New method identifies latent treatment effects from proxy models.
problem Identifying heterogeneous treatment effects under unobserved confounding.
method Compressed observable operator and spectral analysis of treatment effects.
result Eigenvalues of the operator represent latent treatment effects.
New method uses latent variables to estimate treatment effects from single-arm trials.
problem Estimating treatment effects from single-arm trials due to lack of external control groups.
method Latent-variable modeling with amortized variational inference for patient matching and direct effect estimation.
result Improved performance in direct treatment effect estimation and effect estimation via patient matching compared to previous methods.
A novel disentangled graph autoencoder improves treatment effect estimation from networked observational data.
problem Treatment effect estimation from observational data is challenging due to unconfoundedness assumption and latent confounders.
method Proposes a disentangled variational graph autoencoder to disentangle latent factors and enforce factor independence.
result Extensive experiments show superior performance compared to state-of-the-art approaches.
New method disentangles latent factors for better treatment effect estimation.
problem Estimating treatment effects from observational data when confounders are not the only variables.
method Variational inference to disentangle latent factors into instrumental, confounding, and risk factors.
result The method improves treatment effect estimation accuracy on various datasets.
Paper models treatment effects by clustering patients with distinct survival characteristics.
problem Estimating treatment efficacy in clinical settings with censored outcomes.
method Latent variable approach to model heterogeneous treatment effects.
result The latent structure can mediate base survival rates and reveal actionable phenotypes.
Intact-VAE estimates treatment effects with latent confounders.
problem Estimating treatment effects under unobserved confounding.
method Intact-VAE, a VAE variant, models latent confounders to identify treatment effects.
result Intact-VAE is a consistent estimator of treatment effects under certain settings.
A new VAE model identifies and estimates treatment effects with limited overlap.
problem Identifying and estimating treatment effects when subjects with certain features belong to a single treatment group.
method Developed a latent variable model to estimate a prognostic score, which is sufficient for treatment effects. The model is a new type of VAE called β-Intact-VAE.
result The model identifies individualized treatment effects and provides TE error bounds.
We link disjoint longitudinal data for rare disease patients using latent representations and mixed-effects regression.
problem Analyzing treatment switches in rare diseases with limited data and changing measurement instruments.
method We embed item values into a shared latent space using variational autoencoders and apply mixed-effects regression to quantify treatment effects.
result Our approach allows for statistical inference and quantifies the impact of treatment switches in spinal muscular atrophy.
Estimating treatment effects in time series with hidden confounding.
problem Estimating treatment effects in time series with hidden confounding.
method A neural framework that learns individual-level counterfactuals and flexible matching procedures.
result Improves counterfactual estimation under latent bias.
Proposes a new VAE model to estimate treatment effects from confounded data.
problem Estimating treatment effects in the presence of confounding variables.
method Intact-VAE, a variant of variational autoencoder (VAE), using a latent variable for confounders.
result Proves identification of treatment effects under unconfoundedness and shows state-of-the-art performance.
The paper identifies causal effects in latent variable models using higher-order cumulants.
problem Challenges in identifying causal effects in latent variable models with latent confounders.
method Using higher-order cumulants, the paper addresses two challenging setups: a single proxy variable and underspecified instrumental variables.
result Causal effects are identifiable with a single proxy or instrument.
The estimation of treatment effects is a pervasive problem in medicine. Existing methods for estimating treatment effects from longitudinal observational data assume that there are no hidden confounders, an assumption that is not testable in practice and, if it does not hold, leads to biased estimates. In this paper, w…
Paper uses Gaussian processes to handle shared latent confounders in causal inference.
problem Bias in causal effect estimates due to shared latent confounders.
method Hierarchical Bayesian model, Gaussian processes with structured latent confounders (GP-SLC), Monte Carlo inference algorithm.
result GP-SLC provides accurate estimates of individual treatment effects with minimal assumptions.
CDVAE estimates treatment effects over time by accounting for unobserved variables.
problem Estimating treatment effects over time in the presence of unobserved confounders.
method Causal Dynamic Variational Autoencoder (CDVAE) that addresses unconfoundedness and unobserved heterogeneity.
result CDVAE outperforms existing methods in estimating Conditional Average Treatment Effects (CATEs).
New method better identifies irrelevant variables for more accurate treatment effect estimation.
problem Handling irrelevant variables in treatment effect estimation with deep disentanglement.
method Deep embedding method to disentangle pre-treatment variables, explicitly identify and represent irrelevant variables, and orthogonalize them.
result Better identification and representation of irrelevant variables lead to more precise treatment effect prediction.
Framework integrates mental disorder measurements for personalized treatment.
problem Optimizing treatment for mental disorders with latent mental states and heterogeneity.
method Measurement theory and multi-layer neural network for complex treatment effects.
result Learned treatment policies outperform alternatives on heterogeneous treatment effects.
