The article explains how to estimate confusion matrices for classifiers using unlabeled data.
problem Estimating sensitivity and specificity of binary medical diagnostic tests without gold standard tests.
method Modifying diagnostic test solutions to estimate confusion matrices for classifiers on unlabeled data.
result The approach can be used to estimate accuracy statistics for supervised or unsupervised binary classifiers on unlabeled data.
AI predicts medical specialty diagnostic choices from EHR records.
problem Predicting timely medical specialty diagnostic workups for patients.
method Ensemble of feed-forward neural networks trained on EHR data.
result Significantly higher accuracy compared to traditional checklists.
Improves reliability of medical diagnosis uncertainty estimates.
problem Label uncertainty in medical diagnosis.
method Post-hoc alpha-calibration method for neural network classifiers. result Significantly enhances reliability of uncertainty estimates.
Machine learning promises to revolutionize clinical decision making and diagnosis. In medical diagnosis a doctor aims to explain a patient's symptoms by determining the diseases \emph{causing} them. However, existing diagnostic algorithms are purely associative, identifying diseases that are strongly correlated with a …
Paper detects biases in medical imaging ML models using counterfactual analysis.
problem Bias in medical imaging ML models negatively impacts generalization performance.
method Counterfactual invariance framework combining conditional latent diffusion models and statistical hypothesis testing.
result The method identifies and quantifies biases without direct access to counterfactual data.
Interpretable deep learning is a fundamental building block towards safer AI, especially when the deployment possibilities of deep learning-based computer-aided medical diagnostic systems are so eminent. However, without a computational formulation of black-box interpretation, general interpretability research rely hea…
Proposes a new method for medical diagnosis using network-based representation learning.
problem Improving medical diagnosis accuracy through better data representation.
method Heterogeneous network-based model and modified metapath2vec algorithm for learning latent node representations.
result Significant performance boost in symptom/disease classification and disease prediction tasks.
Machine learning detects NASH patients from medical claims data.
problem Detecting undiagnosed NASH patients for screening and management.
method Gradient-boosted decision trees trained on administrative medical claims data.
result Model precision for NASH detection is significantly higher than NASH incidence.
Unified framework explains few-shot multimodal medical imaging performance.
problem Limited labeled data in rare diseases and low-resource settings.
method PAC learning, VC theory, PAC Bayesian analysis, information gain, Chain of Thought reasoning.
result Unified theoretical framework for few-shot multimodal medical imaging.
Simplifies decision-making during medical exams with cost-efficient feature acquisition.
problem Guiding physicians during examination acquisition for accurate and efficient diagnosis.
method Dropout at input layer and integrated gradients at test-time for dynamic feature importance.
result More cost- and feature-efficient than prior approaches, achieving higher overall accuracy.
Paper tackles medical image diagnosis with unsupervised domain adaptation.
problem Limited labeled samples and label noise in medical images.
method Collaborative Unsupervised Domain Adaptation (UDA) algorithm.
result Empirical results show superiority of the proposed method.
AI enhances cancer diagnostics using spectroscopy.
problem Early and accurate cancer diagnosis.
method Combining AI with spectroscopy-based techniques.
result AI improves cancer diagnostics speed and safety.
Bayesian CNN estimates uncertainty in COVID-19 detection.
problem Uncertainty in deep learning predictions for medical diagnosis.
method Drop-weight based Bayesian Convolutional Neural Networks (BCNN).
result Uncertainty correlates with prediction accuracy.
Paper uses AI to predict medications from medical codes, improving accuracy in healthcare.
problem Predicting medications from incomplete or incorrect medical codes is challenging.
method Robust Recurrent Neural Networks (RNNs) with decay mechanism and noise injection.
result The method accurately predicts medication orders from contaminated medical codes.
Risk adjustment has become an increasingly important tool in healthcare. It has been extensively applied to payment adjustment for health plans to reflect the expected cost of providing coverage for members. Risk adjustment models are typically estimated using linear regression, which does not fully exploit the informa…
Paper proposes machine learning model for early Alzheimer's diagnosis.
problem Early and accurate diagnosis of Alzheimer's Disease.
method Machine learning models, demographic, biomarker, and cognitive test data.
result 90% accuracy and 87% accuracy in predicting Alzheimer's development.
