Proposes a method for generating prediction intervals in dose-response models using conformal prediction.
problem Uncertainty quantification in continuous treatments for personalized healthcare decisions.
method Causal dose-response problem framed as covariate shift, using weighted conformal prediction with propensity estimation and kernel functions.
result Demonstrates the significance of covariate shift assumptions for robust prediction intervals.
Estimating what would be an individual's potential response to varying levels of exposure to a treatment is of high practical relevance for several important fields, such as healthcare, economics and public policy. However, existing methods for learning to estimate counterfactual outcomes from observational data are ei…
Paper develops methods to estimate derivative of dose-response curve for continuous treatments.
problem Estimating the derivative of the dose-response curve for continuous treatments.
method Doubly robust (DR) inference method using kernel smoothing, bias-corrected IPW and DR estimators.
result Proposes novel bias-corrected IPW and DR estimators for continuous treatments.
Controlled interventions provide the most direct source of information for learning causal effects. In particular, a dose-response curve can be learned by varying the treatment level and observing the corresponding outcomes. However, interventions can be expensive and time-consuming. Observational data, where the treat…
Proposes estimators for complex dose-response curves using kernel methods.
problem Estimating complex dose-response curves with continuous treatments, mediators, and covariates.
method Kernel ridge regression with sequential kernel embedding technique.
result Simple estimators for mediated and time-varying dose response curves with nonasymptotic uniform rates.
Exploratory cancer drug studies test multiple tumor cell lines against multiple candidate drugs. The goal in each paired (cell line, drug) experiment is to map out the dose-response curve of the cell line as the dose level of the drug increases. We propose Bayesian Tensor Filtering (BTF), a hierarchical Bayesian model …
Proposes a method to estimate causal effects of continuous treatments using instrumental variables.
problem Estimating causal effects of continuous treatments in the presence of unmeasured confounders.
method Introduces a novel framework using instrumental variables and a uniform regular weighting function to identify and estimate average dose-response functions.
result Establishes the asymptotic properties of the proposed methods for estimating average dose-response functions.
Proposes DeepSDRF for continuous treatment recommendation from clinical survival data.
problem Continuous treatment recommendation in medical settings with survival data.
method Deep Survival Dose Response Function (DeepSDRF) for learning conditional average dose response (CADR) function.
result Similar performance of recommender algorithms based on random search and reinforcement learning.
ContiVAE estimates individual dose-response curves from unobserved confounders using observational data.
problem Estimating causal effects of continuous treatments considering unobserved confounders.
method Variational auto-encoder with a Tilted Gaussian prior distribution modeling hidden confounders as latent variables.
result ContiVAE outperforms existing methods by up to 62% in predicting individual dose-response curves.
Method bounds continuous-valued treatment effects when confounding variables are hidden.
problem Inferring causal effects of continuous treatments when hidden confounders are present.
method Novel methodology to bound average and conditional average continuous-valued treatment effects.
result Method gives tighter coverage of true dose-response curve than existing methods.
Kernel methods identify treatment effects with unobserved confounding using negative controls.
problem Learning causal relationships with unmeasured confounding.
method Kernel ridge regression algorithms for nonparametric treatment effects.
result Uniform consistency and finite sample rates of convergence proved.
Kernel method estimates long-term effects from short-term data.
problem Estimating long-term effects from short-term data in continuous actions.
method Kernel ridge regression to embed and extrapolate long-term effects.
result Uniform consistency and nonasymptotic error bounds for the estimator.
Paper introduces new estimator for continuous treatment effects.
problem Estimating the average dose-response function of continuous treatments.
method Utilizes ADML and DML tools, with a novel debiasing method.
result Proves asymptotic normality and shows good performance in simulations.
SHIFT improves robustness in estimating dose-response functions with heavy-tailed contamination.
problem Outliers bias estimates of average dose-response functions in heavy-tailed data.
method SHIFT combines cross-fit nuisance orthogonalization, Welsch-loss, and defensive OLS refit.
result SHIFT reduces RMSE from 1.03 to 0.33 on localized contamination test.
Many modern data sets are sampled with error from complex high-dimensional surfaces. Methods such as tensor product splines or Gaussian processes are effective/well suited for characterizing a surface in two or three dimensions but may suffer from difficulties when representing higher dimensional surfaces. Motivated by…
Develops a scalable model for drug combination prediction in cancer.
problem Accurate prediction of drug combinations for cancer treatment.
method Permutation invariant multi-output Gaussian Processes with variational approximation and deep generative model.
result Model efficiently borrows information across drug combinations and provides uncertainty quantification.
