Chronic obstructive pulmonary disease (COPD) is a lung disease where early detection benefits the survival rate. COPD can be quantified by classifying patches of computed tomography images, and combining patch labels into an overall diagnosis for the image. As labeled patches are often not available, image labels are p…
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48 results for “obstructive lung disease”
BSFP method reveals latent patterns in multi-omic data for predicting lung function in HIV-associated OLD.
problem Limited understanding of multi-omic molecular phenomena and clinical outcomes in obstructive lung disease.
method Bayesian Simultaneous Factorization and Prediction (BSFP) method for multi-omic data, accommodating imputation and full posterior inference.
result BSFP reveals distinct clusters of patients with OLD and multi-omic patterns related to lung function decline.
Deep Learning of Semi-Competing Risk Data via a New Neural Expectation-Maximization Algorithmstat.ML
New algorithm predicts lung cancer progression and mortality.
problem Predicting semi-competing risk outcomes in lung cancer.
method Neural Expectation-Maximization algorithm for multi-state outcomes.
result Estimates non-parametric baseline hazards and risk functions.
Accurately and precisely characterizing the morphology of small pulmonary structures from Computed Tomography (CT) images, such as airways and vessels, is becoming of great importance for diagnosis of pulmonary diseases. The smaller conducting airways are the major site of increased airflow resistance in chronic obstru…
Computer-aided diagnosis system for diffuse lung diseases (DLDs) is necessary for the objective assessment of the lung diseases. In this paper, we develop semantic segmentation model for 5 kinds of DLDs. DLDs considered in this work are consolidation, ground glass opacity, honeycombing, emphysema, and normal. Convoluti…
Automated segmentation of anatomical structures is a crucial step in image analysis. For lung segmentation in computed tomography, a variety of approaches exist, involving sophisticated pipelines trained and validated on different datasets. However, the clinical applicability of these approaches across diseases remains…
CNN-MoE based framework for classification of respiratory anomalies and lung disease detectioneess.AS
Paper presents a deep learning framework for classifying respiratory anomalies and lung diseases from sound recordings.
problem Classifying respiratory anomalies and lung diseases from respiratory sound recordings.
method The framework uses front-end feature extraction to transform sound into spectrograms, and a deep learning network to classify these features.
result The proposed deep learning system outperforms current state-of-the-art methods on the ICBHI benchmark dataset.
Lung cancer is one of the death threatening diseases among human beings. Early and accurate detection of lung cancer can increase the survival rate from lung cancer. Computed Tomography (CT) images are commonly used for detecting the lung cancer.Using a data set of thousands of high-resolution lung scans collected from…
Finding and Following of Honeycombing Regions in Computed Tomography Lung Images by Deep Learningcs.CV
In recent years, besides the medical treatment methods in medical field, Computer Aided Diagnosis (CAD) systems which can facilitate the decision making phase of the physician and can detect the disease at an early stage have started to be used frequently. The diagnosis of Idiopathic Pulmonary Fibrosis (IPF) disease by…
Model estimates lung well-aerated volume from CT images, independent of patient and imaging parameters.
problem Lack of clear connection between quantitative metrics in lung CT images and physiology.
method Patient-independent model using Gaussian fit to lower CT histogram data points.
result Model estimates well-aerated volume (WAVE) independent of CT reconstruction parameters and respiratory cycle.
New method uses probabilistic independence to discover disease signatures from medical records.
problem Insufficiently precise diagnosis of clinical disease leading to treatment failures.
method Unsupervised machine learning using probabilistic independence to disentangle disease patterns.
result Inferred 2000 clinical disease signatures from medical records, improving cancer prediction.
Lung segmentation from abnormal CXRs using data imputation.
problem Segmenting lungs from CXRs with high opacity caused by respiratory ailments.
method Modified CNN-based segmentation network with deep generative model for data imputation.
result The model can segment lungs from abnormal CXRs, extending to cases with extreme abnormalities.
Quantitative CT predicts ILD patterns and prognosis.
problem Diagnosing and predicting prognosis of fibrosing ILD patterns.
method High-resolution CT texture features, TM model for classification and survival analysis.
result TM model outperforms histogram-based model in distinguishing UIP from non-UIP patterns and allows for survival group partitioning.
Researchers use clustering to differentiate COVID-19 lung scans.
problem Identifying infected individuals with COVID-19.
method Applied unsupervised clustering techniques using PCA, K-Means++, and RCC.
result KM++ and RCC algorithms improved in clustering COVID-19 lung scans.