Proposes a new framework for evaluating diagnostic models with multiple co-primary endpoints.
problem Overoptimistic assessments of predictive performance in automated medical testing devices.
method Multiple testing framework for diagnostic accuracy studies with co-primary endpoints, using a parametric simultaneous test procedure and Bayesian approach to determine optimal number of models.
result Our approach leads to a better final diagnostic model and increased statistical power.
Bias in training data affects diagnostic algorithms' performance.
problem Bias in training data leads to biased predictions in diagnostic algorithms.
method Survey of MICCAI 2018 proceedings, analysis of a skin lesions dataset, adversarial training setup.
result Classifier performance varies significantly between subgroups based on age and sex.
Study proposes a statistical test for Vision Transformer's attention mechanisms.
problem ViT's attention mechanisms may focus on irrelevant regions, leading to unreliable evidence.
method Selective inference framework to quantify statistical significance of attentions as p-values.
result Proposed method enables reliable quantification of false positive detection probability of attentions.
Supervised topic models can help clinical researchers find interpretable cooccurence patterns in count data that are relevant for diagnostics. However, standard formulations of supervised Latent Dirichlet Allocation have two problems. First, when documents have many more words than labels, the influence of the labels w…
The hybrid clustering-classification neural network is proposed. This network allows increasing a quality of information processing under the condition of overlapping classes due to the rational choice of a learning rate parameter and introducing a special procedure of fuzzy reasoning in the clustering process, which o…
Optimizes classification algorithms with bounds on error rates.
problem Bounding uncertainties in classifier outputs for diagnostic testing.
method Set-theoretic and probabilistic arguments to derive uniform error bounds.
result Optimal partition minimizes the largest Gershgorin radius of the confusion matrix.
This paper benchmarks OoDD methods for medical imaging.
problem Medical models trained for one domain may fail on images from a different domain.
method Defined 3 categories of OoD examples and benchmarked methods in 3 medical imaging domains.
result Simple binary classifier on feature representation yields best accuracy and AUPRC.
What has happened in machine learning lately, and what does it mean for the future of medical image analysis? Machine learning has witnessed a tremendous amount of attention over the last few years. The current boom started around 2009 when so-called deep artificial neural networks began outperforming other established…
Simulates patient pathways to detect delayed rare disease diagnoses.
problem Delayed rare disease diagnoses in France, causing health system and patient harm.
method Probabilistic modelling of patient pathways to create an alert system.
result Alert system detects and refers wandering patients to CRMRs.
Machine-learned diagnosis models have shown promise as medical aides but are trained under a closed-set assumption, i.e. that models will only encounter conditions on which they have been trained. However, it is practically infeasible to obtain sufficient training data for every human condition, and once deployed such …
Increasingly large electronic health records (EHRs) provide an opportunity to algorithmically learn medical knowledge. In one prominent example, a causal health knowledge graph could learn relationships between diseases and symptoms and then serve as a diagnostic tool to be refined with additional clinical input. Prior…
Develops a new method to create object models from medical images.
problem Variability in anatomical structures and textures limits observer performance.
method Progressive Growing AmbientGAN (ProAmGAN) for creating stochastic object models from medical imaging measurements.
result Demonstrates the effectiveness of ProAmGAN in creating realistic object models.
BBNN improves neural network accuracy and uncertainty quantification.
problem Overfitting and lack of interpretability in probabilistic neural networks.
method Boosted Bayesian Neural Networks (BBNN) using Boosting Variational Inference (BVI).
result BBNN achieves ~5% higher accuracy and superior uncertainty quantification.
Systematic review of multimodal data challenges and solutions.
problem Challenges in integrating diverse data types for improved diagnostics and personalized care.
method Synthesizing findings from 69 studies on technical obstacles and recent methodological advances.
result Promising solutions like transfer learning, generative models, attention mechanisms, and neural architecture search.
Dynamic memory prevents forgetting in continuous learning of medical images.
problem Catastrophic forgetting in machine learning models over time due to domain shifts.
method Dynamic memory to store and replay diverse training data subsets.
result Dynamic memory mitigates forgetting without knowing when shifts occur.
Method quantifies uncertainties in complex MRF models.
problem Uncertainties in MRF predictions due to data, modeling, and approximations.
method Information-based uncertainty quantification using MRF graphical structure.
result Tight bounds on predictions for quantities of interest in MRFs.
