The paper develops a method to learn robust decision policies from observational data, reducing high-cost outcomes.
problem Learning safe decision policies from observational data with high-risk outcomes.
method Develops a method to learn policies that reduce high-cost outcomes, valid under finite samples and uneven feature overlap.
result Validates the method with real and synthetic data, providing statistical bounds on decision costs.
Clinical notes contain a large amount of clinically valuable information that is ignored in many clinical decision support systems due to the difficulty that comes with mining that information. Recent work has found success leveraging deep learning models for the prediction of clinical outcomes using clinical notes. Ho…
Machine learning algorithms are increasingly involved in sensitive decision-making process with adversarial implications on individuals. This paper presents mdfa, an approach that identifies the characteristics of the victims of a classifier's discrimination. We measure discrimination as a violation of multi-differenti…
Study builds models to predict post-cardiac arrest outcomes using patient data.
problem Lack of accurate prognostication methods for patients resuscitated from cardiac arrest.
method Integrated electronic health records (EHR) and physiological time series (PTS) data to train machine learning classifiers.
result Combined EHR-PTS24 models outperformed models using either EHR or PTS24 alone in predicting survival and neurological outcomes.
Copula-based fusion improves breast cancer risk stratification.
problem Combining clinical and genomic risk scores using simple rules fails to capture their joint relationship.
method Used copulas to model the joint relationship between clinical and genomic risk scores.
result Copula-based fusion improves risk stratification, identifying subgroups with the worst prognosis.
We consider thin incomplete financial markets, where traders with heterogeneous preferences and risk exposures have motive to behave strategically regarding the demand schedules they submit, thereby impacting prices and allocations. We argue that traders relatively more exposed to market risk tend to submit more elasti…
Study optimal liquidation under high risk aversion and small price impact.
problem Optimal liquidation of options under high risk aversion and linear price impact.
method Analyzes Bachelier model with linear price impact, computes utility indifference prices, and finds asymptotically optimal portfolios.
result Establishes a scaling limit for vanishing price impact and computes corresponding utility indifference prices.
After admission to emergency department (ED), patients with critical illnesses are transferred to intensive care unit (ICU) due to unexpected clinical deterioration occurrence. Identifying such unplanned ICU transfers is urgently needed for medical physicians to achieve two-fold goals: improving critical care quality a…
We introduce an off-policy evaluation procedure for highlighting episodes where applying a reinforcement learned (RL) policy is likely to have produced a substantially different outcome than the observed policy. In particular, we introduce a class of structural causal models (SCMs) for generating counterfactual traject…
Parametric insurance offers better risk-sharing in high-risk settings than traditional indemnity insurance.
problem High-risk environments where traditional indemnity insurance is unaffordable or ineffective.
method Comparison of excess-of-loss indemnity insurance and parametric insurance within a mean-variance framework, considering fixed costs and binding budget constraints.
result Parametric insurance yields higher welfare for risk-averse individuals, especially when indemnity insurance is impractical.
The paper shows how to audit fairness in decisions with hidden risk factors.
problem Estimating fairness in decisions influenced by hidden, unobservable risk factors.
method Derives unbiased estimates of risk using historical data and audits existing decision-making systems.
result One can compute meaningful bounds on treatment rates for high-risk individuals, even with hidden confounders.
Study improves summarization reliability in risky scenarios.
problem Reliability of automatic summarization in high-risk contexts.
method Conditional generation with Bayesian inference and entropy regularization.
result Significant improvement in robustness and reliability of summarization.
Study proposes managing COVID-19 without economy shutdowns.
problem Avoiding lockdowns while maintaining healthcare system capacity.
method Detailed heterogeneous epidemiological model, calibrated to data.
result Countries can avoid lockdowns if ICU beds per million > 100.
The paper tackles distribution-free prediction intervals for multi-source data.
problem Challenges in achieving valid inferences due to distribution shifts and privacy concerns.
method Derives efficient influence functions, incorporates machine learning, and proposes data-adaptive strategies.
result Achieves parametric rates of convergence to nominal coverage probabilities for prediction intervals.
Machine learning predicts trauma patient mortality risk.
problem Predicting mortality risk in trauma patients using traditional regression models.
method Transfer learning-based machine learning algorithm applied to trauma patient data.
result Machine learning model achieved similar performance to contemporary models without restrictive criteria.
