DTM learns disease trajectories from EHR data.
problem Understanding disease progression and clinical outcomes.
method Probabilistic model (DTM) using variational inference.
result DTM learns meaningful disease trajectories and their clinical associations.
The paper proposes a deep generative model for complex disease trajectories.
problem Modeling and analyzing complex disease trajectories.
method Deep generative time series approach with semi-supervised latent processes.
result The model can discover novel aspects of diseases and cluster them into new sub-types.
Model predicts disease progression by leveraging multi-resolution data.
problem Personalized prediction of disease trajectories.
method Hierarchical latent variable model sharing statistical strength across different resolutions.
result Significant improvements in predictive accuracy compared to state-of-the-art methods.
Generative model for SSc disease trajectories using deep learning.
problem Modeling complex disease trajectories in Systemic Sclerosis.
method Semi-supervised deep generative model with latent temporal processes.
result Learned latent processes enable personalized monitoring and prediction.
Deep learning improves disease trajectory forecasting.
problem Limitations of joint models in forecasting disease trajectories.
method Proposes a deep learning approach to enhance joint modeling.
result Improvements in performance and scalability demonstrated.
Deep learning improves forecasting of Alzheimer's disease trajectories.
problem Limitations of standard joint models in forecasting disease trajectories over time.
method Adopting a deep learning approach to enhance joint modeling flexibility and scalability.
result Improvements in performance and scalability compared to traditional methods.
Model predicts disease progression using multiple patient health markers.
problem Predicting disease trajectory in chronic diseases with heterogeneity and multiple biomarkers.
method Probabilistic generative model using Gaussian processes and latent class models.
result Model improves predictions of chronic kidney disease progression compared to state of the art.
Develops CSI for predicting disease progression from sparse data.
problem Lack of frequent clinical metrics for disease progression.
method Machine learning framework (CSI) for analyzing disease progression from sparse observations.
result CSI effectively predicts disease progression from sparse data.
Predicts cognitive subscores over time in Alzheimer's Disease.
problem Predicting cognitive changes over time in Alzheimer's Disease.
method Convolutional Neural Network architecture for subscore prediction from MRI scans.
result Mean performance metrics are comparable to existing techniques.
New method subtypes irregular patient data for disease progression.
problem Irregular observation patterns in patient data.
method Probabilistic model + mixture model for asynchronous trajectories.
result 13% reduction in cross-entropy error for vital signs forecasting.
Method predicts biomarker trajectories with uncertainty bands for Alzheimer's disease.
problem Uncertainty in biomarker predictions poses risks in clinical deployment.
method Conformal prediction for randomly-timed biomarker trajectories.
result Conformal bands achieve desired coverage and are tighter than baseline.
DKT transfers biomarker information between neurodegenerative diseases.
problem Estimating biomarker trajectories in rare neurodegenerative diseases with limited data.
method DKT is a joint-disease generative model that transfers biomarker progressions from common neurodegenerative diseases to rare ones.
result DKT estimates plausible multimodal biomarker trajectories in rare diseases like PCA using only unimodal data.
Deep learning predicts Alzheimer's Disease progression with high accuracy.
problem Predicting multiple aspects of Alzheimer's Disease progression.
method Unsupervised deep learning on 1908 patients' 18-month clinical data.
result Model accurately predicts ADAS-Cog scores and identifies word recall as a predictor.
Modeling disease progression in brain images using monotonic Gaussian Processes.
problem Disentangling spatio-temporal disease trajectories from brain imaging data.
method Spatio-temporal matrix factorization with anatomically plausible priors, monotonic Gaussian Processes, and sparse codes.
result Monotonic Gaussian Processes model realistic disease trajectories in brain imaging data.
MATCH-Net uses CNNs to predict disease trajectories accurately.
problem Inaccurate prediction of disease trajectories in survival analysis.
method Developed a Missingness-Aware Temporal Convolutional Hitting-time Network (MATCH-Net).
result Demonstrated state-of-the-art performance in real-world Alzheimer's data.
PASS model predicts disease progression with both accuracy and interpretability.
problem Balancing accurate disease prediction with clinically interpretable models.
method Phased LSTM units with attention mechanism for non-stationary state dynamics.
result PASS model achieves superior predictive accuracy and interpretable representations.
Method predicts brain structure progression in Alzheimer's from baseline MRI.
problem Predicting longitudinal brain structure changes in Alzheimer's disease.
method Large deformation diffeomorphic metric mapping (LDDMM) with personalized trajectories.
result Method successfully predicts brain structure changes from baseline data.
