Deep generative model discovers inhibitors for unknown targets.
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Motivation: Proteins are known to undergo conformational changes in the course of their functions. The changes in conformation are often attributable to a small fraction of residues within the protein. Therefore identification of these variable regions is important for an understanding of protein function. Results: We …
Paper introduces a method to predict molecule properties from diverse data sources.
SILVR generates new molecules fitting protein binding sites.
QSAR models struggle to predict activity cliffs, but graph isomorphism features improve AC-sensitivity.
CogMol designs novel drug-like molecules for SARS-CoV-2 targets.
The paper defines wave-front singularities using explicit analytic functions.
New inequality helps map stability in minimal surfaces.
Defines signed quasiregular curves and proves growth theorem.
This encyclopedia article briefly reviews without proofs some of the main results in cotangent bundle reduction. The article recalls most the necessary prerequisites to understand the main results.
Method reweights auxiliary tasks to reduce data need for main task.
Study identifies clusters of EU countries with similar young mortality patterns.
This encyclopedia article briefly reviews without proofs some of the main results in symplectic reduction. The article recalls most the necessary prerequisites to understand the main results, namely, group actions, momentum maps, and coadjoint orbits, among others.
The main new notions are the notions of tangent-like spaces and local monoids. The main result is the pasage from a local monoid to its tangent-like space which is a local Leibniz algebra.
We investigate Kähler metrics conformal to gradient Ricci solitons, and base metrics of warped product gradient Ricci solitons. The latter we name quasi-solitons. A main assumption that is employed is functional dependence of the soliton potential, with the conformal factor in the first case, and with the warping funct…
We extend the techniques of [CH] to build an inductive procedure for studying actions in the boundary of the Culler-Vogtmann Outer Space, the main novelty being an adaptation of he classical Rauzy-Veech induction for studying actions of surface type. As an application, we prove that a tree in the boundary of Outer spac…
We describe an error in the proof of a key proposition, which was necessary for the proof of the main result. Alternate proofs of the main result are given by Ozsvath-Stipsicz-Szabo and Dai-Hom-Stoffregen-Truong.
This paper studies compactifications of moduli spaces involving closed Riemann surfaces. The first main result identifies the homeomorphism types of these compactifications. The second main result introduces orbicell decompositions on these spaces using semistable ribbon graphs extending the earlier work of Looijenga.
The main result of this paper is a new and direct proof of the natural transformation from the surgery exact sequence in topology to the analytic K-theory sequence of Higson and Roe. Our approach makes crucial use of analytic properties and new index theorems for the signature operator on Galois coverings with boundary…
Detecting and aggregating sentiments toward people, organizations, and events expressed in unstructured social media have become critical text mining operations. Early systems detected sentiments over whole passages, whereas more recently, target-specific sentiments have been of greater interest. In this paper, we pres…
This is a survey work on Lie algebras with ad-invariant metrics. We summarize main features, notions and constructions, in the aim of bringing into consideration the main research on the topic. We also give some list of examples in low dimensions.
In the main theorem of this paper we treat the problem of existence of minimizers of the isoperimetric problem under the assumption of small volumes. Applications of the main theorem to asymptotic expansions of the isoperimetric problem are given.
This note is an expanded and updated version of our entry with the same title for the 2006 Encyclopedia of Mathematical Physics. We give a brief overview of graded Poisson algebras, their main properties and their main applications, in the contexts of super differentiable and of derived algebraic geometry.
Through the main example of the Ornstein-Uhlenbeck semigroup, the Bakry-Emery criterion is presented as a main tool to get functional inequalities as Poincaré or logarithmic Sobolev inequalities. Moreover an alternative method using the optimal mass transportation, is also given to obtain the logarithmic Sobolev inequa…
Understanding how features interact with each other is of paramount importance in many scientific discoveries and contemporary applications. Yet interaction identification becomes challenging even for a moderate number of covariates. In this paper, we suggest an efficient and flexible procedure, called the interaction …
There is a gap in the proof of the main theorem in the article [ShCh13a] on optimal bounds for the Morse lemma in Gromov-hyperbolic spaces. We correct this gap, showing that the main theorem of [ShCh13a] is correct. We also describe a computer certification of this result.
Simulation reveals relationships in stock market pyramid schemes.
