Model trains agents to optimize saving and investment strategies for diverse retirement needs.
problem Optimal saving and investment strategies for individuals in varied employment and income profiles.
method Deep reinforcement learning to train intelligent agents with heterogeneous profiles.
result Flexible methodology estimates lifetime consumption and investment choices for different profiles.
New method resolves causal heterogeneity by defining a resolution profile.
problem Causal subgroup analyses often oversimplify heterogeneity into a small number of groups.
method Introduces a resolution profile as a functional of the causal feature law, using Bayesian-bootstrap inference.
result Shows that the resolution profile is a continuous path with discontinuities at knots, providing integer-valued subgroup numbers.
This paper optimizes cybersecurity resource allocation in networks with heterogeneous attacker and defender valuations.
problem Optimizing cybersecurity resource allocation in networks with heterogeneous attacker and defender valuations.
method Combining strategic behavior of players with contagion dynamics, a method is extended to determine optimal resource allocation based on simple network metrics weighted by risk profiles.
result The asymmetry between attacker and defender valuations drives optimal attack and defense strategies, shaping system resilience.
Background: While machine learning (ML) models are rapidly emerging as promising screening tools in critical care medicine, the identification of homogeneous subphenotypes within populations with heterogeneous conditions such as pediatric sepsis may facilitate attainment of high-predictive performance of these prognost…
Bayesian approach clusters survival data for better risk prediction.
problem Identifying subpopulations with distinct risk profiles in survival analysis.
method Bayesian nonparametric approach in a clustered latent space.
result Consistent improvements in predictive performance and interpretability.
Modeling correlated mutations in cancer for personalized treatment.
problem Identifying mutations for personalized cancer therapy in heterogeneous profiles.
method Proposed correlated zero-inflated negative binomial process with mixed beta-Bernoulli and variational inference.
result Identified biologically relevant correlations between somatic mutations.
We investigate the trading behavior of Finnish individual investors trading the stocks selected to compute the OMXH25 index in 2003 by tracking the individual daily investment decisions. We verify that the set of investors is a highly heterogeneous system under many aspects. We introduce a correlation based method that…
Tissue heterogeneity is a major confounding factor in studying individual populations that cannot be resolved directly by global profiling. Experimental solutions to mitigate tissue heterogeneity are expensive, time consuming, inapplicable to existing data, and may alter the original gene expression patterns. Here we a…
We introduce the anti-profile Support Vector Machine (apSVM) as a novel algorithm to address the anomaly classification problem, an extension of anomaly detection where the goal is to distinguish data samples from a number of anomalous and heterogeneous classes based on their pattern of deviation from a normal stable c…
CR-UOT improves matching of heterogeneous single-cell omics profiles.
problem Matching nonnegative finite Radon measures across heterogeneous spaces.
method Cost-regularized unbalanced optimal transport (CR-UOT) framework.
result CR-UOT improves alignment of heterogeneous single-cell omics profiles.
Various types of structures that enable a group of individuals to pool their mortality risk have been proposed in the literature. Collectively, the structures are called pooled annuity funds. Since the pooled annuity funds propose different methods of pooling mortality risk, we investigate the connections between them …
In online social networks people often express attitudes towards others, which forms massive sentiment links among users. Predicting the sign of sentiment links is a fundamental task in many areas such as personal advertising and public opinion analysis. Previous works mainly focus on textual sentiment classification, …
The paper analyzes ridge regression with random features for non-identically distributed data.
problem Analyzing ridge regression performance for data with heterogeneous variance profiles.
method Combining linear-plus-chaos approximation and operator-valued free probability.
result Derives asymptotic equivalents for training and test risks under non-identically distributed data.
New model clusters cells and individuals, revealing genetic influences on cell types.
problem Clustering nested data with group-level and observation-level variables.
method Nested Atoms Model (NAM), Bayesian nonparametric approach.
result Identifies clusters of genetically similar individuals with homogeneous cell-type profiles.
V1 cortex reconstructs images as Poisson equation solutions with varying weights.
problem Reconstructing images from V1 cortical cell receptive profiles.
method Solves a heterogeneous Poisson equation with varying weights representing neural connectivity.
result Reconstructions converge to homogeneous solutions using homogenization techniques.
Profile graphical models represent multivariate dependence under varying risk factors.
problem Capturing varying conditional independence structures across different levels of a risk factor.
method Introducing a novel class of graphical models (profile graphical models) that represent multivariate dependence under varying risk factors, and developing a Bayesian approach for learning shared sparsity structures.
result Demonstrated enhanced ability to capture subject-specific differences in protein network data from acute myeloid leukemia.
