Automated tests detect interactions in unstructured data.
problem Detecting interactions between latent variables in low-dimensional systems.
method Derive two interaction tests based on pairwise interventions and integrate them into an active learning pipeline.
result Tests can identify more known biological interactions than random search and standard active learning baselines.
Drug-drug interactions (DDIs) are a major cause of preventable hospitalizations and deaths. Predicting the occurrence of DDIs helps drug safety professionals allocate investigative resources and take appropriate regulatory action promptly. Traditional DDI prediction methods predict DDIs based on the similarity between …
A graph neural network detects beneficial feature interactions for recommender systems.
problem Feature interactions are crucial but not all are beneficial for recommendation accuracy.
method Graph neural network with L0 activation regularization for edge prediction.
result The model outperforms baselines and automatically identifies beneficial feature interactions.
Collaborative Trees model analyzes feature interactions and additive effects.
problem Analyzing complex statistical associations between features and response variables.
method Proposes a novel tree model and its bagging version to decompose mean decrease in impurity and visualize feature contributions.
result Demonstrates the superior capability of the tree model in estimating additive effects and interaction effects.
Signed pairwise interactions conflate uniqueness, redundancy, and synergy
problem Signed pairwise interactions conflate uniqueness, redundancy, and synergy
method Stochastic Hi-Fi
result Stochastic Hi-Fi recovers structure missed by scalar baselines
STNN-DDI predicts drug interactions using substructure-aware neural networks.
problem Predicting drug-drug interactions (DDIs) to avoid side effects in poly-drug treatments.
method Designing a novel Substructure-ware Tensor Neural Network (STNN-DDI) that learns a 3-D tensor of substructure-substructure interactions.
result Significant improvement in AUC, AUPR, Accuracy, and Precision compared to state-of-the-art models.
Programmatic Motion Concepts learn human actions from paired videos.
problem Learning motion concepts from paired video and action sequences.
method Semi-supervised learning architecture for hierarchical motion representation.
result Outperforms established baselines, especially in small data settings.
The paper proposes a method to analyze categorical feature interactions in large datasets using graph covariance and LLMs.
problem Analyzing complex datasets with numerous categorical features and timestamps.
method Binarization of categorical features using one-hot encoding, computation of graph covariance, identifying significant feature pairs, and using LLMs to generate explanations.
result The method identifies meaningful feature pairs and potential data stories underlying categorical feature interactions.
Synthetic lethality (SL) is a promising concept for novel discovery of anti-cancer drug targets. However, wet-lab experiments for detecting SLs are faced with various challenges, such as high cost, low consistency across platforms or cell lines. Therefore, computational prediction methods are needed to address these is…
A generalized continuous economic model is proposed for random markets. In this model, agents interact by pairs and exchange their money in a random way. A parameter controls the effectiveness of the transactions between the agents. We show in a rigorous way that this type of markets reach their asymptotic equilibrium …
Analysis of Vlasov plasma dynamics using matched pair Lie-Poisson formulation.
problem Understanding the dynamics of Vlasov plasma and its kinetic moments.
method Hamiltonian (Lie-Poisson) analysis and matched pair decomposition.
result Observation of mutual interactions between subdynamics in Vlasov plasma.
CatGCN improves GCNs by modeling feature interactions for categorical node features.
problem Suboptimal initial node representations in GCNs due to lack of feature interaction modeling.
method Integrates explicit interaction modeling (local and global) into initial node representation learning for categorical node features.
result CatGCN enhances initial node representations through feature interaction modeling, leading to improved model performance.
Deep model learns protein interfaces from high-order interactions.
problem Predicting protein interfaces from amino acid pairs.
method Graph neural networks and convolutional neural networks for 2D dense predictions.
result Our method consistently improves interface prediction performance.
Visual reranking is effective to improve the performance of the text-based video search. However, existing reranking algorithms can only achieve limited improvement because of the well-known semantic gap between low level visual features and high level semantic concepts. In this paper, we adopt interactive video search…
Proposes MGMN for end-to-end graph similarity learning.
problem Lack of cross-level interactions in graph similarity learning.
method Multi-level graph matching network (MGMN) combining node-graph matching and siamese graph neural networks.
result MGMN outperforms state-of-the-art models on graph-graph classification and regression tasks.
