Robust policies improve ICU transfer outcomes by predicting patient deterioration.
problem Higher mortality rates for unplanned ICU transfers.
method Markov Decision Process model to predict patient severity and optimize transfer policies.
result Robust policies are more aggressive in transferring patients than nominal policies, improving overall patient care.
Machine learning improves early detection of patient deterioration in Brazilian hospitals.
problem Challenges in recognizing clinical deterioration in hospital settings.
method Application of machine learning to analyze EHR data from multiple hospitals.
result Machine learning models outperformed traditional protocols by 25 percentage points in AUC.
Activity and motion analysis has the potential to be used as a diagnostic tool for mental disorders. However, to-date, little work has been performed in turning stratification measures of activity into useful symptom markers. The research presented in this thesis has focused on the identification of objective activity …
After admission to emergency department (ED), patients with critical illnesses are transferred to intensive care unit (ICU) due to unexpected clinical deterioration occurrence. Identifying such unplanned ICU transfers is urgently needed for medical physicians to achieve two-fold goals: improving critical care quality a…
Intensive care clinicians are presented with large quantities of patient information and measurements from a multitude of monitoring systems. The limited ability of humans to process such complex information hinders physicians to readily recognize and act on early signs of patient deterioration. We used machine learnin…
We develop a personalized real time risk scoring algorithm that provides timely and granular assessments for the clinical acuity of ward patients based on their (temporal) lab tests and vital signs. Heterogeneity of the patients population is captured via a hierarchical latent class model. The proposed algorithm aims t…
Critically ill patients in regular wards are vulnerable to unanticipated clinical dete- rioration which requires timely transfer to the intensive care unit (ICU). To allow for risk scoring and patient monitoring in such a setting, we develop a novel Semi- Markov Switching Linear Gaussian Model (SSLGM) for the inpatient…
Model predicts wound and episode-level readmission risk and time to re-admit.
problem Identify patients at high risk of re-admission to prevent wound recurrences and reduce healthcare costs.
method Data-driven analysis of wound care and episode-level patient data.
result Model achieves high recall and precision for predicting re-admission risk and time.
Objectives: Electronic health records (EHRs) are only a first step in capturing and utilizing health-related data - the challenge is turning that data into useful information. Furthermore, EHRs are increasingly likely to include data relating to patient outcomes, functionality such as clinical decision support, and gen…
Much work aims to explain a model's prediction on a static input. We consider explanations in a temporal setting where a stateful dynamical model produces a sequence of risk estimates given an input at each time step. When the estimated risk increases, the goal of the explanation is to attribute the increase to a few r…
The emergence of an ageing population is a significant public health concern. This has led to an increase in the number of people living with progressive neurodegenerative disorders like dementia. Consequently, the strain this is places on health and social care services means providing 24-hour monitoring is not sustai…
Novel framework identifies pump-specific deterioration rates using Bayesian hierarchical hazard modeling and causal discovery.
problem Challenges in asset management due to heterogeneous deterioration rates in pump equipment.
method Bayesian hierarchical hazard modeling with causal discovery, GPU-accelerated No-U-Turn Sampling (NUTS), and DirectLiNGAM.
result Identified striking heterogeneity in deterioration rates, with negative effects 400 times larger than positive effects.
New monitoring method detects ML risk models' performance changes in medical interventions.
problem Monitoring ML risk models in healthcare is complicated by confounding medical interventions.
method Developed a new score-based CUSUM monitoring procedure with dynamic control limits.
result Valid inference is possible if conditional exchangeability or time-constant selection bias hold.
Study develops a dynamic risk model for COVID-19 mortality using UK Biobank data.
problem Developing tools to monitor high-risk patients during the COVID-19 pandemic.
method Data-driven random forest classification model using baseline characteristics and symptoms.
result Model predicts COVID-19 mortality with excellent performance (AUC: 0.91), identifying novel predictors.
Simulation framework assesses ROI of chronic disease adherence and policy timing.
problem Uncertainty in ROI of adherence-enhancing interventions under heterogeneous patient behavior and socioeconomic variation.
method Simulation-based framework integrating disease progression, time-varying adherence, and policy timing.
result Early and adaptive interventions yield highest ROI, exceeding 20% under certain conditions.
The paper monitors model deterioration using uncertainty estimation.
problem Challenges in monitoring deployed machine learning models.
method Non-parametric bootstrapped uncertainty estimates and SHAP values.
result The approach detects model deterioration and uncertainty effectively.
