Unified deep learning predicts Parkinson's disease from medical images.
problem Diagnosing Parkinson's disease accurately from medical images.
method Transfer learning and domain adaptation using deep convolutional and recurrent neural networks.
result The approach effectively predicts Parkinson's disease across different medical environments.
Develops a two-stage conformal prediction method for Parkinson's disease medication needs.
problem Heterogeneous disease progression and treatment response in Parkinson's Disease.
method Two-stage conformal prediction framework with statistical guarantees.
result Quantifies uncertainty in medication needs predictions, improving clinical trust and quality of life.
Enhances medical code predictions for multi-morbidity patients using text classification.
problem Improving accuracy in predicting medical codes for patients with multiple illnesses.
method Used machine learning techniques, including multi-label medical text classification, to enhance predictions.
result High dimensional embeddings pre-trained on health data significantly improve multi-label classification performance.
Paper uses AI to predict medications from medical codes, improving accuracy in healthcare.
problem Predicting medications from incomplete or incorrect medical codes is challenging.
method Robust Recurrent Neural Networks (RNNs) with decay mechanism and noise injection.
result The method accurately predicts medication orders from contaminated medical codes.
CASCADE improves uncertainty communication in Parkinson's disease medication management.
problem Uncertainty in clinical decision-making for Parkinson's disease patients.
method CASCADE uses a novel conformal prediction framework to adaptively scale prediction intervals based on classification uncertainty.
result CASCADE produces more efficient and robust prediction intervals for Parkinson's disease patients.
Background: The problem of predicting whether a drug combination of arbitrary orders is likely to induce adverse drug reactions is considered in this manuscript. Methods: Novel kernels over drug combinations of arbitrary orders are developed within support vector machines for the prediction. Graph matching methods are …
Improves reliability of medical diagnosis uncertainty estimates.
problem Label uncertainty in medical diagnosis.
method Post-hoc alpha-calibration method for neural network classifiers. result Significantly enhances reliability of uncertainty estimates.
Predicting highrisk vascular diseases is a significant issue in the medical domain. Most predicting methods predict the prognosis of patients from pathological and radiological measurements, which are expensive and require much time to be analyzed. Here we propose deep attention models that predict the onset of the hig…
Deep learning predicts ICU mortality with enhanced interpretability.
problem Improving mortality prediction accuracy and clinician trust in AI.
method Trained a deep learning model on MIMIC-III to interpret nursing notes.
result Model reaches ROC of 0.8629, outperforming SAPS-II.
Representation learning (RL) plays an important role in extracting proper representations from complex medical data for various analyzing tasks, such as patient grouping, clinical endpoint prediction and medication recommendation. Medical data can be divided into two typical categories, outpatient and inpatient, that h…
Deep learning methods exhibit promising performance for predictive modeling in healthcare, but two important challenges remain: -Data insufficiency:Often in healthcare predictive modeling, the sample size is insufficient for deep learning methods to achieve satisfactory results. -Interpretation:The representations lear…
Personalized predictive medicine necessitates the modeling of patient illness and care processes, which inherently have long-term temporal dependencies. Healthcare observations, recorded in electronic medical records, are episodic and irregular in time. We introduce DeepCare, an end-to-end deep dynamic neural network t…
LMM predicts healthcare costs and risks with improved accuracy.
problem Wasteful healthcare spending and inefficiencies in risk prediction.
method Generative pre-trained transformer trained on patient event sequences.
result Improves cost prediction by 14.1% and chronic conditions prediction by 1.9%.
The widespread availability of electronic health records (EHRs) promises to usher in the era of personalized medicine. However, the problem of extracting useful clinical representations from longitudinal EHR data remains challenging. In this paper, we explore deep neural network models with learned medical feature embe…
HRTPP improves TPP interpretability and accuracy in medical event modeling.
problem Lack of interpretability in TPPs for medical event sequences.
method Hybrid-Rule Temporal Point Processes (HRTPP) integrating temporal logic rules and numerical features.
result HRTPP outperforms state-of-the-art interpretable TPPs in predictive performance and clinical interpretability.
Deep learning models exhibit state-of-the-art performance for many predictive healthcare tasks using electronic health records (EHR) data, but these models typically require training data volume that exceeds the capacity of most healthcare systems. External resources such as medical ontologies are used to bridge the da…
Hierarchical-CPI improves variable importance measurement for medical data.
problem Limited interpretability of complex medical models.
method Hierarchical-CPI measures conditional variable importance with statistical control, handling correlated data.
result Hierarchical-CPI outperforms existing methods in medical datasets.
