New method identifies proxies for causal effects on multiple outcomes.
problem Estimating causal effects in scenarios with multiple outcomes and treatments.
method Causal discovery method leveraging multiple outcomes as proxies for each treatment effect.
result Parallel studies of multiple outcomes can assist in causal identification.
New method combines multiple data sources for optimal decision-making with limited outcomes.
problem Optimal decision-making with limited outcome data from multiple heterogeneous sources.
method Calibrated optimal decision-making method leveraging common intermediate outcomes.
result Proposed estimator of conditional mean outcome is asymptotically normal and more efficient.
Reduces variance in noisy social outcomes to improve policy evaluation and optimization.
problem Improving access to opportunity through personalized treatment decisions.
method Data-driven dimensionality-reduction using reduced rank regression to denoise multiple outcomes.
result Improves estimation error in policy evaluation and optimization, including on real-world data.
The paper develops methods for causal inference from single-cell RNA sequencing data with multiple outcomes.
problem Causal inference from single-cell RNA sequencing data with multiple heterogeneous outcomes.
method Generic semiparametric inference framework for doubly robust estimation with multiple derived outcomes.
result Demonstrates the use of semiparametric inferential results for estimating causal effects in genomics.
The paper studies causal effects of multiple treatments in healthcare databases with rare outcomes.
problem Estimating causal effects of multiple treatments in healthcare databases with rare outcomes.
method The paper designs three sets of simulations and compares the operating characteristics of three types of methods: Bayesian Additive Regression Trees (BART), regression adjustment on multivariate spline of generalized propensity scores (RAMS), and inverse probability of treatment weighting (IPTW) with multinomial logistic regression or generalized boosted models.
result BART and RAMS provide lower bias and mean squared error compared to IPTW methods.
InVA models image outcomes from multiple modalities, outperforming standard VAEs.
problem Understanding relationships across multiple imaging modalities in neuroimaging.
method Integrative Variational Autoencoder (InVA) framework for image-on-image regression.
result InVA accurately predicts PET scans from structural MRI, outperforming conventional models.
Study introduces a new method to estimate causal mediation with multiple mediators.
problem Estimating causal effects with multiple mediators and confounders.
method Simulates potential outcomes using parametric and nonparametric models.
result General approach to estimating various causal mediation quantities.
Bayesian optimization learns DM preferences for multi-outcome experiments.
problem Optimizing expensive experiments with unknown utility functions and multiple outcomes.
method Alternates preference learning and Bayesian optimization, using pairwise comparisons.
result Preference exploration strategies improve Bayesian optimization performance.
The statistical comparison of multiple algorithms over multiple data sets is fundamental in machine learning. This is typically carried out by the Friedman test. When the Friedman test rejects the null hypothesis, multiple comparisons are carried out to establish which are the significant differences among algorithms. …
Estimating the long-term effects of treatments is of interest in many fields. A common challenge in estimating such treatment effects is that long-term outcomes are unobserved in the time frame needed to make policy decisions. One approach to overcome this missing data problem is to analyze treatments effects on an int…
Technology and collaboration enable dramatic increases in the size of psychological and psychiatric data collections, but finding structure in these large data sets with many collected variables is challenging. Decision tree ensembles like random forests (Strobl, Malley, and Tutz, 2009) are a useful tool for finding st…
Treatment effects can be estimated from observational data as the difference in potential outcomes. In this paper, we address the challenge of estimating the potential outcome when treatment-dose levels can vary continuously over time. Further, the outcome variable may not be measured at a regular frequency. Our propos…
Explains agent behavior through intended outcomes in reinforcement learning.
problem Proving impossibility of general post-hoc explanations in reinforcement learning.
method Derives local explanations based on intention for Q-function approximations, proving consistency with learned Q-values.
result Demonstrates the necessity of collecting information during training for accurate explanations.
BCF models estimate causal effects on multiple outcomes in TIMSS data.
problem Estimating causal effects on multiple outcomes in educational data.
method Bayesian Additive Regression Trees (BART) for multivariate causal inference.
result Positive and negative effects of home study conditions and school absence on student achievement.
A new method removes biases in data integration by using surrogate control outcomes.
problem Data integration methods can be biased due to data-dependent processes.
method Post-integrated inference method using surrogate control outcomes to account for latent heterogeneity.
result The method provides consistent and efficient estimators under minimal assumptions and potential misspecifications.