Early diagnosis of interstitial lung diseases is crucial for their treatment, but even experienced physicians find it difficult, as their clinical manifestations are similar. In order to assist with the diagnosis, computer-aided diagnosis (CAD) systems have been developed. These commonly rely on a fixed scale classifie…
For many complex diseases, there is a wide variety of ways in which an individual can manifest the disease. The challenge of personalized medicine is to develop tools that can accurately predict the trajectory of an individual's disease, which can in turn enable clinicians to optimize treatments. We represent an indivi…
Chronic Pulmonary Aspergillosis (CPA) is a complex lung disease caused by infection with Aspergillus. Computed tomography (CT) images are frequently requested in patients with suspected and established disease, but the radiological signs on CT are difficult to quantify making accurate follow-up challenging. We propose …
The aim of this contribution is to derive a general matrix formula for the net period premium paid in more than one state. For this purpose we propose to combine actuarial technics with the graph optimization methodology. The obtained result is useful for example to more advanced models of dread disease insurances allo…
Development of a Machine-Learning System to Classify Lung CT Scan Images into Normal/COVID-19 Classeess.IV
System classifies lung CT scans into normal or COVID-19 using machine learning.
problem Detecting COVID-19 infection in lung CT scans.
method MLS with CBA+KE thresholding, feature extraction, selection, and classification.
result SVM with FFV achieved 89.80% detection accuracy.
Disease Detection in Weakly Annotated Volumetric Medical Images using a Convolutional LSTM Networkcs.CV
We explore a solution for learning disease signatures from weakly, yet easily obtainable, annotated volumetric medical imaging data by analyzing 3D volumes as a sequence of 2D images. We demonstrate the performance of our solution in the detection of emphysema in lung cancer screening low-dose CT images. Our approach u…
Nodule2vec: a 3D Deep Learning System for Pulmonary Nodule Retrieval Using Semantic Representationcs.IR
System converts 3D lung nodule images into embeddings for retrieval.
problem Retrieving similar 3D lung nodule images for radiologist decision support.
method 3D deep learning, semantic representation, transfer learning, similarity score.
result System can measure similarity between nodule annotations and CBIR results.
Deep Belief Network predicts lncRNA-disease associations with high accuracy.
problem Accurately identifying lncRNA-disease associations to understand lncRNA functionality and disease mechanism.
method Proposes a DBN-based model using heterogeneous networks and DBN for feature learning.
result Obtained AUC of 0.96 and AUPR of 0.967 on standard dataset.
Modeling disease progression in longitudinal EHR data using continuous-time hidden Markov modelscs.LG
Modeling disease progression in healthcare administrative databases is complicated by the fact that patients are observed only at irregular intervals when they seek healthcare services. In a longitudinal cohort of 76,888 patients with chronic obstructive pulmonary disease (COPD), we used a continuous-time hidden Markov…
This study improves lung tumor segmentation in mice MRI scans with nnU-Net, reducing annotation needs.
problem Accurate lung tumor segmentation in mice MRI scans for drug discovery.
method Optimized nnU-Net 3D model for lung tumor segmentation with minimal annotations.
result nnU-Net 3D models outperform 2D models in MRI mice scans, requiring fewer annotations.
Using Apple Machine Learning Algorithms to Detect and Subclassify Non-Small Cell Lung Cancerq-bio.QM
Lung cancer continues to be a major healthcare challenge with high morbidity and mortality rates among both men and women worldwide. The majority of lung cancer cases are of non-small cell lung cancer type. With the advent of targeted cancer therapy, it is imperative not only to properly diagnose but also sub-classify …
Numerous lung diseases, such as idiopathic pulmonary fibrosis (IPF), exhibit dilation of the airways. Accurate measurement of dilatation enables assessment of the progression of disease. Unfortunately the combination of image noise and airway bifurcations causes high variability in the profiles of cross-sectional areas…
U-Det: A Modified U-Net architecture with bidirectional feature network for lung nodule segmentationeess.IV
U-Det improves lung nodule segmentation in CT images.
problem Challenging shapes and surroundings of lung nodules in CT images.
method End-to-end deep learning with Bi-FPN, Mish activation, and class weights.
result U-Det achieves 82.82% Dice similarity coefficient, comparable to human experts.
Study identifies biomarkers for lung cancer in female non-smokers.
problem Identifying prognostic biomarkers for stage III NSCLC in non-smoking females.
method Gene expression profiling and XGBoost machine learning algorithm.
result Top biomarkers validated in literature, with AUC score of 0.835.