AI predicts medical specialty diagnostic choices from EHR records.
problem Predicting timely medical specialty diagnostic workups for patients.
method Ensemble of feed-forward neural networks trained on EHR data.
result Significantly higher accuracy compared to traditional checklists.
Deep learning predicts readmissions from less structured data.
problem Predicting readmissions from non-standard, unstructured medical records.
method Proposes a deep learning architecture that handles less structured data, including Spanish text.
result Achieves AUROC of 0.76 on a Chilean medical dataset, comparable to US results.
The paper investigates interpretability techniques for deep learning models in medical data.
problem Understanding the logic behind predictions of black-box models in medical decision-making.
method Applied deep neural networks and random forests to a medical dataset. Used autoencoders and local interpretable models to provide insights.
result Local interpretable models and autoencoders provide meaningful insights into cancer predictions, identifying distinct and non-generalizable features.
Feature engineering remains a major bottleneck when creating predictive systems from electronic medical records. At present, an important missing element is detecting predictive regular clinical motifs from irregular episodic records. We present Deepr (short for Deep record), a new end-to-end deep learning system that …
Smart bin monitors predict medication adherence with high accuracy.
problem Predicting chronic medication adherence to improve healthcare efficiency.
method Machine learning models trained on IoT device data.
result High predictive performance (ROC AUC 0.86).
Enhances uncertainty estimation in medical image segmentation.
problem Frequency-related noise in medical imaging leads to biased uncertainty estimates.
method Extends MC-Dropout to the frequency domain for better uncertainty estimation.
result MC-Frequency Dropout improves calibration and uncertainty in semantic segmentation.
Study on how imprecise medical data affects predictions in hyperthyroidism.
problem Impact of imprecise medical data on prediction results.
method Formulated a model for data imprecisions, generated imprecise samples, defined measures to evaluate impacts, and performed experiments.
result Small imprecisions can lead to large ranges of predicted results, potentially causing mis-labeling and inappropriate actions.
This research improves uncertainty estimation for medical predictions, enhancing model trust and decision support.
problem Improving model uncertainty estimation for rare medical conditions.
method Developed and refined heuristics for selecting uncertainty estimation techniques, distinguishing them by clinical use-case. Also, compared ensembles vs. auto-encoders for detecting out-of-domain examples.
result Auto-encoders outperform ensembles in detecting out-of-domain examples, highlighting their importance for medical tabular data.
Prediction models can harm patients even when accurate, leading to self-fulfilling prophecies.
problem Prediction models can lead to harmful decisions that worsen patient outcomes.
method Formal characterization of harmful prediction models and analysis of their impact.
result Well-calibrated models are ineffective for decision-making as they do not change the data distribution.
ConCare personalizes healthcare predictions by capturing EMR features.
problem Predicting patient outcomes from EMR data with personalization.
method Captures personal characteristics and time-aware distribution in EMR data.
result Improves healthcare prediction accuracy through personalized health context.
A reinforcement learning method predicts medical outcomes from masked feature vectors.
problem Predicting medical outcomes from limited feature data.
method Reinforcement learning with iterative feature selection and a guesser network.
result The method outperforms baselines and is highly interpretable.
Automatic representation learning of key entities in electronic health record (EHR) data is a critical step for healthcare informatics that turns heterogeneous medical records into structured and actionable information. Here we propose ME2Vec, an algorithmic framework for learning low-dimensional vectors of the most co…
Learning from electronic medical records (EMR) is challenging due to their relational nature and the uncertain dependence between a patient's past and future health status. Statistical relational learning is a natural fit for analyzing EMRs but is less adept at handling their inherent latent structure, such as connecti…
Proposes a new method for medical diagnosis using network-based representation learning.
problem Improving medical diagnosis accuracy through better data representation.
method Heterogeneous network-based model and modified metapath2vec algorithm for learning latent node representations.
result Significant performance boost in symptom/disease classification and disease prediction tasks.
A new model answers questions about medical images.
problem Lack of transparency in deep learning models for medical imaging.
method A question-centric model that queries image models directly.
result The model achieves equal or higher accuracy than existing methods.
