A novel dose-finding design for cancer clinical trials using level set estimation.
problem Finding the maximum tolerated dose (MTD) in phase I cancer clinical trials.
method Proposes a novel dose-finding design based on level set estimation (LSE) to determine the next dose.
result The proposed LSE design achieves higher accuracy in estimating the MTD and lower risk of overdosing compared to existing designs.
SDF-Bayes finds safe drug combinations safely, balancing optimism and caution.
problem Finding safe drug combinations in clinical trials with multiple drugs and patient heterogeneity.
method SDF-Bayes uses Bayesian statistics to choose the most likely MTD while ensuring safety constraints.
result SDF-Bayes outperforms existing methods in both accuracy and safety for drug combination trials.
SEEDA optimizes dose allocation in clinical trials to balance efficacy and safety.
problem Complex relationships between efficacy and toxicity in new drug trials.
method Adaptive clinical trial methodology that maximizes cumulative efficacy while ensuring safety constraints.
result SEEDA outperforms existing methods in finding optimal doses with higher success rates and fewer patients.
Shared Keyboard design improves phase I clinical trials by borrowing information across doses.
problem Interim decisions based on current dose data may overlook signals from neighboring doses.
method Bayesian model-assisted design using Beta kernel process with kernel-weighted pseudo-counts.
result Significant improvements in identifying maximum tolerated dose and safety.
Gaussian surrogates improve Poisson imaging performance at low doses.
problem Improving Poisson imaging performance at low doses.
method Analysis of Poisson and Gaussian surrogate reconstruction objectives under Poisson noise.
result Gaussian surrogates can achieve MSE comparable to Poisson MAP at low doses.
The Lethal Dose Conjecture limits how much poisoned data can be tolerated.
problem Limiting the impact of poisoned data in machine learning models.
method Theoretical analysis and provable defenses (DPA, FA) based on majority voting.
result DPA and FA are asymptotically optimal defenses against data poisoning.
New methods use RL and DA to improve dosing precision and reduce side effects.
problem Improving precision and safety of anticancer drug dosing.
method Bayesian data assimilation and reinforcement learning.
result Significantly reduces incidence of severe side effects.
From a fresh data science perspective, this thesis discusses the prediction of coronary artery disease based on genetic variations at the DNA base pair level, called Single-Nucleotide Polymorphisms (SNPs), collected from the Ontario Heart Genomics Study (OHGS). First, the thesis explains two commonly used supervised le…
EI-MTD defends edge intelligence against adversarial attacks with dynamic scheduling.
problem Adversarial attacks on edge intelligence models.
method EI-MTD uses differential knowledge distillation to create robust member models and a dynamic scheduling policy based on a Bayesian Stackelberg game.
result EI-MTD effectively protects edge intelligence from black-box adversarial attacks.
Introduces a new geometric method for optimal experimental design.
problem Restrictive invariance properties of traditional OED approaches based on probability densities.
method Mutual transport dependence (MTD) using optimal transport theory.
result Demonstrates high-quality designs and flexibility compared to standard methods.
Study uses MTD model to optimize portfolios by capturing complex financial asset relationships.
problem Capturing nonlinear and directional relationships in financial markets.
method Directed and weighted financial networks using Mixture Transition Distribution (MTD) model.
result Portfolio optimization with network-based assortativity measures outperforms classical methods.
Kernel method optimizes personalized dose rules for patients.
problem Finding optimal individualized dose rules for patients.
method Kernel assisted learning method for estimating optimal dose rules.
result The method identifies the optimal individualized dose rule and produces favorable outcomes.
Proposes a framework for automated radiation therapy treatment planning with uncertainty quantification.
problem Quantifying uncertainties in dose-related quantities for automated treatment planning.
method Three-step pipeline: feature extraction, dose statistic prediction, and dose mimicking.
result Probabilistic treatment plans agree better with clinical counterparts than non-probabilistic ones.
Modeling the impact of the order flow on asset prices is of primary importance to understand the behavior of financial markets. Part I of this paper reported the remarkable improvements in the description of the price dynamics which can be obtained when one incorporates the impact of past returns on the future order fl…
New method estimates optimal dose intervals for personalized treatment.
problem Learning optimal dose intervals from observational data.
method Probability dose interval (PDI) method using DC algorithm.
result Consistent policy with risk converging to best-in-class at root-n rate.
