Laboratory testing and medication prescription are two of the most important routines in daily clinical practice. Developing an artificial intelligence system that can automatically make lab test imputations and medication recommendations can save costs on potentially redundant lab tests and inform physicians of a more…
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48 results for “medical testing”
Effective medical test suggestions benefit both patients and physicians to conserve time and improve diagnosis accuracy. In this work, we show that an agent can learn to suggest effective medical tests. We formulate the problem as a stage-wise Markov decision process and propose a reinforcement learning method to train…
The article explains how to estimate confusion matrices for classifiers using unlabeled data.
problem Estimating sensitivity and specificity of binary medical diagnostic tests without gold standard tests.
method Modifying diagnostic test solutions to estimate confusion matrices for classifiers on unlabeled data.
result The approach can be used to estimate accuracy statistics for supervised or unsupervised binary classifiers on unlabeled data.
Research benchmarks LLMs in medical domain to reduce hallucinations.
problem Hallucinations in medical LLMs can lead to incorrect information.
method Developed Med-HALT dataset and testing methods.
result Significant performance differences among LLMs identified.
Machine learning constructs problem-based medical records from electronic health records.
problem Difficulty in finding relevant medical information for clinical questions.
method Knowledge base completion using machine learning on electronic health records.
result Automatic construction of problem-based groupings of medications, procedures, and lab tests.
Trust Issues: Uncertainty Estimation Does Not Enable Reliable OOD Detection On Medical Tabular Datacs.LG
New research finds uncertainty estimation techniques fail to reliably detect abnormal medical cases.
problem Uncertainty estimation does not reliably detect out-of-distribution patients in medical tabular data.
method A series of tests on various uncertainty estimation techniques on real-world medical data.
result Almost all techniques fail to identify out-of-distribution patients, contradicting earlier findings.
Generative models solve medical imaging inverse problems without needing paired data.
problem Reconstructing medical images from partial measurements.
method Score-based generative models trained on medical images, then sampling to reconstruct images consistent with measurements and physical model.
result Comparable or better performance in CT and MRI tasks, with improved generalization to unknown measurement processes.
Sparse learning has been shown to be effective in solving many real-world problems. Finding sparse representations is a fundamentally important topic in many fields of science including signal processing, computer vision, genome study and medical imaging. One important issue in applying sparse representation is to find…
Adapts CNN for robust medical image segmentation across different scanners and protocols.
problem Performance degradation of CNNs in medical image segmentation due to mismatch between training and test images.
method Designs a segmentation CNN as a concatenation of a shallow normalization CNN and a deep CNN. At test time, adapts the normalization sub-network for each test image using a denoising autoencoder.
result Consistently improves performance on multi-center MRI datasets of brain, heart, and prostate.
Paper detects bias in AI medical models using CART.
problem Ensuring fairness in AI medical decision support systems.
method Uses Classification and Regression Trees (CART) algorithm to identify bias.
result Validated the CART approach in both synthetic and real-world data.
A deep learning approach classifies medical images hierarchically.
problem Limitations of traditional supervised classifiers in medical image classification.
method Hierarchical Medical Image Classification (HMIC) using deep learning models.
result HMIC achieved better performance in classifying medical images hierarchically.
Study improves CNN medical image segmentation accuracy and reliability.
problem Over-confident predictions and silent failures in out-of-distribution data.
method Multi-task learning and spectral analysis of CNN feature maps.
result Joint multi-task learning models outperform dedicated models and detect OOD data more accurately.
Efficient equivariant MobileNetV2 for medical applications on mobile devices.
problem Limited computational resources for deep learning models in medical applications.
method Design and optimize an equivariant version of MobileNetV2 with model quantization.
result Achieved close-to state-of-the-art performance on medical dataset with improved efficiency.
Paper detects biases in medical imaging ML models using counterfactual analysis.
problem Bias in medical imaging ML models negatively impacts generalization performance.
method Counterfactual invariance framework combining conditional latent diffusion models and statistical hypothesis testing.
result The method identifies and quantifies biases without direct access to counterfactual data.
Word embeddings are a popular approach to unsupervised learning of word relationships that are widely used in natural language processing. In this article, we present a new set of embeddings for medical concepts learned using an extremely large collection of multimodal medical data. Leaning on recent theoretical insigh…
Improves medical note processing by training model on related concepts and global context.
problem Scarce and imbalanced labeled training data limits generalizability of automated abbreviation disambiguation models.
method Data augmentation using related medical concepts and global context information within medical notes.
result Model accuracy improved by almost 14% on CASI dataset and 4% on i2b2 dataset.
