Develops methods for near-optimal personalized treatment recommendations.
problem Assigning optimal treatments to patients based on individual characteristics.
method Outcome weighted learning framework to estimate near-optimal alternative individualized treatment recommendations (A-ITR).
result Consistency of proposed methods and upper bound for risk between optimal and estimated recommendations.
RL algorithms with medical integration improve personalized treatment recommendations.
problem Developing effective personalized treatment strategies for chronic diseases.
method Integrating medical knowledge into RL algorithms for DTR.
result Enhanced treatment recommendations with increased confidence.
The causal effect of a treatment can vary from person to person based on their individual characteristics and predispositions. Mining for patterns of individual-level effect differences, a problem known as heterogeneous treatment effect estimation, has many important applications, from precision medicine to recommender…
Medical practitioners use survival models to explore and understand the relationships between patients' covariates (e.g. clinical and genetic features) and the effectiveness of various treatment options. Standard survival models like the linear Cox proportional hazards model require extensive feature engineering or pri…
Study optimal and equitable encouragement policies for treatment adherence.
problem Optimal treatment adherence policies in the presence of human non-adherence.
method Covariate-conditional no-direct-effect model of encouragement; tractable policy characterizations under constraints.
result Induced treatment take-up is the fairness target, not recommendation rates.
Fuses ITRs for primary and secondary outcomes to minimize harm.
problem Learn an ITR maximizing primary outcome while minimizing harm to secondary outcomes.
method Introduces fusion penalty to encourage similar recommendations for different outcomes. Two algorithms estimate the ITR using surrogate loss functions.
result Agreement rate between primary and secondary optimal ITRs converges faster than ignoring secondary outcomes.
Framework assesses variable importance for heterogeneous treatment effects.
problem High-risk domains need reliable methods to assess treatment effect heterogeneity.
method Inferential framework based on Shapley values and semiparametric theory.
result Valid inference on variable importance for heterogeneous treatment effects.
The paper learns personalized treatment rules from observational data.
problem Developing effective treatment policies for individual patients.
method Contextual bandit approach to minimize expected risk of treatment policies.
result The proposed method outperforms physicians and baseline approaches in IV and VP administration.
Proposes a new decision rule for continuous treatments.
problem Developing personalized treatment recommendations for continuous treatments.
method Jump interval-learning method to estimate conditional mean of outcomes.
result Optimal interval-valued decision rule (I2DR) for continuous treatments.
Researchers develop a method to measure treatment effects in settings with shared states.
problem Measuring treatment effects in settings with shared states like prices, recommendations, or social signals.
method Double machine learning (DML) theorem with conditions for efficient inference under shared-state interference.
result Efficient estimation of average direct effect (ADE) and global average treatment effect (GATE) in various models.
Causal ML predicts treatment outcomes, aiding personalized medicine.
problem Predicting individualized treatment effects for personalized medicine.
method Flexible, data-driven methods using causal inference with clinical trial and real-world data.
result Causal ML allows for estimating individualized treatment effects.
Framework integrates mental disorder measurements for personalized treatment.
problem Optimizing treatment for mental disorders with latent mental states and heterogeneity.
method Measurement theory and multi-layer neural network for complex treatment effects.
result Learned treatment policies outperform alternatives on heterogeneous treatment effects.
There is tremendous interest in precision medicine as a means to improve patient outcomes by tailoring treatment to individual characteristics. An individualized treatment rule formalizes precision medicine as a map from patient information to a recommended treatment. A treatment rule is defined to be optimal if it max…
Proposes a fusion method for many treatment groups in ITRs.
problem Challenges in handling many treatment groups with data sparsity and covariate imbalance.
method Calibration-weighted treatment fusion procedure that balances covariates and fuses similar treatments.
result Ensures robust treatment group recovery and policy value compared to existing methods.
New method estimates optimal dose intervals for personalized treatment.
problem Learning optimal dose intervals from observational data.
method Probability dose interval (PDI) method using DC algorithm.
result Consistent policy with risk converging to best-in-class at root-n rate.
