This paper proposes synthetic augmentation for nuclei image segmentation in medical pathology.
arXiv research
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Deep object detection improves mitotic nucleus detection in breast cancer biopsies.
Separating overlapped nuclei is a major challenge in histopathology image analysis. Recently published approaches have achieved promising overall performance on public datasets; however, their performance in segmenting overlapped nuclei are limited. To address the issue, we propose the bending loss regularized network …
A cascaded multi-planar scheme with a modified residual U-Net architecture was used to segment thalamic nuclei on conventional and white-matter-nulled (WMn) magnetization prepared rapid gradient echo (MPRAGE) data. A single network was optimized to work with images from healthy controls and patients with multiple scler…
A deep learning framework segments deep cerebellar nuclei from 7T MRI, improving accuracy and consistency.
Detection of cell nuclei in microscopic images is a challenging research topic, because of limitations in cellular image quality and diversity of nuclear morphology, i.e. varying nuclei shapes, sizes, and overlaps between multiple cell nuclei. This has been a topic of enduring interest with promising recent success sho…
Cell nuclei detection is a challenging research topic because of limitations in cellular image quality and diversity of nuclear morphology, i.e. varying nuclei shapes, sizes, and overlaps between multiple cell nuclei. This has been a topic of enduring interest with promising recent success shown by deep learning method…
Best performing nuclear segmentation methods are based on deep learning algorithms that require a large amount of annotated data. However, collecting annotations for nuclear segmentation is a very labor-intensive and time-consuming task. Thereby, providing a tool that can facilitate and speed up this procedure is very …
Efficient and precise classification of histological cell nuclei is of utmost importance due to its potential applications in the field of medical image analysis. It would facilitate the medical practitioners to better understand and explore various factors for cancer treatment. The classification of histological cell …
Nuclear segmentation in histology images is a challenging task due to significant variations in the shape and appearance of nuclei. One of the main hurdles in nuclear instance segmentation is overlapping nuclei where a smart algorithm is needed to separate each nucleus. In this paper, we introduce a proposal-free deep …
An algorithm reduces breast cancer detection data complexity using effect sizes.
Based on the work of Durhuus-J{ó}nsson and Benedetti-Ziegler, we revisit the question of the number of triangulations of the 3-ball. We introduce a notion of nucleus (a triangulation of the 3-ball without internal nodes, and with each internal face having at most 1 external edge). We show that every triangulation can b…
NucleusDiff models atomic nuclei interactions to prevent separation violations in drug design.
In the recent years, Riemannian shape analysis of curves and surfaces has found several applications in medical image analysis. In this paper we present a numerical discretization of second order Sobolev metrics on the space of regular curves in Euclidean space. This class of metrics has several desirable mathematical …
Accurate and robust cell nuclei classification is the cornerstone for a wider range of tasks in digital and Computational Pathology. However, most machine learning systems require extensive labeling from expert pathologists for each individual problem at hand, with no or limited abilities for knowledge transfer between…
Fink AGN classifier achieves high accuracy in classifying active galactic nuclei.
In this paper, we present UNet++, a new, more powerful architecture for medical image segmentation. Our architecture is essentially a deeply-supervised encoder-decoder network where the encoder and decoder sub-networks are connected through a series of nested, dense skip pathways. The re-designed skip pathways aim at r…
CAggNet improves medical image segmentation by fusing coarse and fine features.
Mogami introduced in 1995 a large class of triangulated 3-dimensional pseudomanifolds, henceforth called "Mogami pseudomanifolds". He proved an exponential bound for the size of this class in terms of the number of tetrahedra. The question of whether all 3-balls are Mogami has remained open since, a positive answer wou…
The paper proposes a novel Kernelized image segmentation scheme for noisy images that utilizes the concept of Smallest Univalue Segment Assimilating Nucleus (SUSAN) and incorporates spatial constraints by computing circular colour map induced weights. Fuzzy damping coefficients are obtained for each nucleus or center p…
In this note we show that there are 4-manifolds not containing Gompf nucleus ; in this way we answer Problem 4.98 of Kirby's problem list in the negative.
