REP predicts drug response at every stage of treatment using time-course gene expression data.
problem Lack of dynamic drug response prediction from time-course gene expression data.
method REP framework that predicts drug response values at every stage of a long-term treatment using recursive structure and tensor completion.
result REP can estimate drug response at any stage of a given treatment from initial gene expression levels.
This study improves early prediction of CPAP therapy compliance.
problem Predicting early compliance with CPAP therapy to improve patient outcomes.
method Built classifiers for compliance at three CPAP therapy follow-up points.
result Month 3 classifier achieved highest f1-score of 87% in cross-validation and test.
In this paper we present a method for simultaneously segmenting brain tumors and an extensive set of organs-at-risk for radiation therapy planning of glioblastomas. The method combines a contrast-adaptive generative model for whole-brain segmentation with a new spatial regularization model of tumor shape using convolut…
Knowledge-based planning (KBP) is an automated approach to radiation therapy treatment planning that involves predicting desirable treatment plans before they are then corrected to deliverable ones. We propose a generative adversarial network (GAN) approach for predicting desirable 3D dose distributions that eschews th…
Proposes a framework for automated radiation therapy treatment planning with uncertainty quantification.
problem Quantifying uncertainties in dose-related quantities for automated treatment planning.
method Three-step pipeline: feature extraction, dose statistic prediction, and dose mimicking.
result Probabilistic treatment plans agree better with clinical counterparts than non-probabilistic ones.
New disease drug trials use ML to predict best therapy.
problem Developing new drugs faster than usual clinical trials.
method Use Neural Network to predict drug effects from patient data.
result Neural Network outperforms traditional placebo-controlled trials.
Study improves drug synergy prediction using ensemble learning.
problem Predicting drug synergy in complex diseases.
method Investigated different compound representations and proposed an ensemble model.
result Ensemble model outperforms baseline models.
Study uses machine learning to optimize antibiotic therapy for MRSA skin infections.
problem Optimizing antibiotic choice for MRSA skin infections due to reduced treatment options and side effects.
method Propensity score matching, machine learning models (SVM, RF, LASSO), counterfactual analysis.
result RF model shows stronger treatment heterogeneity and potential for therapy change.
Guidelines for the management of atherosclerotic cardiovascular disease (ASCVD) recommend the use of risk stratification models to identify patients most likely to benefit from cholesterol-lowering and other therapies. These models have differential performance across race and gender groups with inconsistent behavior a…
Study uses machine learning to predict heart failure in cancer patients.
problem Early detection of cancer patients at risk for cardiotoxicity.
method Examined four machine learning algorithms on 143,199 cancer patients.
result Gradient boosting model achieved best AUC score of 0.9077.
We develop a prediction-based prescriptive model for learning optimal personalized treatments for patients based on their Electronic Health Records (EHRs). Our approach consists of: (i) predicting future outcomes under each possible therapy using a robustified nonlinear model, and (ii) adopting a randomized prescriptiv…
Machine learning predicts biologic therapy outcomes in psoriasis patients.
problem Predicting long-term biologic therapy outcomes in psoriasis patients.
method Machine learning algorithms were used to predict drug discontinuation and treatment duration.
result Machine learning models accurately predict outcomes with high diagnostic accuracy and low MAE.
Develops algorithm to find subgroups with different treatment effects in HIV patients.
problem Estimating treatment effects in EHR data with challenges like time-varying confounding.
method SDLD algorithm combining generalized interaction tree and longitudinal targeted maximum likelihood estimation.
result Identifies subgroups of HIV patients at higher risk of weight gain with dolutegravir-containing ARTs.
latrend simplifies longitudinal clustering for numeric measurements.
problem Clustering of longitudinal data to identify common trends over time.
method Unified framework for applying various clustering methods.
result Facilitates comparison and rapid prototyping of new methods.
Determining whether hypotensive patients in intensive care units (ICUs) should receive fluid bolus therapy (FBT) has been an extremely challenging task for intensive care physicians as the corresponding increase in blood pressure has been hard to predict. Our study utilized regression models and attention-based recurre…
Paper uses imitation learning to create efficient insulin policies from MPC demonstrations.
problem Resource-constrained medical devices struggle with complex MPC optimizations and state estimation errors.
method Imitation learning of neural network policies from MPC-computed demonstrations, using Bayesian inference with Monte Carlo Dropout.
result Trained policies generalize well to different patient cohorts, outperforming traditional MPC with state estimation.
