Opioid overdose is a growing public health crisis in the United States. This crisis, recognized as "opioid epidemic," has widespread societal consequences including the degradation of health, and the increase in crime rates and family problems. To improve the overdose surveillance and to identify the areas in need of p…
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21 results for “opioid overdose”
Model predicts drug overdose hotspots using EMS and toxicology data.
problem Predicting drug overdose hotspots to focus limited services.
method Spatial-temporal point process model integrating EMS and toxicology data.
result Model improves prediction accuracy by integrating heterogeneous data.
Study uses machine learning to analyze state drug policies and reduce overdose deaths.
problem Epidemic opioid overdose rates and ineffective state-level policies.
method Hierarchical clustering of 138 binomial variables to generate policy bundles, then regression analysis.
result Balancing certain policies leads to reduced overdose deaths, but only after second year.
The opioid epidemic in the United States claims over 40,000 lives per year, and it is estimated that well over two million Americans have an opioid use disorder. Over-prescription and misuse of prescription opioids play an important role in the epidemic. Individuals who are prescribed opioids, and who are diagnosed wit…
We describe two recently proposed machine learning approaches for discovering emerging trends in fatal accidental drug overdoses. The Gaussian Process Subset Scan enables early detection of emerging patterns in spatio-temporal data, accounting for both the non-iid nature of the data and the fact that detecting subtle p…
Identifying anomalous patterns in real-world data is essential for understanding where, when, and how systems deviate from their expected dynamics. Yet methods that separately consider the anomalousness of each individual data point have low detection power for subtle, emerging irregularities. Additionally, recent dete…
Identifying Risk of Opioid Use Disorder for Patients Taking Opioid Medications with Deep Learningcs.LG
Deep learning predicts opioid use disorder risk in patients.
problem Identifying patients at high risk of opioid use disorder.
method Applied LSTM models to analyze electronic health records of opioid users.
result LSTM model outperformed other methods with F1 score of 0.8023 and AUCROC of 0.9369.
Computational chemists typically assay drug candidates by virtually screening compounds against crystal structures of a protein despite the fact that some targets, like the Opioid Receptor and other members of the GPCR family, traverse many non-crystallographic states. We discover new conformational states of …
The dearth of prescribing guidelines for physicians is one key driver of the current opioid epidemic in the United States. In this work, we analyze medical and pharmaceutical claims data to draw insights on characteristics of patients who are more prone to adverse outcomes after an initial synthetic opioid prescription…
Opioid addiction is a severe public health threat in the U.S, causing massive deaths and many social problems. Accurate relapse prediction is of practical importance for recovering patients since relapse prediction promotes timely relapse preventions that help patients stay clean. In this paper, we introduce a Generati…
A novel dose-finding design for cancer clinical trials using level set estimation.
problem Finding the maximum tolerated dose (MTD) in phase I cancer clinical trials.
method Proposes a novel dose-finding design based on level set estimation (LSE) to determine the next dose.
result The proposed LSE design achieves higher accuracy in estimating the MTD and lower risk of overdosing compared to existing designs.
Enhanced framework selects features for unbiased causal inference.
problem Unbiased estimation of causal quantities in causal inference.
method Three-stage computational framework balancing treatment and non-treatment variables.
result Significantly reduces bias and variance in estimating causal quantities.
We introduce a machine learning approach for extracting fine-grained representations of protein evolution from molecular dynamics datasets. Metastable switching linear dynamical systems extend standard switching models with a physically-inspired stability constraint. This constraint enables the learning of nuanced repr…
Kernel method optimizes personalized dose rules for patients.
problem Finding optimal individualized dose rules for patients.
method Kernel assisted learning method for estimating optimal dose rules.
result The method identifies the optimal individualized dose rule and produces favorable outcomes.
Warped DLMs improve forecasting for count time series.
problem Limited options for modeling count time series data.
method Introduces a semiparametric methodology using warping of Gaussian DLMs.
result Demonstrates improved forecasting capabilities for count time series.
The paper proposes a fair reinforcement learning framework to prevent healthcare disparities.
problem Unfair reinforcement learning policies in healthcare can lead to socioeconomically-disadvantaged subgroups being underprivileged.
method The paper introduces a counterfactual fairness framework and a sequential data preprocessing algorithm to achieve fair sequential decision making.
result The proposed approach greatly enhances fair access to counseling in a digital health dataset designed to reduce opioid misuse.
Shared Keyboard: An improved Bayesian design for phase I clinical trials via Beta kernel processstat.AP
Shared Keyboard design improves phase I clinical trials by borrowing information across doses.
problem Interim decisions based on current dose data may overlook signals from neighboring doses.
method Bayesian model-assisted design using Beta kernel process with kernel-weighted pseudo-counts.
result Significant improvements in identifying maximum tolerated dose and safety.
Measurement error in observational datasets can lead to systematic bias in inferences based on these datasets. As studies based on observational data are increasingly used to inform decisions with real-world impact, it is critical that we develop a robust set of techniques for analyzing and adjusting for these biases. …
Bayesian method corrects timing misalignment in recurrent event studies.
problem Estimating differences in event rates under two treatments with timing misalignment.
method g-computation procedure with joint semiparametric Bayesian model.
result Correctly estimates average causal effects under right-censoring.
Do we know if a short selling ban or a Tobin Tax result in more stable asset prices? Or do they in fact make things worse? Just like medicine regulatory measures in financial markets aim at improving an already complex system. And just like medicine these interventions can cause side effects which are even harder to as…
Paper proposes a machine learning-based method for estimating mediation effects.
problem Challenges in estimating mediation effects with multiple, continuous mediators.
method Developed a one-step estimation algorithm using machine learning and Riesz learning.
result Proposed method can estimate mediation effects from just two statistical estimands.