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arXiv research

A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.

168,695 papers · 148 categories

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99198297396 · Jun 202019922001200920172026
48 results for immune repertoire classification

DeepRC uses Hopfield networks and attention to classify immune repertoires.

problem Classifying the vast number of immunosequences of an individual.
method Integrates transformer-like attention into deep learning architectures.
result DeepRC outperforms other methods in predictive performance.

AdvImmune improves certifiable robustness of GNNs against adversarial attacks.

problem Vulnerability of graph neural networks to adversarial attacks.
method Proposes AdvImmune, an algorithm that optimizes with meta-gradient to improve certifiable robustness.
result Remarkably improves the ratio of robust nodes by 12%, 42%, 65% with an affordable immune budget of only 5% edges.

Many immunization strategies have been proposed to prevent infectious viruses from spreading through a network. In this study, we propose efficient immunization strategies to prevent a default contagion that might occur in a financial network. An essential difference from the previous studies on immunization strategy i…

2013-08-03abs ↗pdf ↗

We information-theoretically reformulate two measures of capacity from statistical learning theory: empirical VC-entropy and empirical Rademacher complexity. We show these capacity measures count the number of hypotheses about a dataset that a learning algorithm falsifies when it finds the classifier in its repertoire …

2011-11-23abs ↗pdf ↗

In their seminal work Carr and Lee (2008) show how to robustly price and replicate a variety of claims written on the quadratic variation of a risky asset under the assumption that the asset's volatility process is independent of the Brownian motion that drives the asset's price. Additionally, they propose a correlatio…

2018-09-26abs ↗pdf ↗

Estimates vaccine effectiveness and immune correlates in TND studies with missing data.

problem Confounding and missing data in TND studies of vaccine effectiveness and immune correlates.
method Targeted maximum likelihood estimation using a semiparametric logistic regression model.
result Valid causal inference of vaccine effectiveness and immune correlates in TND studies with missing exposure data.

Paper uses bond pricing and convexity adjustments to explain herd immunity paradox.

problem Early onset of herd immunity contradicts R value estimates from early stage growth.
method Utilizes Vasicek's bond pricing formula and de Finetti's Theorem approach.
result Reduces modeling discrepancy to simple convexity formulas.

MINN-SA enhances cancer detection using TCR sequences with better interpretability.

problem Challenges in detecting cancers using TCR sequences due to one-to-many correspondence.
method Multiple Instance Neural Networks based on Sparse Attention (MINN-SA).
result MINN-SA achieves highest AUC scores on 10 cancer types compared to existing MIL approaches.

Background. In Italy, in recent years, vaccination coverage for key immunizations as MMR has been declining to worryingly low levels. In 2017, the Italian Gov't expanded the number of mandatory immunizations introducing penalties to unvaccinated children's families. During the 2018 general elections campaign, immunizat…

2019-12-31abs ↗pdf ↗

Bayesian optimization of antibodies learns from immune system evolution.

problem Efficiently optimizing antibody sequences in a large space of possibilities.
method Bayesian optimization guided by a generative model of evolving antibody sequences.
result CloneBO optimizes antibodies more efficiently than previous methods.

In this paper we outline initial concepts for an immune inspired algorithm to evaluate price time series data. The proposed solution evolves a short term pool of trackers dynamically through a process of proliferation and mutation, with each member attempting to map to trends in price movements. Successful trackers fee…

2010-04-22abs ↗pdf ↗

Learning algorithms are enabling robots to solve increasingly challenging real-world tasks. These approaches often rely on demonstrations and reproduce the behavior shown. Unexpected changes in the environment may require using different behaviors to achieve the same effect, for instance to reach and grasp an object in…

2018-11-07abs ↗pdf ↗

Autonomous agents that must exhibit flexible and broad capabilities will need to be equipped with large repertoires of skills. Defining each skill with a manually-designed reward function limits this repertoire and imposes a manual engineering burden. Self-supervised agents that set their own goals can automate this pr…

2019-03-08abs ↗pdf ↗

A new PGA algorithm ensures stable, robust, and noise-immune solutions for non-negative inverse problems.

problem Stable convergence and suboptimal solutions in inverse problems due to negative values and high sensitivity to hyperparameters.
method A novel multiplicative update proximal gradient algorithm (SSO-PGA) that enforces non-negativity and boundedness through a learnable sigmoid-based operator.
result Significantly surpasses traditional PGA and other state-of-the-art algorithms in performance and stability.

