Paper proposes robust methods for estimating optimal treatment rules with censored survival data.
problem Estimating optimal treatment rules for censored survival data.
method Developed two robust criteria and a sampling-based difference-of-convex algorithm for learning optimal treatment rules.
result Proposed methods show improved performance compared to existing methods in simulations and real data.
LI-ITR combines flexible ML with interpretable approximations for personalized treatment rules.
problem Combining flexibility and interpretability in personalized treatment rules.
method Uses variational autoencoders and a mixture of interpretable experts.
result Accurately recovers true local coefficients and optimal treatment strategies.
Paper extends transfer learning for decision rules, improving treatment rule estimation.
problem Estimating optimal individualized treatment rules under changing conditions.
method Bayes decision rules and low-dimensional empirical risk minimization.
result Consistent estimators and risk bounds established under mild conditions.
The paper develops deep learning models for personalized treatment rules in survival analysis.
problem Deriving optimal treatment rules for bivariate survival outcomes in randomized trials.
method Adaptive prediction-powered learning using deep neural networks and stochastic policies.
result Maximizes joint survival probability beyond fixed time points (t1,t2). Boosting algorithms improve estimation of personalized treatment rules.
problem Estimating optimal personalized treatment rules in clinical settings.
method Additive regression trees with boosting technique based on XGBoost.
result Efficient and accurate estimation of complex treatment rules.
A new method improves efficiency in finding optimal personalized treatment rules.
problem Heteroscedasticity and misspecified treatment-free effect models affect optimal ITR estimation.
method E-Learning framework that accounts for covariate-treatment dependent variance of residuals.
result E-Learning framework improves efficiency of optimal ITR estimation.
New method for robust inference on optimal treatment regimes without model specification.
problem Inference on optimal treatment regimes without specifying outcome regression models.
method Smoothed robust estimator and resampling-based inference.
result Asymptotic normal distribution and accurate inference for optimal treatment regimes.
RATE metrics evaluate treatment prioritization rules, subsuming existing methods.
problem Comparing and testing the quality of treatment prioritization rules.
method Rank-weighted average treatment effect (RATE) metrics.
result RATE metrics enable asymptotically exact inference in various study settings.
Proposes a new decision rule for continuous treatments.
problem Developing personalized treatment recommendations for continuous treatments.
method Jump interval-learning method to estimate conditional mean of outcomes.
result Optimal interval-valued decision rule (I2DR) for continuous treatments.
Dynamic treatment regimes are of growing interest across the clinical sciences as these regimes provide one way to operationalize and thus inform sequential personalized clinical decision making. A dynamic treatment regime is a sequence of decision rules, with a decision rule per stage of clinical intervention; each de…
The paper develops methods to estimate optimal treatment sequences under policy constraints.
problem Estimating the best sequence of treatments over multiple stages for individuals.
method Empirical welfare maximization approach, solving treatment assignment sequentially or simultaneously.
result Established convergence rates and upper bounds for estimation methods.
Optimal biomarker combinations for treatment-selection can be derived by minimizing total burden to the population caused by the targeted disease and its treatment. However, when multiple biomarkers are present, including all in the model can be expensive and hurt model performance. To remedy this, we consider feature …
The paper learns personalized treatment rules from observational data.
problem Developing effective treatment policies for individual patients.
method Contextual bandit approach to minimize expected risk of treatment policies.
result The proposed method outperforms physicians and baseline approaches in IV and VP administration.
The paper develops a method to optimize individualized treatment rules for cost-effectiveness.
problem Developing cost-effective individualized treatment rules for healthcare policy.
method Using conditional random forest and net-monetary-benefit (NMB) to estimate optimal CE-ITR.
result The approach optimizes healthcare resource allocation by maximizing health gains and minimizing costs.
Paper proposes a new framework for individualized treatment rules that generalize better across different distributions.
problem Existing individualized treatment rules may not generalize well when training and testing distributions differ.
method Distributionally robust individualized treatment rules (DR-ITR) framework that maximizes worst-case value function across close distributions.
result Calibrated DR-ITR outperforms standard ITR in generalizability.
Developed a new algorithm to improve dynamic treatment regimens.
problem Non-convergence of Q-learning-based Q-shared algorithm in dynamic treatment regimens.
method Penalized Q-shared algorithm to address convergence issues.
result The penalized Q-shared algorithm converges and outperforms the original in various settings.