We propose a Bayesian model that predicts recovery curves based on information available before the disruptive event. A recovery curve of interest is the quantified sexual function of prostate cancer patients after prostatectomy surgery. We illustrate the utility of our model as a pre-treatment medical decision aid, pr…
Study improves confidence measures in medical imaging pipelines by addressing bias.
problem Bias in metric-based imaging pipelines compromises the efficiency of prediction intervals.
method Formalized symmetric and asymmetric CP formulations, analyzed bias effects, and validated empirically.
result Symmetric intervals are inflated by bias, while asymmetric intervals remain unaffected.
Machine-assisted treatment recommendations hold a promise to reduce physician time and decision errors. We formulate the task as a sequence-to-sequence prediction model that takes the entire time-ordered medical history as input, and predicts a sequence of future clinical procedures and medications. It is built on the …
The issue of disagreements amongst human experts is a ubiquitous one in both machine learning and medicine. In medicine, this often corresponds to doctor disagreements on a patient diagnosis. In this work, we show that machine learning models can be trained to give uncertainty scores to data instances that might result…
Paper detects bias in AI medical models using CART.
problem Ensuring fairness in AI medical decision support systems.
method Uses Classification and Regression Trees (CART) algorithm to identify bias.
result Validated the CART approach in both synthetic and real-world data.
Study predicts colorectal polyp recurrence using medical records and statistical models.
problem Identifying patient characteristics influencing colorectal polyp recurrence.
method Natural language processing for extracting polyp characteristics, Kaplan-Meier curves, Cox proportional hazards modeling, random survival forest models.
result Polyp size, number, location, and patient smoking status significantly influence recurrence risk.
Study improves CNN medical image segmentation accuracy and reliability.
problem Over-confident predictions and silent failures in out-of-distribution data.
method Multi-task learning and spectral analysis of CNN feature maps.
result Joint multi-task learning models outperform dedicated models and detect OOD data more accurately.
We propose using canonical correlation analysis (CCA) to generate features from sequences of medical billing codes. Applying this novel use of CCA to a database of medical billing codes for patients with diverticulitis, we first demonstrate that the CCA embeddings capture meaningful relationships among the codes. We th…
Develops a neural model to predict event occurrence and timing.
problem Standard event time models ignore the distinction between event occurrence probability and predicted time.
method Introduces a conditional event time model using a neural network with a binary stochastic layer.
result Shows superior event occurrence and timing predictions on various datasets.
Study predicts future hospitalizations to manage COVID-19 patient surge.
problem Managing hospitalization needs during COVID-19 pandemic.
method Used 4 recurrent neural networks to predict hospitalization changes.
result Sequence to sequence model with attention achieved high accuracy and AUC.
Paper proposes sharing models instead of data for smart health predictions.
problem Sharing sensitive medical data is legally restricted and challenging.
method Train a teacher model on sensitive data, then transfer its knowledge to a student model without accessing original data.
result Student model mimics teacher model performance in making accurate predictions.
Stability in clinical prediction models is crucial for transferability between studies, yet has received little attention. The problem is paramount in high dimensional data which invites sparse models with feature selection capability. We introduce an effective method to stabilize sparse Cox model of time-to-events usi…
COMPASS improves uncertainty quantification for medical segmentation metrics.
problem Uncertainty quantification for medical segmentation metrics is crucial for clinical decision-making.
method COMPASS leverages deep neural network inductive biases to generate efficient, metric-based conformal prediction intervals.
result COMPASS produces significantly tighter intervals than traditional conformal prediction methods on medical image segmentation tasks.
We have recently seen many successful applications of recurrent neural networks (RNNs) on electronic medical records (EMRs), which contain histories of patients' diagnoses, medications, and other various events, in order to predict the current and future states of patients. Despite the strong performance of RNNs, it is…
Paper introduces conformal prediction for reliable uncertainty quantification in landmark localization.
problem Systematic underestimation of total predictive uncertainty in landmark localization.
method Conformal prediction framework for multi-output regression, generating flexible prediction regions.
result Methods outperform existing approaches in validity and efficiency across 2D and 3D datasets.
With the expeditious advancement of information technologies, health-related data presented unprecedented potentials for medical and health discoveries but at the same time significant challenges for machine learning techniques both in terms of size and complexity. Those challenges include: the structured data with var…