We study the problem of finding the optimal dosage in early stage clinical trials through the multi-armed bandit lens. We advocate the use of the Thompson Sampling principle, a flexible algorithm that can accommodate different types of monotonicity assumptions on the toxicity and efficacy of the doses. For the simplest…
Determining the optimal initial dose for warfarin is a critically important task. Several factors have an impact on the therapeutic dose for individual patients, such as patients' physical attributes (Age, Height, etc.), medication profile, co-morbidities, and metabolic genotypes (CYP2C9 and VKORC1). These wide range f…
Proposes a method for generating prediction intervals in dose-response models using conformal prediction.
problem Uncertainty quantification in continuous treatments for personalized healthcare decisions.
method Causal dose-response problem framed as covariate shift, using weighted conformal prediction with propensity estimation and kernel functions.
result Demonstrates the significance of covariate shift assumptions for robust prediction intervals.
Warfarin dosing remains challenging due to narrow therapeutic index and highly individual variability. Incorrect warfarin dosing is associated with devastating adverse events. Remarkable efforts have been made to develop the machine learning based warfarin dosing algorithms incorporating clinical factors and genetic va…
A new cycleGAN architecture reduces memory and parameter requirements for low-dose CT denoising.
problem Efficient unsupervised low-dose CT denoising with minimal memory and parameter usage.
method Single switchable generator using AdaIN layers for efficient training and inference.
result The proposed method outperforms previous cycleGAN approaches with half the parameters.
Develops a two-stage conformal prediction method for Parkinson's disease medication needs.
problem Heterogeneous disease progression and treatment response in Parkinson's Disease.
method Two-stage conformal prediction framework with statistical guarantees.
result Quantifies uncertainty in medication needs predictions, improving clinical trust and quality of life.
A ML-based method reconstructs 3D organ doses from 2D radiographs for pediatric abdominal radiotherapy.
problem Reconstructing detailed 3D dose distributions for childhood cancer survivors using limited 2D radiographs.
method Surrogate-free ML approach using 142 abdominal planning CTs, 300 artificial plans, and evolutionary algorithm.
result Accurate 3D dose reconstructions with MAEs ≤ 1.7 Gy for edge organs, validated on independent dataset.
The distribution of absorbed dose in radionuclide therapy with Lu177 can be approximated by convolving an image of the time-integrated activity distribution with a dose voxel kernel representing different tissue types. This fast but inaccurate approximation is unsuitable for personalised dosimetry because it negle…
Warfarin is one of the most commonly used oral blood anticoagulant agent in the world, the proper dose of Warfarin is difficult to establish not only because it is substantially variant among patients, but also adverse even severe consequences of taking an incorrect dose. Typical practice is to prescribe an initial dos…
New method reduces sample complexity for robust learning.
problem Developing simple, sample-efficient learning algorithms for robust classification.
method Tolerant empirical risk minimization (RERM) for robust learning.
result Tolerant RERM requires only O(VC(H)dlog(D/γδ)/ε^2) samples for robustness regions of diameter D.
In coronary CT angiography, a series of CT images are taken at different levels of radiation dose during the examination. Although this reduces the total radiation dose, the image quality during the low-dose phases is significantly degraded. To address this problem, here we propose a novel semi-supervised learning tech…
Proposes a new method to measure and avoid harm in machine learning decisions.
problem Measuring and avoiding harm in machine learning algorithms.
method Formal definition of harm and benefit using causal models, counterfactual objective functions.
result Demonstrates that standard machine learning methods can lead to harmful policies under distributional shifts.
DoSE improves OOD detection by estimating model probability density.
problem Poor specificity of model likelihoods for OOD detection.
method DoSE uses density of states concept to avoid direct model probability comparison.
result DoSE achieves state-of-the-art performance on OOD detection benchmarks.
Estimating what would be an individual's potential response to varying levels of exposure to a treatment is of high practical relevance for several important fields, such as healthcare, economics and public policy. However, existing methods for learning to estimate counterfactual outcomes from observational data are ei…
We consider the problem of engineering robust direct perception neural networks with output being regression. Such networks take high dimensional input image data, and they produce affordances such as the curvature of the upcoming road segment or the distance to the front vehicle. Our proposal starts by allowing a neur…
New framework uses score-based priors to solve ill-conditioned polynomial equations, improving signal recovery from noisy data.
problem Recovering signals from low-order moments in inverse problems, especially ill-conditioned polynomial equations.
method Integrates score-based diffusion priors with moment-based estimators to regularize and solve nonlinear inverse problems.
result Diffusion priors improve recovery from third-order moments and make super-resolution MTD feasible.
