Paper proposes embedding medical concepts from claims data for better risk adjustment models.
problem Lack of efficient representation of medical histories in risk adjustment models.
method Semantic embeddings of medical concepts from diagnostic, procedure, and prescription codes.
result Embedding-based models outperform commercial risk adjustment models in prospective risk score prediction.
Somed2Vec learns medical concept embeddings from SNOMED-CT, improving healthcare analytics.
problem Lack of effective vector representations for medical concepts in healthcare analytics.
method Graph-based representation learning using random walks and Poincaré embeddings on SNOMED-CT.
result Concept embeddings from SNOMED-CT significantly outperform state-of-the-art embeddings.
Deep learning methods exhibit promising performance for predictive modeling in healthcare, but two important challenges remain: -Data insufficiency:Often in healthcare predictive modeling, the sample size is insufficient for deep learning methods to achieve satisfactory results. -Interpretation:The representations lear…
This work abstracts deep neural networks into concept graphs for better interpretability in medical tasks.
problem Lack of interpretability in deep learning models, especially in medical domains.
method Developed a graphical representation of medical image processing models to understand concept-based reasoning.
result Extracted a concept-level graph that reveals the decision-making process of deep learning models.
Paper proposes a graph network for EHR data that learns robust representations.
problem Learning robust representations for EHR data with implicit connections.
method Variationally regularized encoder-decoder graph network.
result Model outperforms existing methods in various EHR predictive tasks.
Improves medical note processing by training model on related concepts and global context.
problem Scarce and imbalanced labeled training data limits generalizability of automated abbreviation disambiguation models.
method Data augmentation using related medical concepts and global context information within medical notes.
result Model accuracy improved by almost 14% on CASI dataset and 4% on i2b2 dataset.
Evaluating the clinical similarities between pairwise patients is a fundamental problem in healthcare informatics. A proper patient similarity measure enables various downstream applications, such as cohort study and treatment comparative effectiveness research. One major carrier for conducting patient similarity resea…
Deep learning skin lesion classifier explained using CAVs.
problem Limited acceptance of deep learning CAD systems due to opaque decision-making.
method Mapped human understandable concepts to RECOD model using CAVs.
result Classifier learns and encodes disease-related concepts in its latent representation.
Word embeddings are a popular approach to unsupervised learning of word relationships that are widely used in natural language processing. In this article, we present a new set of embeddings for medical concepts learned using an extremely large collection of multimodal medical data. Leaning on recent theoretical insigh…
The paper proposes a deep generative model for complex disease trajectories.
problem Modeling and analyzing complex disease trajectories.
method Deep generative time series approach with semi-supervised latent processes.
result The model can discover novel aspects of diseases and cluster them into new sub-types.
The widespread availability of electronic health records (EHRs) promises to usher in the era of personalized medicine. However, the problem of extracting useful clinical representations from longitudinal EHR data remains challenging. In this paper, we explore deep neural network models with learned medical feature embe…
Automated generation of medical reports from chest x-rays using expert annotations.
problem Generating long, unstructured text from medical images with context and consistency.
method First learn visually-informative medical concepts from raw reports, then use these concepts to auto-generate structured reports from images.
result Validation on OpenI dataset shows auto-generated reports are consistent with manual annotations.
MedCAT extracts valuable medical information from unstructured text.
problem Extracting structured information from unstructured biomedical documents.
method Unsupervised machine learning for disambiguation of entities.
result Improved entity detection and linking compared to existing tools.
Proposes a new method for medical diagnosis using network-based representation learning.
problem Improving medical diagnosis accuracy through better data representation.
method Heterogeneous network-based model and modified metapath2vec algorithm for learning latent node representations.
result Significant performance boost in symptom/disease classification and disease prediction tasks.
Machine learning constructs problem-based medical records from electronic health records.
problem Difficulty in finding relevant medical information for clinical questions.
method Knowledge base completion using machine learning on electronic health records.
result Automatic construction of problem-based groupings of medications, procedures, and lab tests.
ME2Vec learns medical entity vectors from EHR data.
problem Learning structured information from EHR data.
method Graph-based medical entity embedding using diverse graph embedding techniques.
result ME2Vec outperforms baselines in disease diagnosis prediction.