The literature of heavy tails (typically) starts with a random walk and finds mechanisms that lead to fat tails under aggregation. We follow the inverse route and show how starting with fat tails we get to thin-tails when deriving the probability distribution of the response to a random variable. We introduce a general…
Proposes a new method for estimating non-pathwise differentiable functional parameters.
problem Estimating dose-response curves for continuous exposure.
method Targeted Highly Adaptive Lasso (HAL) for non-pathwise differentiable functional parameters.
result The Targeted HAL-MLE achieves dimension-free rates up to log(n) factors and outperforms other methods in simulations.
New framework for managing medical risks using convex responses.
problem Medical risk management and dosing optimization.
method Analyzes convex and concave dose-response functions, defines antifragility.
result Proposes a mathematical framework for integrating nonlinearities in oncology.
Proposes VCNet for estimating ADRFs of continuous treatments.
problem Estimating ADRFs of continuous treatments from observational data.
method VCNet for improved model expressiveness and continuity; targeted regularization for finite sample performance.
result Improves model expressiveness and continuity of ADRFs.
Kernel ridge regression for causal inference with missing data.
problem Estimating treatment effects with missing data in selected samples.
method Kernel ridge regression estimators for nonparametric dose response curves and semiparametric treatment effects.
result Uniform consistency and finite sample rates for continuous treatment, root-n consistency for discrete treatment.
Proposes a new method to measure and avoid harm in machine learning decisions.
problem Measuring and avoiding harm in machine learning algorithms.
method Formal definition of harm and benefit using causal models, counterfactual objective functions.
result Demonstrates that standard machine learning methods can lead to harmful policies under distributional shifts.
A new algorithm uses concavity in Gaussian processes to optimize decisions in bandit problems.
problem Optimizing decisions in sequential problems with context-dependent rewards.
method Proposes a UCB algorithm using a shape-constrained reward function estimator based on a Gaussian Process model with concavity constraints.
result Derives regret bounds for the proposed UCB algorithm.
Mixed effects (ME) models inform a vast array of problems in the physical and social sciences, and are pervasive in meta-analysis. We consider ME models where the random effects component is linear. We then develop an efficient approach for a broad problem class that allows nonlinear measurements, priors, and constrain…
The vast majority of current machine learning algorithms are designed to predict single responses or a vector of responses, yet many types of response are more naturally organized as matrices or higher-order tensor objects where characteristics are shared across modes. We present a new machine learning algorithm BaTFLE…
Develops scalable methods to assess sensitivity and uncertainty in continuous treatment effects.
problem Estimating effects of continuous-valued interventions from observational data, especially when ignorability and positivity assumptions are violated.
method Continuous treatment-effect marginal sensitivity model (CMSM), scalable algorithm, uncertainty-aware deep models.
result Derives bounds that agree with observed data and a defined level of hidden confounding.
GCF estimates heterogeneous treatment effects for continuous treatments in online marketplaces.
problem Estimating heterogeneous treatment effects for continuous treatments in online marketplaces.
method Kernel-based doubly robust estimator and distance-based splitting criterion.
result GCF estimates heterogeneous treatment effects for continuous treatments effectively.
Efficient estimators for smooth Hilbert-valued parameters with theoretical guarantees.
problem Estimating smooth Hilbert-valued parameters with theoretical guarantees.
method Pathwise differentiable Hilbert-valued parameters, efficient influence functions, regularized one-step estimators.
result Theoretical guarantees for efficient estimators even when nuisance functions are arbitrary.
ALMAB-DC optimizes expensive black-box experiments using active learning and distributed computing.
problem Efficiently optimizing expensive, gradient-free objectives in computational statistics and machine learning.
method Combines active learning, multi-armed bandits, and distributed asynchronous computing.
result Achieves lower simple regret and superior performance in various tasks compared to non-ALMAB baselines.
New method estimates extreme outcomes in heavy-tailed data, breaking circular dependence.
problem Estimating outcomes for extreme events in heavy-tailed data.
method Proposes an ADRF estimator that includes a structured tail-shape output and a diagnostic to evaluate tail shape.
result Successfully reduces MAE in deep-tail and conditional-shortfall predictions.