Novel U-learning method for predicting continuous outcomes from high-dimensional data.
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Over the last years, huge resources of biological and medical data have become available for research. This data offers great chances for machine learning applications in health care, e.g. for precision medicine, but is also challenging to analyze. Typical challenges include a large number of possibly correlated featur…
In this study, we tested the interaction effect of multimodal datasets using a novel method called the kernel method for detecting higher order interactions among biologically relevant mulit-view data. Using a semiparametric method on a reproducing kernel Hilbert space (RKHS), we used a standard mixed-effects linear mo…
Proposes spBART for risk prediction using epigenetic signatures and covariates.
A Deep Autoencoder based content retrieval algorithm is proposed for prediction and differentiation of cancer types based on the presence of epigenetic patterns of DNA methylation identified in genetic regions known as CpG islands. The developed deep learning system uses a CpG island state classification sub-system to …
Bayesian method selects important covariates in modal regression.
With the wealth of high-throughput sequencing data generated by recent large-scale consortia, predictive gene expression modelling has become an important tool for integrative analysis of transcriptomic and epigenetic data. However, sequencing data-sets are characteristically large, and previously modelling frameworks …
In this paper we propose network methodology to infer prognostic cancer biomarkers based on the epigenetic pattern DNA methylation. Epigenetic processes such as DNA methylation reflect environmental risk factors, and are increasingly recognised for their fundamental role in diseases such as cancer. DNA methylation is a…
DNA Methylation has been the most extensively studied epigenetic mark. Usually a change in the genotype, DNA sequence, leads to a change in the phenotype, observable characteristics of the individual. But DNA methylation, which happens in the context of CpG (cytosine and guanine bases linked by phosphate backbone) dinu…
The research reported in this paper identifies the epigenetic biomarker (methylation beta pattern) of breast cancer. Many cancers are triggered by abnormal gene expression levels caused by aberrant methylation of CpG sites in the DNA. In order to develop early diagnostics of cancer-causing methylations and to develop a…
Method converts age labels into distributions to improve speaker age estimation.
Preterm newborns undergo various stresses that may materialize as learning problems at school-age. Sleep staging of the Electroencephalogram (EEG), followed by prediction of their brain-age from these sleep states can quantify deviations from normal brain development early (when compared to the known age). Current auto…
SFCNeXt estimates brain age from small MRI datasets.
We solve a lifecycle model in which the consumer's chronological age does not move in lockstep with calendar time. Instead, biological age increases at a stochastic non-linear rate in time like a broken clock that might occasionally move backwards. In other words, biological age could actually decline. Our paper is ins…
Despite the remarkable progress in face recognition related technologies, reliably recognizing faces across ages still remains a big challenge. The appearance of a human face changes substantially over time, resulting in significant intra-class variations. As opposed to current techniques for age-invariant face recogni…
The paper uses AI to analyze ECG data, revealing age-related changes and identifying key features.
Machine learning analysis of neuroimaging data can accurately predict chronological age in healthy people and deviations from healthy brain ageing have been associated with cognitive impairment and disease. Here we sought to further establish the credentials of "brain-predicted age" as a biomarker of individual differe…
Bayesian CNN estimates uncertainty in bone age prediction.
3D CNN accurately classifies infant neurodevelopmental age from MRI scans.
Develops a method to analyze SARS-CoV-2 viral load vs. age, finding a significant increase.