Spatial Deconfounder tackles interference and confounding in spatial data.
problem Interference and unmeasured spatial factors confound causal inference in spatial domains.
method Two-stage method using CVAE with spatial prior to reconstruct confounder, then estimate causal effects.
result Nonparametric identification of direct and spillover effects under weak assumptions.
ICA accurately estimates treatment effects even with confounders.
problem Estimating treatment effects in the presence of confounding variables.
method Uses Independent Component Analysis (ICA) to identify latent sources and estimate mixing coefficients.
result Linear ICA can consistently estimate multiple treatment effects, even with Gaussian confounders, and is more sample-efficient than Orthogonal Machine Learning (OML).
New framework for choosing optimal proxy metrics from past experiments.
problem Difficult to measure long-term treatment effects in experiments.
method Statistical framework to define and construct optimal proxy metrics.
result Optimal proxy metric depends on experiment's sample size.
CausalBGM uses AI to infer causal effects from complex data.
problem Challenges in causal inference with high-dimensional covariates.
method AI-powered Bayesian generative modeling approach to estimate individual treatment effects.
result CausalBGM consistently outperforms existing methods in high-dimensional scenarios.
DEBIAS learns causal effects from psychiatric longitudinal data by optimizing outcome weights.
problem Causal inference challenges in psychiatric longitudinal data due to symptom heterogeneity and latent confounding.
method DEBIAS algorithm that optimizes outcome weights to maximize durable treatment effects and minimize confounding.
result DEBIAS consistently outperforms state-of-the-art methods in recovering causal effects for clinically interpretable composite outcomes.
Paper proposes MIM-DRCFR to learn disentangled factors for better treatment effect estimation.
problem Learning disentangled factors precisely for individual-level treatment effect estimation.
method Multi-task learning framework with MI minimization criteria.
result MIM-DRCFR outperforms state-of-the-art methods in treatment effect estimation.
GWIB improves counterfactual regression by balancing latent distributions and reducing selection bias.
problem Selection bias between control and treatment groups negatively impacts counterfactual regression performance.
method GWIB uses Gromov-Wasserstein information bottleneck to maximize mutual information between covariates and outcomes while penalizing kernelized mutual information between latent representations and covariates.
result GWIB consistently outperforms state-of-the-art CFR methods in ITE estimation tasks.
Bayesian method estimates causal effects with proxy networks.
problem Estimating causal effects with only proxy measurements of a latent interference network.
method Structural causal model with Block Gibbs sampler and Locally Informed Proposals.
result Accurately estimates causal effects even with noisy proxy networks.
New method estimates causal effects of multiple versions of treatment.
problem Ignoring multiple versions of treatment leads to biased causal effect estimates.
method Mixture-of-Experts framework for estimating version-specific causal effects.
result Effective method for estimating causal effects of latent versions.
CausalEGM estimates causal effects by encoding confounders, improving performance in high-dimensional settings.
problem Challenges in estimating causal effects with high-dimensional confounders.
method CausalEGM framework using generative modeling to decouple confounders and estimate causal effects.
result CausalEGM outperforms existing methods in binary and continuous treatment settings, especially with large sample sizes and high-dimensional confounders.
ContiVAE estimates individual dose-response curves from unobserved confounders using observational data.
problem Estimating causal effects of continuous treatments considering unobserved confounders.
method Variational auto-encoder with a Tilted Gaussian prior distribution modeling hidden confounders as latent variables.
result ContiVAE outperforms existing methods by up to 62% in predicting individual dose-response curves.
Estimating the individual treatment effect (ITE) from observational data is essential in medicine. A central challenge in estimating the ITE is handling confounders, which are factors that affect both an intervention and its outcome. Most previous work relies on the unconfoundedness assumption, which posits that all th…
Causal inference from observational data requires assumptions. These assumptions range from measuring confounders to identifying instruments. Traditionally, causal inference assumptions have focused on estimation of effects for a single treatment. In this work, we construct techniques for estimation with multiple treat…
Reduces selection bias in estimating individual treatment effects.
problem Selection bias in counterfactual reasoning.
method Auto-encoder with regularized loss based on Pearson Correlation Coefficient.
result Improves performance in estimating individual treatment effects.
New method estimates treatment effects over time with unobserved confounders.
problem Estimating treatment effects from observational data with unobserved confounders.
method Sequential Deconfounder using Gaussian process latent variable model.
result Unbiased estimates of individualized treatment responses over time.
Proposes a novel method to cluster individuals based on treatment effects.
problem Identifying subpopulations with different treatment responses.
method Clusters individuals using a learned kernel derived from causal forests, revealing latent subgroup structures.
result Captures meaningful treatment effect heterogeneity through kernelized clustering.