Deep neural network identifies potential SARS-CoV-2 inhibitors.
problem Finding novel therapies for SARS-CoV-2.
method Used ChemAI, a deep neural network trained on 220M data points, to screen and rank one billion molecules from the ZINC database.
result Identified 30,000 top-ranked compounds for further bioassays.
Spinal cord stimulation has enabled humans with motor complete spinal cord injury (SCI) to independently stand and recover some lost autonomic function. Quantifying the quality of bipedal standing under spinal stimulation is important for spinal rehabilitation therapies and for new strategies that seek to combine spina…
Enforcing safety is a key aspect of many problems pertaining to sequential decision making under uncertainty, which require the decisions made at every step to be both informative of the optimal decision and also safe. For example, we value both efficacy and comfort in medical therapy, and efficiency and safety in robo…
Deep learning model improves medical diagnosis and reduces patient time.
problem Ineffective and slow methods for synthesizing multimodal medical data.
method Cross-modal deep learning architecture with co-attention mechanism.
result Model outperforms previous methods by 2.35% and is 53% more efficient.
Develops a neural surrogate for proton dose calculation using Monte Carlo dropout uncertainty.
problem Computational demand in proton therapy workflows requiring repeated evaluations.
method Integrates Monte Carlo dropout into a neural network surrogate for fast, differentiable dose predictions and uncertainty quantification.
result Shows significant speedups over MC while retaining uncertainty information.
A new graphical model for discrete data without parametric restrictions.
problem Discrete data modeling with restrictions.
method Additive conditional independence and penalized estimation of precision operator.
result Consistency of the estimator in ultrahigh-dimensional settings.
New methods use RL and DA to improve dosing precision and reduce side effects.
problem Improving precision and safety of anticancer drug dosing.
method Bayesian data assimilation and reinforcement learning.
result Significantly reduces incidence of severe side effects.
Deep learning predicts response to HER2-targeted breast cancer therapy.
problem Predicting response to HER2-targeted neoadjuvant chemotherapy.
method Developed and validated a deep learning approach using pre-treatment dynamic breast MRI.
result Deep learning model achieved strong performance in predicting pathological complete response.
Study uses LLMs to create personalized treatment plans for rare gynecological tumors.
problem Suboptimal management and poor prognosis due to low incidence and heterogeneity of rare gynecological tumors.
method Developed a digital twin system using LLMs to integrate clinical and biomarker data.
result LLM-enabled digital twins efficiently model individual patient trajectories and identify potential treatment options.
Tree-based model averaging improves CATE estimation from diverse sites.
problem Limited sample size and privacy concerns prevent accurate personalized treatment effect estimation.
method Tree-based model averaging approach to estimate CATEs from multiple heterogeneous sites.
result Improved accuracy in estimating conditional average treatment effects (CATEs) across sites.
New methods for estimating treatment effects with missing data.
problem Missing outcome data complicates estimating treatment effects.
method Proposed two de-biased machine learning estimators (mDR-learner and mEP-learner) to address under-representation.
result Oracle efficiency of the proposed estimators under reasonable conditions.
Develops methods for finding counterfactual explanations in sequential decision making.
problem Finding counterfactual explanations for sequential decision making processes.
method Formal characterization of sequential actions and states using Markov decision processes and Gumbel-Max structural causal model. Introduces a polynomial time algorithm based on dynamic programming.
result Algorithm finds optimal counterfactual explanations for sequential decision making.
Drug resistance is still a major challenge in cancer therapy. Drug combination is expected to overcome drug resistance. However, the number of possible drug combinations is enormous, and thus it is infeasible to experimentally screen all effective drug combinations considering the limited resources. Therefore, computat…
Machine learning builds personalized pediatric abdominal phantoms.
problem Lack of individualized phantoms for radiation therapy studies.
method Combining imaging and machine learning to automatically build phantoms.
result Automatically constructed phantoms more accurately represent patient anatomy.