Paper tackles missing data in medical records using advanced optimization.
problem Missing data in medical records hinders machine learning applications.
method Applied multi-level stochastic optimization for imputation.
result The method significantly outperforms current approaches and reduces error up to 75%.
Proposes a statistical test for VAE-based anomaly detection reliability.
problem Ensuring reliability of anomaly detection in high-stakes applications.
method Variance Autoencoder (VAE) Test based on selective inference.
result Validates VAE-based anomaly detection with p-values controlling false detection probability.
Generative Adversarial Networks (GANs) have shown remarkable success as a framework for training models to produce realistic-looking data. In this work, we propose a Recurrent GAN (RGAN) and Recurrent Conditional GAN (RCGAN) to produce realistic real-valued multi-dimensional time series, with an emphasis on their appli…
A statistical test controls false positives in anomaly localization using diffusion models.
problem Uncertainty and bias in generative models for anomaly localization.
method Selective inference to quantify significance and control false positives.
result The method effectively controls false positive detection rates.
Quick and accurate medical diagnosis is crucial for the successful treatment of a disease. Using machine learning algorithms, we have built two models to predict a hematologic disease, based on laboratory blood test results. In one predictive model, we used all available blood test parameters and in the other a reduced…
Study shows variability in CNN predictions for medical images, suggesting ensemble averaging to reduce it.
problem Variability in CNN predictions for medical images due to data ordering during training.
method Reproduced CheXNet results with random seeds to identify variability in predictions.
result Averaging predictions from multiple models reduces variability by nearly 70%.
Paper uses AI to improve medical diagnosis accuracy.
problem Improving accuracy of medical diagnoses.
method Heuristic frequentist and Bayesian approaches applied to a nationwide dataset.
result Algorithm outperforms human doctors in detecting abnormal births.
Study proposes a statistical test for Vision Transformer's attention mechanisms.
problem ViT's attention mechanisms may focus on irrelevant regions, leading to unreliable evidence.
method Selective inference framework to quantify statistical significance of attentions as p-values.
result Proposed method enables reliable quantification of false positive detection probability of attentions.
A primary goal of computational phenotype research is to conduct medical diagnosis. In hospital, physicians rely on massive clinical data to make diagnosis decisions, among which laboratory tests are one of the most important resources. However, the longitudinal and incomplete nature of laboratory test data casts a sig…
Study proposes a new approval policy for ML-based medical devices to prevent gradual performance degradation.
problem Gradual deterioration in machine learning model performance over time in medical devices.
method Formulated an automatic algorithmic change protocol (aACP) as an online hypothesis testing problem, considering both error-rate guarantees and non-guaranteed policies.
result Controlled the rate of gradual deterioration (biocreep) in machine learning models without significantly impacting approval of beneficial modifications.
Image segmentation is widely used in a variety of computer vision tasks, such as object localization and recognition, boundary detection, and medical imaging. This thesis proposes deep learning architectures to improve automatic object localization and boundary delineation for salient object segmentation in natural ima…
Counterfactual diagnosisstat.ML
Counterfactual diagnosis improves medical accuracy and safety.
problem Existing diagnostic algorithms struggle with distinguishing correlation from causation.
method Reformulated diagnosis as a counterfactual inference task and derived new counterfactual diagnostic algorithms.
result Counterfactual diagnostic algorithms significantly improve accuracy and safety compared to standard Bayesian algorithms.
Machine learning models detect COVID-19 from routine blood tests.
problem Separating COVID-19 from other viral pneumonias using blood tests.
method Employed random forests and support vector machines on blood data.
result SVM-based classifier achieves 84% accuracy in detecting COVID-19.
On Interpretability of Deep Learning based Skin Lesion Classifiers using Concept Activation Vectorscs.LG
Deep learning skin lesion classifier explained using CAVs.
problem Limited acceptance of deep learning CAD systems due to opaque decision-making.
method Mapped human understandable concepts to RECOD model using CAVs.
result Classifier learns and encodes disease-related concepts in its latent representation.
Viral Load Inference in Non-Adaptive Pooled Testingcond-mat.stat-mech
New method infers viral load from pooled tests.
problem Inefficient viral load inference in pooled testing.
method Message passing algorithm with PCR noise function.
result Accurate viral load inference possible.
Hidden Stratification Causes Clinically Meaningful Failures in Machine Learning for Medical Imagingcs.LG
Machine learning models for medical image analysis often suffer from poor performance on important subsets of a population that are not identified during training or testing. For example, overall performance of a cancer detection model may be high, but the model still consistently misses a rare but aggressive cancer su…
3D dataset for intracranial aneurysms aids deep learning applications.
problem Lack of 3D medical datasets for deep learning.
method Developed an open-access 3D dataset, IntrA, for intracranial aneurysms.
result Demonstrated the challenges and performance of 3D medical datasets.