Protein-protein interaction (PPI) prediction is an important problem in machine learning and computational biology. However, there is no data set for training or evaluation purposes, where all the instances are accurately labeled. Instead, what is available are instances of positive class (with possibly noisy labels) a…
We study the time dependent cross correlations of stock returns, i.e. we measure the correlation as the function of the time shift between pairs of stock return time series using tick-by-tick data. We find a weak but significant effect showing that in many cases the maximum correlation is at nonzero time shift indicati…
Study predicts configurational energy of high entropy alloys using Bayesian methods.
problem Accurately predict the configurational energy of high entropy alloys with limited data.
method Robust data-driven framework based on Bayesian approaches, including effective pair interaction (EPI) model and ensemble sampling.
result Effective prediction of configurational energy with small data, demonstrating robust performance.
New method calibrates MQHawkes model using non-parametric approach, identifying cross-Hawkes and cross-leverage effects.
problem Calibrating complex Hawkes processes with non-parametric methods.
method Non-parametric calibration using General Method of Moments on coarse-grained MQHawkes model.
result Identification of cross-Hawkes and cross-leverage effects in futures markets.
Model simulates correlation emergence in two coupled limit order books.
problem Modeling correlation emergence in coupled limit order books.
method Simulated two coupled diffusive limit order books using random walks in the fluid limit, with trader interactions.
result Demonstrated the recovery of an Epps effect from the model.
This paper tackles selection bias in recommender systems by considering the neighborhood effect.
problem Selection bias in recommender systems due to filtering and user selection.
method Formalizes neighborhood effect as interference problem, introduces treatment representation, and proposes ideal loss.
result Proposed methods achieve unbiased learning when both selection bias and neighborhood effect are present.
Proposes an efficient method for ordered counterfactual explanations.
problem Insufficient explanation of perturbation vectors for executing actions.
method Mixed-Integer Linear Optimization (MILP) approach for evaluating and extracting optimal pairs of actions and orders.
result Demonstrated effectiveness of the proposed method on real datasets.
Study human-machine interaction with private info using offline RL.
problem Confounding bias and distributional mismatch in offline RL for human-guided interaction.
method Developed a novel identification result and OPE method to address confounding bias, and used pessimism to tackle distributional mismatch.
result Policy pair converges to optimal one at satisfactory rate under mild assumptions.
EHBOS enhances HBOS by capturing feature interactions, improving anomaly detection.
problem Limited ability of HBOS to detect anomalies in datasets with feature interactions.
method Incorporates two-dimensional histograms to capture feature pair dependencies.
result EHBOS outperforms HBOS on datasets with critical feature interactions, achieving notable improvements in ROC AUC.
New invariant identifies complex line arrangements with same combinatorics but different embeddings.
problem Identify Zariski pairs with same combinatorics but different line arrangements.
method Study inclusion map of boundary manifold to exterior, analyze homology classes, compute invariant using Sage.
result New invariant distinguishes line arrangements with same combinatorics but different embeddings.
A new framework for offline RL improves policy flexibility and regularity.
problem Lack of environmental interactions in offline RL leads to poor policy performance.
method Proposes a behavior-regularized implicit policy framework with modified policy-matching methods.
result The framework improves policy effectiveness and robustness beyond static datasets.
Predict drug-drug side effects using co-attention neural network.
problem Early detection of polypharmacy side effects in drug combinations.
method Co-attention neural network architecture for DDI prediction.
result State-of-the-art results on predicting side effects from drug types and structures.
A new method detects interactions in machine learning models.
problem Interpreting non-linear and interaction effects in machine learning models.
method Regional effect plots with implicit interaction detection.
result The method quantifies and interprets feature effects reliably, less confounded by interactions.
A neural network predicts drug interactions using attention mechanisms.
problem Predicting drug-drug interactions from massive combinations of drugs.
method Siamese self-attention multi-modal neural network integrating drug characteristics.
result The model achieves AUPR scores ranging from 0.77 to 0.92 on various benchmark datasets.
For sophisticated reinforcement learning (RL) systems to interact usefully with real-world environments, we need to communicate complex goals to these systems. In this work, we explore goals defined in terms of (non-expert) human preferences between pairs of trajectory segments. We show that this approach can effective…
Surrogate-based analysis of interactions via local effect smooths
problem Detecting and characterizing feature interactions in machine learning models
method Surrogate-based analysis using generalized additive models
result Empirical validation of effectiveness for pairwise interactions
Bayesian neural networks detect complex interactions with uncertainty.
problem Estimating global pairwise interaction effects with uncertainty.
method Bayesian neural network for modeling interactions, GEH for estimating interaction effects.
result The method empirically outperforms alternatives and detects interpretable interactions.
