New deep Cox mixture model improves survival analysis performance.
problem Challenges in survival analysis due to censoring and healthcare applications.
method Learning mixtures of Cox regressions with deep neural networks for hazard ratios and non-parametric baseline hazard.
result Our approach outperforms classical and modern survival analysis methods, especially in minority demographics.
Semi-parametric survival analysis methods like the Cox Proportional Hazards (CPH) regression (Cox, 1972) are a popular approach for survival analysis. These methods involve fitting of the log-proportional hazard as a function of the covariates and are convenient as they do not require estimation of the baseline hazard …
Extends deep learning for nonlinear Cox regression variable selection.
problem Variable selection for nonlinear Cox regression model.
method Extends LassoNet to survival data for nonlinear Cox model.
result Valid and effective method demonstrated through simulations.
Proposes isotonic regression for calibrating Deep Cox models' survival probabilities.
problem Poor calibration of Deep Cox models' survival probabilities.
method Isotonic regression for post hoc calibration of Deep Cox models.
result Establishes favorable theoretical guarantees and demonstrates empirical effectiveness.
New statistical properties for mini-batch Cox-NN optimization.
problem Optimizing deep Cox neural networks using mini-batches.
method Developed mini-batch maximum partial-likelihood estimator (mb-MPLE) for Cox-NN.
result mb-MPLE is consistent and achieves optimal convergence rate.
An accurate model of patient-specific kidney graft survival distributions can help to improve shared-decision making in the treatment and care of patients. In this paper, we propose a deep learning method that directly models the survival function instead of estimating the hazard function to predict survival times for …
Develops asymptotic theory for deep Cox models to enable valid inference.
problem Theoretical gaps in deep neural network estimators for Cox models.
method Asymptotic distribution theory linking in-sample optimization error to population risk.
result Pointwise and multivariate asymptotic normality for subsampled ensemble estimators.
Study compares LSTM, Transformer, and Mamba for bladder cancer recurrence analysis.
problem Complex time-dependent data in bladder cancer recurrence analysis.
method Evaluation of LSTM, Transformer, and Mamba models using Cox proportional hazards model.
result LSTM-Cox model outperforms Transformer-Cox and Mamba-Cox models in prediction accuracy.
We consider the intensity-based approach for the modeling of default times of one or more companies. In this approach the default times are defined as the jump times of a Cox process, which is a Poisson process conditional on the realization of its intensity. We assume that the intensity follows the Cox-Ingersoll-Ross …
A new method clusters rows of a matrix of point processes.
problem Challenges in analyzing structured point process data.
method Mixture model of multi-level marked point processes, combined with ES algorithm and FPCA.
result An efficient method for clustering rows of a matrix of point processes.
CoxSE combines deep learning with self-explaining neural networks for survival analysis.
problem Improving predictive power of Cox Proportional Hazards model while maintaining explainability.
method Proposes CoxSE, a locally explainable Cox proportional hazards model using SENN, and CoxSENAM, a hybrid model with NAM.
result CoxSE provides more stable and consistent explanations while maintaining predictive power.
This paper presents an original approach for jointly fitting survival times and classifying samples into subgroups. The Coxlogit model is a generalized linear model with a common set of selected features for both tasks. Survival times and class labels are here assumed to be conditioned by a common risk score which depe…
Proposes a deep neural network for predicting clustered time-to-event data.
problem Predicting clustered time-to-event data with subject-specific frailties.
method Deep neural network based gamma frailty model (DNN-FM) trained using negative profiled h-likelihood.
result Enhances prediction performance compared to existing methods.
Bayesian model improves cure fraction estimation in survival analysis.
problem Estimating cure fraction in survival analysis.
method Hierarchical Bayesian framework for semiparametric mixture cure model.
result Improved accuracy in capturing unobserved heterogeneity.
Enhances Cox model for survival analysis with symbolic non-linear log-risk functions.
problem Limited interpretability and non-linearity in traditional Cox models.
method Introduces GCPH model using Kolmogorov-Arnold Networks for symbolic non-linear log-risk functions.
result GCPH achieves competitive performance and superior interpretability.