Algorithm identifies interpretable subgroups with elevated treatment effects.
problem Estimating high-dimensional, uninterpretable CATE results.
method Rule sets summarizing CATE estimates, optimizing subgroup size and effect size.
result Frontier of Pareto optimal rule sets for subgroup identification.
CRL approach improves understanding of heterogeneous treatment effects in complex diseases.
problem Estimating heterogeneous treatment effects in complex diseases.
method Causal rule learning (CRL) workflow consisting of rule discovery, selection, and analysis.
result CRL outperforms other methods in providing interpretable estimates of HTE.
Fuses ITRs for primary and secondary outcomes to minimize harm.
problem Learn an ITR maximizing primary outcome while minimizing harm to secondary outcomes.
method Introduces fusion penalty to encourage similar recommendations for different outcomes. Two algorithms estimate the ITR using surrogate loss functions.
result Agreement rate between primary and secondary optimal ITRs converges faster than ignoring secondary outcomes.
There is tremendous interest in precision medicine as a means to improve patient outcomes by tailoring treatment to individual characteristics. An individualized treatment rule formalizes precision medicine as a map from patient information to a recommended treatment. A treatment rule is defined to be optimal if it max…
Develops a novel approach for estimating optimal DTRs with multicategory treatments and censored data.
problem Estimating optimal treatment regimes for chronic diseases with censored data.
method Angle-based multicategory classification algorithm for maximizing conditional survival function.
result The proposed method outperforms existing approaches in maximizing conditional survival function.
Proposes a method to create fair ITRs that balance value and fairness.
problem Fairness issues in ITRs that can lead to unfair advantages or disadvantages.
method Optimal transport theory to transform optimal ITRs into fair ITRs.
result Established a theoretical upper bound on value loss for improved trade-off ITRs.
Recent exploration of optimal individualized decision rules (IDRs) for patients in precision medicine has attracted a lot of attention due to the heterogeneous responses of patients to different treatments. In the existing literature of precision medicine, an optimal IDR is defined as a decision function mapping from t…
Proposes robust ITRs integrating multiple datasets to handle posterior shift.
problem Posterior shift in conditional outcome distributions between source and target populations.
method Distributionally robust approach with closed-form solution and adaptive uncertainty tuning.
result Achieves superior performance compared to existing methods in simulations and real-data applications.
Proposes methods for learning optimal dynamic treatment regimes robust to unconfoundedness violations.
problem Estimating optimal dynamic treatment regimes using historical observational data when unconfoundedness is violated.
method Utilizes proximal causal inference framework to propose three nonparametric identification methods, a (K+1)-robust method, and establish a semiparametric efficiency bound.
result Establishes the (K+1)-robust method for learning optimal dynamic treatment regimes, validating its efficiency and multiple robustness through numerical experiments.
Estimates personalized treatment response curves using covariates.
problem Flexible estimation of personalized treatment response curves.
method Sieve based nonparametric estimator of smoothed regimen-response curve function.
result Asymptotic linearity and undersmoothing criteria for efficient estimation.
Develops a weighting framework to generalize ITRs from source to target populations.
problem Challenges in generalizing ITRs from a source population to a target population with differing characteristics.
method A robust sample weighting framework using a reproducing kernel Hilbert space to balance covariates and improve ITR learning methods.
result Improves ITR estimation for the target population compared to other weighting methods.
Method uses semi-supervised learning to estimate optimal treatment regimes from medical records.
problem Estimating optimal treatment regimes from electronic medical records.
method Imputation-based semi-supervised method using unlabeled data.
result Proposed method yields more efficient estimators of optimal treatment regimes.
Proposes a new method to estimate optimal treatment regimes in the presence of endogeneity.
problem Estimating optimal treatment regimes under endogeneity in observational studies or randomized trials.
method Semiparametric instrumental variable approach with binary instrumental variable.
result Identification and estimation of optimal treatment regimes under endogeneity without direct compliance information.
Study optimal and equitable encouragement policies for treatment adherence.
problem Optimal treatment adherence policies in the presence of human non-adherence.
method Covariate-conditional no-direct-effect model of encouragement; tractable policy characterizations under constraints.
result Induced treatment take-up is the fairness target, not recommendation rates.
Paper uses stats to predict treatment choice based on illness probability.
problem Improving treatment decision-making in personalized medicine.
method Statistical decision theory with maximum regret evaluation.
result Estimates illness probability for better treatment choice.
