Deep CNN model predicts neuronal cell health from images.
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Optimized biopharmaceutical seed train design reduces variability and saves time.
Cataloging the neuronal cell types that comprise circuitry of individual brain regions is a major goal of modern neuroscience and the BRAIN initiative. Single-cell RNA sequencing can now be used to measure the gene expression profiles of individual neurons and to categorize neurons based on their gene expression profil…
A method uses autoencoders to align multi-modal neuron data.
Neuronal circuits formed in the brain are complex with intricate connection patterns. Such complexity is also observed in the retina as a relatively simple neuronal circuit. A retinal ganglion cell receives excitatory inputs from neurons in previous layers as driving forces to fire spikes. Analytical methods are requir…
Optimizes biomanufacturing processes with a new digital twin calibration method.
Model detects patterns in noisy binary data, explaining neuron activity in terms of cell assemblies.
Develops a new neural spike train decoding framework using topological data.
GraphDINO learns neuronal morphologies from unlabeled data.
BEAN models neuronal correlations to create interpretable representations.
Multi-domain learning (MDL) aims at obtaining a model with minimal average risk across multiple domains. Our empirical motivation is automated microscopy data, where cultured cells are imaged after being exposed to known and unknown chemical perturbations, and each dataset displays significant experimental bias. This p…
Neural connectomics has begun producing massive amounts of data, necessitating new analysis methods to discover the biological and computational structure. It has long been assumed that discovering neuron types and their relation to microcircuitry is crucial to understanding neural function. Here we developed a nonpara…
Deep convolutional neural networks (CNNs) have demonstrated impressive performance on visual object classification tasks. In addition, it is a useful model for predication of neuronal responses recorded in visual system. However, there is still no clear understanding of what CNNs learn in terms of visual neuronal circu…
Fault-tolerant neural networks inspired by biological error correction codes.
Enhances content moderation with culturally-aware models.
Cultural activity is an inherent aspect of urban life and the success of a modern city is largely determined by its capacity to offer generous cultural entertainment to its citizens. To this end, the optimal allocation of cultural establishments and related resources across urban regions becomes of vital importance, as…
Breiman's two cultures reconciled through blending statistical thinking.
The seemingly stochastic transient dynamics of neocortical circuits observed in vivo have been hypothesized to represent a signature of ongoing stochastic inference. In vitro neurons, on the other hand, exhibit a highly deterministic response to various types of stimulation. We show that an ensemble of deterministic le…
Examines algorithmic modeling across three cultures.
Study shows how national culture influences investors' tendency to hold or sell stocks.
Hippocampal dentate granule cells are among the few neuronal cell types generated throughout adult life in mammals. In the normal brain, new granule cells are generated from progenitors in the subgranular zone and integrate in a typical fashion. During the development of epilepsy, granule cell integration is profoundly…
Decades of research on the neural code underlying spatial navigation have revealed a diverse set of neural response properties. The Entorhinal Cortex (EC) of the mammalian brain contains a rich set of spatial correlates, including grid cells which encode space using tessellating patterns. However, the mechanisms and fu…
Social interactions and personal tastes shape our consumption behavior of cultural products. In this study, we present a computational model of a cultural market and we aim to analyze the behavior of the consumer population as an emergent phenomena. Our results suggest that the final market shares of cultural products …
Breiman discusses two statistical cultures, advocating for more research on 'before' and 'after' the black box.
A neuroscience method to understanding the brain is to find and study the preferred stimuli that highly activate an individual cell or groups of cells. Recent advances in machine learning enable a family of methods to synthesize preferred stimuli that cause a neuron in an artificial or biological brain to fire strongly…
Breiman (2001) proposed to statisticians awareness of two cultures: 1. Parametric modeling culture, pioneered by R.A.Fisher and Jerzy Neyman; 2. Algorithmic predictive culture, pioneered by machine learning research. Parzen (2001), as a part of discussing Breiman (2001), proposed that researchers be aware of many cultu…
The mushroom body is the key network for the representation of learned olfactory stimuli in Drosophila and insects. The sparse activity of Kenyon cells, the principal neurons in the mushroom body, plays a key role in the learned classification of different odours. In the specific case of the fruit fly, the sparseness o…
`Biologically inspired' activation functions, such as the logistic sigmoid, have been instrumental in the historical advancement of machine learning. However in the field of deep learning, they have been largely displaced by rectified linear units (ReLU) or similar functions, such as its exponential linear unit (ELU) v…
Rapid identification of bacteria is essential to prevent the spread of infectious disease, help combat antimicrobial resistance, and improve patient outcomes. Raman optical spectroscopy promises to combine bacterial detection, identification, and antibiotic susceptibility testing in a single step. However, achieving cl…
LSTMs and GRUs are the most common recurrent neural network architectures used to solve temporal sequence problems. The two architectures have differing data flows dealing with a common component called the cell state (also referred to as the memory). We attempt to enhance the memory by presenting a modification that w…
SimCD simultaneously clusters cells and identifies differential gene expression in scRNA-seq data.
Profiling cellular phenotypes from microscopic imaging can provide meaningful biological information resulting from various factors affecting the cells. One motivating application is drug development: morphological cell features can be captured from images, from which similarities between different drug compounds appli…
We propose a neural information processing system which is obtained by re-purposing the function of a biological neural circuit model, to govern simulated and real-world control tasks. Inspired by the structure of the nervous system of the soil-worm, C. elegans, we introduce Neuronal Circuit Policies (NCPs), defined as…
Commentary on Rashomon Effect complicating model selection.
One of the fundamental questions of cultural evolutionary research is how individual-level processes scale up to generate population-level patterns. Previous studies in music have revealed that frequency-based bias (e.g. conformity and novelty) drives large-scale cultural diversity in different ways across domains and …
New method learns complex cell networks from millions of cells.
Sequences of correlated binary patterns can represent many time-series data including text, movies, and biological signals. These patterns may be described by weighted combinations of a few dominant structures that underpin specific interactions among the binary elements. To extract the dominant correlation structures …
BNNs enhance reservoir computing by acting as generalization filters.
In this paper, we introduce a novel method to interpret recurrent neural networks (RNNs), particularly long short-term memory networks (LSTMs) at the cellular level. We propose a systematic pipeline for interpreting individual hidden state dynamics within the network using response characterization methods. The ranked …
A novel circuit motif uses sister cells for inference with correlated priors.
Recent work has studied the emergence of language among deep reinforcement learning agents that must collaborate to solve a task. Of particular interest are the factors that cause language to be compositional -- i.e., express meaning by combining words which themselves have meaning. Evolutionary linguists have found th…
Town hall discusses AI's impact on statistics, culture, and training.
The development of real-time affect detection models often depends upon obtaining annotated data for supervised learning by employing human experts to label the student data. One open question in annotating affective data for affect detection is whether the labelers (i.e., human experts) need to be socio-culturally sim…
Turing test relevance questioned in age of AI.
Weak supervision challenges black-box models, suggesting fusion of modeling cultures.
Study introduces KorFinMTEB for Korean financial texts, revealing model limitations.
A new method uncovers discrete and continuous factors in gene expression data.
The Audio/Visual Emotion Challenge and Workshop (AVEC 2019) "State-of-Mind, Detecting Depression with AI, and Cross-cultural Affect Recognition" is the ninth competition event aimed at the comparison of multimedia processing and machine learning methods for automatic audiovisual health and emotion analysis, with all pa…