Representation learning (RL) plays an important role in extracting proper representations from complex medical data for various analyzing tasks, such as patient grouping, clinical endpoint prediction and medication recommendation. Medical data can be divided into two typical categories, outpatient and inpatient, that h…
Framework evaluates medical image classification methods using a probabilistic model and a Twenty Questions paradigm.
problem Lack of detailed understanding of how machine learning methods make decisions in medical imaging.
method Inspired by the Turing Test, uses a probabilistic model and a Twenty Questions paradigm to evaluate classification methods based on task-specific concepts.
result Probabilistic model exposes dataset and method biases, reducing the number of queries needed for confident performance evaluation.
OMTL uses ontology to learn from imbalanced EHR data.
problem Imbalanced and small usable data for phenotypes in EHRs.
method Ontology-driven multi-task learning framework.
result Improved learning performance on phenotypes.
System suggests clinical concepts in real-time for faster note creation.
problem Efficiently creating structured clinical notes with minimal keystrokes.
method Contextual autocompletion using shallow neural networks.
result Reduces keystrokes by 67% in real hospital environments.
Improves medication name inference for telemedicine and conversational agents.
problem Challenges in mapping user-friendly medication names to standardized ones.
method Entity-boosted two-tower neural network for ranking SMN to DMP.
result State-of-the-art results achieved with improved attention-based ranking.
Tensor networks improve medical image classification performance.
problem Improving medical image classification accuracy.
method Extending tensor networks to medical image analysis, focusing on 2D images.
result Tensor networks achieve comparable performance to deep learning methods with fewer hyperparameters and resources.
RL algorithms with medical integration improve personalized treatment recommendations.
problem Developing effective personalized treatment strategies for chronic diseases.
method Integrating medical knowledge into RL algorithms for DTR.
result Enhanced treatment recommendations with increased confidence.
Deep reinforcement learning improves medical test suggestions.
problem Improving accuracy of disease diagnosis through better medical test recommendations.
method Formulated as a stage-wise Markov decision process, trained using reinforcement learning with a new action policy representation and exploration scheme.
result Significant improvement in disease diagnosis accuracy with better medical test suggestions.
Paper detects bias in AI medical models using CART.
problem Ensuring fairness in AI medical decision support systems.
method Uses Classification and Regression Trees (CART) algorithm to identify bias.
result Validated the CART approach in both synthetic and real-world data.
Study reveals differences in medical image models' hidden representation refinement.
problem Understanding how intrinsic dimensionality changes in neural network hidden representations across different domains.
method Analysis of 11 natural and medical image datasets using 6 network architectures.
result Medical image models refine hidden representations earlier, suggesting differences in feature abstraction.
MedGraph learns patient visit embeddings from EMRs, capturing both attributes and temporal sequences.
problem Limited EMR embedding methods fail to capture patient demographics, utilisation, and code descriptions.
method MedGraph constructs an attributed bipartite graph and uses a point process to model temporal sequences.
result MedGraph outperforms state-of-the-art methods in medical risk prediction tasks.
Sparse learning has been shown to be effective in solving many real-world problems. Finding sparse representations is a fundamentally important topic in many fields of science including signal processing, computer vision, genome study and medical imaging. One important issue in applying sparse representation is to find…
Explanations for deep neural network predictions in terms of domain-related concepts can be valuable in medical applications, where justifications are important for confidence in the decision-making. In this work, we propose a methodology to exploit continuous concept measures as Regression Concept Vectors (RCVs) in th…
Zero-Shot Learning helps learn new concepts without examples, useful for COVID-19 diagnosis.
problem Learning new concepts without examples, especially in medical imaging.
method Uses existing knowledge and auxiliary information to predict unknown concepts.
result Effective in diagnosing COVID-19 from chest X-rays.
Medical imaging models may encode demographic attributes without violating fairness, depending on the approach.
problem Discrimination in medical imaging models due to encoding demographic attributes.
method Examined marginal and class-conditional representation invariance, traditional fairness notions, and counterfactual fairness.
result Demographically invariant models may not necessarily be fair, and encoding demographic attributes can be advantageous.
Paper detects biases in medical imaging ML models using counterfactual analysis.
problem Bias in medical imaging ML models negatively impacts generalization performance.
method Counterfactual invariance framework combining conditional latent diffusion models and statistical hypothesis testing.
result The method identifies and quantifies biases without direct access to counterfactual data.