The vision for precision medicine is to use individual patient characteristics to inform a personalized treatment plan that leads to the best healthcare possible for each patient. Mobile technologies have an important role to play in this vision as they offer a means to monitor a patient's health status in real-time an…
Dynamic treatment recommendation systems based on large-scale electronic health records (EHRs) become a key to successfully improve practical clinical outcomes. Prior relevant studies recommend treatments either use supervised learning (e.g. matching the indicator signal which denotes doctor prescriptions), or reinforc…
A treatment regime is a function that maps individual patient information to a recommended treatment, hence explicitly incorporating the heterogeneity in need for treatment across individuals. Patient responses are dichotomous and can be predicted through an unknown relationship that depends on the patient information …
Proposes DeepSDRF for continuous treatment recommendation from clinical survival data.
problem Continuous treatment recommendation in medical settings with survival data.
method Deep Survival Dose Response Function (DeepSDRF) for learning conditional average dose response (CADR) function.
result Similar performance of recommender algorithms based on random search and reinforcement learning.
The paper addresses treatment recommendation problems by optimizing distributional characteristics.
problem Optimizing treatment recommendations based on distributional targets.
method Characterizes the problem's difficulty and proposes near-optimal policies.
result Characterizes the difficulty of the problem and proposes near-regret optimal policies.
SAFER improves personalized treatment recommendations for dynamic clinical contexts.
problem Personalized treatment optimization in evolving clinical contexts with safety concerns.
method Integrates structured EHR and clinical notes, uses conformal prediction for safe recommendations.
result SAFER outperforms state-of-the-art baselines in recommendation metrics and mortality rates.
The field of precision medicine aims to tailor treatment based on patient-specific factors in a reproducible way. To this end, estimating an optimal individualized treatment regime (ITR) that recommends treatment decisions based on patient characteristics to maximize the mean of a pre-specified outcome is of particular…
Proposes methods for learning optimal dynamic treatment regimes robust to unconfoundedness violations.
problem Estimating optimal dynamic treatment regimes using historical observational data when unconfoundedness is violated.
method Utilizes proximal causal inference framework to propose three nonparametric identification methods, a (K+1)-robust method, and establish a semiparametric efficiency bound.
result Establishes the (K+1)-robust method for learning optimal dynamic treatment regimes, validating its efficiency and multiple robustness through numerical experiments.
Proposes a framework for personalized treatment recommendations using observational data.
problem Estimating patient-level treatment effects from observational data.
method Integrates existing methods for learning patient-level causal models.
result Improves patient outcomes in heart failure patients with acute kidney injury.
BRACE addresses noncompliance in bandits, offering methods for recommendation and treatment policies.
problem Noncompliance in bandit problems complicates learning objectives and treatment effects.
method BRACE formalizes objective-choice, identifies direct-control regimes, and proposes a phase-doubling algorithm for IV inversion.
result BRACE delivers valid policy values and structural uncertainty, even under weak identification and homogeneity failure.
The complexity of human cancer often results in significant heterogeneity in response to treatment. Precision medicine offers potential to improve patient outcomes by leveraging this heterogeneity. Individualized treatment rules (ITRs) formalize precision medicine as maps from the patient covariate space into the space…
Proposes a method to create fair ITRs that balance value and fairness.
problem Fairness issues in ITRs that can lead to unfair advantages or disadvantages.
method Optimal transport theory to transform optimal ITRs into fair ITRs.
result Established a theoretical upper bound on value loss for improved trade-off ITRs.
Proposes a generalized causal tree for handling multiple treatments in uplift modeling.
problem Handling multiple treatments in uplift modeling.
method Generalizes causal tree algorithm to handle multiple discrete and continuous-valued treatments.
result Demonstrates improved performance over existing methods in experiments and real data examples.
Inverse classification uses an induced classifier as a queryable oracle to guide test instances towards a preferred posterior class label. The result produced from the process is a set of instance-specific feature perturbations, or recommendations, that optimally improve the probability of the class label. In this work…
It is crucial to provide compatible treatment schemes for a disease according to various symptoms at different stages. However, most classification methods might be ineffective in accurately classifying a disease that holds the characteristics of multiple treatment stages, various symptoms, and multi-pathogenesis. More…
New model recommends stocks considering individual preferences and diversification.
problem Inaccurate stock price predictions and ignoring investment theories.
method Portfolio Temporal Graph Network Recommender (PfoTGNRec) incorporating diversification-enhancing sampling.
result PfoTGNRec outperforms state-of-the-art models in real-world data.
Heteroskedasticity biases uplift model rankings, leading to inefficient treatment allocation.
problem Bias in uplift model rankings due to heteroskedasticity.
method Theoretical analysis and simulation on real-world data.
result Heteroskedasticity can cause individuals with high treatment effects to be ranked at the bottom, leading to inefficient treatment allocation.