Deep learning is a hierarchical inference method formed by subsequent multiple layers of learning able to more efficiently describe complex relationships. In this work, Deep Gaussian Mixture Models are introduced and discussed. A Deep Gaussian Mixture model (DGMM) is a network of multiple layers of latent variables, wh…
Proposes a new model to analyze CT scans for lung cancer patients.
problem Analyzing survival risks of lung cancer patients using CT scans.
method Penalized Deep Partially Linear Cox Model (Penalized DPLC) incorporating SCAD penalty and deep neural network.
result The model effectively selects important texture features and estimates nonparametric components.
A new model avoids the PH assumption for right-censored survival data.
problem Inflexibility of Cox model when PH assumption fails.
method Deep partially linear transformation model (DPLTM) for right-censored data.
result The DPLTM avoids the curse of dimensionality and retains interpretability.
DGMEs use Gaussian mixtures to quantify uncertainty in deep learning.
problem Quantifying uncertainty in complex predictive densities.
method DGMEs use a Gaussian mixture model with an EM algorithm for parameter learning.
result DGMEs outperform state-of-the-art models in uncertainty quantification.
Medical practitioners use survival models to explore and understand the relationships between patients' covariates (e.g. clinical and genetic features) and the effectiveness of various treatment options. Standard survival models like the linear Cox proportional hazards model require extensive feature engineering or pri…
Active-set algorithm improves Cox regression for shape-restricted covariates.
problem Improving Cox regression for shape-restricted covariates.
method Shape-restricted inference using active-set optimization for spline basis expansion.
result Active-set algorithm produces accurate linear covariate effect estimates.
We introduce a mixture model for censored durations (C-mix), and develop maximum likelihood inference for the joint estimation of the time distributions and latent regression parameters of the model. We consider a high-dimensional setting, with datasets containing a large number of biomedical covariates. We therefore p…
Firm size data usually do not show the normality that is often assumed in statistical analysis such as regression analysis. In this study we focus on two firm size data: the number of employees and sale. Those data deviate considerably from a normal distribution. To improve the normality of those data we transform them…
Improved survival analysis using square root Cox's models and neural networks.
problem Feature selection in survival analysis.
method Square root Cox's survival analysis by the fittest linear and neural networks model, directly tuning penalty parameter λ.
result Substantially improved over traditional methods, achieving phase transition in feature selection.
MEC-Cox: A Machine-Learning-Assisted Generalized Entropy Calibration Method for Estimating ATT Marginal Hazard-Ratio
problem Estimating ATT marginal hazard-ratio in externally controlled survival trials
method Machine-learning-assisted generalized entropy calibration for IPW Cox regression
result Reduces bias, increases efficiency, and improves coverage
Deep neural networks converge to Gaussian mixtures as layer width increases.
problem Understanding the distribution of outputs from deep neural networks.
method Proof and experiments with a simple model showing the convergence of neural network outputs to Gaussian mixtures.
result Neural networks converge to Gaussian mixtures as the width of the last hidden layer increases.
Adapts bandit algorithms for online survival analysis under Cox PH model.
problem Online survival analysis challenges in a bandit framework.
method Adapts three bandit algorithms to balance exploration and exploitation.
result Demonstrates sublinear regret bounds and effective learning of treatment policies.
NMDR estimates complex mixtures of distributions efficiently.
problem Estimating complex finite mixtures of distributions in high-dimensional settings.
method Flexible additive predictors, neural networks, and deep learning optimizers.
result Competitive performance in complex scenarios compared to existing approaches.
The study examines Cox models for lifetime loan default risk, addressing biased estimates by incorporating recurrent events.
problem Ignoring recurrent default events in Cox models leads to biased and inaccurate PD estimates.
method Investigates and compares different Cox models (Andersen-Gill and Prentice-Williams-Peterson) for lifetime loan default risk.
result The Andersen-Gill model underperforms compared to the Prentice-Williams-Person model and the time to first default model.
Flexible Cox model for time-dependent covariates with complex sparsity patterns.
problem Lack of flexibility in enforcing specific sparsity patterns in time-dependent Cox models.
method Proposes a flexible framework for variable selection in time-dependent Cox models, accommodating complex selection rules.
result Achieves accurate estimation with low false alarm rates for complex covariate structures.