Proposes a framework to explain KS deterioration in credit risk models.
problem Inconsistent and ad hoc diagnosis of KS decline in credit risk models.
method Counterfactual diagnostic framework attributing KS decline to sampling variability, portfolio composition, covariate shift, and residual deterioration.
result The proposed approach provides more interpretable and governance-relevant explanations than threshold-based review alone.
Proposes efficient algorithm for system-level I&M decisions under uncertainty.
problem Optimal management strategies for deteriorating civil engineering systems.
method Factored partially observable Markov decision process with Bayesian networks and DDMAC reinforcement learning.
result DDMAC policies offer substantial benefits over heuristic approaches in system-level cost optimization.
Accelerated gradient method's stability deteriorates exponentially with steps.
problem Algorithmic stability of Nesterov's accelerated gradient method.
method Analysis of two notions of algorithmic stability for Nesterov's accelerated gradient method.
result Stability of Nesterov's accelerated method deteriorates exponentially with the number of gradient steps.
Federated CTMC model estimates bridge deterioration hazards without sharing raw data.
problem Bridge inspection data privacy and cross-organizational data sharing constraints.
method Federated CTMC hazard model with local optimization and FedAvg aggregation.
result Federated model converges on global benchmark parameters without data transfer.
Random forest model predicts sewer pipe deterioration with high accuracy.
problem Challenges in predicting and scheduling sewer pipe inspections.
method Random forest classification model for sewer pipe condition prediction.
result Model achieved excellent AUC of 0.81 in a case study for City of LA.
Study optimizes inspection and monitoring of deteriorating structures using POMDPs.
problem Optimizing decision-making for deteriorating engineering systems with uncertain observations.
method Developed theoretical and computational foundations for Value of Information (VoI) and Value of Structural Health Monitoring (VoSHM) in POMDPs.
result POMDP policies inherently leverage VoI to guide optimal observational actions, improving long-term cost.
Study evaluates federated learning with differential privacy on MIMIC-III, improving model performance with careful parameter tuning.
problem Training machine learning models on privacy-sensitive data sets locked in healthcare facilities.
method Extensive evaluation of federated and differential privacy techniques on MIMIC-III dataset, analyzing various parameters.
result Careful parameter tuning is crucial for federated learning with differential privacy, especially for data distribution and communication strategies.
AI system predicts acute critical illness from EHRs with explainability.
problem Lack of clinical interpretability in AI predictions for acute critical illness.
method Developed an explainable AI early warning score (xAI-EWS) system.
result System provides clinicians with insights into EHR data explaining predictions.
Machine learning for healthcare often trains models on de-identified datasets with randomly-shifted calendar dates, ignoring the fact that data were generated under hospital operation practices that change over time. These changing practices induce definitive changes in observed data which confound evaluations which do…
Training on some out-of-distribution data improves generalization error before it deteriorates.
problem Generalization error improves with some out-of-distribution data but deteriorates with more.
method Synthetic datasets and deep networks on computer vision benchmarks.
result Non-monotonic trend in generalization error with OOD samples.
The U.S. water distribution system contains thousands of miles of pipes constructed from different materials, and of various sizes, and age. These pipes suffer from physical, environmental, structural and operational stresses, causing deterioration which eventually leads to their failure. Pipe deterioration results in …
Improved forecasting of suicide attempts using LSGPs for patients with little data.
problem Challenges in predicting suicide attempts due to their rarity and patient heterogeneity.
method Introduced Latent Similarity Gaussian Processes (LSGPs) to capture patient heterogeneity.
result LSGPs outperform baseline models, even without kernel-design, and offer new insights into patient similarity.
Efficiently fine-tunes patient-independent seizure detection models with tensor kernel machine.
problem Improving seizure detection accuracy for wearable devices.
method Transfer learning with tensor kernel machine using canonical polyadic decomposition.
result Patient fine-tuned model achieves high performance with smaller model size.
The Lasso is a computationally efficient regression regularization procedure that can produce sparse estimators when the number of predictors (p) is large. Oracle inequalities provide probability loss bounds for the Lasso estimator at a deterministic choice of the regularization parameter. These bounds tend to zero if …
Personalized models explain TB treatment outcomes considering patient context.
problem Heterogeneity in TB treatment outcomes due to co-morbidities.
method Multi-task learning approach encoding patient context into personalized models.
result Identifies anemia, age of onset, and HIV as influential for treatment efficacy.
Simulates patient pathways to detect delayed rare disease diagnoses.
problem Delayed rare disease diagnoses in France, causing health system and patient harm.
method Probabilistic modelling of patient pathways to create an alert system.
result Alert system detects and refers wandering patients to CRMRs.
