Survey of deep learning methods for medical anomaly detection.
problem Medical anomaly detection using machine learning.
method Thorough review of deep learning techniques across various medical domains.
result Comparison and contrast of deep learning models and their limitations.
HRTPP improves TPP interpretability and accuracy in medical event modeling.
problem Lack of interpretability in TPPs for medical event sequences.
method Hybrid-Rule Temporal Point Processes (HRTPP) integrating temporal logic rules and numerical features.
result HRTPP outperforms state-of-the-art interpretable TPPs in predictive performance and clinical interpretability.
Deep learning predicts ICU mortality with enhanced interpretability.
problem Improving mortality prediction accuracy and clinician trust in AI.
method Trained a deep learning model on MIMIC-III to interpret nursing notes.
result Model reaches ROC of 0.8629, outperforming SAPS-II.
Survey on understanding neural networks for medical applications.
problem Black-box nature of deep neural networks hinders their use in critical applications.
method Comprehensive review of interpretability studies in neural networks.
result Interpretability research is crucial for the acceptance of neural networks in medical diagnosis.
Unified framework explains few-shot multimodal medical imaging performance.
problem Limited labeled data in rare diseases and low-resource settings.
method PAC learning, VC theory, PAC Bayesian analysis, information gain, Chain of Thought reasoning.
result Unified theoretical framework for few-shot multimodal medical imaging.
The paper investigates interpretability techniques for deep learning models in medical data.
problem Understanding the logic behind predictions of black-box models in medical decision-making.
method Applied deep neural networks and random forests to a medical dataset. Used autoencoders and local interpretable models to provide insights.
result Local interpretable models and autoencoders provide meaningful insights into cancer predictions, identifying distinct and non-generalizable features.
This study interprets machine learning models to identify biomarkers for severe COVID-19 infection.
problem The black-box nature of machine learning models makes it difficult for medical researchers to understand and trust their predictions.
method The study uses permutation feature importance, Partial Dependence Plot, Individual Conditional Expectation, Accumulated Local Effects, Local Interpretable Model-agnostic Explanations, and Shapley Additive Explanation to interpret four machine learning models.
result The study identifies NTproBNP, CRP, LDH, LYM, leukocytes, eosinophils, and platelets as biomarkers associated with severe COVID-19 infection.
CAT framework improves AI medical screening fairness and reliability.
problem Imbalanced data, varying performance across cohorts, and patient-level inconsistencies in traditional metrics.
method CAT framework introduces patient-level assessment, entropy-based distribution weighting, and cohort-weighted sensitivity and specificity.
result Enhanced predictive reliability, fairness, and interpretability of AI-driven medical screening models.
MAGIC-Flow generates and classifies medical images with interpretability.
problem Challenges in generative modeling for medical imaging.
method Conditional multiscale normalizing flow architecture.
result MAGIC-Flow creates realistic, diverse samples and improves classification.
Hierarchical-CPI improves variable importance measurement for medical data.
problem Limited interpretability of complex medical models.
method Hierarchical-CPI measures conditional variable importance with statistical control, handling correlated data.
result Hierarchical-CPI outperforms existing methods in medical datasets.
We have recently seen many successful applications of recurrent neural networks (RNNs) on electronic medical records (EMRs), which contain histories of patients' diagnoses, medications, and other various events, in order to predict the current and future states of patients. Despite the strong performance of RNNs, it is…
A new metric FRD improves comparing medical images.
problem Comparing medical images for distribution or domain differences.
method Developed a new metric FRD using standardized radiomic features.
result FRD outperforms other metrics in various medical imaging applications.
The paper investigates deep neural networks for medical imaging applications, providing interpretable results.
problem Uninterpretable decisions made by deep neural networks in medical imaging applications.
method Investigation of deep neural networks for malaria, diabetic retinopathy, brain tumor, and tuberculosis detection in various imaging modalities. Visualization of class activation mappings provided.
result Visualization of class activation mappings enhances understanding of deep neural networks and aids doctors in decision-making.
Proposes a deep learning model for probabilistic forecasting that is also interpretable.
problem Inability to explain predictions of neural network-based time series forecasting methods.
method Deep Autoregressive Networks (DANLIP) for locally interpretable probabilistic forecasting.
result DANLIP provides interpretable predictions with comparable performance to state-of-the-art methods.
Framework harmonizes EHR data across institutions for better analysis.
problem Heterogeneity of medical codes and terminologies hinder EHR data analysis.
method MASH (Multi-source Automated Structured Hierarchy) uses neural optimal transport and learned hyperbolic embeddings to align and structure EHR data.
result MASH generates interpretable hierarchical graphs for unstructured local laboratory codes.
