A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.
StageNet improves health risk prediction by integrating disease stage information.
Paper characterizes early-stage dementia signatures from sensor data.
It is crucial to provide compatible treatment schemes for a disease according to various symptoms at different stages. However, most classification methods might be ineffective in accurately classifying a disease that holds the characteristics of multiple treatment stages, various symptoms, and multi-pathogenesis. More…
Machine learning classifies Parkinson's Disease stages from walker sensors data.
New fair regression method improves fairness in chronic kidney disease classification.
Alzheimer's Disease (AD) is characterized by a cascade of biomarkers becoming abnormal, the pathophysiology of which is very complex and largely unknown. Event-based modeling (EBM) is a data-driven technique to estimate the sequence in which biomarkers for a disease become abnormal based on cross-sectional data. It can…
Develops a two-stage conformal prediction method for Parkinson's disease medication needs.
Machine learning detects subtle glucose changes for early diabetes diagnosis.
Alzheimer's disease is a major cause of dementia. Its diagnosis requires accurate biomarkers that are sensitive to disease stages. In this respect, we regard probabilistic classification as a method of designing a probabilistic biomarker for disease staging. Probabilistic biomarkers naturally support the interpretation…
Alzheimer's disease (AD) is the most common neurodegenerative disease in older people. Despite considerable efforts to find a cure for AD, there is a 99.6% failure rate of clinical trials for AD drugs, likely because AD patients cannot easily be identified at early stages. This project investigated machine learning app…
Longitudinal patient data has the potential to improve clinical risk stratification models for disease. However, chronic diseases that progress slowly over time are often heterogeneous in their clinical presentation. Patients may progress through disease stages at varying rates. This leads to pathophysiological misalig…
Disease-gene prediction (DGP) refers to the computational challenge of predicting associations between genes and diseases. Effective solutions to the DGP problem have the potential to accelerate the therapeutic development pipeline at early stages via efficient prioritization of candidate genes for various diseases. In…
Study uses machine learning and survival analysis to predict CKD progression.
MicroRNAs (miRNAs) play crucial roles in multifarious biological processes associated with human diseases. Identifying potential miRNA-disease associations contributes to understanding the molecular mechanisms of miRNA-related diseases. Most of the existing computational methods mainly focus on predicting whether a miR…
In recent years, besides the medical treatment methods in medical field, Computer Aided Diagnosis (CAD) systems which can facilitate the decision making phase of the physician and can detect the disease at an early stage have started to be used frequently. The diagnosis of Idiopathic Pulmonary Fibrosis (IPF) disease by…
Bayesian networks and ML improve COVID-19 symptom classification and severity analysis.
This study evaluates handwriting features to diagnose Parkinson's disease.
Deep learning ensemble improves Alzheimer vs. Mild Cognitive Impairment diagnosis.
Effective medical test suggestions benefit both patients and physicians to conserve time and improve diagnosis accuracy. In this work, we show that an agent can learn to suggest effective medical tests. We formulate the problem as a stage-wise Markov decision process and propose a reinforcement learning method to train…
Given genetic variations and various phenotypical traits, such as Magnetic Resonance Imaging (MRI) features, we consider two important and related tasks in biomedical research: i)to select genetic and phenotypical markers for disease diagnosis and ii) to identify associations between genetic and phenotypical data. Thes…
Modeling disease progression using irregular time intervals in EHRs.
Electronic health records (EHRs) have contributed to the computerization of patient records and can thus be used not only for efficient and systematic medical services, but also for research on biomedical data science. However, there are many missing values in EHRs when provided in matrix form, which is an important is…
New method predicts AD progression using MEG brain networks.
Evidence suggests Rapid-Eye-Movement (REM) Sleep Behaviour Disorder (RBD) is an early predictor of Parkinson's disease. This study proposes a fully-automated framework for RBD detection consisting of automated sleep staging followed by RBD identification. Analysis was assessed using a limited polysomnography montage fr…
Radiomics identifies subtle cardiac changes in hypertension.
Machine learning improves CHD screening accuracy from 70% to 87.7%.
New test identifies specific biological parameters for personalized CVD detection.
Study proposes deep learning techniques to diagnose and differentiate Celiac Disease and Environmental Enteropathy from biopsy images.
Estimates and infers multi-stage stationary treatment policies with variable selection.
HAMN combines CF models to improve drug repositioning.
Here we present DIVE: Data-driven Inference of Vertexwise Evolution. DIVE is an image-based disease progression model with single-vertex resolution, designed to reconstruct long-term patterns of brain pathology from short-term longitudinal data sets. DIVE clusters vertex-wise biomarker measurements on the cortical surf…
Developed shrinkage methods for Poisson regression models with experts to handle multicollinearity.
Event-based models (EBM) are a class of disease progression models that can be used to estimate temporal ordering of neuropathological changes from cross-sectional data. Current EBMs only handle scalar biomarkers, such as regional volumes, as inputs. However, regional aggregates are a crude summary of the underlying hi…
CASCADE improves uncertainty communication in Parkinson's disease medication management.
Deep learning predicts AMD progression from longitudinal fundus images.
Proposes a new method for dynamic treatment regimes that improves sample efficiency and stability.
RL algorithms with medical integration improve personalized treatment recommendations.
This paper proposes a general adaptive procedure for budget-limited predictor design in high dimensions called two-stage Sampling, Prediction and Adaptive Regression via Correlation Screening (SPARCS). SPARCS can be applied to high dimensional prediction problems in experimental science, medicine, finance, and engineer…
Standard models assign disease progression to discrete categories or stages based on well-characterized clinical markers. However, such a system is potentially at odds with our understanding of the underlying biology, which in highly complex systems may support a (near-)continuous evolution of disease from inception to…
Hypertension is a major risk factor for stroke, cardiovascular disease, and end-stage renal disease, and its prevalence is expected to rise dramatically. Effective hypertension management is thus critical. A particular priority is decreasing the incidence of uncontrolled hypertension. Early identification of patients a…
DNA Methylation has been the most extensively studied epigenetic mark. Usually a change in the genotype, DNA sequence, leads to a change in the phenotype, observable characteristics of the individual. But DNA methylation, which happens in the context of CpG (cytosine and guanine bases linked by phosphate backbone) dinu…
In the United States, heart disease is the leading cause of death for both men and women, accounting for 610,000 deaths each year [1]. Physicians use Magnetic Resonance Imaging (MRI) scans to take images of the heart in order to non-invasively estimate its structural and functional parameters for cardiovascular diagnos…
Machine learning aids in diagnosing Parkinson's disease with higher accuracy.
Acute Kidney Injury (AKI) is a common clinical syndrome characterized by the rapid loss of kidney excretory function, which aggravates the clinical severity of other diseases in a large number of hospitalized patients. Accurate early prediction of AKI can enable in-time interventions and treatments. However, AKI is hig…
In this work, we present a comparison of a shallow and a deep learning architecture for the automated segmentation of white matter lesions in MR images of multiple sclerosis patients. In particular, we train and test both methods on early stage disease patients, to verify their performance in challenging conditions, mo…
A new algorithm learns optimal personalized treatment plans online with low regret.
Malignant Pleural Mesothelioma (MPM) or malignant mesothelioma (MM) is an atypical, aggressive tumor that matures into cancer in the pleura, a stratum of tissue bordering the lungs. Diagnosis of MPM is difficult and it accounts for about seventy-five percent of all mesothelioma diagnosed yearly in the United States of …
Study identifies five AD subtypes using graph diffusion and similarity learning.