Fetal brain imaging is a cornerstone of prenatal screening and early diagnosis of congenital anomalies. Knowledge of fetal gestational age is the key to the accurate assessment of brain development. This study develops an attention-based deep learning model to predict gestational age of the fetal brain. The proposed mo…
Accurate diagnosis is crucial for preventing the progression of Parkinson's, as well as improving the quality of life with individuals with Parkinson's disease. In this paper, we develop a sex-specific and age-dependent classification method to diagnose the Parkinson's disease using the online handwriting recorded from…
One of the most prevalent symptoms among the elderly population, dementia, can be detected by classifiers trained on linguistic features extracted from narrative transcripts. However, these linguistic features are impacted in a similar but different fashion by the normal aging process. Aging is therefore a confounding …
Twitter provides an open and rich source of data for studying human behaviour at scale and is widely used in social and network sciences. However, a major criticism of Twitter data is that demographic information is largely absent. Enhancing Twitter data with user ages would advance our ability to study social network …
Estimates future ICU demand using age-structured data and logistic modeling.
In power systems, an asset class is a group of power equipment that has the same function and shares similar electrical or mechanical characteristics. Predicting failures for different asset classes is critical for electric utilities towards developing cost-effective asset management strategies. Previously, physical ag…
Accelerated gradient (AG) methods are breakthroughs in convex optimization, improving the convergence rate of the gradient descent method for optimization with smooth functions. However, the analysis of AG methods for non-convex optimization is still limited. It remains an open question whether AG methods from convex o…
Italy's daily COVID-19 cases stratified by age groups.
Predicts user age and gender on Tumblr using rich content.
A new FL algorithm reduces communication overhead by selectively updating model parameters.
AGE improves graph embedding by smoothing features and iteratively enhancing node embeddings.
Study reveals that cryptocurrency price variations follow power-law distributions, influenced by age and market capitalization.
From a young age humans learn to use grammatical principles to hierarchically combine words into sentences. Action grammars is the parallel idea, that there is an underlying set of rules (a "grammar") that govern how we hierarchically combine actions to form new, more complex actions. We introduce the Action Grammar Re…
The paper proposes a method to integrate prior information into penalized regression.
Machine learning models predict brain age with systematic bias, corrected in this study.
Proposes a new model for mortality forecasting considering age groups and cohort effects.
Optimal annuitization strategy depends on age, labor income, and mortality risk.
This paper solves the problem of optimal dynamic consumption, investment, and healthcare spending with isoelastic utility, when natural mortality grows exponentially to reflect Gompertz' law and investment opportunities are constant. Healthcare slows the natural growth of mortality, indirectly increasing utility from c…
VNNs transfer well across datasets for brain age prediction using cortical thickness features.
We present a Bayesian hierarchical multi-view mixture model termed Symphony that simultaneously learns clusters of cells representing cell types and their underlying gene regulatory networks by integrating data from two views: single-cell gene expression data and paired epigenetic data, which is informative of gene-gen…
4-dim intrinsic (material) Riemannian metric of the material 4-D space-time continuum is utilized as the characteristic of the aging processes developing in the material. Manifested through variation of basic material characteristics such as density, moduli of elasticity, yield stress, strength, and toughness.,…
The paper uses distance correlation for brain connectivity and a novel multi-task learning model for age prediction.
In order to investigate the breast cancer prediction problem on the aging population with the grades of DCIS, we conduct a tree augmented naive Bayesian network experiment trained and tested on a large clinical dataset including consecutive diagnostic mammography examinations, consequent biopsy outcomes and related can…
We derive a cut-and-paste surgery formula of Seiberg--Witten invariants for negative definite plumbed rational homology 3-spheres. It is similar to (and motivated by) Okuma's recursion formula [arXiv:math.AG/0610464, 4.5] targeting analytic invariants of splice quotient singularities. The two formulas combined provide …
In the age of data driven solution, the customer demographic attributes, such as gender and age, play a core role that may enable companies to enhance the offers of their services and target the right customer in the right time and place. In the marketing campaign, the companies want to target the real user of the GSM …
In this paper, we develop an expected utility model for the retirement behavior in the decumulation phase of Australian retirees with sequential family status subject to consumption, housing, investment, bequest and government provided means-tested Age Pension. We account for mortality risk and risky investment assets,…
Predicts the age of astronomical transients from real-time data.
Develops a GP framework for age and year-specific mortality surfaces.