A Covariate-Adjusted Homogeneity Test with Application to Facial Recognition Accuracy Assessmentstat.AP
The paper proposes a test to assess rater accuracy while accounting for rater covariates.
problem Assessing the accuracy of raters in medical imaging and forensic studies.
method Covariate-adjusted homogeneity test to determine differences in accuracy among multiple rater groups.
result The proposed test identifies statistically significant differences among five participant groups in a face recognition study.
FELICIA uses a centralized adversary to improve synthetic medical image generation.
problem Collaborative learning with limited and biased data in medical image analysis.
method Federated generative modeling with a centralized adversary.
result Data owners can generate high-quality synthetic images with high utility without sharing real data.
Smart bin monitors predict medication adherence with high accuracy.
problem Predicting chronic medication adherence to improve healthcare efficiency.
method Machine learning models trained on IoT device data.
result High predictive performance (ROC AUC 0.86).
Statistical inference based on lossy or incomplete samples is often needed in research areas such as signal/image processing, medical image storage, remote sensing, signal transmission. In this paper, we propose a nonparametric testing procedure based on samples quantized to bits through a computationally efficient…
Deep learning model improves X-ray disease detection accuracy in Thai patients.
problem Lack of large-scale validation of AI algorithms for medical image diagnosis in Thailand.
method Development and testing of a deep learning algorithm using 421,859 local chest radiographs.
result Convolutional neural networks achieve remarkable performance in detecting 13 common abnormality conditions on chest X-ray.
The paper proposes a deep generative model for complex disease trajectories.
problem Modeling and analyzing complex disease trajectories.
method Deep generative time series approach with semi-supervised latent processes.
result The model can discover novel aspects of diseases and cluster them into new sub-types.
Simplifies decision-making during medical exams with cost-efficient feature acquisition.
problem Guiding physicians during examination acquisition for accurate and efficient diagnosis.
method Dropout at input layer and integrated gradients at test-time for dynamic feature importance.
result More cost- and feature-efficient than prior approaches, achieving higher overall accuracy.
This research improves uncertainty estimation for medical predictions, enhancing model trust and decision support.
problem Improving model uncertainty estimation for rare medical conditions.
method Developed and refined heuristics for selecting uncertainty estimation techniques, distinguishing them by clinical use-case. Also, compared ensembles vs. auto-encoders for detecting out-of-domain examples.
result Auto-encoders outperform ensembles in detecting out-of-domain examples, highlighting their importance for medical tabular data.
DAD++ improves test-time adversarial defense without access to training data.
problem Improving adversarial robustness of pre-trained models without access to training data.
method Test-time Data-free Adversarial Defense (DAD++) with detection and correction schemes.
result DAD++ significantly improves adversarial robustness with minimal clean accuracy drop.
Investigates the number of experiments needed for statistical significance in medication testing.
problem Determining the number of experiments needed for a statistically significant result.
method Examines binomial and general probability distributions, considering placebo efficacy and varying distributions.
result The number of experiments needed can be significantly higher when placebo efficacy is considered.
Paper proposes machine learning model for early Alzheimer's diagnosis.
problem Early and accurate diagnosis of Alzheimer's Disease.
method Machine learning models, demographic, biomarker, and cognitive test data.
result 90% accuracy and 87% accuracy in predicting Alzheimer's development.
CP-ROC bands improve graph classification accuracy and uncertainty quantification.
problem Uncertainty quantification and robustness to distributional shifts in graph classification.
method Conditional Prediction ROC (CP-ROC) bands for graph classification, developed for TGNNs and adaptable to GNNs.
result Statistically guaranteed coverage for CP-ROC under local exchangeability condition, improving prediction reliability.
It is widely accepted that optimization of medical imaging system performance should be guided by task-based measures of image quality (IQ). Task-based measures of IQ quantify the ability of an observer to perform a specific task such as detection or estimation of a signal (e.g., a tumor). For binary signal detection t…
Patient journeys are compared to find clusters of similar disease trajectories.
problem Discovering shared health outcomes among patient journeys.
method Comparing longitudinal health data to identify clusters of similar patient trajectories.
result Clusters of patient journeys with similar health outcomes can be identified.
Advances in deep learning for natural images have prompted a surge of interest in applying similar techniques to medical images. The majority of the initial attempts focused on replacing the input of a deep convolutional neural network with a medical image, which does not take into consideration the fundamental differe…