The burgeoning need for kidney transplantation mandates immediate attention. Mismatch of deceased donor-recipient kidney leads to post-transplant death. To ensure ideal kidney donor-recipient match and minimize post-transplant deaths, the paper develops a prediction model that identifies factors that determine the prob…
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48 results for “kidney transplantation”
Machine learning improves kidney transplant outcomes prediction.
problem Improving prediction of kidney transplant success.
method Random forest machine learning model trained on kidney donor risk index data.
result Random forest predicted 2,148 more successful transplants than the risk index.
Electronic Health Records (EHRs) have been heavily used to predict various downstream clinical tasks such as readmission or mortality. One of the modalities in EHRs, clinical notes, has not been fully explored for these tasks due to its unstructured and inexplicable nature. Although recent advances in deep learning (DL…
A Convolutional Neural Network was used to predict kidney function in patients with chronic kidney disease from high-resolution digital pathology scans of their kidney biopsies. Kidney biopsies were taken from participants of the NEPTUNE study, a longitudinal cohort study whose goal is to set up infrastructure for obse…
A novel 3D U-Net approach improves kidney tumor segmentation in medical imaging.
problem Challenging manual annotation and great medical impact of kidney tumor segmentation.
method End-to-end cascaded U-Nets with a localization network.
result Achieves Sørensen-Dice coefficients of 0.902 for kidney and 0.408 for tumor segmentation.
Kidney function evaluation using dynamic contrast-enhanced MRI (DCE-MRI) images could help in diagnosis and treatment of kidney diseases of children. Automatic segmentation of renal parenchyma is an important step in this process. In this paper, we propose a time and memory efficient fully automated segmentation method…
Paper learns data-driven organ matching rules from observational data.
problem Tackles organ transplantation compatibility using observational data.
method Representation learning to cluster donors and apply recipient transformations.
result Model outperforms human experts in predicting transplant outcomes.
3D U-Net improves kidney and tumor segmentation from CT scans.
problem Manual segmentation by clinicians is laborious and error-prone.
method Multi-scale supervised 3D U-Net with deep supervision and post-processing.
result MSS U-Net achieves high Dice coefficients (0.969 for kidney, 0.805 for tumor) on KiTS19 dataset.
Background: Many authors have described MELD as a predictor of short-term mortality in the liver transplantation waiting list. However MELD score accuracy to predict long term mortality has not been statistically evaluated. Objective: The aim of this study is to analyze the MELD score as well as other variables as a pr…
Conway's drum quiltsmath.GT
John Conway created pairs of domains that sound the same for a special kind of music.
problem Creating domains that sound the same for a special kind of music.
method Using his theory of quilts, Conway developed pairs of glueing diagrams.
result Conway's pairs of domains are isospectral for the Laplace operator.
Study dynamic matching in heterogeneous networks using ODE model.
problem Dynamic matching in heterogeneous networks with compatibility restrictions.
method Introduced an ODE model to evaluate matching algorithms.
result Demonstrated trade-off between quick matching and optimal matching.
The morphometry of a kidney tumor revealed by contrast-enhanced Computed Tomography (CT) imaging is an important factor in clinical decision making surrounding the lesion's diagnosis and treatment. Quantitative study of the relationship between kidney tumor morphology and clinical outcomes is difficult due to data scar…
We study isospectrality for manifolds with mixed Dirichlet-Neumann boundary conditions and express the well-known transplantation method in graph- and representation-theoretic terms. This leads to a characterization of transplantability in terms of monomial relations in finite groups and allows for the generating of ne…
Study uses machine learning and survival analysis to predict CKD progression.
problem Early detection and management of CKD to reduce ESRD risk.
method Combines machine learning and classical statistical models to identify novel CKD progression predictors.
result Deep learning models outperform other methods in predicting CKD progression.
This paper focuses on a new task, i.e., transplanting a category-and-task-specific neural network to a generic, modular network without strong supervision. We design an functionally interpretable structure for the generic network. Like building LEGO blocks, we teach the generic network a new category by directly transp…
This paper focuses on a new task, i.e., transplanting a category-and-task-specific neural network to a generic, modular network without strong supervision. We design a functionally interpretable structure for the generic network. Like building LEGO blocks, we teach the generic network a new category by directly transpl…
TransformerLSR models longitudinal, recurrent, and survival data jointly.
problem Joint modeling of longitudinal measurements, recurrent events, and survival data with dependencies.
method Transformer-based deep learning framework integrating deep temporal point processes and latent structure representation.
result TransformerLSR effectively models all three components simultaneously, demonstrating necessity and effectiveness through simulations and real-world data.