New algorithm speeds up causal inference for large data.
problem Efficiently estimating causal effects from large data.
method Causal Bag of Little Bootstraps (cBLOBS).
result Significantly improved computational efficiency with consistent estimates.
The paper tracks patient recovery using graphs of joint movement data.
problem Tracking individual patient recovery trajectories in physical therapy.
method Bayesian learning of Random Geometric Graphs from joint movement data.
result Optimal exercise routines can be recommended based on patient recovery data.
Characterizing a patient's progression through stages of sepsis is critical for enabling risk stratification and adaptive, personalized treatment. However, commonly used sepsis diagnostic criteria fail to account for significant underlying heterogeneity, both between patients as well as over time in a single patient. W…
Feature selection predicts immune state changes in RA mouse model.
problem Predicting the immune state change after RA immunotherapy.
method Feature selection algorithms applied to mouse CIA model data.
result Selected features predict both T cell markers and treatment efficacy.
The objectives of this "perspective" paper are to review some recent advances in sparse feature selection for regression and classification, as well as compressed sensing, and to discuss how these might be used to develop tools to advance personalized cancer therapy. As an illustration of the possibilities, a new algor…
Sleep plays a vital role in human health, both mental and physical. Sleep disorders like sleep apnea are increasing in prevalence, with the rapid increase in factors like obesity. Sleep apnea is most commonly treated with Continuous Positive Air Pressure (CPAP) therapy. Presently, however, there is no mechanism to moni…
Method scales up ML science by measuring multiple molecules at once.
problem Scaling up ML-driven science with wet lab experiments.
method Neural extension of compressed sensing for function space.
result Proves orders-of-magnitude gains in information density.
Machine learning detects and classifies cognitive distortions in mental health texts.
problem Detect and classify cognitive distortions in mental health texts to improve treatment.
method Machine learning framework using crowdsourced and therapy dataset.
result Model achieved high F1 scores for detecting and classifying cognitive distortions.
This article proposes a method for mathematical modeling of human movements related to patient exercise episodes performed during physical therapy sessions by using artificial neural networks. The generative adversarial network structure is adopted, whereby a discriminative and a generative model are trained concurrent…
The development of machine learning systems for the diagnosis of rare diseases is challenging mainly due the lack of data to study them. Despite this challenge, this paper proposes a system for the Computer Aided Diagnosis (CAD) of low-prevalence, congenital muscular dystrophies from confocal microscopy images. The pro…
Game teaches ASD teenagers to imitate gestures.
problem Improving social interactions of ASD teenagers.
method Adapted robot-based imitation game with machine learning for pose detection.
result Preliminary results show game can elicit expected responses.
Lung cancer continues to be a major healthcare challenge with high morbidity and mortality rates among both men and women worldwide. The majority of lung cancer cases are of non-small cell lung cancer type. With the advent of targeted cancer therapy, it is imperative not only to properly diagnose but also sub-classify …
Survey on understanding neural networks for medical applications.
problem Black-box nature of deep neural networks hinders their use in critical applications.
method Comprehensive review of interpretability studies in neural networks.
result Interpretability research is crucial for the acceptance of neural networks in medical diagnosis.
Review of machine learning methods for detecting depression from resting EEG.
problem Detecting depression from resting-state EEG recordings.
method Machine learning combined with nonlinear analysis on EEG data.
result Improved reliability of depression detection models.
Adherence can be defined as "the extent to which patients take their medications as prescribed by their healthcare providers"[Osterberg and Blaschke, 2005]. World Health Organization's reports point out that, in developed countries, only about 50% of patients with chronic diseases correctly follow their treatments. Thi…
Neural network estimates rigid motion in stroke imaging to improve image quality.
problem Rigid patient motion during C-arm CBCT imaging reduces image quality.
method Neural network trained to regress reprojection error based on image information.
result Neural network outperforms entropy-based method in motion estimation.
Electronic Medical Records (EMR) are a rich source of patient information, including measurements reflecting physiologic signs and administered therapies. Identifying which variables are useful in predicting clinical outcomes can be challenging. Advanced algorithms such as deep neural networks were designed to process …
Transforms any test into anytime-valid with sample savings.
problem Sequential data invalidates classical test guarantees.
method Predicts test outcomes to create anytime-valid stopping rules.
result Ensures Type-I error control and near-optimal power.