and integrates regularized regression methods.
Machine learning approach to dynamic risk modeling of mortality in COVID-19: a UK Biobank studycs.LG
Study develops a dynamic risk model for COVID-19 mortality using UK Biobank data.
problem Developing tools to monitor high-risk patients during the COVID-19 pandemic.
method Data-driven random forest classification model using baseline characteristics and symptoms.
result Model predicts COVID-19 mortality with excellent performance (AUC: 0.91), identifying novel predictors.
We have recently seen many successful applications of recurrent neural networks (RNNs) on electronic medical records (EMRs), which contain histories of patients' diagnoses, medications, and other various events, in order to predict the current and future states of patients. Despite the strong performance of RNNs, it is…
Relaxed Parameter Sharing: Effectively Modeling Time-Varying Relationships in Clinical Time-Seriescs.LG
Recurrent neural networks (RNNs) are commonly applied to clinical time-series data with the goal of learning patient risk stratification models. Their effectiveness is due, in part, to their use of parameter sharing over time (i.e., cells are repeated hence the name recurrent). We hypothesize, however, that this trait …
Innovative game theory approach optimizes survival analysis metrics.
problem Survival analysis models trained with maximum likelihood do not directly optimize criteria like Brier score or Bernoulli log likelihood.
method Inverse-Weighted Survival Games: Construct objectives from re-weighted estimates featuring the other model, holding the latter fixed during training.
result Games optimize Brier score on simulations and real-world data.
Estimating Model Performance on External Samples from Their Limited Statistical Characteristicsstat.ML
Method estimates model performance on external samples from limited statistical characteristics.
problem Limited access to multiple datasets due to privacy and commercial restrictions.
method Search for weights that match external statistics and are closest to uniform, using model performance on weighted internal sample as an estimation.
result Estimated external performance is closer to actual performance than internal performance.
Stability in clinical prediction models is crucial for transferability between studies, yet has received little attention. The problem is paramount in high dimensional data which invites sparse models with feature selection capability. We introduce an effective method to stabilize sparse Cox model of time-to-events usi…
This paper identifies and addresses biases in medical imaging research.
problem Challenges in medical imaging research, including biases in datasets, methods, and evaluation metrics.
method Literature review and analysis of potential biases.
result Recommendations to counteract biases in future research.
Bayesian optimization improves classifier selection for acute infection and mortality.
problem Improving accuracy of acute infection and mortality prediction.
method Comparison of hyperparameter optimization methods (grid search, random sampling, Bayesian optimization).
result Bayesian optimization outperforms grid search or random sampling for in-hospital mortality classifiers.
Rational expectations as a tool for predicting failure of weighted k-out-of-n reliability systemsphysics.soc-ph
Economics tool predicts failure times in reliability systems.
problem Predicting optimal failure times in weighted k-out-of-n reliability systems with heterogeneous component failure.
method Using rational expectations to analyze and predict failure times in reliability systems with heterogeneous component failure.
result Different measures are optimal for predicting system failure depending on component failure distributions.
Bayesian Joint Model of Multi-Sensor and Failure Event Data for Multi-Mode Failure Predictionstat.ME
Unified model predicts multi-mode failure with multi-sensor data.
problem Independent failure mode and RUL prediction ignores inherent relationship.
method Hierarchical Bayesian framework with Cox model, Gaussian process, and multinomial distributions.
result Robust uncertainty quantification and accurate prediction of multi-mode failure.
Framework classifies machine learning failures into intentional and unintentional.
problem Understanding and preventing failures in machine learning systems.
method Developed a taxonomy of machine learning failure modes.
result Stakeholders found the framework useful for discussing machine learning failures.
PAGER detects failures in deep regression models using a new framework.
problem Detecting failures in deep regression models.
method PAGER uses a combination of epistemic uncertainty and manifold non-conformity scores.
result PAGER accurately characterizes and detects failures in deep regressors.
Improved forecasting of suicide attempts using LSGPs for patients with little data.
problem Challenges in predicting suicide attempts due to their rarity and patient heterogeneity.
method Introduced Latent Similarity Gaussian Processes (LSGPs) to capture patient heterogeneity.
result LSGPs outperform baseline models, even without kernel-design, and offer new insights into patient similarity.
Efficiently fine-tunes patient-independent seizure detection models with tensor kernel machine.
problem Improving seizure detection accuracy for wearable devices.
method Transfer learning with tensor kernel machine using canonical polyadic decomposition.
result Patient fine-tuned model achieves high performance with smaller model size.