We say that a germ G of a geometric structure can be transplanted into a manifold M if there is a suitable geometric structure on M which agrees with G on a neighborhood of some point P of M. We show for a wide variety of geometric structures that this transplantation is always possible provided that M does in fact adm…
New fair regression method improves fairness in chronic kidney disease classification.
problem Mitigating societal bias in health care for multiple groups.
method Penalized fair regression framework for multiple groups, with penalties for true positive rate disparity.
result Achieves fairness-accuracy frontier beyond existing methods in simulations and real-world data.
Acute Kidney Injury (AKI) is a common clinical syndrome characterized by the rapid loss of kidney excretory function, which aggravates the clinical severity of other diseases in a large number of hospitalized patients. Accurate early prediction of AKI can enable in-time interventions and treatments. However, AKI is hig…
Novel framework detects CKD in diabetic patients using sparse EHR representations.
problem Early detection of CKD in diabetic patients.
method Sparse longitudinal representations of EHR data.
result Proposed model achieves higher predictive performance than baselines.
25% of people who received a liver transplant will go on to develop diabetes within the next 5 years. These thousands of individuals are at 2-fold higher risk of cardiovascular events, graft loss, infections, as well as lower long-term survival. This is partly due to the medication used during and/or after transplant t…
Method learns evolving policies in healthcare contexts.
problem Understanding non-stationary behavior in evolving decision-making processes.
method Inverse Contextual Bandits (ICB) approach for learning interpretable representations of non-stationary behavior.
result Demonstrated applicability and accuracy of ICB method in liver transplantation policies.
An accurate model of patient-specific kidney graft survival distributions can help to improve shared-decision making in the treatment and care of patients. In this paper, we propose a deep learning method that directly models the survival function instead of estimating the hazard function to predict survival times for …
Proposes a framework for personalized treatment recommendations using observational data.
problem Estimating patient-level treatment effects from observational data.
method Integrates existing methods for learning patient-level causal models.
result Improves patient outcomes in heart failure patients with acute kidney injury.
We study the behavior of a Time-Aware Long Short-Term Memory Autoencoder, a state-of-the-art method, in the context of learning latent representations from irregularly sampled patient data. We identify a key issue in the way such recurrent neural network models are being currently used and show that the solution of the…
Acute Kidney Injury (AKI), a sudden decline in kidney function, is associated with increased mortality, morbidity, length of stay, and hospital cost. Since AKI is sometimes preventable, there is great interest in prediction. Most existing studies consider all patients and therefore restrict to features available in the…
New method for finding optimal treatment regimes in medical settings with time-varying unobserved factors.
problem Finding optimal treatment regimes in medical settings with time-varying unobserved factors.
method Extend Dynamic Treatment Regimes (DTRs) to Ambiguous Dynamic Treatment Regimes (ADTRs), connect to Ambiguous Partially Observable Mark Decision Processes (APOMDPs), and develop Reinforcement Learning methods.
result Established theoretical results for learning methods, including consistency and asymptotic normality.
Acute kidney injury (AKI) in critically ill patients is associated with significant morbidity and mortality. Development of novel methods to identify patients with AKI earlier will allow for testing of novel strategies to prevent or reduce the complications of AKI. We developed data-driven prediction models to estimate…
This paper presents the first deep reinforcement learning (DRL) framework to estimate the optimal Dynamic Treatment Regimes from observational medical data. This framework is more flexible and adaptive for high dimensional action and state spaces than existing reinforcement learning methods to model real-life complexit…
We prove that C. Loewner's inequality for the torus is satisfied by all hyperelliptic surfaces X, as well. We first construct the Loewner loops on the (mildly singular) companion tori, locally isometric to X away from the Weierstrass points. The loops are then transplanted to X, and surgered to obtain a Loewner loop on…
Prediction of the future trajectory of a disease is an important challenge for personalized medicine and population health management. However, many complex chronic diseases exhibit large degrees of heterogeneity, and furthermore there is not always a single readily available biomarker to quantify disease severity. Eve…
This study improves AKI prediction precision using CNN on EHR data.
problem Improving early prediction of AKI in ICU patients.
method Convolutional Neural Network (CNN) on EHR data.
result Best AUROC up to 0.988 on MIMIC-III and 0.936 on eICU data sets.