New method estimates optimal personalized treatment rules from mixed data sources.
problem Combining RCT and observational data for personalized treatment rules.
method Doubly robust estimator for value function, maximizing within pre-specified ITR class.
result Consistent and asymptotically normal optimal value estimator with N−1/3 rate of convergence. Paper derives policy rules from observational data for hepatitis C treatment.
problem Improving treatment guidelines for HIV/HCV co-infected patients.
method Weighted K-means algorithm for estimating CATEs, decision tree implementation.
result Identifies a subgroup with high spontaneous HCV clearance rate.
The estimation of optimal treatment regimes is of considerable interest to precision medicine. In this work, we propose a causal k-nearest neighbor method to estimate the optimal treatment regime. The method roots in the framework of causal inference, and estimates the causal treatment effects within the nearest neig…
Bayesian model estimates ACT impact on pediatric AML survival.
problem Estimating ACT impact on survival in AML patients with treatment timing issues.
method Generative Bayesian semi-parametric model with Gamma Process priors.
result Posterior inference for ACT efficacy under dynamic rules.
Develops deep jump learning for continuous treatment OPE.
problem Estimating mean outcomes under new treatment rules using historical data from different rules.
method Adaptive deep discretization of continuous treatment space using deep learning and multi-scale change point detection.
result Validated method through theoretical results, simulations, and real application to Warfarin Dosing.
Binary classification rules based on covariates typically depend on simple loss functions such as zero-one misclassification. Some cases may require more complex loss functions. For example, individual-level monitoring of HIV-infected individuals on antiretroviral therapy (ART) requires periodic assessment of treatment…
The paper uses machine learning to find causal rules from business process logs.
problem Discovering causal relationships in business process logs.
method Action rule mining followed by causal machine learning (uplift trees).
result Identifies treatments with high causal effect on outcomes.
Meta-analysis improves personalized treatment rules across multiple sites.
problem Lack of generalizability in learning individualized treatment rules across different medical sites.
method Developed a method for individual-level meta-analysis of ITRs, borrowing sign-coherency information between sites.
result Jointly learned site-specific ITRs with improved generalizability.
Given two possible treatments, there may exist subgroups who benefit greater from one treatment than the other. This problem is relevant to the field of marketing, where treatments may correspond to different ways of selling a product. It is similarly relevant to the field of public policy, where treatments may corresp…
Q-learning adapted to find near-equivalent treatment strategies.
problem Finding optimal treatment sequences in dynamic treatment regimes.
method Introducing a worst-value tolerance criterion to find sets of near-equivalent policies.
result Constructs families of near-equivalent treatment strategies.
RL algorithms with medical integration improve personalized treatment recommendations.
problem Developing effective personalized treatment strategies for chronic diseases.
method Integrating medical knowledge into RL algorithms for DTR.
result Enhanced treatment recommendations with increased confidence.
The paper tackles fair policy targeting by optimizing allocation rules to minimize unfairness.
problem Discrimination in individualized treatments of social welfare programs.
method Formulated as a mixed-integer linear program, solved using off-the-shelf algorithms, derived regret bounds and small sample guarantees.
result Designs fair and efficient treatment allocation rules within the Pareto frontier.
The vision for precision medicine is to use individual patient characteristics to inform a personalized treatment plan that leads to the best healthcare possible for each patient. Mobile technologies have an important role to play in this vision as they offer a means to monitor a patient's health status in real-time an…
Many applied decision-making problems have a dynamic component: The policymaker needs not only to choose whom to treat, but also when to start which treatment. For example, a medical doctor may choose between postponing treatment (watchful waiting) and prescribing one of several available treatments during the many vis…
PDX studies help personalize cancer treatment.
problem Precision medicine in cancer treatment.
method Machine learning methods for estimating optimal ITRs from PDX data.
result Superlearner approach combining multiple ITRs improves personalized treatment recommendations.
Expands statistical background for knee osteoarthritis treatment models.
problem Developing optimal exercise and weight loss treatments for knee osteoarthritis.
method Precision medicine models and jackknife cross-validation method.
result Jackknife estimator provides consistent value function estimation.
GEAR uses auxiliary data to estimate optimal decisions in studies with limited primary outcomes.
problem Estimating optimal decisions when primary outcomes are not available in experimental samples.
method GEAR uses augmented inverse propensity weighting to estimate optimal decisions based on auxiliary data.
result GEAR estimators and value estimators have established asymptotic properties and are validated in simulations and a real application.