DCMA uses generative models to analyze treatment effects on entire outcome distributions.
problem Traditional mediation analysis focuses on summary contrasts, missing complex distributional changes.
method DCMA learns conditional generative models for mediators and outcome, reconstructing interventional distributions via Monte Carlo simulation.
result DCMA captures both summary effects and rich distributional contrasts like energy distance and Wasserstein distance.
DCMA uses generative models to analyze complex treatment effects on outcome distributions.
problem Analyzing complex and nonlinear causal mechanisms through outcome-level summary contrasts.
method Generative learning framework for identifying and estimating treatment effects on entire outcome distributions.
result Reconstructs interventional outcome distributions via Monte Carlo forward simulation, capturing both summary and distributional contrasts.
Analyzes how financial network dependencies can lead to multiple equilibrium outcomes and optimal bailout strategies.
problem Multiple equilibrium outcomes in financial networks due to dependency cycles.
method Characterized necessary and sufficient conditions for bank solvency, and provided upper bounds on optimal bailout payments.
result Minimum bailout payments needed to ensure systemic solvency and prevent cascading defaults.
There is tremendous interest in precision medicine as a means to improve patient outcomes by tailoring treatment to individual characteristics. An individualized treatment rule formalizes precision medicine as a map from patient information to a recommended treatment. A treatment rule is defined to be optimal if it max…
A new method for optimizing stakes in a single event with multiple outcomes.
problem Maximizing expected log wealth in a single event with multiple outcomes.
method Using implicit state positions to derive the optimal stake formula.
result A compact formula and greedy algorithm for support selection.
Kernel-based learning predicts ICU escalation from COVID-19 chest X-rays.
problem Predicting ICU escalation from chest X-rays using complex data patterns.
method Generalized Linear Models with Integrated Multiple Additive Regression with Kernels (GLIMARK).
result GLIMARK effectively predicts ICU escalation from chest X-rays.
SNPL learns safe policies for multi-objective interventions with high confidence.
problem Designing effective digital interventions balancing multiple objectives with noisy data.
method Leverages algorithmic stability to learn policies with high-confidence guarantees.
result Offers dramatic improvements in safety and policy gains with smaller sample sizes.
Bayesian model predicts iron deficiency from multi-source multi-way molecular data.
problem Predicting iron deficiency in rhesus monkeys from multi-source multi-way molecular data.
method Developed a Bayesian approach with a linear model incorporating multi-way dependence and varying signal sizes across sources.
result Model accurately classifies iron deficiency in monkeys and outperforms simpler models.
We study notions of fairness in decision-making systems when individuals have diverse preferences over the possible outcomes of the decisions. Our starting point is the seminal work of Dwork et al. which introduced a notion of individual fairness (IF): given a task-specific similarity metric, every pair of individuals …
DynForest R package predicts outcomes with time-dependent predictors.
problem Handling time-dependent predictors in random forest models.
method Random forests with time-dependent predictors summarized using flexible linear mixed models.
result DynForest can predict continuous, categorical, and survival outcomes.
PEER tackles multi-response regression with incomplete outcomes efficiently.
problem Challenges in estimating, predicting, and computing with large-scale multi-response regression and incomplete outcomes.
method PEER converts multi-response regression into parallel univariate-response regressions.
result PEER achieves consistency in estimation, prediction, and variable selection.
CCN estimates full potential outcome distributions without restrictive assumptions.
problem Estimating CATE is insufficient; full potential outcome distributions provide greater insights.
method Collaborating Causal Networks (CCN) learns full potential outcome distributions without restrictive assumptions.
result CCN learns distributions that asymptotically capture true potential outcome distributions.
Framework integrates mental disorder measurements for personalized treatment.
problem Optimizing treatment for mental disorders with latent mental states and heterogeneity.
method Measurement theory and multi-layer neural network for complex treatment effects.
result Learned treatment policies outperform alternatives on heterogeneous treatment effects.
The paper tackles long-term treatment effects with persistent confounders using sequential short-term outcomes.
problem Estimating long-term treatment effects with persistent unmeasured confounders.
method Exploiting the sequential structure of short-term outcomes, the paper develops three novel identification strategies and corresponding estimators.
result The proposed methods outperform existing approaches in handling persistent confounders.
Outlier detection aims to identify unusual data instances that deviate from expected patterns. The outlier detection is particularly challenging when outliers are context dependent and when they are defined by unusual combinations of multiple outcome variable values. In this paper, we develop and study a new conditiona…
A method selects candidates based on predictions with statistical control.
problem Screening candidates for resource-intensive steps like hiring or drug discovery.
method Wraps around any prediction model to produce a subset of candidates with controlled false selection rate.
result Empirically demonstrates selection of candidates whose predictions exceed a data-dependent threshold.
