Study identifies subphenotypes of pediatric sepsis to improve ML predictive performance.
arXiv research
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Bayesian approach clusters survival data for better risk prediction.
Modeling correlated mutations in cancer for personalized treatment.
New method resolves causal heterogeneity by defining a resolution profile.
Paper tackles cancer mutation data challenges by creating useful low-dimensional representations.
New method explains high-dimensional sphere data with latent factors.
Latent factor models have achieved great success in personalized recommendations, but they are also notoriously difficult to explain. In this work, we integrate regression trees to guide the learning of latent factor models for recommendation, and use the learnt tree structure to explain the resulting latent factors. S…
Sparse GFA identifies disease factors in FTD subgroups.
Efficiently matches random graphs with inhomogeneous edge probabilities.
New model generates realistic single-cell gene expression data.
We extend multi-way, multivariate ANOVA-type analysis to cases where one covariate is the view, with features of each view coming from different, high-dimensional domains. The different views are assumed to be connected by having paired samples; this is a common setup in recent bioinformatics experiments, of which we a…
XSP profiles ML models across hardware and software stacks.
StepMix estimates mixture models with covariates for social science applications.
Gene expression profiles have been widely used to characterize patterns of cellular responses to diseases. As data becomes available, scalable learning toolkits become essential to processing large datasets using deep learning models to model complex biological processes. We present an autoencoder to capture nonlinear …
Despite great advances, molecular cancer pathology is often limited to the use of a small number of biomarkers rather than the whole transcriptome, partly due to computational challenges. Here, we introduce a novel architecture of Deep Neural Networks (DNNs) that is capable of simultaneous inference of various properti…
The analysis of mixed data has been raising challenges in statistics and machine learning. One of two most prominent challenges is to develop new statistical techniques and methodologies to effectively handle mixed data by making the data less heterogeneous with minimum loss of information. The other challenge is that …
We introduce a novel latent grouping model for predicting the relevance of a new document to a user. The model assumes a latent group structure for both users and documents. We compared the model against a state-of-the-art method, the User Rating Profile model, where only users have a latent group structure. We estimat…
The paper develops methods to infer membership probabilities and rank network nodes using the DCMM model.
A new framework for adaptive behavior using reusable value profiles.
Identifying customer segments in retail banking portfolios with different risk profiles can improve the accuracy of credit scoring. The Variational Autoencoder (VAE) has shown promising results in different research domains, and it has been documented the powerful information embedded in the latent space of the VAE. We…
Ordinal data is omnipresent in almost all multiuser-generated feedback - questionnaires, preferences etc. This paper investigates modelling of ordinal data with Gaussian restricted Boltzmann machines (RBMs). In particular, we present the model architecture, learning and inference procedures for both vector-variate and …
Flatsomatic compresses cancer mutation data with VAEs, maintaining predictive power.
New method uses deep learning for better monitoring of industrial processes.
We study the behavior of a Time-Aware Long Short-Term Memory Autoencoder, a state-of-the-art method, in the context of learning latent representations from irregularly sampled patient data. We identify a key issue in the way such recurrent neural network models are being currently used and show that the solution of the…
Unsupervised method selects genes for tumor subtype discovery.
Stable blowup profile identified for wave maps in all dimensions.
A novel criterion selects optimal distance metrics for cell profile analysis.
Generative profiling improves real-time task timing for varied resource contexts.
SIMPLE method quantifies uncertainty in network membership profiles.
Generative model tailors anticancer drugs based on transcriptomic data.
Machine learning detects subtle glucose changes for early diabetes diagnosis.
The possibility of using player engagement predictions to profile high spending video game users is explored. In particular, individual-player survival curves in terms of days after first login, game level reached and accumulated playtime are used to classify players into different groups. Lifetime value predictions fo…
Until recently, transcriptomics was limited to bulk RNA sequencing, obscuring the underlying expression patterns of individual cells in favor of a global average. Thanks to technological advances, we can now profile gene expression across thousands or millions of individual cells in parallel. This new type of data has …
Dimensionality-reduction methods are a fundamental tool in the analysis of large data sets. These algorithms work on the assumption that the "intrinsic dimension" of the data is generally much smaller than the ambient dimension in which it is collected. Alongside their usual purpose of mapping data into a smaller dimen…
Extends multidimensional scaling to analyze three-way asymmetric proximities.
Estimates statistical power for cluster analysis in biomedical research.
We propose in this contribution a method for l one regularization in prototype based relevance learning vector quantization (LVQ) for sparse relevance profiles. Sparse relevance profiles in hyperspectral data analysis fade down those spectral bands which are not necessary for classification. In particular, we consider …
ProtoX-AD: A self-explainable time series anomaly detection framework
We present a novel, log-radius profile representation for convex curves and define a new operation for combining the shape features of curves. Unlike the standard, angle profile-based methods, this operation accurately combines the shape features in a visually intuitive manner. This method have implications in shape an…
Building behavior profiles of Android applications (apps) with holistic, rich and multi-view information (e.g., incorporating several semantic views of an app such as API sequences, system calls, etc.) would help catering downstream analytics tasks such as app categorization, recommendation and malware analysis signifi…
Expanding on techniques of concentration of measure, we develop a quantitative framework for modeling liquidity risk using convex risk measures. The fundamental objects of study are curves of the form , where is a convex risk measure and a random variable, and we call such a curve a \emph{liqu…
In online social networks people often express attitudes towards others, which forms massive sentiment links among users. Predicting the sign of sentiment links is a fundamental task in many areas such as personal advertising and public opinion analysis. Previous works mainly focus on textual sentiment classification, …
Analyzes Gerstner's trochoidal waves and their geometric properties.
The linking genotype to phenotype is the fundamental aim of modern genetics. We focus on study of links between gene expression data and phenotype data through integrative analysis. We propose three approaches. 1) The inherent complexity of phenotypes makes high-throughput phenotype profiling a very difficult and labor…
Cataloging the neuronal cell types that comprise circuitry of individual brain regions is a major goal of modern neuroscience and the BRAIN initiative. Single-cell RNA sequencing can now be used to measure the gene expression profiles of individual neurons and to categorize neurons based on their gene expression profil…
Multi-output Gaussian processes have received increasing attention during the last few years as a natural mechanism to extend the powerful flexibility of Gaussian processes to the setup of multiple output variables. The key point here is the ability to design kernel functions that allow exploiting the correlations betw…
Profile graphical models represent multivariate dependence under varying risk factors.
Study ridge regression for non-identically distributed data with varying variances.