PGEL learns embeddings to diversify protein motifs while maintaining biological function.
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We study soft persistence (existence in subsequent temporal layers of motifs from the initial layer) of motif structures in Triangulated Maximally Filtered Graphs (TMFG) generated from time-varying Kendall correlation matrices computed from stock prices log-returns over rolling windows with exponential smoothing. We ob…
Method finds motifs in knowledge graphs, revealing their structure.
Improved scaffold generation for protein motifs using SE(3) flow matching.
MotiFiesta learns network motifs efficiently.
Networks are a fundamental tool for modeling complex systems in a variety of domains including social and communication networks as well as biology and neuroscience. Small subgraph patterns in networks, called network motifs, are crucial to understanding the structure and function of these systems. However, the role of…
Paper proposes DTW-SOM for visual exploration of time-series motifs.
Researchers create exact minimal surfaces with helical motifs in biological structures.
Behaviors of several laboratory animals can be modeled as sequences of stereotyped behaviors, or behavioral motifs. However, identifying such motifs is a challenging problem. Behaviors have a multi-scale structure: the animal can be simultaneously performing a small-scale motif and a large-scale one (e.g. \textit{chewi…
odeN efficiently approximates multiple temporal motifs in large networks.
Complex systems, such as airplanes, cars, or financial markets, produce multivariate time series data consisting of a large number of system measurements over a period of time. Such data can be interpreted as a sequence of states, where each state represents a prototype of system behavior. An important problem in this …
Synthetic Petri Dish predicts neural architecture performance faster.
Paper discovers manoeuvres from vehicle telematics data.
Time series motifs play an important role in the time series analysis. The motif-based time series clustering is used for the discovery of higher-order patterns or structures in time series data. Inspired by the convolutional neural network (CNN) classifier based on the image representations of time series, motif diffe…
A motif-based framework identifies local spillover structures in financial markets.
Generative graph models create instances of graphs that mimic the properties of real-world networks. Generative models are successful at retaining pairwise associations in the underlying networks but often fail to capture higher-order connectivity patterns known as network motifs. Different types of graphs contain diff…
New method learns diverse protein scaffolds for motif design.
Model improves robustness of neural network sequences without transition failures.
New method clusters weighted directed networks using motifs.
New method uses diffusion models to generate proteins with specific motifs.
New method discovers time series motifs under DTW, significantly reducing computations.
Proposes a motif-preserving Graph Neural Network for financial default prediction.
In this paper, we introduce the notion of motif closure and describe higher-order ranking and link prediction methods based on the notion of closing higher-order network motifs. The methods are fast and efficient for real-time ranking and link prediction-based applications such as web search, online advertising, and re…
Generalized belief propagation converges to optimal solutions on graphs with motifs.
Time Series Motif Discovery (TSMD) is defined as searching for patterns that are previously unknown and appear with a given frequency in time series. Another problem strongly related with TSMD is Word Segmentation. This problem has received much attention from the community that studies early language acquisition in ba…
Paper constructs motifs from planar tilings for DP weaves and polycatenanes.
The paper models musical motif transformations in Beethoven's works.
TF-MoDISco (Transcription Factor Motif Discovery from Importance Scores) is an algorithm for identifying motifs from basepair-level importance scores computed on genomic sequence data. This technical note focuses on version v0.5.6.5. The implementation is available at https://github.com/kundajelab/tfmodisco/tree/v0.5.6…
Motivated by the concept of network motifs we construct certain clustering methods (functors) which are parametrized by a given collection of motifs (or representers).
When analyzing the genome, researchers have discovered that proteins bind to DNA based on certain patterns of the DNA sequence known as "motifs". However, it is difficult to manually construct motifs due to their complexity. Recently, externally learned memory models have proven to be effective methods for reasoning ov…
The discovery of time series motifs has emerged as one of the most useful primitives in time series data mining. Researchers have shown its utility for exploratory data mining, summarization, visualization, segmentation, classification, clustering, and rule discovery. Although there has been more than a decade of exten…
When each data point is a large graph, graph statistics such as densities of certain subgraphs (motifs) can be used as feature vectors for machine learning. While intuitive, motif counts are expensive to compute and difficult to work with theoretically. Via graphon theory, we give an explicit quantitative bound for the…
Graph generation techniques are increasingly being adopted for drug discovery. Previous graph generation approaches have utilized relatively small molecular building blocks such as atoms or simple cycles, limiting their effectiveness to smaller molecules. Indeed, as we demonstrate, their performance degrades significan…
Investigates how diversification preferences relate to risk attitudes.
New approach learns latent motifs in networks for mesoscale structure analysis.
Study examines diversification of mid-mountain ski tourism.
KCoreMotif clusters large networks efficiently by exploiting k-core decomposition and motifs.
Diversification increases systemic risk, contrary to belief.
This paper classifies periodic weaves and their universal cover, extending Tait's conjectures.
The paper proposes a new approach to portfolio selection that maximizes diversification and return.
A new diversification measure DQ derived from risk measures addresses limitations of existing indices.
Paper introduces lexical ratio to measure portfolio diversification.
A widely applied diversification paradigm is the naive diversification choice heuristic. It stipulates that an economic agent allocates equal decision weights to given choice alternatives independent of their individual characteristics. This article provides mathematically and economically sound choice theoretic founda…
Risk diversification is one of the dominant concerns for portfolio managers. Various portfolio constructions have been proposed to minimize the risk of the portfolio under some constrains including expected returns. We propose a portfolio construction method that incorporates the complex valued principal component anal…
Paper defines and analyzes mathematical equivalence of periodic tangles.
One of the findings of the recent literature is that the 2008 financial crisis caused reduction in international diversification benefits. To fully understand the possible potential from diversification, we build an empirical model which combines generalised autoregressive score copula functions with high frequency dat…
Bayesian network models are finding success in characterizing enzyme-catalyzed reactions, slow conformational changes, predicting enzyme inhibition, and genomics. In this work, we apply them to statistical modeling of peptides by simultaneously identifying amino acid sequence motifs and using a motif-based model to cla…
Diversification improves profits for heavy-tailed investments.