Background: Parkinson's disease (PD) is a prevalent long-term neurodegenerative disease. Though the diagnostic criteria of PD are relatively well defined, the current medical imaging diagnostic procedures are expertise-demanding, and thus call for a higher-integrated AI-based diagnostic algorithm. Methods: In this pape…
CovidCare uses EMR data to predict patient outcomes in emerging epidemics.
problem Intelligent prognosis for patients with emerging infectious diseases during rapid epidemics.
method Transfer learning and knowledge distillation from existing EMR data.
result CovidCare outperforms baseline methods in predicting patient length of stay.
This paper presents an example of how demographical characteristics of patients influence their susceptibility to certain medical conditions. In this paper, we investigate the association of health conditions to age of patients in a heterogeneous population. We show that besides the symptoms a patients is having, the a…
New method accounts for uncertainty in medical AI evaluations.
problem Uncertainty in ground truth affects AI model performance estimates.
method Statistical aggregation approach to infer probabilities of medical conditions.
result Performance estimates are significantly lower when uncertainty is accounted for.
Study finds AI can predict diverse cardiac and non-cardiac diagnoses from a single ECG.
problem Narrow focus of ECG analysis models for diverse medical conditions.
method Exploratory study using a single AI model to predict multiple ICD codes.
result Model achieved AUROC scores > 0.8 for 253 cardiac and 172 non-cardiac diagnoses.
Exploring a new method to explain AI models in medical devices.
problem Lack of explainability in AI models used in medical devices.
method Using the Jacobian matrix to measure model response stability to small perturbations.
result A first step towards a perturbation-based explanation of AI models.
In medicine, visualizing chromosomes is important for medical diagnostics, drug development, and biomedical research. Unfortunately, chromosomes often overlap and it is necessary to identify and distinguish between the overlapping chromosomes. A segmentation solution that is fast and automated will enable scaling of co…
Objective: Ultrasound elastography is gaining traction as an accessible and useful diagnostic tool for such things as cancer detection and differentiation and thyroid disease diagnostics. Unfortunately, state of the art shear wave imaging techniques, essential to promote this goal, are limited to high-end ultrasound ha…
Deep chest X-ray classifiers show bias in predicting diagnoses.
problem Bias in deep learning classifiers predicting diagnoses from chest X-rays.
method Trained convolutional neural networks on multiple public datasets to predict 14 diagnostic labels.
result True positive rates vary significantly among different protected attributes, indicating bias.
We present a model for predicting electrocardiogram (ECG) abnormalities in short-duration 12-lead ECG signals which outperformed medical doctors on the 4th year of their cardiology residency. Such exams can provide a full evaluation of heart activity and have not been studied in previous end-to-end machine learning pap…
We developed an automated deep learning system to detect hip fractures from frontal pelvic x-rays, an important and common radiological task. Our system was trained on a decade of clinical x-rays (~53,000 studies) and can be applied to clinical data, automatically excluding inappropriate and technically unsatisfactory …
Cost-efficient feature selection for multi-label classification in medicine.
problem Feature selection in multi-label classification with cost constraints.
method Sequential feature selection maximizing conditional mutual information, followed by cost-free feature selection using shadow features.
result The method effectively reduces prediction costs in medical applications.
Framework detects brain tumors robustly from MRI images.
problem Low clinical incidence of brain tumor cases makes diagnosis challenging.
method YOLOv8n for detection, DeiT for classification, PTP metric for evaluation.
result F1-score of 0.92 achieved with reduced computational resources.
New method infers viral load from pooled tests.
problem Inefficient viral load inference in pooled testing.
method Message passing algorithm with PCR noise function.
result Accurate viral load inference possible.
Computational paralinguistic analysis is increasingly being used in a wide range of cyber applications, including security-sensitive applications such as speaker verification, deceptive speech detection, and medical diagnostics. While state-of-the-art machine learning techniques, such as deep neural networks, can provi…
Interpretability is a key factor in the design of automatic classifiers for medical diagnosis. Deep learning models have been proven to be a very effective classification algorithm when trained in a supervised way with enough data. The main concern is the difficulty of inferring rationale interpretations from them. Dif…