Models predict patients at risk of uncontrolled hypertension.
problem Identifying patients at risk of uncontrolled hypertension.
method Developed machine learning models (logistic regression and recurrent neural networks) using EHR data.
result Best model achieved AUROC of 0.719, outperforming baseline.
Develops a model for personalized diabetes and hypertension treatment using robust regression and K-NN.
problem Optimal personalized treatment rules for patients based on EHRs.
method Robust regression informed K-NN approach for predicting and selecting optimal treatments.
result Algorithm leads to larger reduction in HbA1c for diabetics and systolic BP for hypertensive patients compared to alternatives.
Predicting highrisk vascular diseases is a significant issue in the medical domain. Most predicting methods predict the prognosis of patients from pathological and radiological measurements, which are expensive and require much time to be analyzed. Here we propose deep attention models that predict the onset of the hig…
A new method uses literature constraints to improve phenotyping from EHR data.
problem Improving phenotyping from electronic health records (EHR) data.
method Constrained tensor factorization with literature constraints.
result Improved phenotyping results for hypertensive patients.
Traditional medicine typically applies one-size-fits-all treatment for the entire patient population whereas precision medicine develops tailored treatment schemes for different patient subgroups. The fact that some factors may be more significant for a specific patient subgroup motivates clinicians and medical researc…
Radiomics identifies subtle cardiac changes in hypertension.
problem Subtle cardiac alterations in hypertension not captured by conventional imaging.
method Combines feature selection and machine learning for identifying structural and tissue changes.
result Radiomics model detects changes beyond conventional imaging.
Novel framework detects CKD in diabetic patients using sparse EHR representations.
problem Early detection of CKD in diabetic patients.
method Sparse longitudinal representations of EHR data.
result Proposed model achieves higher predictive performance than baselines.
Privacy-preserving synthetic data from EHRs for learning and inference.
problem Sharing sensitive EHR data while maintaining patient privacy.
method Differentially private normalizing flows for density estimation and variational inference.
result Privacy-preserving synthetic data can yield good utility at a reasonable privacy cost.
PNNs improve personalized healthcare policies using mixed integer programming.
problem Learning treatment policies for patients with limited data.
method Prescriptive networks (PNNs) trained with mixed integer programming.
result PNNs outperform existing methods in reducing peak blood pressure.
This study improves early prediction of CPAP therapy compliance.
problem Predicting early compliance with CPAP therapy to improve patient outcomes.
method Built classifiers for compliance at three CPAP therapy follow-up points.
result Month 3 classifier achieved highest f1-score of 87% in cross-validation and test.
Paper tackles cost-sensitive diagnosis and learning in healthcare, assigning feature costs based on patient discomfort.
problem Cost-sensitive feature acquisition in healthcare datasets.
method Assigns feature costs based on patient discomfort and provides a method for acquiring a subset of features.
result Comparison of cost-sensitive feature acquisition methods on health datasets.
SCM models identify subpopulations for hypertension risk factors.
problem Discovering subpopulations based on vulnerability to risk factors.
method Supervised cadre model (SCM) for multivariate regression and binary classification.
result 25 environmental factors significantly associated with hypertension, including 8 subpopulation-specific associations.
Improves Bayesian optimization for expensive function evaluations.
problem Optimizing expensive functions with noisy, non-differentiable outputs.
method Proposes a new improvement-based acquisition function.
result Performs at least as well as state-of-the-art acquisition functions, often better.
The paper tackles optimal policy learning with asymmetric counterfactual utilities in healthcare decisions.
problem Learning optimal policies from observed data with asymmetric counterfactual utilities.
method The approach involves identifying and minimizing the maximum expected utility loss using statistical decision theory and solving intermediate classification problems.
result One can learn minimax loss decision rules from observed data.
Study finds that only a fraction of data is needed for accurate patient-level prediction models.
problem Developing predictive models for patient-level outcomes using large observational data.
method Empirical assessment of sample size effects on model performance and complexity using learning curves.
result A median reduction of 9.5% to 78.5% in the number of observations and 8.6% to 68.3% in the number of predictors can be achieved with adequate sample size.
PHASE predicts surgical complications from physiological signals.
problem Predicting adverse surgical outcomes from physiological signals.
method Self-supervised transfer learning for physiological signals.
result PHASE outperforms other approaches in predicting five surgical complications.
