CausalLongPFN predicts counterfactual outcomes from time-series data.
problem Predicting future outcomes under varying treatments in time-series data with confounding and heterogeneity.
method Prior-fitted network pretrained on synthetic episodes of temporal structural causal models.
result CausalLongPFN outperforms domain-trained models on factual and counterfactual prediction tasks.
This paper reviews random forest methods for analyzing longitudinal data in precision medicine.
problem Analyzing longitudinal data for precision medicine.
method Extensions of random forest for longitudinal data analysis.
result Categorization of random forest methods for different data structures and repeated measurements.
EB-VAE combines tumor growth and dropout data for personalized treatment response modeling.
problem Challenges in integrating longitudinal tumor measurements, dropout information, and genetic covariates.
method Extended EB-VAE framework to jointly model longitudinal and time-to-event data, incorporating dropout hazard and genetic covariates.
result Hybrid decoder formulation yields consistent treatment-effect parameters and prior predictive performance comparable to neural decoder.
CDVAE estimates treatment effects over time by accounting for unobserved variables.
problem Estimating treatment effects over time in the presence of unobserved confounders.
method Causal Dynamic Variational Autoencoder (CDVAE) that addresses unconfoundedness and unobserved heterogeneity.
result CDVAE outperforms existing methods in estimating Conditional Average Treatment Effects (CATEs).
Develops algorithm to find subgroups with different treatment effects in HIV patients.
problem Estimating treatment effects in EHR data with challenges like time-varying confounding.
method SDLD algorithm combining generalized interaction tree and longitudinal targeted maximum likelihood estimation.
result Identifies subgroups of HIV patients at higher risk of weight gain with dolutegravir-containing ARTs.
VTD uses deep embeddings to estimate treatment effects from longitudinal data without unconfoundedness assumption.
problem Challenges in estimating individualized treatment effects from longitudinal observational data due to confounding bias.
method Leverages deep variational embeddings and observed proxies to learn hidden confounders.
result Effective in estimating treatment effects when hidden confounding is the leading bias.
DEBIAS learns causal effects from psychiatric longitudinal data by optimizing outcome weights.
problem Causal inference challenges in psychiatric longitudinal data due to symptom heterogeneity and latent confounding.
method DEBIAS algorithm that optimizes outcome weights to maximize durable treatment effects and minimize confounding.
result DEBIAS consistently outperforms state-of-the-art methods in recovering causal effects for clinically interpretable composite outcomes.
Develops methods for causal inference in longitudinal data.
problem Estimating Individual Treatment Effects (ITEs) in high-dimensional, time-varying data.
method Causal Dynamic Variational Autoencoder (CDVAE) and long-term counterfactual regression framework.
result CDVAE outperforms baselines and improves state-of-the-art models, approaching oracle performance.
Develops a deep survival model for causal inference in longitudinal studies.
problem Estimating treatment effects on time-to-event outcomes in observational studies with time-dependent covariates.
method TCS model using potential outcomes framework and ensemble of recurrent subnetworks.
result Identifies conditional average treatment effects and individual treatment effect heterogeneity over time.
Study optimal treatment assignment policies under strategic agent responses.
problem Learning optimal treatment policies with strategic agents complicates estimation.
method Dynamic model with threshold convergence to mean-field equilibrium, consistent estimator for policy gradient.
result Threshold for treatment assignment converges to mean-field equilibrium threshold under large but finite number of agents.
The estimation of treatment effects is a pervasive problem in medicine. Existing methods for estimating treatment effects from longitudinal observational data assume that there are no hidden confounders, an assumption that is not testable in practice and, if it does not hold, leads to biased estimates. In this paper, w…
We link disjoint longitudinal data for rare disease patients using latent representations and mixed-effects regression.
problem Analyzing treatment switches in rare diseases with limited data and changing measurement instruments.
method We embed item values into a shared latent space using variational autoencoders and apply mixed-effects regression to quantify treatment effects.
result Our approach allows for statistical inference and quantifies the impact of treatment switches in spinal muscular atrophy.
Proposes Deep LTMLE for estimating dynamic treatment effects in longitudinal studies.
problem Estimating counterfactual mean outcomes under dynamic treatment policies in longitudinal settings.
method Uses a transformer architecture with temporal-difference learning for initial estimation, followed by TMLE correction and statistical inference.
result Demonstrates superior performance in complex, long-term scenarios compared to existing methods.
Developed a flexible Bayesian g-formula for causal survival analysis with time-dependent confounding.
problem Estimating causal survival curves in longitudinal observational studies with time-varying treatments and confounding.
method Incorporated Bayesian Additive Regression Trees (BART) into the g-formula to model time-evolving generative components and mitigate bias due to model misspecification.
result Demonstrated improved empirical performance and practical utility of the proposed method through simulations and real-world data analysis.
