Deep neural networks are a family of computational models that have led to a dramatical improvement of the state of the art in several domains such as image, voice or text analysis. These methods provide a framework to model complex, non-linear interactions in large datasets, and are naturally suited to the analysis of…
A tutorial on various methods for clustering longitudinal data.
problem Identifying groups with different trends in longitudinal data.
method Group-based trajectory modeling, growth mixture modeling, longitudinal k-means.
result Strengths, limitations, and model extensions of the methods are discussed.
HL-VAE extends VAE for heterogeneous temporal and longitudinal data.
problem Handling heterogeneous data in temporal and longitudinal datasets.
method Proposes HL-VAE, an extension of existing VAEs for temporal and longitudinal data, incorporating likelihood models for various data types.
result HL-VAE achieves competitive performance in missing value imputation and predictive accuracy.
LPCI provides valid prediction intervals for longitudinal data.
problem Current conformal prediction methods for time series data lack cross-sectional coverage when applied to longitudinal datasets.
method Modeling residual data as a quantile fixed-effects regression problem, constructing prediction intervals with a trained quantile regressor.
result LPCI achieves valid cross-sectional coverage and outperforms existing benchmarks in terms of longitudinal coverage rates.
A scalable model for high-dimensional longitudinal data.
problem Modeling high-dimensional, non-linear, time-varying longitudinal data.
method LMM-VAE, combining linear mixed models and amortized variational inference.
result Competitive performance across simulated and real-world datasets.
New method models longitudinal data using variational inference and normalizing flows.
problem Handling high-dimensional longitudinal data with time dependency.
method Variational inference with normalizing flows for latent variables.
result The method achieves better likelihood estimates and more reliable missing data imputation.
latrend simplifies longitudinal clustering for numeric measurements.
problem Clustering of longitudinal data to identify common trends over time.
method Unified framework for applying various clustering methods.
result Facilitates comparison and rapid prototyping of new methods.
Proposes L-VAE for longitudinal data analysis.
problem Analyse high-dimensional longitudinal data with missing values.
method Uses a multi-output additive Gaussian process (GP) prior to extend VAE's capability.
result Achieves highly accurate predictive performance.
Joint models for longitudinal and time-to-event data are commonly used in longitudinal studies to forecast disease trajectories over time. While there are many advantages to joint modeling, the standard forms suffer from limitations that arise from a fixed model specification, and computational difficulties when applie…
Efficiently estimates longitudinal networks by merging sparse networks.
problem Estimating longitudinal networks with sparse and temporal data.
method Adaptive network merging, tensor decomposition, point process.
result Significantly reduces estimation error and provides guidance for network merging.
Proposes a neural network for dynamic risk prediction of AMD using longitudinal fundus images.
problem Dynamic risk prediction for progressive eye disorders like AMD.
method tdCoxSNN, a time-dependent Cox survival neural network integrating CNN.
result Demonstrates commendable predictive performance in AMD and PBC datasets.
TransformerLSR models longitudinal, recurrent, and survival data jointly.
problem Joint modeling of longitudinal measurements, recurrent events, and survival data with dependencies.
method Transformer-based deep learning framework integrating deep temporal point processes and latent structure representation.
result TransformerLSR effectively models all three components simultaneously, demonstrating necessity and effectiveness through simulations and real-world data.
New method for analyzing multiple longitudinal data processes.
problem Exploring associations between multiple random processes observed jointly.
method Functional Generalized Canonical Correlation Analysis (FGCCA) based on multiblock Regularized Generalized Canonical Correlation Analysis (RGCCA).
result FGCCA framework is robust to sparsely and irregularly observed data.
Develops privacy-preserving methods for longitudinal linear regression.
problem Protecting individual information in longitudinal data with privacy-preserving statistics.
method Proposes a user-level private regression estimator and a privatized covariance estimator for longitudinal linear regression under user-level differential privacy.
result Establishes theoretical guarantees for practical user-level differential privacy estimation and inference in longitudinal linear regression.
TraCeR uses transformers to analyze survival data with longitudinal covariates.
problem Handling longitudinal covariates and assessing model calibration in survival analysis.
method Transformer-based survival analysis framework with factorized self-attention architecture.
result TraCeR achieves significant performance improvements over state-of-the-art methods.
Model uses smartphone data to assess MS trajectories.
problem Personalized longitudinal MS assessment.
method Imputation, generalized estimation equation, ensemble learning, fine-tuning.
result Promising model for predicting MS over time.
Transformers simplify modeling of small longitudinal cohort data by reducing parameters and incorporating attention mechanisms.
problem Challenges in modeling longitudinal cohort data due to complex temporal dependencies and large dataset requirements.
method Simplified transformer architecture with attention mechanism, autoregressive model, and kernel-based temporal decay.
result The approach recovers contextual dependencies even with small datasets, identifying temporal patterns in stress and mental health.