Develops a RNN model to predict obesity status improvement using irregular activity data.
problem Predicting obesity status improvement using irregular activity data.
method Develops a RNN-based time-aware architecture to handle irregular observation times and extract relevant features from longitudinal patient records.
result Achieves an accuracy of 77-86% in predicting obesity status improvement.
Paper introduces a method to learn physics between digital twins using imperfect models.
problem Learning physics from imperfect data and low-fidelity models.
method Bayesian Hierarchical modeling with physics-informed Gaussian processes.
result Models learning between digital twins are less uncertain than independent models but not over-confident.
Generative Adversarial Model improves RV segmentation accuracy in MRI.
problem Accurate segmentation of the right ventricular blood pool from cine MRI sequences.
method Combines FCNN, Gated Recurrent Units (GRU), Generative Adversarial Networks (GAN), and L1 loss function.
result Improves Dice Index and Hausdorff Distance by 0.05 and 3.49 mm respectively.
Study compares estimators for causal mediation analysis with multiple mediators.
problem Estimating causal effects through multiple mediators in observational studies.
method Parametric and non-parametric estimators, including multiply robust and double machine learning approaches.
result Advanced estimators perform well across various settings and real data.
In this paper, we propose a new deep feature selection method based on deep architecture. Our method uses stacked auto-encoders for feature representation in higher-level abstraction. We developed and applied a novel feature learning approach to a specific precision medicine problem, which focuses on assessing and prio…
The paper uses geometric methods to classify medical data histograms.
problem Classifying medical data histograms for disease diagnosis.
method Information geometry of beta distributions for comparing and classifying histograms.
result Geometric tools, particularly negatively curved Fisher information, enable unique mean calculation and K-means classification.
Improved forecasting of suicide attempts using LSGPs for patients with little data.
problem Challenges in predicting suicide attempts due to their rarity and patient heterogeneity.
method Introduced Latent Similarity Gaussian Processes (LSGPs) to capture patient heterogeneity.
result LSGPs outperform baseline models, even without kernel-design, and offer new insights into patient similarity.
Efficiently fine-tunes patient-independent seizure detection models with tensor kernel machine.
problem Improving seizure detection accuracy for wearable devices.
method Transfer learning with tensor kernel machine using canonical polyadic decomposition.
result Patient fine-tuned model achieves high performance with smaller model size.
Personalized models explain TB treatment outcomes considering patient context.
problem Heterogeneity in TB treatment outcomes due to co-morbidities.
method Multi-task learning approach encoding patient context into personalized models.
result Identifies anemia, age of onset, and HIV as influential for treatment efficacy.
Simulates patient pathways to detect delayed rare disease diagnoses.
problem Delayed rare disease diagnoses in France, causing health system and patient harm.
method Probabilistic modelling of patient pathways to create an alert system.
result Alert system detects and refers wandering patients to CRMRs.
Clusters of ACS patients identified for better therapeutic stratification.
problem Data-driven classification and subtyping of ACS patients for improved treatment.
method Outcome-driven clustering using a multi-task neural network with attention.
result Seven patient clusters with distinct characteristics and risk profiles identified.
The paper presents a method to score patient engagement in care programs and predicts their response.
problem Improving health outcomes of high-need patients through better patient engagement.
method Data-driven behavioral engagement scoring pipeline for two aspects of patient engagement.
result The scoring method successfully predicts patient engagement and provides interpretable insights.
Model predicts wound and episode-level readmission risk and time to re-admit.
problem Identify patients at high risk of re-admission to prevent wound recurrences and reduce healthcare costs.
method Data-driven analysis of wound care and episode-level patient data.
result Model achieves high recall and precision for predicting re-admission risk and time.
Currently, approximately 30% of epileptic patients treated with antiepileptic drugs (AEDs) remain resistant to treatment (known as refractory patients). This project seeks to understand the underlying similarities in refractory patients vs. other epileptic patients, identify features contributing to drug resistance acr…
System detects multiple patients' behaviors in real-time using mmWave radar and CNN.
problem Real-time patient behavior monitoring in hospitals.
method Used mmWave radar for tracking and collecting Doppler patterns. Created a three-layer CNN model for behavior classification.
result System achieved very good inference accuracy in predicting patient behaviors in real-time.
Deep learning model creates patient representations for scalable EHR-based stratification.
problem Challenges in summarizing and representing patient data from EHRs prevent scalable stratification analysis.
method Unsupervised framework based on deep learning (ConvAE) using word embeddings, CNNs, and autoencoders.
result ConvAE significantly outperformed baselines in clustering diverse patient cohorts, identifying clinically relevant subtypes.