While studying response trajectory, often the population of interest may be diverse enough to exist distinct subgroups within it and the longitudinal change in response may not be uniform in these subgroups. That is, the timeslope and/or influence of covariates in longitudinal profile may vary among these different sub…
Develops a new density ratio estimator for causal inference.
problem Estimation of density ratio functions in statistics.
method Super learning approach with a novel loss function.
result Empirical validation of the density ratio super learner's performance.
Estimating the effect of a treatment on a given outcome, conditioned on a vector of covariates, is central in many applications. However, learning the impact of a treatment on a continuous temporal response, when the covariates suffer extensively from measurement error and even the timing of the treatments is uncertain…
We study the problem of estimating the continuous response over time to interventions using observational time series---a retrospective dataset where the policy by which the data are generated is unknown to the learner. We are motivated by applications where response varies by individuals and therefore, estimating resp…
New method for analyzing multiple longitudinal data processes.
problem Exploring associations between multiple random processes observed jointly.
method Functional Generalized Canonical Correlation Analysis (FGCCA) based on multiblock Regularized Generalized Canonical Correlation Analysis (RGCCA).
result FGCCA framework is robust to sparsely and irregularly observed data.
Proposes a method for generating prediction intervals in dose-response models using conformal prediction.
problem Uncertainty quantification in continuous treatments for personalized healthcare decisions.
method Causal dose-response problem framed as covariate shift, using weighted conformal prediction with propensity estimation and kernel functions.
result Demonstrates the significance of covariate shift assumptions for robust prediction intervals.
Develops a method to estimate treatment effects using noisy proxies over time.
problem Estimating individualized treatment effects from noisy proxies of confounders.
method Deconfounding Temporal Autoencoder (DTA) combining autoencoder and causal regularization.
result Improves treatment effect estimates by leveraging noisy proxies and learning hidden confounders.
Unified framework for response-adaptive targeting in multi-treatment experiments
problem Improving ethical and statistical efficiency in multi-treatment clinical trials
method Response-adaptive targeting strategies
result Unified framework for α-Rebalancing Targeting Strategies (αRTS) Bayesian model ranks treatments in multi-response experiments.
problem Identifying the best treatment among competing ideal properties.
method Bayesian approach with Markov Chain Monte Carlo algorithm.
result Reliable inference of treatment ranks in practice.
CDM models counterfactual outcomes in longitudinal data with improved accuracy.
problem Predicting counterfactual outcomes in longitudinal data with complex time-dependent confounding.
method Causal Diffusion Model (CDM) using denoising diffusion architecture with relational self-attention.
result CDM outperforms state-of-the-art methods in generating full probabilistic distributions of counterfactual outcomes.
The goal of personalized decision making is to map a unit's characteristics to an action tailored to maximize the expected outcome for that unit. Obtaining high-quality mappings of this type is the goal of the dynamic regime literature. In healthcare settings, optimizing policies with respect to a particular causal pat…
Estimates personalized treatment response curves using covariates.
problem Flexible estimation of personalized treatment response curves.
method Sieve based nonparametric estimator of smoothed regimen-response curve function.
result Asymptotic linearity and undersmoothing criteria for efficient estimation.
Treatment effects can be estimated from observational data as the difference in potential outcomes. In this paper, we address the challenge of estimating the potential outcome when treatment-dose levels can vary continuously over time. Further, the outcome variable may not be measured at a regular frequency. Our propos…
New method calibrates asynchronous, error-prone covariates for longitudinal data.
problem Estimation biases and slow convergence in analyzing time-varying covariates with measurement error.
method Functional calibration approach based on functional principal component analysis.
result Asymptotically unbiased and consistent estimators for time-invariant coefficients; optimal convergence rate for time-varying coefficients.
Develops a Causal Transformer for estimating counterfactual outcomes from longitudinal data.
problem Estimating counterfactual outcomes over time from observational data is challenging due to complex, long-range dependencies.
method Combines three transformer subnetworks with separate inputs for time-varying covariates, previous treatments, and previous outcomes into a joint network with in-between cross-attentions. Uses a custom, end-to-end training procedure with a counterfactual domain confusion loss to address confounding bias.
result Achieves superior performance over current baselines in synthetic and real-world datasets.
New method estimates treatment effects over time with unobserved confounders.
problem Estimating treatment effects from observational data with unobserved confounders.
method Sequential Deconfounder using Gaussian process latent variable model.
result Unbiased estimates of individualized treatment responses over time.
Estimating what would be an individual's potential response to varying levels of exposure to a treatment is of high practical relevance for several important fields, such as healthcare, economics and public policy. However, existing methods for learning to estimate counterfactual outcomes from observational data are ei…
Previous algorithms for constructing regression tree models for longitudinal and multiresponse data have mostly followed the CART approach. Consequently, they inherit the same selection biases and computational difficulties as CART. We propose an alternative, based on the GUIDE approach, that treats each longitudinal d…
Proposes DeepSDRF for continuous treatment recommendation from clinical survival data.
problem Continuous treatment recommendation in medical settings with survival data.
method Deep Survival Dose Response Function (DeepSDRF) for learning conditional average dose response (CADR) function.
result Similar performance of recommender algorithms based on random search and reinforcement learning.