New method identifies proxies for causal effects on multiple outcomes.
problem Estimating causal effects in scenarios with multiple outcomes and treatments.
method Causal discovery method leveraging multiple outcomes as proxies for each treatment effect.
result Parallel studies of multiple outcomes can assist in causal identification.
CFR-Pro enhances treatment effect estimation by incorporating local proximity.
problem Treatment selection bias in HTE estimation from observational data.
method Proximity-enhanced CounterFactual Regression (CFR-Pro) with pair-wise proximity regularizer and subspace projector.
result Significantly outperforms competitors in HTE estimation accuracy.
Proposes ESCFR to estimate treatment effects from biased data.
problem Treatment selection bias in observational data.
method Stochastic optimal transport with relaxed mass-preserving and proximal factual outcome regularizers.
result Significantly better performance in estimating treatment effects.
New method recovers latent confounders from high-dimensional proxy variables.
problem Detecting latent confounders from high-dimensional proxy variables.
method Proxy Confounder Factorization (PCF) framework using ICA-PCF and GD-PCF.
result ICA-PCF recovers confounders with high correlation and low error in synthetic and real-world data.
Scientists develop a model to identify treatment responders from non-responders.
problem Analyzing samples that respond to treatment in studies.
method Causal two-groups (C2G) model, empirical Bayes procedures.
result The C2G model controls false discovery rate and has near-optimal power.
In the context of individual-level causal inference, we study the problem of predicting whether someone will respond or not to a treatment based on their features and past examples of features, treatment indicator (e.g., drug/no drug), and a binary outcome (e.g., recovery from disease). As a classification task, the pr…
Modeling disease progression using irregular time intervals in EHRs.
problem Challenges in analyzing temporal data from EHRs.
method Developed a Markovian generative model using EHR data.
result Model accurately recovers underlying disease progression patterns from irregular time intervals.
LUQ-Learning adapts Q-learning for healthcare decisions considering patient preferences.
problem Optimizing treatment decisions for multivariate outcomes based on individual preferences.
method Latent Utility Q-Learning (LUQ-Learning) framework that adapts Q-learning for composite outcomes.
result LUQ-Learning achieves highly competitive performance compared to alternative methods in simulations.
BGM-IV uses AI to estimate causal effects in complex data.
problem Estimating causal effects in high-dimensional, nonlinear settings with endogeneity.
method Structured latent generative modeling for posterior inference in a causally structured latent space.
result BGM-IV outperforms existing methods in high-dimensional covariate regimes.
Modeling spillover effects from observational data is an important problem in economics, business, and other fields of research. % It helps us infer the causality between two seemingly unrelated set of events. For example, if consumer spending in the United States declines, it has spillover effects on economies that de…
Develops methods for causal inference in longitudinal data.
problem Estimating Individual Treatment Effects (ITEs) in high-dimensional, time-varying data.
method Causal Dynamic Variational Autoencoder (CDVAE) and long-term counterfactual regression framework.
result CDVAE outperforms baselines and improves state-of-the-art models, approaching oracle performance.
NeuralCSA uses neural networks to analyze causal effects under unobserved confounding.
problem Challenges in causal inference from observational data due to unobserved confounding.
method Proposes a neural framework (NeuralCSA) for generalized causal sensitivity analysis.
result Demonstrates theoretical and empirical validity of NeuralCSA for causal inference.
Proposes a method to estimate treatment effects using instruments.
problem Estimating treatment effects from observational data is challenging when unconfoundedness is violated.
method Leverages instruments to estimate bounds on conditional average treatment effect (CATE) through a mapping to a discrete representation space and a two-step procedure.
result Demonstrates theoretical validity and reduced estimation variance in finite-sample settings.
SAMS-VAE models cellular perturbations using sparse additive mechanisms.
problem Modeling effects of diverse interventions on cells.
method Sparse Additive Mechanism Shift Variational Autoencoder (SAMS-VAE).
result SAMS-VAE identifies disentangled, perturbation-specific latent subspaces.
Proposes CoDEAL for estimating heterogeneous treatment effects in panel data models.
problem Estimating heterogeneous treatment effects in causal panel data models with covariate effects.
method Covariate-Adjusted Deep Causal Learning (CoDEAL) integrating neural networks and autoencoders.
result Establishes theoretical guarantees and demonstrates compelling performance in simulations and real data.
New method for estimating counterfactual means in adaptive experiments.
problem Inference for counterfactual means in sequentially designed experiments with adaptive treatment policies.
method Latent factor model and nearest neighbors method for estimation.
result Asymptotically valid confidence intervals for counterfactual means established.