Robust cancer screening model using pre-trained ensembles for biomarkers.
problem Detecting early-stage cancer, especially in hard-to-diagnose cases like pancreatic cancer.
method Meta-trained Hyperfast model for robust classification, combined with ensembling of XGBoost and LightGBM.
result Achieved highest AUC of 0.9929 and robust performance on imbalanced datasets.
Celiac Disease (CD) and Environmental Enteropathy (EE) are common causes of malnutrition and adversely impact normal childhood development. CD is an autoimmune disorder that is prevalent worldwide and is caused by an increased sensitivity to gluten. Gluten exposure destructs the small intestinal epithelial barrier, res…
Histopathology tissue samples are widely available in two states: paraffin-embedded unstained and non-paraffin-embedded stained whole slide RGB images (WSRI). Hematoxylin and eosin stain (H&E) is one of the principal stains in histology but suffers from several shortcomings related to tissue preparation, staining proto…
A Convolutional Neural Network was used to predict kidney function in patients with chronic kidney disease from high-resolution digital pathology scans of their kidney biopsies. Kidney biopsies were taken from participants of the NEPTUNE study, a longitudinal cohort study whose goal is to set up infrastructure for obse…
Study proposes deep learning techniques to diagnose and differentiate Celiac Disease and Environmental Enteropathy from biopsy images.
problem Challenging histopathologic overlap between Celiac Disease and Environmental Enteropathy in biopsy images.
method Color balancing and Random Multimodel Deep Learning (RMDL) architecture to address staining variability.
result Proposed deep learning techniques improve diagnosis accuracy of Celiac Disease and Environmental Enteropathy.
In order to investigate the breast cancer prediction problem on the aging population with the grades of DCIS, we conduct a tree augmented naive Bayesian network experiment trained and tested on a large clinical dataset including consecutive diagnostic mammography examinations, consequent biopsy outcomes and related can…
Mammography is the most effective and available tool for breast cancer screening. However, the low positive predictive value of breast biopsy resulting from mammogram interpretation leads to approximately 70% unnecessary biopsies with benign outcomes. Data mining algorithms could be used to help physicians in their dec…
PersonalizedUS assesses breast cancer risk with local coverage guarantees.
problem Manual BI-RADS scoring leads to unnecessary biopsies and mental health burden.
method Conformal prediction for precise, personalized risk estimates.
result Local coverage guarantees with high sensitivity and specificity.
Machine learning classifies colorectal tissue using photoacoustic microscopy.
problem Traditional diagnostic methods for colorectal cancer are limited in detail and painful.
method Machine learning applied to acoustic resolution photoacoustic microscopy.
result Machine learning accurately classified benign and malignant tissue.
A deep learning approach classifies medical images hierarchically.
problem Limitations of traditional supervised classifiers in medical image classification.
method Hierarchical Medical Image Classification (HMIC) using deep learning models.
result HMIC achieved better performance in classifying medical images hierarchically.
Colorectal cancer, largely arising from precursor lesions called polyps, remains one of the leading causes of cancer-related death worldwide. Current clinical standards require the resection and histopathological analysis of polyps due to test accuracy and sensitivity of optical biopsy methods falling substantially bel…
Method detects batch heterogeneity in genomic data.
problem Batch effects confound genomic diagnostics.
method Bayesian model evidence clustering.
result Detects batch effects without known labels.
Deep object detection improves mitotic nucleus detection in breast cancer biopsies.
problem Challenges in automated mitotic nucleus detection in breast cancer histopathological images.
method Adapted Mask R-CNN for deep object detection, initially selects candidate regions with maximum recall, refines them with multi-object loss function.
result Improved discrimination ability (F-score of 0.86) and significant precision (0.86) for mitotic nuclei compared to two-stage models.
Hierarchical CNNs improve diagnosis of GI diseases from histopathological images.
problem Diagnosing GI diseases from histopathological images is challenging due to heterogeneity and shared features.
method Embedded a class hierarchy into a VGGNet to address the hierarchical structure of GI diseases.
result The hierarchical model achieved better results than a flat model for multi-category diagnosis of GI disorders.
Optimizes liquidity provision intervals for profitable AMM participation.
problem Financial losses from poor liquidity provision intervals and reallocation costs.
method Developed a tractable stochastic optimization problem.
result Computes optimal liquidity provision intervals for profitable liquidity concentration.
Study shows how crypto asset liquidity is affected by wash trading and proposes treatment to reduce liquidity diffusion.
problem Understanding and reducing crypto asset wash trading to improve liquidity.
method Proposed a two-component model for liquidity (jump and diffusion) and demonstrated the effectiveness of autoregressive models.
result Treatment on wash trading significantly reduces liquidity diffusion but not liquidity jump.