We introduce a new generalization of Gompf nuclei and give applications. We construct infinitely many exotic smooth structures for a large class of compact 4-manifolds with boundary, regarding topological invariants. We prove that a large class of closed 3-manifolds (including disjoint unions of Stein fillable 3-manifo…
Histopathology tissue samples are widely available in two states: paraffin-embedded unstained and non-paraffin-embedded stained whole slide RGB images (WSRI). Hematoxylin and eosin stain (H&E) is one of the principal stains in histology but suffers from several shortcomings related to tissue preparation, staining proto…
A two-layer neural network model that systematically includes correlations among input variables to arbitrary order and is designed to implement Bayes inference has been adapted to classify breast cancer tumors as malignant or benign, assigning a probability for either outcome. The inputs to the network represent measu…
Set classification problems arise when classification tasks are based on sets of observations as opposed to individual observations. In set classification, a classification rule is trained with sets of observations, where each set is labeled with class information, and the prediction of a class label is performed a…
The above named paper has been withdrawn. A colleague has observed a gap in the proof of isotopy invariance, which can be repaired by reducing the coefficients (which lie in (1/6)Z) of the antisymmetric kanji with chords incident with more than one component modulo 8Z. An analogous issue arises in considering the effec…
We consider few-body bound state systems and provide precise definitions of Borromean and Brunnian systems. The initial concepts are more than a hundred years old and originated in mathematical knot-theory as purely geometric considerations. About thirty years ago they were generalized and applied to the binding of sys…
In the area of traditional physics the atomic nucleus belongs to the most complex systems. It involves essentially all elements that characterize complexity including the most distinctive one whose essence is a permanent coexistence of coherent patterns and of randomness. From a more interdisciplinary perspective, thes…
CNN identifies AGN host galaxies from Sloan Digital Sky Survey data.
The limits of the nuclear landscape are determined by nuclear binding energies. Beyond the proton drip lines, where the separation energy becomes negative, there is not enough binding energy to prevent protons from escaping the nucleus. Predicting properties of unstable nuclear states in the vast territory of proton em…
In a previous paper we have constructed an invariant of four-dimensional manifolds with boundary in the form of an element in the stable homotopy group of the Seiberg-Witten Floer spectrum of the boundary. Here we prove that when one glues two four-manifolds along their boundaries, the Bauer-Furuta invariant of the res…
We implement machine learning algorithms to nuclear data. These algorithms are purely data driven and generate models that are capable to capture intricate trends. Gradient boosted trees algorithm is employed to generate a trained model from existing nuclear data, which is used for prediction for data of damping parame…
The chart of the nuclides is limited by particle drip lines beyond which nuclear stability to proton or neutron emission is lost. Predicting the range of particle-bound isotopes poses an appreciable challenge for nuclear theory as it involves extreme extrapolations of nuclear masses beyond the regions where experimenta…
Explanations for deep neural network predictions in terms of domain-related concepts can be valuable in medical applications, where justifications are important for confidence in the decision-making. In this work, we propose a methodology to exploit continuous concept measures as Regression Concept Vectors (RCVs) in th…
The mass, or binding energy, is the basis property of the atomic nucleus. It determines its stability, and reaction and decay rates. Quantifying the nuclear binding is important for understanding the origin of elements in the universe. The astrophysical processes responsible for the nucleosynthesis in stars often take …
Generative Distribution Embeddings learn multiscale representations of distributions.
We compare correlations and coherent structures in nuclei and financial markets. In the nuclear physics part we review giant resonances which can be interpreted as a coherent structure embedded in chaos. With similar methods we investigate the financial empirical correlation matrix of the DAX and Dow Jones. We will sho…
This work speeds up DFT simulations using approximate Gaussian processes.
Theoretical models of the strong nuclear interaction contain unknown coupling constants (parameters) that must be determined using a pool of calibration data. In cases where the models are complex, leading to time consuming calculations, it is particularly challenging to systematically search the corresponding paramete…
Statistical shape analysis can be done in a Riemannian framework by endowing the set of shapes with a Riemannian metric. Sobolev metrics of order two and higher on shape spaces of parametrized or unparametrized curves have several desirable properties not present in lower order metrics, but their discretization is stil…
Nuclear magnetic resonance (NMR) spectroscopy exploits the magnetic properties of atomic nuclei to discover the structure, reaction state and chemical environment of molecules. We propose a probabilistic generative model and inference procedures for NMR spectroscopy. Specifically, we use a weighted sum of trigonometric…
New invariant calculates 4-manifolds using trisection diagrams and combings.
Statistical modeling of nuclear data provides a novel approach to nuclear systematics complementary to established theoretical and phenomenological approaches based on quantum theory. Continuing previous studies in which global statistical modeling is pursued within the general framework of machine learning theory, we …
The region of heavy calcium isotopes forms the frontier of experimental and theoretical nuclear structure research where the basic concepts of nuclear physics are put to stringent test. The recent discovery of the extremely neutron-rich nuclei around Ca [Tarasov, 2018] and the experimental determination of masse…
The paper constructs non-smoothable actions on spin 4-manifolds.
We invoke a Gaussian mixture model (GMM) to jointly analyse two traditional emission-line classification schemes of galaxy ionization sources: the Baldwin-Phillips-Terlevich (BPT) and vs. [NII]/H (WHAN) diagrams, using spectroscopic data from the Sloan Digital Sky Survey Data Release 7 and SEAGal/STARLI…
Committee neural network models improve accuracy and enable active learning for interatomic potentials.
Highly accurate potential energy surfaces are of key interest for the detailed understanding and predictive modeling of chemical systems. In recent years, several new types of force fields, which are based on machine learning algorithms and fitted to ab initio reference calculations, have been introduced to meet this r…