Study compares neural and statistical models for Parkinson's disease progression from voice data.
problem Difficult statistical analysis of longitudinal voice biomarkers due to subject correlation, small cohorts, and varied disease trajectories.
method Evaluated Neural Mixed Effects (NME), Generalized Neural Network Mixed Models (GNMMs), and semi-parametric Generalized Additive Mixed Models (GAMMs).
result GAMMs achieve stronger predictive performance and retain interpretable smooth effects and subject-level structure.
Deep learning predicts AMD progression from longitudinal fundus images.
problem Predicting future stages of age-related macular degeneration (AMD).
method InceptionV3 feature vectors, interval scaling, Recurrent Neural Network.
result 0.878 sensitivity, 0.887 specificity, 0.950 AUC.
Joint models for longitudinal and time-to-event data are commonly used in longitudinal studies to forecast disease trajectories over time. Despite the many advantages of joint modeling, the standard forms suffer from limitations that arise from a fixed model specification and computational difficulties when applied to …
CPTD improves prediction intervals in time series regression with cross-sectional data.
problem Constructing valid prediction intervals in time series regression with a cross-section.
method Conformal Prediction with Temporal Dependence (CPTD) for post-hoc, light-weight approach.
result CPTD maintains cross-sectional validity while improving longitudinal coverage.
Develops a deep survival model for causal inference in longitudinal studies.
problem Estimating treatment effects on time-to-event outcomes in observational studies with time-dependent covariates.
method TCS model using potential outcomes framework and ensemble of recurrent subnetworks.
result Identifies conditional average treatment effects and individual treatment effect heterogeneity over time.
GANs improve longitudinal data imputation but face challenges in missing data and class imbalance.
problem Missing data and class imbalance in longitudinal data.
method GANs applied to longitudinal data imputation (LDI).
result GANs show potential but need more versatile approaches.
LLmFPCA-detect detects anomalies in sparse longitudinal text data using LLMs and mFPCA.
problem Challenges in detecting patterns and anomalies in sparse longitudinal textual data.
method Pairs LLM-based text embeddings with mFPCA to detect clusters and anomalies.
result LLmFPCA-detect outperforms state-of-the-art baselines on Amazon and Wikipedia datasets.
Study compares resampling methods for rare event prediction in longitudinal studies.
problem Predicting rare events in longitudinal follow-up studies.
method Comparison of resampling methods to improve standard regression models.
result Effect of sampling rate on model predictive performance.
There is an emerging trend in the reinforcement learning for healthcare literature. In order to prepare longitudinal, irregularly sampled, clinical datasets for reinforcement learning algorithms, many researchers will resample the time series data to short, regular intervals and use last-observation-carried-forward (LO…
Deep learning for integrating diverse clinical measurements.
problem Combining data from different measurement instruments in longitudinal clinical registries.
method Domain adaptation using deep learning for mapping items from different instruments.
result Domain adaptation can recover latent trajectories even with limited data and misalignment.
Enhances generative model for clinical data privacy and accuracy.
problem Data privacy in electronic patient records.
method Improves a time-series generative model with privacy safeguards.
result DP-TimeGAN achieves a mean authenticity of 0.778 on the CKD dataset.
Study uses 1D-CNNs to forecast mortality in ELSA survey.
problem Forecasting mortality in the middle-aged and older population.
method 1D-CNNs applied to longitudinal data with various over/undersampling and activation functions.
result Swish nonlinearity outperforms other functions in forecasting mortality.
Prediction of the future trajectory of a disease is an important challenge for personalized medicine and population health management. However, many complex chronic diseases exhibit large degrees of heterogeneity, and furthermore there is not always a single readily available biomarker to quantify disease severity. Eve…
While studying response trajectory, often the population of interest may be diverse enough to exist distinct subgroups within it and the longitudinal change in response may not be uniform in these subgroups. That is, the timeslope and/or influence of covariates in longitudinal profile may vary among these different sub…
The paper studies quandles over a hyperboloid and computes a knot invariant.
problem Computing knot invariants for specific algebraic structures.
method Defined quandles over a hyperboloid and computed a longitudinal mapping invariant.
result Computed a new knot invariant for SL(2,R). We study regularized estimation in high-dimensional longitudinal classification problems, using the lasso and fused lasso regularizers. The constructed coefficient estimates are piecewise constant across the time dimension in the longitudinal problem, with adaptively selected change points (break points). We present an…
Automates kernel discovery for longitudinal data analysis.
problem Handling irregularly sampled, sparse longitudinal data with multilevel correlation.
method Combines deep neural networks and non-parametric kernel methods to discover complex multilevel correlation structure.
result Significantly outperforms state-of-the-art methods on benchmark data sets.