DIVE models brain disease progression with high spatial resolution.
problem Reconstruct long-term brain pathology from short-term data.
method Clusters vertex-wise biomarker measurements, estimates average trajectories, and identifies disease-specific patterns.
result Reveals distinct patterns of pathology in different diseases and biomarker types.
BEHRT improves disease prediction in EHRs by 8-10%.
problem Early disease detection in EHRs for better patient outcomes.
method Deep neural sequence transduction model for EHRs.
result BEHRT improves average precision by 8.0-10.8% compared to state-of-the-art models.
Model predicts future clinical outcomes of progressive diseases.
problem Predicting disease progression with variable patient histories and missing data.
method Probabilistic model using sigmoidal function and approximate Bayesian inference.
result Model accurately predicts clinical scores at future time-points.
Tool models nonlinear brain changes across Alzheimer's spectrum.
problem Limited GLM methods for nonlinear neuroimaging analysis.
method Voxelwise nonlinear regression for brain atrophy modeling.
result Distinct nonlinear brain atrophy patterns in Alzheimer's disease.
Model learns spatiotemporal patterns on graphs from longitudinal data.
problem Learning spatiotemporal patterns on graphs from longitudinal data.
method Mixed-effects model with stochastic Expectation-Maximization algorithm (MCMC-SAEM).
result Personalized model accurately predicts cortical thickness maps in patients.
Method learns shape changes over time from longitudinal data.
problem Tackles learning shape trajectories from repeated observations.
method Combines statistical and deformation models on a diffeomorphism manifold.
result Shows gender and genetic differences in hippocampal atrophy progression.
Bayesian meta-learning predicts Alzheimer's disease progression.
problem Predicting individual Alzheimer's disease progression from limited data.
method Bayesian meta-learning approach that dynamically predicts disease score distributions.
result Bayesian meta-learner outperforms single-task models and deterministic meta-learners, especially for long-term predictions.
Model uses smartphone data to assess MS trajectories.
problem Personalized longitudinal MS assessment.
method Imputation, generalized estimation equation, ensemble learning, fine-tuning.
result Promising model for predicting MS over time.
A method to explain disease transformation using biomarker covariance matrices.
problem Understanding disease transformation from a healthy baseline.
method Modeling healthy and disease states of biomarker covariance matrices to characterize perturbations.
result Disease perturbs the biomarker covariance structure, allowing for mechanistic explanations and individual patient prognosis.
New model learns continuous disease progression from RNA-seq data.
problem Continuous disease progression not captured by discrete categories.
method Covariate latent variable models for learning a low-dimensional data representation.
result Identifies genes stratifying patients on an immune-response trajectory.
Enhances disease progression modeling using LLMs for complex brain connectivity.
problem Inaccurate predictions of disease spread due to oversimplified brain connectivity models.
method Uses LLMs to synthesize multi-modal relationships and learn disease trajectories from longitudinal data.
result Superior prediction accuracy and interpretability compared to traditional methods.
DDP models dynamic comorbidity networks from event data.
problem Understanding complex temporal patterns of co-occurring diseases.
method Developed deep diffusion processes (DDP) to model dynamic comorbidity networks.
result DDP enables accurate risk prediction and interpretable disease trajectories.
We link disjoint longitudinal data for rare disease patients using latent representations and mixed-effects regression.
problem Analyzing treatment switches in rare diseases with limited data and changing measurement instruments.
method We embed item values into a shared latent space using variational autoencoders and apply mixed-effects regression to quantify treatment effects.
result Our approach allows for statistical inference and quantifies the impact of treatment switches in spinal muscular atrophy.
Proposes LSTM algorithm for robust Alzheimer's disease progression modeling with missing data.
problem Challenges in modeling disease progression using incomplete longitudinal data.
method Utilizes Long Short-Term Memory (LSTM) networks for Alzheimer's disease progression modeling with a generalized training rule for handling missing data.
result Achieves significantly lower mean absolute error (MAE) than alternatives with p < 0.05.
Patient journeys are compared to find clusters of similar disease trajectories.
problem Discovering shared health outcomes among patient journeys.
method Comparing longitudinal health data to identify clusters of similar patient trajectories.
result Clusters of patient journeys with similar health outcomes can be identified.
Modeling disease progression using irregular time intervals in EHRs.
problem Challenges in analyzing temporal data from EHRs.
method Developed a Markovian generative model using EHR data.
result Model accurately recovers underlying disease progression patterns from irregular time intervals.