Currently, approximately 30% of epileptic patients treated with antiepileptic drugs (AEDs) remain resistant to treatment (known as refractory patients). This project seeks to understand the underlying similarities in refractory patients vs. other epileptic patients, identify features contributing to drug resistance acr…
Cluster analysis aims at separating patients into phenotypically heterogenous groups and defining therapeutically homogeneous patient subclasses. It is an important approach in data-driven disease classification and subtyping. Acute coronary syndrome (ACS) is a syndrome due to sudden decrease of coronary artery blood f…
The health outcomes of high-need patients can be substantially influenced by the degree of patient engagement in their own care. The role of care managers includes that of enrolling patients into care programs and keeping them sufficiently engaged in the program, so that patients can attain various goals. The attainmen…
The paper develops a method to predict the latent deterioration phase in limit order books before stress is observed.
problem Limit order books can transition rapidly from stable to stressed conditions, making it difficult to detect the latent deterioration phase.
method The paper formalizes a three-regime causal data-generating process and proposes a trigger-based detector combining MAX aggregation of complementary signal channels, a rising-edge condition, and adaptive thresholding.
result The proposed method achieves mean lead-time of +18.6 timesteps with perfect precision and moderate coverage, outperforming classical change-point and microstructure baselines.
System detects multiple patients' behaviors in real-time using mmWave radar and CNN.
problem Real-time patient behavior monitoring in hospitals.
method Used mmWave radar for tracking and collecting Doppler patterns. Created a three-layer CNN model for behavior classification.
result System achieved very good inference accuracy in predicting patient behaviors in real-time.
Deep learning model creates patient representations for scalable EHR-based stratification.
problem Challenges in summarizing and representing patient data from EHRs prevent scalable stratification analysis.
method Unsupervised framework based on deep learning (ConvAE) using word embeddings, CNNs, and autoencoders.
result ConvAE significantly outperformed baselines in clustering diverse patient cohorts, identifying clinically relevant subtypes.
Characterizing a patient's progression through stages of sepsis is critical for enabling risk stratification and adaptive, personalized treatment. However, commonly used sepsis diagnostic criteria fail to account for significant underlying heterogeneity, both between patients as well as over time in a single patient. W…
Longitudinal patient data has the potential to improve clinical risk stratification models for disease. However, chronic diseases that progress slowly over time are often heterogeneous in their clinical presentation. Patients may progress through disease stages at varying rates. This leads to pathophysiological misalig…
Study automates detection of visitation disruptions in ICU patients.
problem Difficulty in detecting frequent visitation disruptions in ICU patients.
method Used DensePose R-CNN model to count people in video frames, analyzed disruptions and patient outcomes.
result Automated method detects visitation disruptions, impacts on pain and length of stay examined.
Bayesian methods improve group testing for identifying infected patients.
problem Identifying infected patients from group testing results with false positives.
method Bayesian inference and belief propagation algorithm, combined with expectation-maximization method.
result True-positive rate improved by considering credible intervals.
Paper predicts IVF pregnancy rates from basic patient info.
problem Predicting IVF pregnancy rates from patient characteristics.
method Clustering patients into groups, then SVM models for each group.
result Support vector machine models achieve best overall performance.
Study quantifies firm risks from nature decline, showing significant equity losses.
problem Estimating the financial impact of nature deterioration on companies.
method Developed metrics (Country Degradation Index, Nature Risk Score) and assessed five environmental hazards.
result Global equities lose 26.8% in a nature decline scenario, with worst firms losing 75%.
Model identifies key problems in HIV patients' records.
problem Complex and time-consuming task of identifying patient problems from electronic health records.
method Unsupervised phenotyping approach that jointly learns phenotypes from structured and unstructured data.
result Learned phenotypes and their relatedness are clinically valid and surpass existing methods.
Evaluating the clinical similarities between pairwise patients is a fundamental problem in healthcare informatics. A proper patient similarity measure enables various downstream applications, such as cohort study and treatment comparative effectiveness research. One major carrier for conducting patient similarity resea…
Study develops electronic phenotypes of ICU patient acuity.
problem Limited time for patient acuity assessments and imprecise clinical trajectory prediction.
method Developed electronic phenotypes using automated variable retrieval in electronic health records.
result Identified three phenotypes: persistently stable, persistently unstable, and transitioning from unstable to stable.
Deep learning clusters patient time-series data for better prognosis.
problem Clustering time-series data for patient phenotyping and prognosis.
method Deep predictive clustering with novel loss functions for future outcome distribution.
result Model achieves superior clustering performance and identifies meaningful patient subgroups.