With the increased need for multi-center magnetic resonance imaging studies, problems arise related to differences in hardware and software between centers. Namely, current algorithms for brain volume quantification are unreliable for the longitudinal assessment of volume changes in this type of setting. Currently most…
CausalLongPFN predicts counterfactual outcomes from time-series data.
problem Predicting future outcomes under varying treatments in time-series data with confounding and heterogeneity.
method Prior-fitted network pretrained on synthetic episodes of temporal structural causal models.
result CausalLongPFN outperforms domain-trained models on factual and counterfactual prediction tasks.
New method calibrates asynchronous, error-prone covariates for longitudinal data.
problem Estimation biases and slow convergence in analyzing time-varying covariates with measurement error.
method Functional calibration approach based on functional principal component analysis.
result Asymptotically unbiased and consistent estimators for time-invariant coefficients; optimal convergence rate for time-varying coefficients.
Model trains passing events on a bridge using multilevel Gaussian process.
problem Represent aggregate train-passing events from a bridge monitoring system.
method Formulate a combined model with low-rank approximation hierarchical Gaussian process, incorporating domain expertise as constraints.
result Allow for simulation of previously unobserved train types.
Framework learns continuous dynamics from sparse trajectories.
problem Learning dynamics from sparsely sampled and high-dimensional trajectories.
method Interpolative Multi-Marginal Flow Matching (IMMFM) framework.
result IMMFM outperforms existing methods in forecasting and downstream tasks.
Develops new algorithms for QRF to handle mixed-frequency and longitudinal data.
problem Handling mixed-frequency and longitudinal data in quantile regression.
method Mixed-Frequency Quantile Regression Forest (MIDAS-QRF) and Finite Mixture Quantile Regression Forest (FM-QRF).
result Valid and flexible models for complex empirical settings in financial risk management and climate-change impact evaluation.
CDM models counterfactual outcomes in longitudinal data with improved accuracy.
problem Predicting counterfactual outcomes in longitudinal data with complex time-dependent confounding.
method Causal Diffusion Model (CDM) using denoising diffusion architecture with relational self-attention.
result CDM outperforms state-of-the-art methods in generating full probabilistic distributions of counterfactual outcomes.
This paper explores the capability of deep neural networks to capture key characteristics of vehicle dynamics, and their ability to perform coupled longitudinal and lateral control of a vehicle. To this extent, two different artificial neural networks are trained to compute vehicle controls corresponding to a reference…
Flexible model tackles high-dimensional, missing data, and stochastic processes.
problem High-dimensional longitudinal data with structured missingness and unknown measurement time points.
method Latent variable model using Gaussian processes and variational autoencoder.
result Competitive performance on simulated and real datasets.
Finite mixture models have become a popular tool for clustering. Amongst other uses, they have been applied for clustering longitudinal data and clustering high-dimensional data. In the latter case, a latent Gaussian mixture model is sometimes used. Although there has been much work on clustering using latent variables…
Bayesian Causal Forests model assesses part-time work's impact on student growth.
problem Estimating causal effects of part-time work on student growth in mathematics achievement.
method Longitudinal Bayesian Causal Forests model combining non-parametric and difference-in-differences methods.
result Negative impact of part-time work for most students, potential benefits for those with low school belonging, widening achievement gap identified.
Develops algorithm to find subgroups with different treatment effects in HIV patients.
problem Estimating treatment effects in EHR data with challenges like time-varying confounding.
method SDLD algorithm combining generalized interaction tree and longitudinal targeted maximum likelihood estimation.
result Identifies subgroups of HIV patients at higher risk of weight gain with dolutegravir-containing ARTs.
Develops a Causal Transformer for estimating counterfactual outcomes from longitudinal data.
problem Estimating counterfactual outcomes over time from observational data is challenging due to complex, long-range dependencies.
method Combines three transformer subnetworks with separate inputs for time-varying covariates, previous treatments, and previous outcomes into a joint network with in-between cross-attentions. Uses a custom, end-to-end training procedure with a counterfactual domain confusion loss to address confounding bias.
result Achieves superior performance over current baselines in synthetic and real-world datasets.
DEBIAS learns causal effects from psychiatric longitudinal data by optimizing outcome weights.
problem Causal inference challenges in psychiatric longitudinal data due to symptom heterogeneity and latent confounding.
method DEBIAS algorithm that optimizes outcome weights to maximize durable treatment effects and minimize confounding.
result DEBIAS consistently outperforms state-of-the-art methods in recovering causal effects for clinically interpretable composite outcomes.