Study uses GMM-UBM and i-vectors to assess Parkinson's patients via speech, handwriting, and gait.
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Paper uses TDA for automated Parkinson's disease classification and severity assessment.
Sparse GFA identifies disease factors in FTD subgroups.
Mining discriminative subgraph patterns from graph data has attracted great interest in recent years. It has a wide variety of applications in disease diagnosis, neuroimaging, etc. Most research on subgraph mining focuses on the graph representation alone. However, in many real-world applications, the side information …
Paper characterizes early-stage dementia signatures from sensor data.
Automated methods for Alzheimer's disease (AD) classification have the potential for great clinical benefits and may provide insight for combating the disease. Machine learning, and more specifically deep neural networks, have been shown to have great efficacy in this domain. These algorithms often use neurological ima…
When searching for gene pathways leading to specific disease outcomes, additional information on gene characteristics is often available that may facilitate to differentiate genes related to the disease from irrelevant background when connections involving both types of genes are observed and their relationships to the…
Improves disease progression prediction using auxiliary surrogate labels and health markers.
Fast, accurate thalamus segmentation method for MS and ET.
Case vs control comparisons have been the classical approach to the study of neurological diseases. However, most patients will not fall cleanly into either group. Instead, clinicians will typically find patients that cannot be classified as having clearly progressed into the disease state. For those subjects, very lit…
Imaging fluorescent disease biomarkers in tissues and skin is a non-invasive method to screen for health conditions. We report an automated process that combines intraoral fluorescent porphyrin biomarker imaging, clinical examinations and machine learning for correlation of systemic health conditions with periodontal d…
This study evaluates handwriting features to diagnose Parkinson's disease.
Epilepsy is an important public health issue. An appropriate epileptiform discharge pattern detection of this neurological disease is a typical problem in biomedical engineering. In this paper, a new method is proposed for spike-and-wave discharge pattern detection based on Kendall's Tau-b coefficient. The proposed app…
Deep learning is attracting significant interest in the neuroimaging community as a means to diagnose psychiatric and neurological disorders from structural magnetic resonance images. However, there is a tendency amongst researchers to adopt architectures optimized for traditional computer vision tasks, rather than des…
Epilepsy is a neurological disorder classified as the second most serious neurological disease known to humanity, after stroke. Localization of the epileptogenic zone is an important step for epileptic patient treatment, which starts with epileptic spike detection. The common practice for spike detection of brain signa…
Sparse symmetric tensor regression reduces brain connectivity complexity.
PR-GNN identifies salient brain regions for ASD biomarkers.
After admission to emergency department (ED), patients with critical illnesses are transferred to intensive care unit (ICU) due to unexpected clinical deterioration occurrence. Identifying such unplanned ICU transfers is urgently needed for medical physicians to achieve two-fold goals: improving critical care quality a…
Web-based framework detects Parkinson's disease from speech recordings.
Drawing an inspiration from behavioral studies of human decision making, we propose here a general parametric framework for a reinforcement learning problem, which extends the standard Q-learning approach to incorporate a two-stream framework of reward processing with biases biologically associated with several neurolo…
Study builds models to predict post-cardiac arrest outcomes using patient data.
WISDoM uses the Wishart distribution to analyze neurological data like EEG and brain connectivity.
Recordings of electrical brain activity carry information about a person's cognitive health. For recording EEG signals, a very common setting is for a subject to be at rest with its eyes closed. Analysis of these recordings often involve a dimensionality reduction step in which electrodes are grouped into 10 or more re…
NeuroQuery synthesizes brain mapping evidence across diverse concepts.
DVNet efficiently segments large neurovascular datasets using skip connections.
New edge features improve GNN performance in biological datasets.
Resource-efficient oblique trees reduce neural signal classification costs.
Graphical models have gained a lot of attention recently as a tool for learning and representing dependencies among variables in multivariate data. Often, domain scientists are looking specifically for differences among the dependency networks of different conditions or populations (e.g. differences between regulatory …
Deep learning models predict epileptic seizures with high accuracy.
Autism Spectrum Disorder (ASD) is a developmental disorder that often impairs a child's normal development of the brain. According to CDC, it is estimated that 1 in 6 children in the US suffer from development disorders, and 1 in 68 children in the US suffer from ASD. This condition has a negative impact on a person's …
The study quantifies geometric differences between axonal branches using splines.
AI enhances personalized drug development and decision-making in pharma.
Biological and social systems consist of myriad interacting units. The interactions can be represented in the form of a graph or network. Measurements of these graphs can reveal the underlying structure of these interactions, which provides insight into the systems that generated the graphs. Moreover, in applications s…
Develops a semi-supervised learning method to generate missing neuroimaging modalities.
Neuroimaging modalities such as functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) provide information about neurological functions in complementary spatiotemporal resolutions; therefore, fusion of these modalities is expected to provide better understanding of brain activity. In this paper, …
R-PLS improves analysis of brain functional connectivity matrices.
Bayesian hypergraph inference models disease pathways from EHR data.
New algorithm extracts shared latent space for cortico-muscular interactions.
Bayesian model identifies health disparities in disease progression.
Disease phenotyping algorithms process observational clinical data to identify patients with specific diseases. Supervised phenotyping methods require significant quantities of expert-labeled data, while unsupervised methods may learn non-disease phenotypes. To address these limitations, we propose the Semi-Supervised …
Bayesian meta-learning predicts Alzheimer's disease progression.
Clinical researchers use disease progression models to understand patient status and characterize progression patterns from longitudinal health records. One approach for disease progression modeling is to describe patient status using a small number of states that represent distinctive distributions over a set of obser…
It is crucial to provide compatible treatment schemes for a disease according to various symptoms at different stages. However, most classification methods might be ineffective in accurately classifying a disease that holds the characteristics of multiple treatment stages, various symptoms, and multi-pathogenesis. More…
Drug repositioning is an attractive cost-efficient strategy for the development of treatments for human diseases. Here, we propose an interpretable model that learns disease self-representations for drug repositioning. Our self-representation model represents each disease as a linear combination of a few other diseases…
Elucidating the genetic basis of human diseases is a central goal of genetics and molecular biology. While traditional linkage analysis and modern high-throughput techniques often provide long lists of tens or hundreds of disease gene candidates, the identification of disease genes among the candidates remains time-con…
Alzheimer's disease (AD) is a degenerative brain disease impairing a person's ability to perform day to day activities. The clinical manifestations of Alzheimer's disease are characterized by heterogeneity in age, disease span, progression rate, impairment of memory and cognitive abilities. Due to these variabilities, …
Deep Belief Network predicts lncRNA-disease associations with high accuracy.
Enhances disease progression modeling using LLMs for complex brain connectivity.