MCU-Net combines U-Net and Monte Carlo Dropout for uncertainty in medical image segmentation.
problem Lack of uncertainty representation in deep learning methods for patient-centered healthcare decisions.
method MCU-Net framework using U-Net and Monte Carlo Dropout with four uncertainty metrics.
result MCU-Net maximizes automated performance and refers truly uncertain cases.
Laboratory testing and medication prescription are two of the most important routines in daily clinical practice. Developing an artificial intelligence system that can automatically make lab test imputations and medication recommendations can save costs on potentially redundant lab tests and inform physicians of a more…
This chapter introduces reproducibility in machine learning for medical imaging.
problem Lack of reproducibility in machine learning for medical imaging.
method Distinguishes and defines types of reproducibility, outlines requirements, and discusses utility.
result Discussion on benefits and a plea for a non-dogmatic approach to reproducibility.
TAPER learns unified patient EHR representations for healthcare tasks.
problem Irregular and multimodal data in electronic health records.
method Transformer networks and BERT for embedding structured and unstructured data.
result TAPER model outperforms on mortality, readmission, and length of stay tasks.
Extends linear representation hypothesis to categorical and hierarchical concepts in LLMs.
problem Representing concepts without natural contrasts in large language models.
method Formalizes linear representation hypothesis for categorical and hierarchical concepts, proving relationships between concept hierarchy and representation geometry.
result Validated theoretical results on large language models, estimating representations for 900+ concepts.
Generative concept representations have three major advantages over discriminative ones: they can represent uncertainty, they support integration of learning and reasoning, and they are good for unsupervised and semi-supervised learning. We discuss probabilistic and generative deep learning, which generative concept re…
The paper formalizes how concepts are encoded in text-guided generative models and provides a method to manipulate them.
problem Encoding and manipulating concepts in text-guided generative models.
method Formalizing concepts as subspaces of a representation space, developing algebraic manipulation methods.
result The ability to manipulate concepts in generative models through algebraic operations on the representation.
LLT-ECG classifies ECG signals without backpropagation using linear laws.
problem ECG signal classification efficiency and verifiability.
method Forward linear law identification for ECG signal features.
result State-of-the-art performance on real-world ECG datasets.
Deep neural networks justify medical diagnoses with textual explanations.
problem Improving machine learning in medical diagnosis justification.
method Mapping X-Ray images to textual representations, generating explanations, and multi-task training.
result The method significantly outperforms existing justification methods and achieves high accuracy.
Geometric framework detects concept frustration between human concepts and machine representations.
problem Aligning human concepts with machine learning representations.
method Geometric framework and similarity measures for detecting concept frustration.
result Concept frustration affects machine learning model performance and reorganizes learned concept representations.
Paper reviews neurolinguistics and language technologies, emphasizing mutual enrichment.
problem Understanding brain activity during language processing.
method Brain imaging studies and natural language representations.
result Development of brain-aware natural language representations.
Unified deep learning predicts Parkinson's disease from medical images.
problem Diagnosing Parkinson's disease accurately from medical images.
method Transfer learning and domain adaptation using deep convolutional and recurrent neural networks.
result The approach effectively predicts Parkinson's disease across different medical environments.
The paper explores methods to explain brain tumor segmentation models and extract visualizations.
problem Improving interpretability of deep learning models for brain tumor segmentation.
method Exploring techniques to explain brain tumor segmentation models and extract visualizations.
result Brain tumor segmentation networks learn human-understandable disentangled concepts and use a top-down approach.
Framework harmonizes EHR data across institutions for better analysis.
problem Heterogeneity of medical codes and terminologies hinder EHR data analysis.
method MASH (Multi-source Automated Structured Hierarchy) uses neural optimal transport and learned hyperbolic embeddings to align and structure EHR data.
result MASH generates interpretable hierarchical graphs for unstructured local laboratory codes.
Programmatic Motion Concepts learn human actions from paired videos.
problem Learning motion concepts from paired video and action sequences.
method Semi-supervised learning architecture for hierarchical motion representation.
result Outperforms established baselines, especially in small data settings.
New approach extracts AI model representations for steering and monitoring.
problem Understanding and steering AI models' internal knowledge representation.
method Feature learning advances for scalable linear concept representations.
result Concept representations enable steering and monitoring of AI models.