The main goal of the present article is the computation of the Heegaard Floer homology introduced by Ozsvath and Szabo for a family of plumbed rational homology 3-spheres. The main motivation is the study of the Seiberg-Witten type invariants of links of normal surface singularities.
This manuscript studies manifolds-with-boundary collapsing in the Gromov-Hausdorff topology. The main aim is an understanding of the relationship of the topology and geometry of a limiting sequence of manifolds-with-boundary to that of a limit space, which is presumed to be without geodesic terminals. The main result e…
A2D2E designs optimal evaluations for estimating main effects in black-box models.
Study improves Simpson's estimate for cyclic harmonic bundles.
We propose a Multi-Task Learning (MTL) paradigm based deep neural network architecture, called MTCNet (Multi-Task Crowd Network) for crowd density and count estimation. Crowd count estimation is challenging due to the non-uniform scale variations and the arbitrary perspective of an individual image. The proposed model …
This memoire consists of two main results. In the first one we describe Ricci flow theory and we give an educative way for proving Elliptization Conjecture and then we prove Poincare conjecture which is the second proof of Perelman for Poincare conjecture. In the second one which is the main propose of our memoire, we …
One approach to deal with the statistical inefficiency of neural networks is to rely on auxiliary losses that help to build useful representations. However, it is not always trivial to know if an auxiliary task will be helpful for the main task and when it could start hurting. We propose to use the cosine similarity be…
In this paper, we consider the global regularity for Monge-Ampère type equations with the Neumann boundary conditions on Riemannian manifolds. It is known that the classical solvability of the Neumann boundary value problem is obtained under some necessary assumptions. Our main result extends the main theorem from the …
We provide a computer-assisted proof of the holomorphy of the quartic and the octic meromorphic differentials arising in the main Theorem 4.11 of our paper 'The Classification of Branched Willmore spheres in the -Sphere and the -Sphere' (arXiv:1706.01405), using the free mathematical software Sage.
In this article we study the Kähler Ricci flow, the corresponding parabolic Monge Ampère equation and complete non-compact Kähler Ricci flat manifolds. In our main result Theorem \ref{mainthm} we prove that if is sufficiently close to being Kähler Ricci flat in a suitable sense, then the Kähler Ricci flow \eqr…
We study the cobordism of manifolds with boundary, and its applications to codimension 2 embeddings , using the method of the algebraic theory of surgery. The first main result is a splitting theorem for cobordisms of algebraic Poincaré pairs, which is then applied to describe the behaviour on the c…
Characterizes Legendrian knots in lens spaces.
The main purpose of the present work is to investigate statistical manifolds endowed with almost product structures. We prove that the statistical structure of a para-Kähler-like statistical manifold of constant curvature in the Kurose's sense is a Hessian structure. We also derive the main properties of statistical su…
We study solvency of insurers in a comprehensive model where various economic factors affect the capital developments of the companies. The main interest is in the impact of real growth to ruin probabilities. The volume of the business is allowed to increase or decrease. In the latter case, the study is focused on run-…
The main result presented here is that the flow associated with a riemannian metric and a non zero magnetic field on a compact oriented surface without boundary, under assumptions of hyperbolic type, cannot have the same length spectrum of topologically corresponding periodic orbits as the geodesic flow associated with…
This paper aims at detecting an accurate position of the main entrance of the buildings. The proposed approach relies on the fact that the GPS signals drop significantly when the user enters a building. Moreover, as most of the public buildings provide Wi-Fi services, the Wi-Fi received signal strength (RSS) can be uti…
For submanifolds tangent to the structure vector field in cosymplectic space forms, we establish a basic inequality between the main intrinsic invariants of the submanifold, namely its sectional curvature and scalar curvature on one side; and its main extrinsic invariant, namely squared mean curvature on the other side…
Paper generalizes Hardy-Rogers maps for market equilibrium analysis in duopoly markets.
We present a set of models of the main stylized facts of market price fluctuations. These models comprise dynamical evolution with threshold dynamics and Langevin price equation with multiplicative noise, percolation models to describe the interaction between traders and hierarchical cascade models to unravel the possi…
GAMI-Net improves neural network interpretability while maintaining accuracy.
Almost contact B-metric manifolds of dimension 3 are constructed by a two-parametric family of Lie groups. The class of these manifolds in a known classification of almost contact B-metric manifolds is determined as the direct sum of the main vertical classes. The type of the corresponding Lie algebras in the Bianchi c…