Due to the widespread use of positron emission tomography (PET) in clinical practice, the potential risk of PET-associated radiation dose to patients needs to be minimized. However, with the reduction in the radiation dose, the resultant images may suffer from noise and artifacts that compromise diagnostic performance.…
Develops a neural surrogate for proton dose calculation using Monte Carlo dropout uncertainty.
problem Computational demand in proton therapy workflows requiring repeated evaluations.
method Integrates Monte Carlo dropout into a neural network surrogate for fast, differentiable dose predictions and uncertainty quantification.
result Shows significant speedups over MC while retaining uncertainty information.
Model based iterative reconstruction (MBIR) algorithms for low-dose X-ray CT are computationally expensive. To address this problem, we recently proposed a deep convolutional neural network (CNN) for low-dose X-ray CT and won the second place in 2016 AAPM Low-Dose CT Grand Challenge. However, some of the texture were n…
Proposes a new method for posterior sampling using MMD with negative distance kernel.
problem Posterior sampling and conditional generative modeling.
method Approximates joint distribution using discrete Wasserstein gradient flows of MMD with negative distance kernel.
result Establishes an error bound for posterior distributions and proves the method is a Wasserstein gradient flow.
Paper develops methods to estimate derivative of dose-response curve for continuous treatments.
problem Estimating the derivative of the dose-response curve for continuous treatments.
method Doubly robust (DR) inference method using kernel smoothing, bias-corrected IPW and DR estimators.
result Proposes novel bias-corrected IPW and DR estimators for continuous treatments.
Exploratory cancer drug studies test multiple tumor cell lines against multiple candidate drugs. The goal in each paired (cell line, drug) experiment is to map out the dose-response curve of the cell line as the dose level of the drug increases. We propose Bayesian Tensor Filtering (BTF), a hierarchical Bayesian model …
A new model improves CT image quality from low-dose scans.
problem Improving CT image quality from low-dose scans.
method Multi-layer Residual Sparsifying Transform (MRST) learning model for low-dose CT reconstruction.
result The MRST model outperforms conventional methods in maintaining subtle details.
Obtaining accurate and reliable images from low-dose computed tomography (CT) is challenging. Regression convolutional neural network (CNN) models that are learned from training data are increasingly gaining attention in low-dose CT reconstruction. This paper modifies the architecture of an iterative regression CNN, BC…
Controlled interventions provide the most direct source of information for learning causal effects. In particular, a dose-response curve can be learned by varying the treatment level and observing the corresponding outcomes. However, interventions can be expensive and time-consuming. Observational data, where the treat…
GAN normalizes CT scans for consistent radiomic feature values.
problem Variations in dose levels and slice thickness affect radiomic features sensitivity.
method Used a 3D generative adversarial network (GAN) to normalize reduced dose, thick slice images to normal dose, thinner slice images.
result GAN-based approach led to significantly smaller error in radiomic features.
Proposes estimators for complex dose-response curves using kernel methods.
problem Estimating complex dose-response curves with continuous treatments, mediators, and covariates.
method Kernel ridge regression with sequential kernel embedding technique.
result Simple estimators for mediated and time-varying dose response curves with nonasymptotic uniform rates.
The paper analyzes risk measures and optimal reserve allocation strategies.
problem Risk measures and optimal reserve allocation across multiple lines of business.
method Formalizes expected maximum deficit, introduces implicitly bounded risk measures, and proposes capital allocation approaches.
result Theoretical results on static and dynamic coherence, convexity, and exact optimizations of aggregate minimum reserves.
Image denoising techniques are essential to reducing noise levels and enhancing diagnosis reliability in low-dose computed tomography (CT). Machine learning based denoising methods have shown great potential in removing the complex and spatial-variant noises in CT images. However, some residue artifacts would appear in…
Method bounds continuous-valued treatment effects when confounding variables are hidden.
problem Inferring causal effects of continuous treatments when hidden confounders are present.
method Novel methodology to bound average and conditional average continuous-valued treatment effects.
result Method gives tighter coverage of true dose-response curve than existing methods.
Dynamical system models (including RNNs) often lack the ability to adapt the sequence generation or prediction to a given context, limiting their real-world application. In this paper we show that hierarchical multi-task dynamical systems (MTDSs) provide direct user control over sequence generation, via use of a latent…
A human-in-the-loop ML framework for precision dosing reduces expert workload and removes bias.
problem High cost of data annotation and lack of appropriate data for ML models.
method Incorporates human experts into the model learning loop to improve interpretability and reduce bias.
result The approach learns interpretable rules from data and potentially lowers expert workload.
The paper finds optimal levels for traders in mean-reverting markets.
problem Determining optimal levels for traders in mean-reverting markets.
method Analytical framework using heat potentials.
result Developed an analytical solution for optimal levels.