The incidence of malignant melanoma continues to increase worldwide. This cancer can strike at any age; it is one of the leading causes of loss of life in young persons. Since this cancer is visible on the skin, it is potentially detectable at a very early stage when it is curable. New developments have converged to ma…
The study introduces new liquidity measures and models for assets with extreme liquidity.
problem Modeling assets with extreme liquidity, especially in crypto markets.
method Developed innovative liquidity premium measures, liquidity-adjusted return and volatility models, and used ARMA-GARCH/EGARCH models.
result The liquidity-adjusted models outperform traditional models in predicting asset performance at extreme liquidity.
Automatization of the diagnosis of any kind of disease is of great importance and it's gaining speed as more and more deep learning solutions are applied to different problems. One of such computer aided systems could be a decision support too able to accurately differentiate between different types of breast cancer hi…
A liquidity measure based on consideration and price range is proposed. Initially defined for daily data, Liquidity Index (LIX) can also be estimated via intraday data by using a time scaling mechanism. The link between LIX and the liquidity measure based on weighted average bid-ask spread is established. Using this li…
Research proposes a model to estimate transaction costs and assess asset liquidity risk.
problem Lack of standardized models for asset liquidity risk in asset management.
method Develops a market impact model and a two-regime model based on power-law property.
result Defines liquidity measures and applies model to stocks and bonds.
Improved ARMA-GARCH model for illiquid assets like cryptocurrencies.
problem Inadequate modeling of illiquid assets, especially cryptocurrencies, with traditional ARMA-GARCH models.
method Introducing liquidity-adjusted liquidity jump and diffusion metrics into ARMA-GARCH framework.
result The liquidity-adjusted model improves model fit and volatility sensitivity for cryptocurrencies.
Optimizes liquidity provision in decentralized exchanges with utility indifference market makers.
problem Impermanent loss in decentralized exchanges without transaction fees.
method Mathematical formulation of liquidity provision, focusing on utility indifference market makers.
result No-arbitrage conditions and optimal arbitrage strategies are established.
Third part of a study on liquidity risk in asset management, focusing on managing the asset-liability liquidity risk.
problem Managing the asset-liability liquidity risk in asset management.
method Develops a methodological and practical framework for liquidity stress testing programs.
result Proposes measurement, management, and monitoring tools for controlling the liquidity gap.
Develops a new model to better estimate cryptocurrency and stock volatility.
problem Misrepresentation of volatility and co-movement in traditional models.
method Introduces liquidity-sensitive multivariate volatility framework with novel liquidity measures.
result Liquidity-adjusted models yield more stable and interpretable risk structures.
Optimal early liquidation strategy reduces financial losses during crises.
problem Substantial losses from simultaneous asset liquidation at depressed prices.
method Developed a worst-case approach for optimal early liquidation, considering uncertainty of other banks' decisions.
result Proposed robust optimal strategy maximizes liquid assets' value at clearing, even with uncertainty.
JIT liquidity providers can sometimes reduce overall market liquidity by crowding out passive LPs.
problem JIT liquidity providers can reduce overall market liquidity by crowding out passive LPs.
method Game-theoretic model with asymmetrically informed agents to analyze JIT liquidity provision in blockchain-based decentralized exchanges.
result JIT LPs only provide liquidity to uninformed orders and crowd out passive LPs when order volume is not sufficiently elastic to pool depth, potentially reducing overall market liquidity.
New framework detects crypto wash trading using liquidity measures.
problem Detecting and monitoring wash trading in crypto assets.
method Developed a new framework to detect wash trading through real-time liquidity fluctuation measures.
result Joint elevation in liquidity jump and diffusion indicates wash trading in crypto assets.
We review different approaches for measuring the impact of liquidity on CDS prices. We start with reduced form models incorporating liquidity as an additional discount rate. We review Chen, Fabozzi and Sverdlove (2008) and Buhler and Trapp (2006, 2008), adopting different assumptions on how liquidity rates enter the CD…
We refine toxicity bounds for dynamic liquidation incentives in CP-AMM systems.
problem Ensuring stability in dynamic liquidation incentives in automated market makers.
method Derived state-dependent toxicity bounds for dynamic liquidation incentives, reconciling them with CP-AMM price dynamics.
result State-dependent bounds and liquidity-depth-only condition for dynamic liquidation incentives.
Study finds Indian mutual funds adjust cash holdings based on inflows, impacting stock purchases.
problem Active liquidity management by mutual funds in India.
method Examined cash holdings and stock purchases of Indian equity mutual funds.
result Funds with active liquidity choices outperform, highlighting the importance of this strategy.