Understanding how features interact with each other is of paramount importance in many scientific discoveries and contemporary applications. Yet interaction identification becomes challenging even for a moderate number of covariates. In this paper, we suggest an efficient and flexible procedure, called the interaction …
Graph-augmented CNN predicts drug interactions with high accuracy.
problem Predicting drug-drug interactions (DDIs) with high accuracy.
method Combining graph CNN with an attentive pooling network to extract structural relations between drug pairs.
result Desirable performance with ROC 0.988, F1-score 0.956, and AUPR 0.986.
Modeling continuous movement of entities in latent space for interaction timing.
problem Analyzing timing and frequency of instantaneous interactions.
method Latent position model with continuous trajectories.
result Individual trajectories estimated from interaction data.
A new method purifies interaction effects in models to improve interpretability.
problem Interaction effects can be misinterpreted as separate main effects, complicating model interpretation.
method Proposes pure interaction effects and a Functional ANOVA decomposition algorithm to identify and isolate interaction effects.
result Identifies and separates interaction effects from main effects, showing large disparities in model interpretation.
Study shows stock price interactions increase during crises due to external stimulus.
problem Understanding stock price interactions during economic crises.
method Granger Causality and recurrence analysis on stock price series.
result External stimulus drives stock price interactions during crises.
We consider the task of fitting a regression model involving interactions among a potentially large set of covariates, in which we wish to enforce strong heredity. We propose FAMILY, a very general framework for this task. Our proposal is a generalization of several existing methods, such as VANISH [Radchenko and James…
The leverage effect weakly impacts return distributions, especially for small firms.
problem The leverage effect's impact on return distributions is inconsistent and puzzling.
method Analyzed the determinants of return distributions and proposed an indirect method to measure the interaction effect.
result The interaction effect between leverage and mean-reversion is weak and impacts return distributions mainly for small firms.
A new estimator, OddSHAP, simplifies Shapley value computation by focusing on odd components.
problem Efficient computation of Shapley values in machine learning.
method Proved Shapley value depends on odd components, proposed OddSHAP for polynomial regression on odd subspace.
result OddSHAP achieves state-of-the-art estimation accuracy with reduced sampling.
Dropout regularizes against high-order interactions by canceling interaction rates.
problem Overfitting to high-order interactions in neural networks.
method Analyzes Dropout through the lens of interaction effects, showing how it effectively cancels out the probability of surviving interactions of different orders.
result Dropout regularizes against high-order interactions by effectively canceling out the probability of surviving interactions of different orders.
The identification of novel drug-target (DT) interactions is a substantial part of the drug discovery process. Most of the computational methods that have been proposed to predict DT interactions have focused on binary classification, where the goal is to determine whether a DT pair interacts or not. However, protein-l…
GADGET framework decomposes global feature effects using recursive partitioning.
problem Misleading global feature effects when feature interactions are present.
method Generalized additive decomposition of global effects (GADGET) based on recursive partitioning.
result Minimizes interaction-related heterogeneity of local feature effects.
This paper considers ideal gas-like models of trading markets, where each agent is identified as a gas molecule that interacts with others trading in elastic or money-conservative collisions. Traditionally, these models introduce different rules of random selection and exchange between pair agents. Unlike these traditi…
Bayesian method reconstructs hidden higher-order interactions from network data.
problem Lack of explicit higher-order interactions in pairwise network data.
method Bayesian approach based on parsimony, infers higher-order structures when statistically supported.
result Demonstrated applicability to various datasets, synthetic and empirical.
PliableBVS extends Bayesian lasso for modeling interactions with modifying variables.
problem Modeling interactions between large and small sets of variables, especially in omics studies.
method Bayesian variable selection with spike-and-slab priors and hierarchical structure.
result PliableBVS outperforms pliable lasso in identifying active main and interaction effects.
Feature selection can efficiently identify the most informative features with respect to the target feature used in training. However, state-of-the-art vector-based methods are unable to encapsulate the relationships between feature samples into the feature selection process, thus leading to significant information los…
PredDiff measures prediction changes while marginalizing features, offering new insights into interaction effects.
problem Understanding interaction effects in black-box models.
method Model-agnostic, local attribution method based on probability theory.
result Introduced a new measure for interaction effects between arbitrary feature subsets.