New algorithm optimizes clinical trials by strategically allocating patients.
problem Optimizing patient allocation in sequential recruitment studies.
method Formulated as a Markov Decision Process, an algorithm (RCT-KG) is proposed to minimize errors.
result Significant reduction in errors and fewer patients needed for a given trial size.
Method controls treatment risk in learning beneficial allocations.
problem Learning beneficial treatment allocations with risk control in precision medicine.
method Proposes a certifiable learning method that controls treatment risk with finite samples in the partially identified setting.
result Illustrates method using both simulated and real data.
Improved aggregation methods learn from all ICU events without preprocessing for better patient risk analysis.
problem Lack of efficient methods to dynamically assess patient status in ICU.
method Improved aggregation methods for a deep learning architecture that learns from all events without preprocessing.
result Models achieve strong performance (AUROC 0.87) in patient mortality classification.
Analyzes COVID-19 data to predict mortality, forecast spread, and optimize resource allocation.
problem Challenges in patient triage, treatment, and care management during the pandemic.
method Integrated four-step approach combining descriptive, predictive, and prescriptive analytics.
result Optimized resource allocation and informed policy decisions.
Syntax designs adaptive trials for subpopulations with potential benefits.
problem Identifying subpopulations with positive treatment effects in diverse patient populations.
method Adaptive patient recruitment and synthetic control estimation.
result Syntax outperforms conventional trial designs in identifying beneficial subpopulations.
SEEDA optimizes dose allocation in clinical trials to balance efficacy and safety.
problem Complex relationships between efficacy and toxicity in new drug trials.
method Adaptive clinical trial methodology that maximizes cumulative efficacy while ensuring safety constraints.
result SEEDA outperforms existing methods in finding optimal doses with higher success rates and fewer patients.
Develops adaptive framework for estimating survival effects with censoring.
problem Estimating causal effects in survival data with censoring.
method Derives semiparametric efficiency bound, proposes efficiency-optimal allocation policy, and develops Adaptive Survival Estimator (ASE).
result ASE achieves asymptotic normality via martingale central limit theorem and demonstrates efficiency gains over uniform randomization.
UMAP visualizes patient phenotypes from EHR data for emergency triage.
problem Interpreting high-dimensional EHR data for rapid patient triage.
method UMAP for non-linear dimensionality reduction, Gaussian mixture models for clustering.
result UMAP reveals clinically relevant patient phenotypes from EHR data.
New model predicts ICU patients' stay duration efficiently.
problem Efficient ICU bed allocation under resource constraints.
method Temporal Pointwise Convolution (TPC) model combining temporal and pointwise convolutions.
result Significant performance improvements over LSTM and Transformer models.
Unified framework for response-adaptive targeting in multi-treatment experiments
problem Improving ethical and statistical efficiency in multi-treatment clinical trials
method Response-adaptive targeting strategies
result Unified framework for α-Rebalancing Targeting Strategies (αRTS) Predicts hospital patient discharge within 24 hours to optimize resource allocation.
problem Improving hospital resource management and patient care by prioritizing discharge.
method Used eight years of EHR data to train models predicting 24-hour discharge.
result Best models achieved AUROC of 0.85 and AUPRC of 0.53, well calibrated.
Novel topic modeling approach improves survival prediction for cancer patients.
problem Survival prediction for cancer patients using high-dimensional gene expression data.
method Inspired by topic modeling, a novel methodology using discretized Latent Dirichlet Allocation (dLDA) to derive expressive features from gene expression data.
result Survival estimates are more accurate than standard models, as shown by the Concordance measure.
New model predicts ICU patient stays more accurately.
problem Efficient ICU bed allocation under resource constraints.
method Temporal Pointwise Convolutional Networks (TPC) combining temporal and pointwise convolutions.
result Significant performance improvements over LSTM and Transformer models.
BEHRT improves disease prediction in EHRs by 8-10%.
problem Early disease detection in EHRs for better patient outcomes.
method Deep neural sequence transduction model for EHRs.
result BEHRT improves average precision by 8.0-10.8% compared to state-of-the-art models.
Predictive models identify patients at risk of severe COVID-19.
problem Identifying patients at risk of severe COVID-19 to ease healthcare strain.
method Machine learning on routinely collected clinical data.
result Models predict positive SARS-CoV-2 tests, hospitalizations, and critical care with high accuracy.
Study predicts future hospitalizations to manage COVID-19 patient surge.
problem Managing hospitalization needs during COVID-19 pandemic.
method Used 4 recurrent neural networks to predict hospitalization changes.
result Sequence to sequence model with attention achieved high accuracy and AUC.
