A central problem in neuroscience is reconstructing neuronal circuits on the synapse level. Due to a wide range of scales in brain architecture such reconstruction requires imaging that is both high-resolution and high-throughput. Existing electron microscopy (EM) techniques possess required resolution in the lateral p…
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48 results for “high throughput”
A new method selects inducing points to optimize high-throughput Bayesian optimisation.
problem Current inducing point selection methods sacrifice high-fidelity modeling of promising regions.
method Information-theoretic criterion to select inducing points maximizing global and maximum value uncertainties.
result Surrogate models support high-precision high-throughput Bayesian optimisation.
Given the crucial role of microtubules for cell survival, many researchers have found success using microtubule-targeting agents in the search for effective cancer therapeutics. Understanding microtubule responses to targeted interventions requires that the microtubule network within cells can be consistently observed …
High-speed model accurately simulates neuromorphic devices.
problem Accurately modeling stochastic synapses in large-scale neuromorphic systems.
method Generative vector autoregressive model based on resistive memory cell data.
result Fast, high-throughput model reproduces synaptic parameters and correlations.
High-Throughput Asset Pricingq-fin.GN
EB improves asset pricing by mining large strategies without lookahead bias.
problem Lack of unbiased asset pricing models with out-of-sample performance.
method Empirical Bayes applied to 136,000 long-short strategies.
result EB provides unbiased predictions with transparent intuition.
Many modern data sets are sampled with error from complex high-dimensional surfaces. Methods such as tensor product splines or Gaussian processes are effective/well suited for characterizing a surface in two or three dimensions but may suffer from difficulties when representing higher dimensional surfaces. Motivated by…
High-throughput 3D control training system achieves 100,000 FPS.
problem Lack of efficient, single-machine reinforcement learning systems.
method Sample Factory combines asynchronous sampling and off-policy correction.
result Achieves 100,000 FPS on 3D control problems without sacrificing sample efficiency.
This paper evaluates quantization techniques for deep learning inference.
problem Reducing the size and improving inference of deep neural networks.
method Review and empirical evaluation of quantization parameters for various neural network models.
result 8-bit quantization maintains accuracy within 1% of floating-point models.
High throughput screening of compounds (chemicals) is an essential part of drug discovery [7], involving thousands to millions of compounds, with the purpose of identifying candidate hits. Most statistical tools, including the industry standard B-score method, work on individual compound plates and do not exploit cross…
CoinTossX is a low-latency, open-source matching engine for financial trading.
problem Efficiently matching orders in financial markets with low latency and high throughput.
method Developed in Java, orders submitted via UDP SBE, low-latency message transport (Aeron Media Driver). Separates order generation and matching.
result Demonstrated low-latency, high-throughput performance in various deployment scenarios.
New algorithms speed up learning from large screens of proteins.
problem Lack of scaled data hampers biological machine learning.
method Optimized high throughput screens and generative models.
result Maximized information gain with consistent estimates of .
Hi-RES framework extracts medical relations from articles and EHRs.
problem Manual annotation bottleneck in relation extraction.
method Labeling sentences, creating improved negative samples, using pretrained language models, and combining EHR embeddings.
result Significant accuracy increases in relation extraction, up to 0.998 for disorder-location relations.
Fast 2D Bicephalous Convolutional Autoencoder for Compressing 3D Time Projection Chamber Datastat.ML
BCAE-2D compresses 3D data from a time projection chamber at high speed.
problem Compressing high-speed, sparse 3D data from a time projection chamber.
method 2D Bicephalous Convolutional Autoencoder (BCAE-2D) approach.
result 3x speedup in compression throughput with improved reconstruction accuracy.
Improves matrix multiplication throughput for asymmetric bit-width operands.
problem Matrix multiplications between asymmetric bit-width operands, especially 8- and 4-bit, are not efficiently handled by existing SIMD instructions.
method Proposes a new SIMD matrix multiplication instruction that uses mixed precision on inputs (8- and 4-bit) and accumulates into 16-bit output, improving throughput.
result Offers 2x improvement in throughput compared to existing symmetric-operand-size instructions, with negligible overflow.
Inducing Point Allocation for Sparse Gaussian Processes in High-Throughput Bayesian Optimisationcs.LG
New method optimizes Gaussian process allocation for BO.
problem Existing methods for inducing point allocation in BO hinder performance.
method Proposes a new allocation strategy using quality-diversity decomposition.
result Demonstrates improved BO performance through local high-fidelity modeling.