New metric to measure liquidity position PNL, delta hedging algorithm for automated market makers.
problem Vulnerability of liquidity positions to price changes in underlying assets.
method Proposes a new metric for measuring PNL, delta hedging algorithm for various AMMs.
result New metric more accurately measures net value change due to price movement.
The study examines when large trades are considered news or liquidity shocks in a market model.
problem Understanding when large trades are news or liquidity shocks in a market model.
method A sequential competitive limit order book model with asymmetric information and Student-t tails for liquidity demand.
result Heavy-tailed liquidity demand flattens and concavifies price impact, delaying price discovery.
Study shows HFT improves market liquidity indicators.
problem Impact of high-frequency trading on market liquidity.
method Agent-based simulations comparing HFT and non-HFT markets.
result All liquidity indicators improved in markets with HFTs.
This study examines liquidation risks in DeFi lending markets.
problem Liquidity risks in decentralized finance lending protocols.
method Quantitative analysis of liquidation data from four major DeFi platforms.
result Current liquidation mechanisms incentivize liquidators but lead to excessive collateral sales.
Study calculates liquidity costs for delta hedging of European options.
problem Determining expected liquidity costs in delta hedging.
method Derives an integration formula for liquidity costs, including option prices and delta process.
result Expected liquidity costs can be calculated faster than Monte Carlo simulations.
We present a large-scale study of commonality in liquidity and resilience across assets in an ultra high-frequency (millisecond-timestamped) Limit Order Book (LOB) dataset from a pan-European electronic equity trading facility. We first show that extant work in quantifying liquidity commonality through the degree of ex…
This paper optimizes liquidation strategies in DeFi protocols to prevent MEV attacks.
problem Predatory price manipulations and Maximal Extractable Value (MEV) attacks in DeFi protocols.
method Dynamic program modeling, Constant Product Market Maker (CPMM) transaction fees analysis.
result CPMM transaction fees make liquidation manipulations unprofitable for attackers.
High-fee pools attract more liquidity but execute less volume; low-fee pools have more stable LPs.
problem Optimal liquidity supply and execution on decentralized exchanges with fixed gas costs.
method Analysis of Uniswap data to compare high- and low-fee pools.
result Fragmented liquidity leads to more LPs and competition, improving overall market efficiency.
Uniswap V3 requires more decisions from liquidity providers, making it complex and risky.
problem Complexity and risk in liquidity provision on Uniswap V3.
method Developed a theoretical model and analyzed real data.
result Liquidity provision on Uniswap V3 is highly complex and risky.
Study factors affecting liquidity on decentralized exchanges, introducing new metrics.
problem Understanding and predicting liquidity on decentralized exchanges (DEXs).
method Analyzes platform, blockchain, token pair, and liquidity pool factors; introduces new metrics.
result Identifies how various factors affect liquidity through concentration and total value locked.
Optimal strategy for liquidating portfolios under discrete time intervals.
problem Optimizing liquidation of portfolios with discrete time constraints and impact effects.
method Modeling portfolio liquidation with N risky assets, using VaR for cost measurement, and deriving an optimal liquidation time.
result The optimal liquidation time is only influenced by temporary price impacts, not permanent ones.
Study analyzes impact of concentrated liquidity on trading fees and provider returns.
problem Impact of concentrated liquidity on trading fees and provider returns.
method Comparison of average liquidity provider returns before and after concentrated liquidity introduction; quantification of fundamental strategies performance.
result Concentrated liquidity strategies outperform in certain trading pairs and market conditions.
Study liquidity provision in decentralized exchanges considering risk aversion and replication costs.
problem Economic viability of liquidity provision in decentralized exchanges (DEXs).
method Formulated strategic interactions as a sequential game with risk-averse LP, traders, and arbitrageurs.
result DEX liquidity depth is crucial for risk management, influenced by risk aversion and replication costs.
Mitigates DeFi liquidations with reversible call options.
problem Systemic failures in DeFi due to liquidations.
method Introduces reversible call options to prevent liquidations.
result Reduces liquidated collateral by 89.82% in simulations.
The effect of leverage on liquidity is a tool for analysing the level of liquidity for a given production process. It measures the sensitivity of the level of liquidity that results from changes in the volume of production and unit operating margin. A commercial activity is liquid at the moment when all costs are cover…
Round balls minimize liquid drop model volumes ≤ 1.
problem Minimizing volumes in liquid drop models.
method Proved uniqueness of minimizers for small volumes.
result Round balls uniquely minimize volumes ≤ 1.
Novel method reconstructs liquidity data for CLMMs, optimizing dynamic liquidity strategies.
problem Challenges in evaluating and optimizing CLMMs due to lack of historical liquidity data.
method Reconstructs historical liquidity states from swap transaction data using machine learning.
result Identifies outperformance of dynamic liquidity strategies over uniform allocation benchmarks.