New method groups genetic data into coherent topics for disease insights.
problem Analyzing large, multi-dimensional genetic data sets.
method Conditional Hierarchical Bayesian Tucker Decomposition for genetic data analysis.
result Our models are more coherent than baseline models.
The paper shows how to audit fairness in decisions with hidden risk factors.
problem Estimating fairness in decisions influenced by hidden, unobservable risk factors.
method Derives unbiased estimates of risk using historical data and audits existing decision-making systems.
result One can compute meaningful bounds on treatment rates for high-risk individuals, even with hidden confounders.
Supervised topic models can help clinical researchers find interpretable cooccurence patterns in count data that are relevant for diagnostics. However, standard formulations of supervised Latent Dirichlet Allocation have two problems. First, when documents have many more words than labels, the influence of the labels w…
Evaluation metrics for prediction models don't fully reflect intervention impact.
problem Standard metrics don't accurately reflect reduction in patient outcomes from model use.
method Synthesized and discussed various evaluation methods, analyzed with simulated and real data.
result Evaluations without interventional data are limited or require strong assumptions.
Good predictors of ICU Mortality have the potential to identify high-risk patients earlier, improve ICU resource allocation, or create more accurate population-level risk models. Machine learning practitioners typically make choices about how to represent features in a particular model, but these choices are seldom eva…
CovidCare uses EMR data to predict patient outcomes in emerging epidemics.
problem Intelligent prognosis for patients with emerging infectious diseases during rapid epidemics.
method Transfer learning and knowledge distillation from existing EMR data.
result CovidCare outperforms baseline methods in predicting patient length of stay.
This paper tackles efficient testing strategies for COVID-19 by using a partially observable MDP approach.
problem Greedy testing strategies miss dormant virus areas, leading to inefficient use of testing resources.
method Develops efficient learning strategies based on policy iteration and look-ahead rules for a sequential learning-based resource allocation problem.
result Shows that the testing problem can be effectively managed using a partially observable MDP approach.
AACE learns treatment policies from EHRs using annotations to improve accuracy.
problem Learning treatment policies from multimodal EHRs with bias and inefficiency.
method Annotation-assisted coarsened effects (AACE) method.
result AACE outperforms existing methods in predicting treatment benefit from multimodal EHRs.
Improved forecasting of suicide attempts using LSGPs for patients with little data.
problem Challenges in predicting suicide attempts due to their rarity and patient heterogeneity.
method Introduced Latent Similarity Gaussian Processes (LSGPs) to capture patient heterogeneity.
result LSGPs outperform baseline models, even without kernel-design, and offer new insights into patient similarity.
Efficiently fine-tunes patient-independent seizure detection models with tensor kernel machine.
problem Improving seizure detection accuracy for wearable devices.
method Transfer learning with tensor kernel machine using canonical polyadic decomposition.
result Patient fine-tuned model achieves high performance with smaller model size.
Personalized models explain TB treatment outcomes considering patient context.
problem Heterogeneity in TB treatment outcomes due to co-morbidities.
method Multi-task learning approach encoding patient context into personalized models.
result Identifies anemia, age of onset, and HIV as influential for treatment efficacy.
Simulates patient pathways to detect delayed rare disease diagnoses.
problem Delayed rare disease diagnoses in France, causing health system and patient harm.
method Probabilistic modelling of patient pathways to create an alert system.
result Alert system detects and refers wandering patients to CRMRs.
Clusters of ACS patients identified for better therapeutic stratification.
problem Data-driven classification and subtyping of ACS patients for improved treatment.
method Outcome-driven clustering using a multi-task neural network with attention.
result Seven patient clusters with distinct characteristics and risk profiles identified.
The paper presents a method to score patient engagement in care programs and predicts their response.
problem Improving health outcomes of high-need patients through better patient engagement.
method Data-driven behavioral engagement scoring pipeline for two aspects of patient engagement.
result The scoring method successfully predicts patient engagement and provides interpretable insights.
Model predicts wound and episode-level readmission risk and time to re-admit.
problem Identify patients at high risk of re-admission to prevent wound recurrences and reduce healthcare costs.
method Data-driven analysis of wound care and episode-level patient data.
result Model achieves high recall and precision for predicting re-admission risk and time.
Estimates shared parameters across related learning problems using robust statistics and LASSO.
problem Simultaneously learning related but heterogeneous problems like store demand or patient risk.
method Two-stage multitask learning estimator combining robust statistics and LASSO regression.
result Improved sample complexity bounds for multitask learning, especially beneficial for 'data-poor' instances.