Clinical researchers use disease progression models to understand patient status and characterize progression patterns from longitudinal health records. One approach for disease progression modeling is to describe patient status using a small number of states that represent distinctive distributions over a set of obser…
Many real-world tasks such as classification of digital histopathology images and 3D object detection involve learning from a set of instances. In these cases, only a group of instances or a set, collectively, contains meaningful information and therefore only the sets have labels, and not individual data instances. In…
Identification of Cancer -- Mesothelioma Disease Using Logistic Regression and Association Rulecs.CY
Malignant Pleural Mesothelioma (MPM) or malignant mesothelioma (MM) is an atypical, aggressive tumor that matures into cancer in the pleura, a stratum of tissue bordering the lungs. Diagnosis of MPM is difficult and it accounts for about seventy-five percent of all mesothelioma diagnosed yearly in the United States of …
Computed tomography (CT) examinations are commonly used to predict lung nodule malignancy in patients, which are shown to improve noninvasive early diagnosis of lung cancer. It remains challenging for computational approaches to achieve performance comparable to experienced radiologists. Here we present NoduleX, a syst…
A Semi-Markov Chain Approach to Modeling Respiratory Patterns Prior to Extubation in Preterm Infantseess.SP
After birth, extremely preterm infants often require specialized respiratory management in the form of invasive mechanical ventilation (IMV). Protracted IMV is associated with detrimental outcomes and morbidities. Premature extubation, on the other hand, would necessitate reintubation which is risky, technically challe…
Survival month for non-small lung cancer patients depend upon which stage of lung cancer is present. Our aim is to identify smoking specific gene expression biomarkers in the prognosis of lung cancer patients. In this paper, we introduce the network elastic net, a generalization of network lasso that allows for simulta…
Lung cancer is the leading cause of cancer-related death worldwide. Early diagnosis of pulmonary nodules in Computed Tomography (CT) chest scans provides an opportunity for designing effective treatment and making financial and care plans. In this paper, we consider the problem of diagnostic classification between beni…
One of the challenges of using machine learning techniques with medical data is the frequent dearth of source image data on which to train. A representative example is automated lung cancer diagnosis, where nodule images need to be classified as suspicious or benign. In this work we propose an automatic synthetic lung …
Automatically classifying the tissues types of Region of Interest (ROI) in medical imaging has been an important application in Computer-Aided Diagnosis (CAD), such as classification of breast parenchymal tissue in the mammogram, classify lung disease patterns in High-Resolution Computed Tomography (HRCT) etc. Recently…
Penalized Deep Partially Linear Cox Models with Application to CT Scans of Lung Cancer Patientsstat.ML
Proposes a new model to analyze CT scans for lung cancer patients.
problem Analyzing survival risks of lung cancer patients using CT scans.
method Penalized Deep Partially Linear Cox Model (Penalized DPLC) incorporating SCAD penalty and deep neural network.
result The model effectively selects important texture features and estimates nonparametric components.
X-rays are commonly performed imaging tests that use small amounts of radiation to produce pictures of the organs, tissues, and bones of the body. X-rays of the chest are used to detect abnormalities or diseases of the airways, blood vessels, bones, heart, and lungs. In this work we present a stochastic attention-based…
3D Axial-Attention improves lung nodule classification accuracy.
problem Limited 3D attention in existing methods.
method Proposes 3D Axial-Attention network with 3D positional encoding.
result 3D Axial-Attention achieves state-of-the-art performance.
The state of the art lung nodule detection studies rely on computationally expensive multi-stage frameworks to detect nodules from CT scans. To address this computational challenge and provide better performance, in this paper we propose S4ND, a new deep learning based method for lung nodule detection. Our approach use…
New methods improve genetic studies of complex diseases.
problem Improving genetic studies of complex diseases using high-dimensional clinical data.
method Evaluation of unsupervised disentangled representation learning methods (autoencoders, VAE, beta-VAE, FactorVAE) for genetic association studies.
result FactorVAEs and beta-VAEs outperform standard VAEs and non-variational autoencoders in genetic studies of asthma and COPD.
The ability to accurately classify disease subtypes is of vital importance, especially in oncology where this capability could have a life saving impact. Here we report a classification between two subtypes of non-small cell lung cancer, namely Adeno- carcinoma vs Squamous cell carcinoma. The data consists of approxima…
Deep learning identifies transcriptomic patterns and cell types associated with SARS-CoV-2 infection and COVID-19 severity.
problem Understanding how SARS-CoV-2 varies in infecting and causing severe COVID-19.
method Developed a new approach to generating self-supervised edge features, using Graph Attention Networks (GAT) and Set Transformer.
result Achieved state-of-the-art performance in predicting disease state of individual cells using single-cell RNA sequencing data.
MCPCA analyzes shared factors across multiple data contexts.
problem No tools to recover shared factors across multiple contexts.
method Developed a theoretical and algorithmic framework (MCPCA).
result Reveals shared axes of variation across subsets of contexts.
Proposes ConRad model for lung cancer classification using radiomics and interpretable machine learning.
problem Lack of interpretability in deep neural networks for cancer diagnosis.
method Integration of radiomics and DNN-predicted biomarkers in interpretable classifiers (ConRad).
result ConRad models outperform CNNs in five-fold cross-validation.
New framework distinguishes lung cancer subtypes using MALDI mass spectrometry.
problem Distinguishing between adenocarcinoma and squamous cell carcinoma subtypes in lung cancer.
method Supervised topological data analysis on MALDI mass spectrometry imaging data.
result The proposed framework successfully classifies lung cancer subtypes with competitive results.
Characterization of lung nodules as benign or malignant is one of the most important tasks in lung cancer diagnosis, staging and treatment planning. While the variation in the appearance of the nodules remains large, there is a need for a fast and robust computer aided system. In this work, we propose an end-to-end tra…