New method measures patient similarity over time, improving disease risk prediction.
problem Chronic diseases' varying progression rates and heterogeneous clinical presentations make patient comparison difficult.
method Subsequence alignment to account for pathophysiological misalignment and varying patient presentation times.
result Subsequence alignment outperforms global alignment in predicting disease progression.
Study compares neural and statistical models for Parkinson's disease progression from voice data.
problem Difficult statistical analysis of longitudinal voice biomarkers due to subject correlation, small cohorts, and varied disease trajectories.
method Evaluated Neural Mixed Effects (NME), Generalized Neural Network Mixed Models (GNMMs), and semi-parametric Generalized Additive Mixed Models (GAMMs).
result GAMMs achieve stronger predictive performance and retain interpretable smooth effects and subject-level structure.
Deep learning model creates patient representations for scalable EHR-based stratification.
problem Challenges in summarizing and representing patient data from EHRs prevent scalable stratification analysis.
method Unsupervised framework based on deep learning (ConvAE) using word embeddings, CNNs, and autoencoders.
result ConvAE significantly outperformed baselines in clustering diverse patient cohorts, identifying clinically relevant subtypes.
Method estimates parameters for disease spread models robustly.
problem Estimating parameters for disease spread models.
method Statistical Learning applied to Approximate Bayesian Computation.
result Qualitative properties of disease evolution can be assessed.
New method predicts Alzheimer's risk with individual uncertainty estimates.
problem Predicting conversion from mild cognitive impairment to Alzheimer's disease.
method Persistent homology of clinical trajectories combined with stacking ensemble.
result Pipeline achieves high accuracy and individual-level uncertainty quantification.
New algorithm predicts lung cancer progression and mortality.
problem Predicting semi-competing risk outcomes in lung cancer.
method Neural Expectation-Maximization algorithm for multi-state outcomes.
result Estimates non-parametric baseline hazards and risk functions.
Novel framework predicts brain biomarker trajectories with superior performance.
problem Challenges in estimating longitudinal brain biomarker trajectories due to variability, inconsistencies, and irregular measurements.
method Personalized deep kernel regression with Adaptive Shrinkage Estimation.
result Superior predictive performance compared to state-of-the-art models.
Study uses NMF to analyze multimorbidity patterns in large EHR dataset.
problem Understanding and quantifying multimorbidity patterns over time.
method Non-negative Matrix Factorisation (NMF) for temporal phenotyping.
result Temporal characteristics of disease clusters reveal new multimorbidity patterns.
Markov jump processes (MJPs) are used to model a wide range of phenomena from disease progression to RNA path folding. However, maximum likelihood estimation of parametric models leads to degenerate trajectories and inferential performance is poor in nonparametric models. We take a small-variance asymptotics (SVA) appr…
Framework combines HMM and MTGCN for spatiotemporal causal inference in clinical data.
problem Challenges in observing direct treatment effects in clinical domains.
method Integrates Hidden Markov Model and Multi Task and Multi Graph Convolutional Network for spatiotemporal data.
result Advances predictive causal inference by structurally adapting to spatiotemporal complexities.
Unified method for discovering biclusters and triclusters in longitudinal data.
problem High-dimensional, sparsely sampled, irregularly observed longitudinal data.
method Tri-SfSVD, a unified sparse functional Singular Value Decomposition framework.
result Identified localized structures at the subject, subject-feature, and subject-feature-time levels.
Proposes a flexible neural model for multi-state survival analysis.
problem Limited applicability of Cox models for multi-state and competing events.
method Uses neural ordinary differential equations to solve Kolmogorov forward equations.
result Demonstrates state-of-the-art performance and interpretability.
Proposes a new method for dynamic treatment regimes that improves sample efficiency and stability.
problem Challenges in estimating optimal treatments for individuals with dynamic decision-making stages.
method Focuses on prioritizing alignment between observed and optimal treatment trajectories across decision stages.
result Improves sample efficiency and stability of IPWE-based methods by relaxing the alignment requirement.
Proposes a new model for predicting chronic conditions over time.
problem Predicting complex relationships between multiple chronic conditions.
method Continuous time Bayesian network with adaptive regularization for structure and parameter learning.
result Proposed model provides sparse, intuitive representation of chronic condition relationships.
TNDE quantifies dynamic gene drivers from single-cell snapshots.
problem Reconstructing time-resolved regulatory effects in biological processes.
method Time-varying Network Driver Estimation (TNDE) using shared graph attention encoder and partial optimal transport.
result TNDE identifies stage-specific driver genes in mouse erythropoiesis.