We develop a neural network model to classify liver cancer patients into high-risk and low-risk groups using genomic data. Our approach provides a novel technique to classify big data sets using neural network models. We preprocess the data before training the neural network models. We first expand the data using wavel…
The study designs inherently interpretable machine learning models for high-risk sectors.
problem The need for transparent and explainable machine learning models in regulated industries.
method Qualitative template based on feature effects and model architecture constraints for assessing inherent interpretability.
result Demonstrates the design and evaluation of an interpretable ReLU DNN model for predicting credit default.
Study improves machine learning for estimating survival treatment effects.
problem Estimating heterogeneous survival treatment effects in observational data.
method Flexible machine learning methods in the counterfactual framework, including AFT-BART-NP.
result AFT-BART-NP consistently yields best performance in terms of bias, precision, and frequentist coverage.
Study compares LSTM, Transformer, and Mamba for bladder cancer recurrence analysis.
problem Complex time-dependent data in bladder cancer recurrence analysis.
method Evaluation of LSTM, Transformer, and Mamba models using Cox proportional hazards model.
result LSTM-Cox model outperforms Transformer-Cox and Mamba-Cox models in prediction accuracy.
Risk prediction is central to both clinical medicine and public health. While many machine learning models have been developed to predict mortality, they are rarely applied in the clinical literature, where classification tasks typically rely on logistic regression. One reason for this is that existing machine learning…
A mechanism to share risks and costs with guarantees against extreme outcomes.
problem Softening extreme individual burdens in risk sharing schemes.
method Formalizes Certified Allocation Problem; uses Conformal Risk Sharing with interpretable sharing policy and split conformal calibration.
result Reduces extreme obligations for high-risk agents while controlling harm to others.
The paper studies an oligopolistic equilibrium model of financial agents who aim to share their random endowments. The risk-sharing securities and their prices are endogenously determined as the outcome of a strategic game played among all the participating agents. In the complete-market setting, each agent's set of st…
Proposes a method for generating prediction intervals in dose-response models using conformal prediction.
problem Uncertainty quantification in continuous treatments for personalized healthcare decisions.
method Causal dose-response problem framed as covariate shift, using weighted conformal prediction with propensity estimation and kernel functions.
result Demonstrates the significance of covariate shift assumptions for robust prediction intervals.
Proposes a new method for uncertainty estimation in neural networks.
problem Uncertainty quantification in neural networks for high-risk applications.
method Intuitive framework based on signal-to-noise ratio and variance-gated measure.
result Demonstrates a collapse in diversity of committee machines.
In healthcare, the highest risk individuals for morbidity and mortality are rarely those with the greatest modifiable risk. By contrast, many machine learning formulations implicitly attend to the highest risk individuals. We focus on this problem in point processes, a popular modeling technique for the analysis of the…
Develops a risk score to assist ECMO planning for critically ill patients with viral or unspecified pneumonia.
problem Lack of a risk score to guide ECMO planning for critically ill patients.
method Leverages machine learning to develop the PEER score.
result PEER score predicts mortality and decompensation in patients eligible for ECMO.
Heart failure hospitalization is a severe burden on healthcare. How to predict and therefore prevent readmission has been a significant challenge in outcomes research. To address this, we propose a deep learning approach to predict readmission from clinical notes. Unlike conventional methods that use structured data fo…
AI-driven framework improves enterprise financial audits and risk identification.
problem Manual auditing is inefficient and limited by data complexity and evolving fraud tactics.
method Machine learning algorithms (SVM, RF, KNN) applied to a dataset of audit project counts, violations, and fraud instances.
result Random Forest achieves best performance with F1-score of 0.9012, identifying fraud and compliance anomalies.
Managing patients with chronic diseases is a major and growing healthcare challenge in several countries. A chronic condition, such as diabetes, is an illness that lasts a long time and does not go away, and often leads to the patient's health gradually getting worse. While recent works involve raw electronic health re…
Adapts safe policies for exploration in high-risk settings.
problem Balancing safety and exploration in high-risk environments.
method Uses conformal calibration on a safe reference policy to determine aggressive action limits.
result Safe exploration improves performance without requiring model class identification or hyperparameter tuning.
The paper provides a uniform convergence bound for smooth calibration error and its relationship with functional gradient.
problem Limited theoretical understanding of learning algorithms achieving high accuracy and good calibration.
method Focuses on smooth calibration error, providing a uniform convergence bound and proving the relationship with functional gradient.
result Derives conditions for simultaneous classification and calibration guarantees in gradient boosting trees, kernel boosting, and neural networks.