New diagnostics detect variability in individual risk estimates from machine learning models in healthcare.
problem Variability in individual risk estimates from machine learning models in healthcare, leading to unreliable treatment decisions.
method Proposed evaluation framework using empirical prediction interval width and empirical decision flip rate diagnostics.
result Randomness in optimization and initialization can lead to substantial individual-level variability in risk estimates, affecting clinical decisions.
Proposes a new model for estimating individual treatment effects.
problem Estimating individual treatment effects from observational data is challenging.
method Integrates diffusion modeling and conformal inference with propensity score and covariate approximation.
result Establishes rigorous theoretical guarantees and demonstrates competitive performance.
The paper clarifies the distinction between CATE and ITE under ignorability assumptions.
problem Confusion between CATE and ITE hinders personalized effect estimation.
method Clarifies the distinction between CATE and ITE under ignorability assumptions.
result CATE and ITE are not necessarily the same under ignorability assumptions.
Enhances credit card limit adjustments by considering treatment uncertainty and prediction criteria.
problem Optimal treatment selection under multitreatment scenarios.
method Proposes a comprehensive methodology incorporating conditional value-at-risk and prediction criterion for continuous outcomes.
result Significantly improved policy performance in credit card limit adjustments.
Estimating treatment effects in time series with hidden confounding.
problem Estimating treatment effects in time series with hidden confounding.
method A neural framework that learns individual-level counterfactuals and flexible matching procedures.
result Improves counterfactual estimation under latent bias.
Two-stage recommender systems show better performance when components interact rather than operate independently.
problem Two-stage recommender systems are often treated as sums of their parts, ignoring interactions between components.
method Used synthetic and real-world data to demonstrate interactions between ranker and nominators. Derived a generalization lower bound and proposed a Mixture-of-Experts approach to learn optimal item pools.
result Independent nominator training can lead to performance on par with random recommendations, highlighting the importance of interactions.
GraphITE estimates individual effects of graph-structured treatments.
problem Estimating individual effects of complex treatment structures.
method Graph neural networks and Hilbert-Schmidt Independence Criterion regularization.
result GraphITE outperforms baselines in estimating treatment effects for large numbers of treatments.
Decision makers, such as doctors and judges, make crucial decisions such as recommending treatments to patients, and granting bails to defendants on a daily basis. Such decisions typically involve weighting the potential benefits of taking an action against the costs involved. In this work, we aim to automate this task…
When devising a course of treatment for a patient, doctors often have little quantitative evidence on which to base their decisions, beyond their medical education and published clinical trials. Stanford Health Care alone has millions of electronic medical records (EMRs) that are only just recently being leveraged to i…
The paper integrates AI and expert knowledge to optimize radiotherapy decisions.
problem Optimizing radiation dose planning considering patient-specific information.
method Integrating Gaussian process models with deep neural networks to quantify uncertainty.
result Improves AI model performance and guides clinical decision making.
Estimates individual treatment effects using gradient interpolation and kernel smoothing.
problem Estimating individualized continuous treatment effects in observational data.
method Augment training data with independently sampled treatments and inferred counterfactual outcomes using gradient interpolation and kernel smoothing.
result Our method outperforms state-of-the-art methods on counterfactual estimation error.
TCFimt forecasts causal effects of multiple interventions from individual data.
problem Estimating causal effects of temporal multi-interventions from individual data.
method TCFimt uses adversarial tasks in seq2seq framework to alleviate bias and contrastive learning to decouple effects.
result TCFimt outperforms state-of-the-art methods in predicting future outcomes and choosing optimal treatments.
Proposes auditing for envy-freeness in recommender systems to assess individual preferences.
problem Auditing fairness in recommender systems for individual preferences.
method Formulates a pure exploration problem in multi-armed bandits, proposing a sample-efficient algorithm with theoretical guarantees.
result Algorithm ensures fairness without deteriorating user experience on real-world datasets.
Estimates citation impact to recommend best publication venue.
problem Choosing optimal publication venue for academic papers.
method Treatment effect estimation and bias correction method.
result Effective recommendation of publication venues based on citation potential.
R2P method identifies homogeneous and heterogeneous subgroups for better treatment effect estimation.
problem Current subgroup analysis methods are weak in identifying homogeneous and heterogeneous subgroups and lack confidence estimates.
method R2P uses an arbitrary ITE estimator and quantifies uncertainty robustly.
result R2P produces more homogeneous and heterogeneous partitions than other methods.
LI-ITR combines flexible ML with interpretable approximations for personalized treatment rules.
problem Combining flexibility and interpretability in personalized treatment rules.
method Uses variational autoencoders and a mixture of interpretable experts.
result Accurately recovers true local coefficients and optimal treatment strategies.