Method estimates treatment effects with continuous values, correcting for confounding.
problem Estimating treatment effects with continuous values, dealing with confounding.
method Two-stage kernel ridge regression: first stage learns response, second stage corrects for distribution shift.
result Optimal learning bounds achieved without estimating treatment density, adapts to unknown overlap and kernel spectral decay.
ContiVAE estimates individual dose-response curves from unobserved confounders using observational data.
problem Estimating causal effects of continuous treatments considering unobserved confounders.
method Variational auto-encoder with a Tilted Gaussian prior distribution modeling hidden confounders as latent variables.
result ContiVAE outperforms existing methods by up to 62% in predicting individual dose-response curves.
Paper develops methods to estimate derivative of dose-response curve for continuous treatments.
problem Estimating the derivative of the dose-response curve for continuous treatments.
method Doubly robust (DR) inference method using kernel smoothing, bias-corrected IPW and DR estimators.
result Proposes novel bias-corrected IPW and DR estimators for continuous treatments.
Kernel methods identify treatment effects with unobserved confounding using negative controls.
problem Learning causal relationships with unmeasured confounding.
method Kernel ridge regression algorithms for nonparametric treatment effects.
result Uniform consistency and finite sample rates of convergence proved.
Proposes a method to estimate causal effects of continuous treatments using instrumental variables.
problem Estimating causal effects of continuous treatments in the presence of unmeasured confounders.
method Introduces a novel framework using instrumental variables and a uniform regular weighting function to identify and estimate average dose-response functions.
result Establishes the asymptotic properties of the proposed methods for estimating average dose-response functions.
MMM model clusters mixed-type longitudinal data efficiently.
problem Challenges in clustering multivariate longitudinal mixed-type data.
method MMM model reorganizes data into a three-way structure, using a mixture of matrix-variate normal distributions.
result MMM model handles various data types (continuous, ordinal, binary, nominal, count) and temporal dependence.
Paper introduces new estimator for continuous treatment effects.
problem Estimating the average dose-response function of continuous treatments.
method Utilizes ADML and DML tools, with a novel debiasing method.
result Proves asymptotic normality and shows good performance in simulations.
Method bounds continuous-valued treatment effects when confounding variables are hidden.
problem Inferring causal effects of continuous treatments when hidden confounders are present.
method Novel methodology to bound average and conditional average continuous-valued treatment effects.
result Method gives tighter coverage of true dose-response curve than existing methods.
Optimum in Convex Hulls (OCH) generalizes clinical trial results to broader populations.
problem Clinical trials exclude confounding but limit recruitment; observational data are more inclusive but suffer from confounding.
method OCH uses convex hulls of conditional expectations or densities to approximate the true treatment effect from both observational and trial data.
result OCH estimates the treatment effect with state-of-the-art accuracy in terms of both expectations and densities.
Model trains passing events on a bridge using multilevel Gaussian process.
problem Represent aggregate train-passing events from a bridge monitoring system.
method Formulate a combined model with low-rank approximation hierarchical Gaussian process, incorporating domain expertise as constraints.
result Allow for simulation of previously unobserved train types.
Scientists develop a model to identify treatment responders from non-responders.
problem Analyzing samples that respond to treatment in studies.
method Causal two-groups (C2G) model, empirical Bayes procedures.
result The C2G model controls false discovery rate and has near-optimal power.
Develops methods to identify and estimate causal effects with instrumental variables.
problem Causal inference with confounded treatment assignment and unobserved variables.
method General nonparametric causal framework, debiased machine learning, semiparametric theory.
result Consistent and asymptotically normal estimators for average treatment effect.
C-kNN-LSH identifies similar patient histories for causal inference in longitudinal data.
problem Estimating causal effects from longitudinal trajectories with high-dimensional confounding.
method C-kNN-LSH uses locality-sensitive hashing to find clinical twins and estimate treatment effects.
result C-kNN-LSH outperforms existing methods in capturing recovery heterogeneity and estimating policy values.
Deep learning predicts response to HER2-targeted breast cancer therapy.
problem Predicting response to HER2-targeted neoadjuvant chemotherapy.
method Developed and validated a deep learning approach using pre-treatment dynamic breast MRI.
result Deep learning model achieved strong performance in predicting pathological complete response.
New method estimates effects of multiple nutrients on blood glucose.
problem Estimating physiological response to multiple nutrient treatments.
method Convolution-based multi-output Gaussian process model.
result Improved prediction accuracy and better interpretation of individual nutrient effects.