The paper develops deep learning models for personalized treatment rules in survival analysis.
problem Deriving optimal treatment rules for bivariate survival outcomes in randomized trials.
method Adaptive prediction-powered learning using deep neural networks and stochastic policies.
result Maximizes joint survival probability beyond fixed time points (t1,t2). The complexity of human cancer often results in significant heterogeneity in response to treatment. Precision medicine offers potential to improve patient outcomes by leveraging this heterogeneity. Individualized treatment rules (ITRs) formalize precision medicine as maps from the patient covariate space into the space…
Three approaches learn personalized treatment policies for UTI patients.
problem Learning optimal treatment policies in multiobjective settings with fully observed outcomes.
method Indirect and direct approaches using predictive models and without intermediate models.
result All approaches outperform clinicians in achieving better performance on all outcomes and trade-offs.
Proposes a test to ensure predictive algorithms predict intended outcomes better than unintended ones.
problem Unintended model behavior leading to prediction of unintended outcomes.
method Falsification framework using nonparametric hypothesis testing to compare prediction losses across outcomes.
result Establishes discriminant validity with respect to gender but not race in an admissions setting.
The Labouchere gambling system is hypothesized to increase the probability of winning a predetermined arbitrary profit in a gambling system such as a coin flip or a roulette game in which both payouts and odds are 1:1. However, use of the system increases the downside monetary risk in the event of a streak of multiple …
Gaussian graphical models are widely used to represent conditional dependence among random variables. In this paper, we propose a novel estimator for data arising from a group of Gaussian graphical models that are themselves dependent. A motivating example is that of modeling gene expression collected on multiple tissu…
A new method for safer statistical inference after predictions.
problem Statistical inference with pseudo-outcomes from machine learning predictions.
method Prediction De-Correlated Inference (PDC) framework.
result PDC consistently outperforms supervised methods and can adapt to any model.
BoTier optimizes experiments by balancing multiple objectives hierarchically.
problem Balancing multiple competing objectives in scientific experiments.
method Composite objective that flexibly represents a hierarchy of preferences over outcomes and parameters.
result Demonstrates robust applicability across various use cases and seamless integration.
We consider an agent who is involved in a Markov decision process and receives a vector of outcomes every round. Her objective is to maximize a global concave reward function on the average vectorial outcome. The problem models applications such as multi-objective optimization, maximum entropy exploration, and constrai…
We consider a learning system based on the conventional multiplicative weight (MW) rule that combines experts' advice to predict a sequence of true outcomes. It is assumed that one of the experts is malicious and aims to impose the maximum loss on the system. The loss of the system is naturally defined to be the aggreg…
Develops methods to analyze feature-outcome associations in subpopulations.
problem Challenges in understanding feature-outcome associations in high-dimensional data.
method Geometric decomposition framework using gradient flow and co-monotonicity decomposition.
result Identifies context-dependent patterns and improves statistical power and interpretability.
GraphITE estimates individual effects of graph-structured treatments.
problem Estimating individual effects of complex treatment structures.
method Graph neural networks and Hilbert-Schmidt Independence Criterion regularization.
result GraphITE outperforms baselines in estimating treatment effects for large numbers of treatments.
In this paper we present tools for applied researchers that re-purpose off-the-shelf methods from the computer-science field of machine learning to create a "discovery engine" for data from randomized controlled trials (RCTs). The applied problem we seek to solve is that economists invest vast resources into carrying o…
New method for causal inference in survival outcomes using RDD.
problem Censoring in time-to-event analyses.
method Nonparametric approach with doubly robust censoring corrections.
result Higher efficiency and robustness to misspecification.
Satellite imagery helps assess sustainable development with machine learning.
problem Lack of ground data on sustainable development outcomes.
method Combining satellite imagery with machine learning to model outcomes.
result Machine learning models perform well across multiple sustainable development domains.
Scalable methods integrate multiview data for clinical outcomes.
problem Jointly associate and predict outcomes from multiple data sources.
method Randomized Fourier bases for nonlinear mappings, view-independent low-dimensional representations.
result Identified molecular signatures for COVID-19 status and severity.
Estimates causal contributions of multiple causes on outcome changes.
problem Quantifying the effect of multiple causes on an outcome change.
method Develops a multiply robust estimation strategy combining regression and re-weighting methods.
result The method recovers the target parameter under partial misspecification and is consistent and asymptotically normal.