Deep Rule Forests identifies drug-drug and drug-disease interactions causing AKI.
problem Identifying drug-drug and drug-disease interactions leading to AKI.
method Deep Rule Forests (DRF) algorithm discovering rules from multilayer tree models.
result DRF model outperforms other algorithms in prediction accuracy and interpretability.
Improves feature selection in high-dimensional data using LLM-generated weights.
problem Inaccurate LLM-generated weights degrade feature selection performance.
method Integrates LLM-generated weights into prior inclusion probabilities using LLM Sparsity Prior (LSP).
result Improves prediction accuracy and identifies clinically relevant features.
Local discovery method uncovers direct unfairness in complex systems.
problem Identifying causal pathways of unfairness in complex domains.
method Local discovery for direct discrimination (LD3) method.
result LD3 returns a valid adjustment set (VAS) for assessing unfairness.
New method provides reliable probabilistic bounds for VUR detection.
problem Detect VUR in children without radiation exposure.
method Machine learning with probabilistic bounds for conditional probability.
result Guaranteed bounds contain well-calibrated probabilities.
Introduction. Case Based Reasoning (CBR) is an emerg- ing decision making paradigm in medical research where new cases are solved relying on previously solved similar cases. Usually, a database of solved cases is provided, and every case is described through a set of attributes (inputs) and a label (output). Extracting…
New energy measure for isolated systems in general relativity.
problem Quantifying energy in isolated systems in general relativity.
method Optimal isometric embedding and conformal Killing fields.
result Finite quasi-local energies for asymptotically flat spacetimes.
New CNN architecture improves pediatric image segmentation by homogenizing pose and size.
problem Challenges in segmenting pediatric images due to pose and size heterogeneity.
method Spatial Transformer Network (STN) for pose and scale invariance, combined with UNet for segmentation.
result Improved pediatric segmentation, especially renal tumor delineation, with accelerated processing.
Given a hyperelliptic Klein surface, we construct companion Klein bottles, extending our technique of companion tori already exploited by the authors in the genus 2 case. Bavard's short loops on such companion surfaces are studied in relation to the original surface so to improve a systolic inequality of Gromov's. A ba…
Acute kidney injury (AKI) commonly occurs in hospitalized patients and can lead to serious medical complications. In order to optimally predict AKI before it develops at any time during a hospital stay, we present a novel framework in which AKI is continually predicted automatically from EHR data over the entire hospit…
Acute kidney injury (AKI) is a common and serious complication after a surgery which is associated with morbidity and mortality. The majority of existing perioperative AKI risk score prediction models are limited in their generalizability and do not fully utilize the physiological intraoperative time-series data. Thus,…
Although much progress has been made in classification with high-dimensional features \citep{Fan_Fan:2008, JGuo:2010, CaiSun:2014, PRXu:2014}, classification with ultrahigh-dimensional features, wherein the features much outnumber the sample size, defies most existing work. This paper introduces a novel and computation…
The paper examines how macroeconomic control tools lost effectiveness, leading to a 'dark ages' period.
problem Loss of effectiveness of control tools in macroeconomic stabilization policy.
method Historical analysis of macroeconomic stabilization policy from 1948 to 1993.
result The overstatement of the Lucas critique and Kydland and Prescott's time-inconsistency led to a period of ineffective stabilization policy.
This article considers the quasi-local conserved quantities with respect to a reference spacetime with a cosmological constant. We follow the approach developed by the authors in [25,26,7] and define the quasi-local energy as differences of surface Hamiltonians. The ground state for the gravitational energy is taken to…
In this paper, by extending the notions of harmonic transplantation and harmonic radius in the Heisenberg group, we give an upper bound for the first eigenvalue for the following Dirichlet problem: $$(P_Ω) \left\{ \begin{array}{lllll} -Δ_{\mathbb{H}^1} u & = & λu & \mbox{in} & Ωu & = & 0 & \mbox{on} & \partial Ω, \end{…
Characterization of a patient clinical phenotype is central to biomedical informatics. ICD codes, assigned to inpatient encounters by coders, is important for population health and cohort discovery when clinical information is limited. While ICD codes are assigned to patients by professionals trained and certified in c…