Study develops a dynamic risk model for COVID-19 mortality using UK Biobank data.
problem Developing tools to monitor high-risk patients during the COVID-19 pandemic.
method Data-driven random forest classification model using baseline characteristics and symptoms.
result Model predicts COVID-19 mortality with excellent performance (AUC: 0.91), identifying novel predictors.
New monitoring method detects ML risk models' performance changes in medical interventions.
problem Monitoring ML risk models in healthcare is complicated by confounding medical interventions.
method Developed a new score-based CUSUM monitoring procedure with dynamic control limits.
result Valid inference is possible if conditional exchangeability or time-constant selection bias hold.
Study uses RL to optimize crypto portfolios with two-sided transactions and lending.
problem Managing downside risk and capital optimization in high-risk crypto markets.
method Integrates RL with a new environmental formulation and PnL-based reward function, using SAC agent with CNN-MHA.
result Significantly outperforms benchmarks, especially in high-volatility scenarios.
VTrackIt creates a synthetic dataset with infrastructure and vehicle info for AVs.
problem Lack of infrastructure and pooled vehicle info in existing AV datasets.
method Developed VTrackIt, a synthetic dataset with intelligent infrastructure and pooled vehicle info, and introduced InfraGAN for trajectory predictions.
result VTrackIt reduces high-risk edge cases in AV trajectory predictions.
ICP provides interval predictions with high confidence coverage.
problem High-risk settings where true output must be highly probable.
method ICP is a distribution-free, model-agnostic algorithm.
result ICP outputs prediction intervals with high coverage probability.
High-risk domains require reliable confidence estimates from predictive models. Deep latent variable models provide these, but suffer from the rigid variational distributions used for tractable inference, which err on the side of overconfidence. We propose Stochastic Quantized Activation Distributions (SQUAD), which im…
Investors in Target Date Funds are automatically switched from high risk to low risk assets as their retirements approach. Such funds have become very popular, but our analysis brings into question the rationale for them. Based on both a model with parameters fitted to historical returns and on bootstrap resampling, we…
Developing state-of-the-art approaches for specific tasks is a major driving force in our research community. Depending on the prestige of the task, publishing it can come along with a lot of visibility. The question arises how reliable are our evaluation methodologies to compare approaches? One common methodology to i…
Study utility indifference pricing in a Bachelier model with small linear price impact.
problem Utility indifference pricing in a model with linear price impact.
method Analyzes the Bachelier model with exponential utility indifference prices for vanilla European options.
result Computes the scaling limit of utility indifference prices for a vanishing price impact inversely proportional to risk aversion.
Characterizing a patient's progression through stages of sepsis is critical for enabling risk stratification and adaptive, personalized treatment. However, commonly used sepsis diagnostic criteria fail to account for significant underlying heterogeneity, both between patients as well as over time in a single patient. W…
A Convolutional Neural Network was used to predict kidney function in patients with chronic kidney disease from high-resolution digital pathology scans of their kidney biopsies. Kidney biopsies were taken from participants of the NEPTUNE study, a longitudinal cohort study whose goal is to set up infrastructure for obse…
Conformal prediction provides distribution-free uncertainty quantification for black-box models.
problem Uncertainty quantification for high-risk machine learning applications.
method Conformal prediction creates valid uncertainty sets without distributional assumptions.
result Sets contain the ground truth with a specified probability, e.g., 90%.
Method predicts biomarker trajectories with uncertainty bands for Alzheimer's disease.
problem Uncertainty in biomarker predictions poses risks in clinical deployment.
method Conformal prediction for randomly-timed biomarker trajectories.
result Conformal bands achieve desired coverage and are tighter than baseline.
ENN method uses expectile regression for genetic data analysis of complex diseases.
problem Discover additional genetic variants contributing to complex diseases.
method Developed an expectile neural network (ENN) method integrating expectile regression and neural networks.
result ENN method outperforms existing expectile regression in discovering genetic variants predisposing to sub-populations.
This paper argues, first, that a major problem in the planning of large infrastructure projects is the high level of misinformation about costs and benefits that decision makers face in deciding whether to build, and the high risks such misinformation generates. Second, it explores the causes of misinformation and risk…
We solve the first-passage problem for the Heston random diffusion model. We obtain exact analytical expressions for the survival and hitting probabilities to a given level of return. We study several asymptotic behaviors and obtain approximate forms of these probabilities which prove, among other interesting propertie…
Paper simplifies balancing weights by relaxing outcome assumptions.
problem Estimating missing outcomes in a target population.
method Relaxes outcome assumptions to simplify balancing weights.
result Balancing weights can be simplified with convex loss and minimum worst-case bias.