The exploitation of large-scale population data has the potential to improve healthcare by discovering and understanding patterns and trends within this data. To enable high throughput analysis of cardiac imaging data automatically, a pipeline should comprise quality monitoring of the input images, segmentation of the …
Machine learning methods have shown promise in predicting molecular properties, and given sufficient training data machine learning approaches can enable rapid high-throughput virtual screening of large libraries of compounds. Graph-based neural network architectures have emerged in recent years as the most successful …
We introduce a new, high-throughput, synchronous, distributed, data-parallel, stochastic-gradient-descent learning algorithm. This algorithm uses amortized inference in a compute-cluster-specific, deep, generative, dynamical model to perform joint posterior predictive inference of the mini-batch gradient computation ti…
The study compares different scRNA sequencing methods using a high-dimensional dataset.
problem To identify unique characteristics of different scRNA sequencing methods.
method Quantitative comparison through clustering analysis of a high-dimensional dataset.
result Identifies unique characteristics associated with different scRNA sequencing methods.
PIMA autoencoders discover shared features in multimodal scientific data.
problem Discovering shared information in high-throughput scientific datasets.
method Physics-informed multimodal autoencoders (PIMA) with Gaussian mixture prior and product of experts formulation.
result Accurate cross-modal inference between images and mechanical stress-strain response in lattice metamaterials.
Future advancement of engineering applications is dependent on design of novel materials with desired properties. Enormous size of known chemical space necessitates use of automated high throughput screening to search the desired material. The high throughput screening uses quantum chemistry calculations to predict mat…
A looming question that must be solved before robotic plant phenotyping capabilities can have significant impact to crop improvement programs is scalability. High Throughput Phenotyping (HTP) uses robotic technologies to analyze crops in order to determine species with favorable traits, however, the current practices r…
New method classifies reticulocytes from red blood cells without labels.
problem Classifying reticulocytes from mature red blood cells without fluorescent labels.
method Unsupervised machine learning on morpho-rheological markers.
result Promising results in classifying reticulocytes from mature red blood cells.
The paper proposes a method to learn from both simulation and real-world data.
problem Training autonomous systems in simulation and applying them to real-world environments.
method Balancing samples from simulation and real-world data using a replay buffer.
result The method achieves better performance in real-world tasks compared to training only in simulation.
DeepCoDA provides personalized interpretability for complex health data.
problem Interpreting complex health data, especially compositional data, is challenging.
method DeepCoDA framework for high-dimensional compositional data, personalized interpretability through patient-specific weights.
result DeepCoDA maintains state-of-the-art performance and provides coherent, personalized interpretations.
Proposes a model for identifying 4G cells with network throughput problems.
problem Challenges in identifying 4G cells with network throughput issues due to network complexity and privacy concerns.
method Data-driven model using clustering and Deep Neural Networks (DNNs). Model parameters are learned from a small number of expert-labeled data. Multiple clustering models capture common features for problematic cells.
result The proposed model outperforms a simple classifier in identifying cells with network throughput problems.
Deep reinforcement learning boosts throughput in RF-powered cognitive radio networks.
problem Maximizing throughput in large-scale, decentralized RF-powered cognitive radio networks.
method Proposes deep reinforcement learning to find optimal policies for network throughput maximization.
result Deep reinforcement learning outperforms existing techniques in large-scale RF-CRN environments.
The paper optimizes LLM inference systems through queueing theory.
problem Efficient LLM inference for AI agents under various routing topologies.
method Developed a fluid-limit framework for multi-class batched processing networks under K-FCFS scheduling.
result Proved that work-conserving scheduling algorithms maximize throughput for LLM inference.
Service-induced congestion in memory-constrained LLM serving
problem Service-induced congestion in memory-constrained large language model (LLM) serving
method Developing a discrete-time dynamical model of memory-constrained LLM inference
result The system converges to a unique worst-case limit cycle that is asymptotically stable outside a Lebesgue-measure-zero exact-capture set, with throughput losses as large as 50%.