Distributed learning adapts to diverse devices, improving performance.
problem Training neural networks on devices with varying capabilities and resources.
method Each device trains a customized neural network, sharing parameters with others.
result Achieves higher rewards on more powerful devices without sacrificing weaker ones.
Attributes, such as metadata and profile, carry useful information which in principle can help improve accuracy in recommender systems. However, existing approaches have difficulty in fully leveraging attribute information due to practical challenges such as heterogeneity and sparseness. These approaches also fail to c…
New framework learns complex AI attitudes from heterogeneous data.
problem Heterogeneous ordinal structure in AI attitudes, poorly captured by existing methods.
method Monotone Gaussian score embedding, BNP complexity discovery, confirmatory fixed-K estimation.
result Reduced holdout MSE by 25.8% over single-graph baseline.
A novel criterion selects optimal distance metrics for cell profile analysis.
problem Determining the most accurate distance metric for high-dimensional cell profiles.
method Generalized proposition and corollaries to evaluate and select distance metrics.
result Wasserstein and cosine similarity metrics are optimal for general cases.
Stem uses diffusion models to infer gene expression from H&E images.
problem Inference of gene expression from H&E stained images is time-consuming and expensive.
method Conditional diffusion generative model to infer gene expression.
result Stem achieves state-of-the-art performance in spatial gene expression prediction.
SIMPLE-RC method tests group membership profiles in large networks with weak signals.
problem Testing group membership profiles in large networks with weak signals.
method Random coupling technique to construct maximum SIMPLE tests for subsampled node pairs.
result Asymptotic distributions of SIMPLE-RC test are derived, enabling delicate analysis.
Social, technological and economic time series are divided by events which are usually assumed to be random albeit with some hierarchical structure. It is well known that the interevent statistics observed in these contexts differs from the Poissonian profile by being long-tailed distributed with resting and active per…
Paper addresses data heterogeneity in federated learning for CoxPH models in healthcare.
problem Data heterogeneity in federated learning of CoxPH models for healthcare.
method Feature-based clustering and event-based reporting strategy.
result Enhanced model accuracy and performance in federated survival analysis.
Graphical model has been widely used to investigate the complex dependence structure of high-dimensional data, and it is common to assume that observed data follow a homogeneous graphical model. However, observations usually come from different resources and have heterogeneous hidden commonality in real-world applicati…
Baseline injury categorization is important to traumatic brain injury (TBI) research and treatment. Current categorization is dominated by symptom-based scores that insufficiently capture injury heterogeneity. In this work, we apply unsupervised clustering to identify novel TBI phenotypes. Our approach uses a generaliz…
Paper develops a method to predict cancer patient survival using molecular profiles.
problem Accurately predicting cancer patient survival with complex survival-molecular profile relationships.
method Kernel Cox partially linear regression with a novel regularized garrotized kernel machine (RegGKM) method.
result The proposed method outperforms other methods in predicting survival accuracy.
Daydream predicts DNN optimization efficacy efficiently.
problem Inefficiency and error in evaluating DNN optimizations.
method Models DNN execution with a dependency graph, predicts runtime based on simulation.
result Accurately predicts performance improvements from DNN optimizations.
Cluster analysis aims at separating patients into phenotypically heterogenous groups and defining therapeutically homogeneous patient subclasses. It is an important approach in data-driven disease classification and subtyping. Acute coronary syndrome (ACS) is a syndrome due to sudden decrease of coronary artery blood f…
Gene expression levels in a population vary extensively across tissues. Such heterogeneity is caused by genetic variability and environmental factors, and is expected to be linked to disease development. The abundance of experimental data now enables the identification of features of gene expression profiles that are s…
Unsupervised method selects genes for tumor subtype discovery.
problem High-dimensional tumor gene expression data with noisy variables and heterogeneity.
method Autoencoders for latent space learning, Multiple Kernel Learning for feature selection, clustering.
result Lower redundancy and better clustering performance compared to benchmarks.
Modeling student behaviors and multiple predictions for early intervention.
problem Predicting student outcomes and interactions among multiple tasks.
method Proposes a variant of LSTM and soft-attention mechanism for heterogeneous behaviors, and co-attention mechanism for task interactions.
result Demonstrated effectiveness in predicting student outcomes and interactions.