Currently, approximately 30% of epileptic patients treated with antiepileptic drugs (AEDs) remain resistant to treatment (known as refractory patients). This project seeks to understand the underlying similarities in refractory patients vs. other epileptic patients, identify features contributing to drug resistance acr…
System detects multiple patients' behaviors in real-time using mmWave radar and CNN.
problem Real-time patient behavior monitoring in hospitals.
method Used mmWave radar for tracking and collecting Doppler patterns. Created a three-layer CNN model for behavior classification.
result System achieved very good inference accuracy in predicting patient behaviors in real-time.
Deep learning model creates patient representations for scalable EHR-based stratification.
problem Challenges in summarizing and representing patient data from EHRs prevent scalable stratification analysis.
method Unsupervised framework based on deep learning (ConvAE) using word embeddings, CNNs, and autoencoders.
result ConvAE significantly outperformed baselines in clustering diverse patient cohorts, identifying clinically relevant subtypes.
Characterizing a patient's progression through stages of sepsis is critical for enabling risk stratification and adaptive, personalized treatment. However, commonly used sepsis diagnostic criteria fail to account for significant underlying heterogeneity, both between patients as well as over time in a single patient. W…
Proposes a deep learning framework for evaluating patient similarities from EHRs.
problem Evaluating clinical similarities between patients for various healthcare applications.
method A deep learning framework with medical concept embedding, preserving temporal information.
result Significant improvement in patient similarity evaluation over baselines.
We develop a personalized real time risk scoring algorithm that provides timely and granular assessments for the clinical acuity of ward patients based on their (temporal) lab tests and vital signs. Heterogeneity of the patients population is captured via a hierarchical latent class model. The proposed algorithm aims t…
Longitudinal patient data has the potential to improve clinical risk stratification models for disease. However, chronic diseases that progress slowly over time are often heterogeneous in their clinical presentation. Patients may progress through disease stages at varying rates. This leads to pathophysiological misalig…
Study automates detection of visitation disruptions in ICU patients.
problem Difficulty in detecting frequent visitation disruptions in ICU patients.
method Used DensePose R-CNN model to count people in video frames, analyzed disruptions and patient outcomes.
result Automated method detects visitation disruptions, impacts on pain and length of stay examined.
Model predicts treatment initiation from clinical data using patient-clinician relations.
problem Predicting treatment initiation from clinical time series data considering patient-clinician relations.
method Graph-Augmented Time-Sensitive Model using top eigenvectors of graph Laplacian.
result Relational similarity improves prediction over baselines, e.g., 5% improvement in AUPRC.
A new model uses GPs and latent force models to predict patient responses to drugs.
problem Challenges in modeling short-term effects of drugs on patient physiology.
method Hybrid Gaussian process with latent force model for joint modeling of patient physiology and drug effects.
result The model accurately predicts patient responses to three common drugs, showing competitive performance.
Bayesian methods improve group testing for identifying infected patients.
problem Identifying infected patients from group testing results with false positives.
method Bayesian inference and belief propagation algorithm, combined with expectation-maximization method.
result True-positive rate improved by considering credible intervals.
Paper predicts IVF pregnancy rates from basic patient info.
problem Predicting IVF pregnancy rates from patient characteristics.
method Clustering patients into groups, then SVM models for each group.
result Support vector machine models achieve best overall performance.
The paper optimizes DIA purchase policies using lifecycle models and asset allocation.
problem Determining the optimal allocation to Deferred Income Annuities (DIAs).
method Employed a lifecycle model with utility of consumption and bequest, formalized optimization process, analyzed results, and extended model to include asset allocation.
result Optimal DIA allocation varies based on refundability, asset allocation, and perceived longevity.
Study optimizes resource allocation in noisy systems for better control.
problem Limited attention in stochastic systems with multiplicative noise.
method Analytical and numerical methods for optimal attention allocation.
result Effective resource allocation enhances noise estimation and control decisions.
The paper proposes an asset allocation strategy using the Sortino ratio for better performance.
problem Traditional asset allocation methods like the Sharpe ratio do not penalize negative returns adequately.
method The Sortino ratio is used to maximize asset allocation, penalizing only negative return variances.
result The Sortino ratio-based strategy outperforms traditional methods like the Kelly criterion.
Model identifies key problems in HIV patients' records.
problem Complex and time-consuming task of identifying patient problems from electronic health records.
method Unsupervised phenotyping approach that jointly learns phenotypes from structured and unstructured data.
result Learned phenotypes and their relatedness are clinically valid and surpass existing methods.