Deep learning methods exhibit promising performance for predictive modeling in healthcare, but two important challenges remain: -Data insufficiency:Often in healthcare predictive modeling, the sample size is insufficient for deep learning methods to achieve satisfactory results. -Interpretation:The representations lear…
Interpretable deep learning is a fundamental building block towards safer AI, especially when the deployment possibilities of deep learning-based computer-aided medical diagnostic systems are so eminent. However, without a computational formulation of black-box interpretation, general interpretability research rely hea…
FIGS improves prediction performance while maintaining interpretability, especially in medical domains.
problem Lack of interpretability in machine learning models, particularly in high-stakes domains like medicine.
method Generalizes CART algorithm to grow multiple trees in summation, combining logical rules with addition.
result FIGS achieves state-of-the-art prediction performance and derives interpretable clinical decision instruments (CDIs).
Framework evaluates medical image classification methods using a probabilistic model and a Twenty Questions paradigm.
problem Lack of detailed understanding of how machine learning methods make decisions in medical imaging.
method Inspired by the Turing Test, uses a probabilistic model and a Twenty Questions paradigm to evaluate classification methods based on task-specific concepts.
result Probabilistic model exposes dataset and method biases, reducing the number of queries needed for confident performance evaluation.
A reinforcement learning method predicts medical outcomes from masked feature vectors.
problem Predicting medical outcomes from limited feature data.
method Reinforcement learning with iterative feature selection and a guesser network.
result The method outperforms baselines and is highly interpretable.
DKN adapts to medical imaging data with limited samples and interpretable models.
problem Medical imaging data's unique nature makes general methods like CNN unsuitable.
method DKN uses a Kronecker product structure to adapt to low sample size and provide interpretable models.
result DKN achieves prediction power comparable to CNN and provides model interpretability.
The paper proposes an interpretable off-policy learning algorithm for medical treatments.
problem Lack of interpretable methods for personalized treatment decisions from observational data.
method Hyperbox search approach for interpretable policies in disjunctive normal form.
result The proposed algorithm outperforms state-of-the-art methods in terms of regret and is rated highly interpretable by clinical experts.
New method explains survival analysis models using median-SHAP.
problem Need for explainable AI in medical applications, especially for survival analysis.
method Introduces median-SHAP for explaining survival analysis models.
result Conventionally used mean anchor point can lead to misleading interpretations; median-SHAP provides a better approach.
Paper uses NLP to cluster patient visits for diagnosis validation.
problem Validating if similar patients receive similar diagnoses.
method Representation of medical visits using word embeddings, clustering patients' visits.
result Stable and separated segments of visits positively validated against diagnoses.
We propose a Bayesian model that predicts recovery curves based on information available before the disruptive event. A recovery curve of interest is the quantified sexual function of prostate cancer patients after prostatectomy surgery. We illustrate the utility of our model as a pre-treatment medical decision aid, pr…
Convolutional Neural Networks (CNNs) are propelling advances in a range of different computer vision tasks such as object detection and object segmentation. Their success has motivated research in applications of such models for medical image analysis. If CNN-based models are to be helpful in a medical context, they ne…
Study evaluates different saliency maps for CT image classification.
problem Understanding how deep learning models make decisions in medical imaging.
method Compared several saliency maps using three evaluation metrics.
result Two versions of SmoothGrad performed best across all metrics.
The paper proposes a deep generative model for complex disease trajectories.
problem Modeling and analyzing complex disease trajectories.
method Deep generative time series approach with semi-supervised latent processes.
result The model can discover novel aspects of diseases and cluster them into new sub-types.
Neural network classifies breast cancer lesions using global and local image features.
problem Classifying breast cancer lesions in medical images with high resolution and small regions of interest.
method Proposes a neural network that combines global saliency maps and local patches for pixel-level saliency maps.
result Achieves radiologist-level performance in screening mammography interpretation.
ALIME proposes an autoencoder-based method for making deep learning models locally interpretable.
problem Making opaque deep learning models interpretable, especially in medical applications.
method Inspired by LIME, ALIME uses an autoencoder to generate a more stable and locally faithful explanation around a single instance.
result Our method improves both the stability and local fidelity of explanations compared to traditional LIME.
Deep learning skin lesion classifier explained using CAVs.
problem Limited acceptance of deep learning CAD systems due to opaque decision-making.
method Mapped human understandable concepts to RECOD model using CAVs.
result Classifier learns and encodes disease-related concepts in its latent representation.
A new method relaxes Boolean Matrix Factorization to make it more efficient.
problem High computational cost of solving NP-hard combinatorial optimization problems in Boolean Matrix Factorization.
method Proposes a proximal gradient algorithm using an elastic-binary regularizer to relax BMF.
result Demonstrates improved runtime and better recall, loss, and interpretability on real-world data.