Develops a hybrid MtFA approach for high-dimensional data clustering.
problem Scalability issues in traditional MtFA estimation methods for high-dimensional data.
method Integrates profile likelihood method into EM framework for efficient parameter estimation.
result Demonstrates superior computational efficiency and clustering accuracy compared to existing methods.
Bayesian framework for analyzing heterogeneous covariance data with a novel MoE-Wishart model.
problem Analyzing complex multivariate systems with varying covariance structures.
method Comprehensive Bayesian framework using mixture-of-experts Wishart model with predictor-dependent mixture weights.
result Accurate subpopulation recovery and estimation in heterogeneous covariance scenarios.
Distributed representations have been used to support downstream tasks in healthcare recently. Healthcare data (e.g., electronic health records) contain multiple modalities of data from heterogeneous sources that can provide complementary information, alongside an added dimension to learning personalized patient repres…
The paper develops a hybrid model for optimal order execution in markets with heterogeneous market makers.
problem Optimal liquidation in markets with limited inventory and risk capacity.
method Derives a reduced form model for aggregated inventory dynamics considering price impact.
result Optimal execution can be modeled as a linear-quadratic stochastic control problem.
The analysis of mixed data has been raising challenges in statistics and machine learning. One of two most prominent challenges is to develop new statistical techniques and methodologies to effectively handle mixed data by making the data less heterogeneous with minimum loss of information. The other challenge is that …
A broad spectrum of data from different modalities are generated in the healthcare domain every day, including scalar data (e.g., clinical measures collected at hospitals), tensor data (e.g., neuroimages analyzed by research institutes), graph data (e.g., brain connectivity networks), and sequence data (e.g., digital f…
Improved accuracy in machine learning with Cross-Cluster Weighted Forests.
problem Improving accuracy in machine learning algorithms for datasets with clusters.
method Ensembling Random Forest learners trained on clusters determined by k-means.
result Significant improvements in accuracy and generalizability over traditional Random Forest.
Study uses LLMs to create personalized treatment plans for rare gynecological tumors.
problem Suboptimal management and poor prognosis due to low incidence and heterogeneity of rare gynecological tumors.
method Developed a digital twin system using LLMs to integrate clinical and biomarker data.
result LLM-enabled digital twins efficiently model individual patient trajectories and identify potential treatment options.
Trans-GLMC tackles source heterogeneity in transfer learning for structured clusters.
problem Source heterogeneity makes it hard to use multiple related auxiliary sources effectively.
method Trans-GLMC constructs clusters of sources, then combines global fusion, within-cluster refinement, and target debiasing.
result Improves facility-specific prediction and identifies interpretable communities of hospitals with mutual transferability.
Network data is prevalent in many contemporary big data applications in which a common interest is to unveil important latent links between different pairs of nodes. Yet a simple fundamental question of how to precisely quantify the statistical uncertainty associated with the identification of latent links still remain…
The paper proposes a new evaluation framework for causal inference models.
problem Challenges in estimating causal effects from observational data.
method Complements evaluation of causal inference models with statistical evidence and non-parametric tests.
result Eliminates the influence of a few instances or simulations on benchmarking results.
This paper examines multifractal dynamics in cryptocurrencies using two methodologies.
problem Understanding the multifractal nature of cryptocurrencies and their stochastic processes.
method Two alternative multi-scaling methodologies applied to 84 cryptocurrencies.
result Cryptocurrencies exhibit different degrees of long-range dependence and stochastic processes.
scICML integrates multi-omics data from single cells using co-clustering.
problem High noise and sparsity in multi-omics data from single cells.
method Information-theoretic co-clustering-based multi-view learning.
result Improves clustering performance and provides biological insights.
A method to produce personalized classification models to automatically review online dating profiles on Tinder is proposed, based on the user's historical preference. The method takes advantage of a FaceNet facial classification model to extract features which may be related to facial attractiveness. The embeddings fr…
Profile entropy measures learnability and compressibility of discrete distributions.
problem Understanding the learnability and compressibility of discrete distributions.
method Investigates profile entropy, showing its role in estimation, inference, and compression.
result Profile entropy is a fundamental measure unifying estimation, inference, and compression.
A method to describe Riemann surfaces using graph profiles is proposed.
problem Describing Riemann surfaces in a graph-theoretic framework.
method Graph profiles to represent Riemann surfaces, establishing necessary and sufficient conditions for their existence.
result A criterion for the existence of Riemann surfaces with a given signature.