Machine Learning models are often composed of pipelines of transformations. While this design allows to efficiently execute single model components at training time, prediction serving has different requirements such as low latency, high throughput and graceful performance degradation under heavy load. Current predicti…
Parallel and Distributed Thompson Sampling for Large-scale Accelerated Exploration of Chemical Spacestat.ML
Chemical space is so large that brute force searches for new interesting molecules are infeasible. High-throughput virtual screening via computer cluster simulations can speed up the discovery process by collecting very large amounts of data in parallel, e.g., up to hundreds or thousands of parallel measurements. Bayes…
Understanding functional organization of genetic information is a major challenge in modern biology. Following the initial publication of the human genome sequence in 2001, advances in high-throughput measurement technologies and efficient sharing of research material through community databases have opened up new view…
Ithemal: Accurate, Portable and Fast Basic Block Throughput Estimation using Deep Neural Networkscs.DC
Predicting the number of clock cycles a processor takes to execute a block of assembly instructions in steady state (the throughput) is important for both compiler designers and performance engineers. Building an analytical model to do so is especially complicated in modern x86-64 Complex Instruction Set Computer (CISC…
As Machine Learning (ML) applications increase in data size and model complexity, practitioners turn to distributed clusters to satisfy the increased computational and memory demands. Unfortunately, effective use of clusters for ML requires considerable expertise in writing distributed code, while highly-abstracted fra…
We present the OpenAI Remote Rendering Backend (ORRB), a system that allows fast and customizable rendering of robotics environments. It is based on the Unity3d game engine and interfaces with the MuJoCo physics simulation library. ORRB was designed with visual domain randomization in mind. It is optimized for cloud de…
This paper studies the problem of spectrum shortage in an unmanned aerial vehicle (UAV) network during critical missions such as wildfire monitoring, search and rescue, and disaster monitoring. Such applications involve a high demand for high-throughput data transmissions such as real-time video-, image-, and voice- st…
Wireless communication systems operate in complex time-varying environments. Therefore, selecting the optimal configuration parameters in these systems is a challenging problem. For wireless links, \emph{rate selection} is used to select the optimal data transmission rate that maximizes the link throughput subject to a…
Understanding the morphological changes of primary neuronal cells induced by chemical compounds is essential for drug discovery. Using the data from a single high-throughput imaging assay, a classification model for predicting the biological activity of candidate compounds was introduced. The image recognition model wh…
New algorithm tackles resource allocation in multi-armed bandits to balance speed and throughput.
problem Balancing speed and throughput in stochastic multi-armed bandits with limited resources.
method Proposes an algorithm that trades off between information accumulation and throughput.
result Upper bounds the time taken to find the best arm with a given target success probability.
We characterize and study variable importance (VIMP) and pairwise variable associations in binary regression trees. A key component involves the node mean squared error for a quantity we refer to as a maximal subtree. The theory naturally extends from single trees to ensembles of trees and applies to methods like rando…
ShadowSync: Performing Synchronization in the Background for Highly Scalable Distributed Trainingcs.LG
ShadowSync separates background synchronization for scalable distributed training.
problem Reducing synchronization overhead in distributed training for high scalability.
method Separates synchronization from training and runs it in the background.
result Achieves both high throughput and excellent model quality at scale.
Determining the localization of specific protein in human cells is important for understanding cellular functions and biological processes of underlying diseases. Among imaging techniques, high-throughput fluorescence microscopy imaging is an efficient biotechnology to stain the protein of interest in a cell. In this w…
This paper proposes CodeX, an end-to-end framework that facilitates encoding, bitwidth customization, fine-tuning, and implementation of neural networks on FPGA platforms. CodeX incorporates nonlinear encoding to the computation flow of neural networks to save memory. The encoded features demand significantly lower sto…
As high-throughput biological sequencing becomes faster and cheaper, the need to extract useful information from sequencing becomes ever more paramount, often limited by low-throughput experimental characterizations. For proteins, accurate prediction of their functions directly from their primary amino-acid sequences h…
We consider an ad hoc network where multiple users access the same set of channels. The channel characteristics are unknown and could be different for each user (heterogeneous). No controller is available to coordinate channel selections by the users, and if multiple users select the same channel, they collide and none…
Runtime Concurrency Control and Operation Scheduling for High Performance Neural Network Trainingcs.DC
Training neural network often uses a machine learning framework such as TensorFlow and Caffe2. These frameworks employ a dataflow model where the NN training is modeled as a directed graph composed of a set of nodes. Operations in neural network training are typically implemented by the frameworks as primitives and rep…
Paper introduces OARF benchmark suite for federated learning systems.
problem Limited diversity in federated learning benchmarks.
method Characterizes OARF benchmark suite with diverse data and applications.
result Federated learning can effectively increase end-to-end throughput.
High throughput sequencing techniques have highly impactedon modern biology, widening the gap between sequenced andannotated data. Automatic annotation tools are thereforeof the foremost importance to guide biologists' experiments. However, most of the state-of-the-art methods rely on annotation transfer, offering reli…