Improves tree-based models' interpretability for medical applications.
problem Lack of explainability in tree-based models.
method Developed new algorithms and tools for local and global model understanding.
result Combining local explanations reveals global model structure and identifies non-linear interactions.
This work abstracts deep neural networks into concept graphs for better interpretability in medical tasks.
problem Lack of interpretability in deep learning models, especially in medical domains.
method Developed a graphical representation of medical image processing models to understand concept-based reasoning.
result Extracted a concept-level graph that reveals the decision-making process of deep learning models.
CONFINE enhances neural networks' interpretability without sacrificing accuracy.
problem Lack of interpretability in deep neural networks, especially in healthcare.
method CONFINE uses conformal prediction to generate prediction sets with robust uncertainty estimates.
result CONFINE achieves correct efficiency up to 3.3% higher than original accuracy.
X-Caps improves medical diagnosis explainability by encoding visual attributes in capsules.
problem Uninterpretable predictions from deep neural networks in healthcare.
method Teaches a novel multi-task capsule network to encode high-level visual attributes and malignancy scores.
result X-Caps outperforms state-of-the-art deep dense 3D CNNs in capturing visually interpretable attributes and malignancy prediction.
CPR models complex decision processes by breaking them into context-specific policies, improving interpretability and accuracy.
problem Interpreting dynamic human decision-making processes in medical contexts.
method Develops Contextualized Policy Recovery (CPR) framework for multi-task learning, modeling each context-specific policy as a linear map.
result Achieves state-of-the-art performance in predicting medical decisions, closing the gap between interpretable and black-box methods.
Deep learning models predict ICU readmission with varying accuracy.
problem Predicting ICU readmission risk using deep learning architectures.
method Several deep learning architectures including attention-based models, recurrent layers, neural ODEs, and embeddings were trained on MIMIC-III data.
result Attention-based models with neural ODEs achieved highest predictive accuracy.
The paper advocates for interpretable, accountable, reproducible machine learning in medicine.
problem Black box models in medicine lack transparency and regulatory approval.
method Intrinsically interpretable modeling approaches and collaborative learning paradigms.
result Interpretable machine learning models can support clinical decisions and gain regulatory approval.
New method reduces false positives in weakly supervised pixel-level localization.
problem Reduces false positives in weakly supervised pixel-level localization.
method Proposes a deep learning method using conditional entropy to constrain the localizer.
result Significant improvements in image-level classification and pixel-level localization.
We develop a model using deep learning techniques and natural language processing on unstructured text from medical records to predict hospital-wide 30-day unplanned readmission, with c-statistic .70. Our model is constructed to allow physicians to interpret the significant features for prediction.
Study compares DL models for medical image segmentation, finds synergistic ensemble strategies improve performance.
problem Improving DL models for specialized medical image segmentation using transfer learning.
method Detailed comparisons of TII and LMI models for binary segmentation of medical images.
result Ensemble strategies improve performance by 10% in certain scenarios.
Convex dual network improves neural network reconstruction for medical imaging.
problem Non-convex nature of neural networks hinders their use in sensitive applications.
method Introduces a convex duality framework for a two-layer fully-convolutional ReLU denoising network.
result Training neural networks with weight decay regularization induces path sparsity and piecewise linear filtering.
Study finds non-adherence to schizophrenia meds leads to earlier adverse events.
problem Impact of medication non-adherence on adverse outcomes in schizophrenia patients.
method Survival analysis, causal inference methods (T-learner, S-learner, nearest neighbor matching), different amounts of longitudinal information.
result Non-adherence to schizophrenia meds advances adverse events by 1 to 4 months.
Tensor networks improve medical image classification performance.
problem Improving medical image classification accuracy.
method Extending tensor networks to medical image analysis, focusing on 2D images.
result Tensor networks achieve comparable performance to deep learning methods with fewer hyperparameters and resources.
This paper reviews deep learning methods for handling irregularly sampled medical time series data.
problem Handling irregularly sampled medical time series data for personalized treatment and precise diagnosis.
method Summarizes and compares deep learning methods categorized by technology and task.
result Achieved good results in data imputation and downstream tasks.
G-FIGS uses instance weights to create interpretable models from diverse data.
problem Generalizing to diverse data distributions while maintaining interpretability.
method Estimates group membership probabilities, uses as instance weights in FIGS to grow decision trees.
result Achieves state-of-the-art prediction performance and maintains interpretability.
Certifiable defense method improves robustness of deep learning interpretation.
problem Vulnerability of gradient-based saliency maps to adversarial attacks.
method Sparsified SmoothGrad method, extending certifiably robust smooth classifier bounds.
result Sparsified SmoothGrad method is certifiably robust against adversarial perturbations.