Major histocompatibility complex class two (MHC-II) molecules are trans-membrane proteins and key components of the cellular immune system. Upon recognition of foreign peptides expressed on the MHC-II binding groove, helper T cells mount an immune response against invading pathogens. Therefore, mechanistic identificati…

2017-12-01abs ↗pdf ↗

"How much is my data worth?" is an increasingly common question posed by organizations and individuals alike. An answer to this question could allow, for instance, fairly distributing profits among multiple data contributors and determining prospective compensation when data breaches happen. In this paper, we study the…

2019-02-27abs ↗pdf ↗

Method estimates shared and study-specific factors for multi-study data.

problem Covariance estimation for multi-study data with shared and study-specific components.
method Spectral decomposition for latent factors, surrogate Bayesian regressions for loadings and variances.
result Strong frequentist guarantees and superior performance in simulations and real data.

We develop a novel multi-fidelity framework that goes far beyond the classical AR(1) Co-kriging scheme of Kennedy and O'Hagan (2000). Our method can handle general discontinuous cross-correlations among systems with different levels of fidelity. A combination of multi-fidelity Gaussian Processes (AR(1) Co-kriging) and …

2016-04-26abs ↗pdf ↗

Deep Learning based AI systems have shown great promise in various domains such as vision, audio, autonomous systems (vehicles, drones), etc. Recent research on neural networks has shown the susceptibility of deep networks to adversarial attacks - a technique of adding small perturbations to the inputs which can fool a…

2019-11-22abs ↗pdf ↗

DCENWCNet improves WBC classification with LIME-based explainability.

problem Classifying white blood cells from blood images with high accuracy and interpretability.
method Integrates three CNN architectures with different settings to balance feature learning and performance.
result Achieves highest mean accuracy on the Rabbin-WBC dataset, outperforming state-of-the-art networks.

Computational Intelligence (CI) is a sub-branch of Artificial Intelligence paradigm focusing on the study of adaptive mechanisms to enable or facilitate intelligent behavior in complex and changing environments. There are several paradigms of CI [like artificial neural networks, evolutionary computations, swarm intelli…

2010-06-09abs ↗pdf ↗

We propose strategies to estimate and make inference on key features of heterogeneous effects in randomized experiments. These key features include best linear predictors of the effects using machine learning proxies, average effects sorted by impact groups, and average characteristics of most and least impacted units.…

2017-12-13abs ↗pdf ↗

Current Neural Architecture Search techniques can suffer from a few shortcomings, including high computational cost, excessive bias from the search space, conceptual complexity or uncertain empirical benefits over random search. In this paper, we present ImmuNeCS, an attempt at addressing these issues with a method tha…

2019-11-18abs ↗pdf ↗

EAGLE-Net enhances foundation models by integrating patch-level features for better tissue understanding.

problem Foundation models lack mechanisms for global tissue structure and local context in computational pathology.
method EAGLE-Net combines multi-scale spatial encoding, attention-guided loss functions, and background suppression to aggregate patch-level features into slide-level predictions.
result EAGLE-Net improves classification accuracy and concordance indices across multiple cancer types, producing biologically coherent attention maps.

Topological data analysis aims to extract topological quantities from data, which tend to focus on the broader global structure of the data rather than local information. The Mapper method, specifically, generalizes clustering methods to identify significant global mathematical structures, which are out of reach of man…

2019-10-17abs ↗pdf ↗

LOT framework embeds high-dimensional cell data into interpretable Euclidean space.

problem Lack of interpretable methods for high-dimensional cell data.
method Adapts Linear Optimal Transport (LOT) to irregular point clouds.
result Accurate and interpretable classification and synthetic data generation.

New framework boosts neural network performance and resilience.

problem Susceptibility of compact neural network implementations to system disturbances.
method Realistic crossbar simulations and Mosaics framework to re-use synaptic connections.
result Compact neural networks are noise-immune and perform well under disturbances.

New insights into adversarial vulnerability linked to manifold separability issues.

problem Adversarial vulnerability in machine learning models.
method Characterized data distribution as a low-dimensional manifold, focusing on on/off manifold directions and the impact of first-order vs. second-order optimization methods.
result First-order optimization methods lead to poor convergence in the off-manifold direction, causing adversarial vulnerability in inseparable datasets.

New algorithm classifies and generates genomic sequences using RG-flow categorifier.

problem Classifying and generating genomic sequences for disease prediction.
method RG-flow based categorifier combining quantum field theory, holographic duality, and neural ODEs.
result RG categorifier can classify and generate new sequences from genomic data.