Characterizing a patient's progression through stages of sepsis is critical for enabling risk stratification and adaptive, personalized treatment. However, commonly used sepsis diagnostic criteria fail to account for significant underlying heterogeneity, both between patients as well as over time in a single patient. W…
Proposes a deep learning framework for evaluating patient similarities from EHRs.
problem Evaluating clinical similarities between patients for various healthcare applications.
method A deep learning framework with medical concept embedding, preserving temporal information.
result Significant improvement in patient similarity evaluation over baselines.
We develop a personalized real time risk scoring algorithm that provides timely and granular assessments for the clinical acuity of ward patients based on their (temporal) lab tests and vital signs. Heterogeneity of the patients population is captured via a hierarchical latent class model. The proposed algorithm aims t…
Longitudinal patient data has the potential to improve clinical risk stratification models for disease. However, chronic diseases that progress slowly over time are often heterogeneous in their clinical presentation. Patients may progress through disease stages at varying rates. This leads to pathophysiological misalig…
Study automates detection of visitation disruptions in ICU patients.
problem Difficulty in detecting frequent visitation disruptions in ICU patients.
method Used DensePose R-CNN model to count people in video frames, analyzed disruptions and patient outcomes.
result Automated method detects visitation disruptions, impacts on pain and length of stay examined.
Model predicts treatment initiation from clinical data using patient-clinician relations.
problem Predicting treatment initiation from clinical time series data considering patient-clinician relations.
method Graph-Augmented Time-Sensitive Model using top eigenvectors of graph Laplacian.
result Relational similarity improves prediction over baselines, e.g., 5% improvement in AUPRC.
A new model uses GPs and latent force models to predict patient responses to drugs.
problem Challenges in modeling short-term effects of drugs on patient physiology.
method Hybrid Gaussian process with latent force model for joint modeling of patient physiology and drug effects.
result The model accurately predicts patient responses to three common drugs, showing competitive performance.
Bayesian methods improve group testing for identifying infected patients.
problem Identifying infected patients from group testing results with false positives.
method Bayesian inference and belief propagation algorithm, combined with expectation-maximization method.
result True-positive rate improved by considering credible intervals.
Paper predicts IVF pregnancy rates from basic patient info.
problem Predicting IVF pregnancy rates from patient characteristics.
method Clustering patients into groups, then SVM models for each group.
result Support vector machine models achieve best overall performance.
Hybrid system matches patients with family doctors based on trust and history.
problem Matching patients with suitable family doctors in primary care.
method Hybrid recommender system combining patient trust from consultation histories and temporal dynamics.
result Predictive accuracy is higher than heuristic and collaborative filtering approaches, and trust measure improves performance.
Model identifies key problems in HIV patients' records.
problem Complex and time-consuming task of identifying patient problems from electronic health records.
method Unsupervised phenotyping approach that jointly learns phenotypes from structured and unstructured data.
result Learned phenotypes and their relatedness are clinically valid and surpass existing methods.
Study develops electronic phenotypes of ICU patient acuity.
problem Limited time for patient acuity assessments and imprecise clinical trajectory prediction.
method Developed electronic phenotypes using automated variable retrieval in electronic health records.
result Identified three phenotypes: persistently stable, persistently unstable, and transitioning from unstable to stable.
Cancer patients admitted to ICU had improved survival over 10 years.
problem To assess changes in survival of cancer patients admitted to ICU over 10 years.
method Retrospective analysis of MIMIC-III database, adjusted for confounders using logistic regression.
result Cancer patients had significantly lower 28-day and 1-year mortality rates over 10 years.
Deep learning clusters patient time-series data for better prognosis.
problem Clustering time-series data for patient phenotyping and prognosis.
method Deep predictive clustering with novel loss functions for future outcome distribution.
result Model achieves superior clustering performance and identifies meaningful patient subgroups.
Machine learning detects NASH patients from medical claims data.
problem Detecting undiagnosed NASH patients for screening and management.
method Gradient-boosted decision trees trained on administrative medical claims data.
result Model precision for NASH detection is significantly higher than NASH incidence.
The paper tracks patient recovery using graphs of joint movement data.
problem Tracking individual patient recovery trajectories in physical therapy.
method Bayesian learning of Random Geometric Graphs from joint movement data.
result Optimal exercise routines can be recommended based on patient recovery data.