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arXiv research

A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.

168,786 papers · 148 categories

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20406080 · Jun 202019922001200920172026
48 results for neuronal cell culture

Optimized biopharmaceutical seed train design reduces variability and saves time.

problem Designing robust biotechnological processes with cell cultures.
method Coupling uncertainty-based upstream simulation and Bayes optimization using Gaussian processes.
result Optimized seed train design results in lower cell density variability and reduced process duration.

Optimizes biomanufacturing processes with a new digital twin calibration method.

problem Lack of interpretability and sample efficiency in traditional DoE methods.
method Developed a computational approach to calibrate Bio-SoS digital twin model.
result Guides sample-efficient and interpretable DoEs by quantifying sub-model parameter estimation errors.

Model detects patterns in noisy binary data, explaining neuron activity in terms of cell assemblies.

problem Detecting structure in noisy or approximate repeats of patterns in sparse binary data.
method Probabilistic binary latent variable model based on Noisy-OR model, inferring sparse activity in latent variables.
result Model successfully extracts and explains latent structure in spiking neural data.

GraphDINO learns neuronal morphologies from unlabeled data.

problem Unsupervised learning of neuronal morphologies from unlabeled data.
method Transformer-based approach with novel attention mechanism and data augmentation.
result GraphDINO yields morphological clusterings on par with expert classification.

BEAN models neuronal correlations to create interpretable representations.

problem Hard interpretation of dense-layer representations in DNNs.
method Inspired by neuroscience, BEAN models neuronal correlations and dependencies.
result BEAN enables formation of interpretable neuronal clusters without sacrificing model performance.

Multi-domain learning (MDL) aims at obtaining a model with minimal average risk across multiple domains. Our empirical motivation is automated microscopy data, where cultured cells are imaged after being exposed to known and unknown chemical perturbations, and each dataset displays significant experimental bias. This p…

2019-03-21abs ↗pdf ↗

Deep convolutional neural networks (CNNs) have demonstrated impressive performance on visual object classification tasks. In addition, it is a useful model for predication of neuronal responses recorded in visual system. However, there is still no clear understanding of what CNNs learn in terms of visual neuronal circu…

2017-11-08abs ↗pdf ↗

Fault-tolerant neural networks inspired by biological error correction codes.

problem Achieving reliable computation with unreliable neurons.
method Using biological error correction codes from grid cells in the mammalian cortex to develop a fault-tolerant neural network.
result Noisy biological neurons operate below a fault-tolerance threshold, suggesting a mechanism for reliable computation in the brain.

The seemingly stochastic transient dynamics of neocortical circuits observed in vivo have been hypothesized to represent a signature of ongoing stochastic inference. In vitro neurons, on the other hand, exhibit a highly deterministic response to various types of stimulation. We show that an ensemble of deterministic le…

2013-11-13abs ↗pdf ↗

Examines algorithmic modeling across three cultures.

problem Tackles algorithmic modeling in different cultural contexts.
method Uses parametric regressions, interpretable algorithms, and complex algorithms.
result Extension of Leo Breiman's thesis to include cultural differences.

Study shows how national culture influences investors' tendency to hold or sell stocks.

problem Investors' tendency to hold or sell stocks varies internationally.
method Examined brokerage data from 83 countries, analyzed cultural dimensions and age/gender.
result National culture, specifically long-term orientation and indulgence, influences the disposition effect.

Social interactions and personal tastes shape our consumption behavior of cultural products. In this study, we present a computational model of a cultural market and we aim to analyze the behavior of the consumer population as an emergent phenomena. Our results suggest that the final market shares of cultural products …

2007-07-16abs ↗pdf ↗

Breiman discusses two statistical cultures, advocating for more research on 'before' and 'after' the black box.

problem Statistical modeling lacks exploration of processes before and after the 'black box'.
method Analyzes Breiman's visual metaphor of two statistical cultures.
result Promotes the importance of studying the 'before' and 'after' of data transformations.

A neuroscience method to understanding the brain is to find and study the preferred stimuli that highly activate an individual cell or groups of cells. Recent advances in machine learning enable a family of methods to synthesize preferred stimuli that cause a neuron in an artificial or biological brain to fire strongly…

2019-04-18abs ↗pdf ↗

`Biologically inspired' activation functions, such as the logistic sigmoid, have been instrumental in the historical advancement of machine learning. However in the field of deep learning, they have been largely displaced by rectified linear units (ReLU) or similar functions, such as its exponential linear unit (ELU) v…

2018-03-19abs ↗pdf ↗

LSTMs and GRUs are the most common recurrent neural network architectures used to solve temporal sequence problems. The two architectures have differing data flows dealing with a common component called the cell state (also referred to as the memory). We attempt to enhance the memory by presenting a modification that w…

2018-08-04abs ↗pdf ↗

SimCD simultaneously clusters cells and identifies differential gene expression in scRNA-seq data.

problem Separate clustering and differential expression analysis for scRNA-seq data leads to suboptimal results.
method Develops SimCD, a unified hierarchical gamma-negative binomial model for simultaneous cell clustering and differential expression analysis.
result SimCD outperforms existing methods in discovering cell clusters and capturing dynamic expression changes.

Profiling cellular phenotypes from microscopic imaging can provide meaningful biological information resulting from various factors affecting the cells. One motivating application is drug development: morphological cell features can be captured from images, from which similarities between different drug compounds appli…

2017-11-02abs ↗pdf ↗

Sequences of correlated binary patterns can represent many time-series data including text, movies, and biological signals. These patterns may be described by weighted combinations of a few dominant structures that underpin specific interactions among the binary elements. To extract the dominant correlation structures …

2019-01-22abs ↗pdf ↗

A novel circuit motif uses sister cells for inference with correlated priors.

problem Structured priors in neural systems pose architectural challenges.
method Proposes a novel circuit motif using sister cells to implement correlated priors without direct interactions.
result Demonstrates the efficacy of correlated priors for inference in noisy environments.

Study introduces KorFinMTEB for Korean financial texts, revealing model limitations.

problem Limited evaluation benchmarks for low-resource domains, especially Korean.
method Developed KorFinMTEB, a tailored benchmark for Korean financial texts.
result Models perform better on translated benchmarks than on domain-specific ones.

A new method uncovers discrete and continuous factors in gene expression data.

problem Jointly identifying discrete and continuous factors of variability without supervision.
method cpl-mixVAE framework using multiple interacting networks.
result The method successfully uncovers discrete and continuous factors in gene expression data.