Federated Cox model handles non-proportional hazards in siloed data.
problem Handling non-proportional hazards in federated healthcare data.
method Developed a federated Cox model that relaxes proportional hazards assumption.
result Federated model performs similarly to standard models on clinical datasets.
Audio source separation is the process of separating a mixture (e.g. a pop band recording) into isolated sounds from individual sources (e.g. just the lead vocals). Deep learning models are the state-of-the-art in source separation, given that the mixture to be separated is similar to the mixtures the deep model was tr…
SurvLIME explains survival models by approximating them with Cox models.
problem Explaining complex survival models in machine learning.
method Applies Cox proportional hazards model to approximate survival model locally.
result Demonstrates efficiency through numerical experiments.
A new method for federated survival analysis using Cox models.
problem Non-separability of Cox PH model loss function in federated learning.
method Discrete-time Cox model, separable loss function, federated learning.
result Improved performance and communication efficiency compared to previous methods.
New approach makes survival analysis fairer without specifying sensitive features.
problem Ensuring fairness in survival analysis models across different subpopulations.
method Distributionally robust optimization (DRO) with sample splitting strategy.
result Converted existing survival analysis models into fair versions without specifying sensitive features.
New methods for time-to-event prediction are proposed by extending the Cox proportional hazards model with neural networks. Building on methodology from nested case-control studies, we propose a loss function that scales well to large data sets, and enables fitting of both proportional and non-proportional extensions o…
Study on Volterra Cox-Ingersoll-Ross process, proving asymptotic independence and ergodicity.
problem Analyzing the Volterra Cox-Ingersoll-Ross process and its properties.
method Fine asymptotic analysis of Volterra Riccati equation, affine transformation formula.
result Proves asymptotic independence and ergodicity of the process.
Digital risk scores predict depression and anxiety over 10 years.
problem Identifying individuals at risk of depression and anxiety.
method Developed a 10-year predictive algorithm using UKB cohort, selecting predictors via Cox proportional hazards model and DeepSurv.
result Highly discriminating models for depression and anxiety were developed.
In this paper we propose a Deep Autoencoder MIxture Clustering (DAMIC) algorithm based on a mixture of deep autoencoders where each cluster is represented by an autoencoder. A clustering network transforms the data into another space and then selects one of the clusters. Next, the autoencoder associated with this clust…
Study improves Cox model for predicting stock trading signs using Japanese market data.
problem Improving Cox model for predicting stock trading signs using Japanese market data.
method Added new covariates and used high-frequency trading data for 222 Nikkei 225 stocks.
result Cox-type model performs well in Japanese market and identifies key factors for accurate estimation.
Study compares Cox model and RSF for predicting patient survival, finding RSF superior in certain scenarios.
problem Comparing predictive accuracy of Cox proportional hazards model and Random Survival Forest for patient-specific survival probabilities.
method Conducted a comprehensive comparison study using simulation scenarios and real-world datasets.
result RSF outperforms Cox model in nonproportional hazards settings and with treatment-covariate interactions.
Study adaptive sensing of Cox processes using posterior sampling and positive bases.
problem Adaptive sensing of Cox point processes with intensity function modeling.
method Model intensity function as truncated Gaussian process in positive basis, use Langevin dynamics and posterior sampling.
result Demonstrated improved sensing compared to classical Bayesian experimental design.
The Cox proportional hazards model is ubiquitous in the analysis of time-to-event data. However, when the data dimension p is comparable to the sample size N, maximum likelihood estimates for its regression parameters are known to be biased or break down entirely due to overfitting. This prompted the introduction of …
Paper extends multi-task Gaussian Cox processes for heterogeneous tasks.
problem Modeling multiple heterogeneous correlated tasks jointly.
method Data augmentation and mean-field approximation for non-conjugate Bayesian inference.
result Demonstrates improved performance and inference on synthetic and real data.
Bias - variance decomposition of the expected error defined for regression and classification problems is an important tool to study and compare different algorithms, to find the best areas for their application. Here the decomposition is introduced for the survival analysis problem. In our experiments, we study bias -…
T-SCI improves Cox-MLP's guaranteed coverage for censored data.
problem Losing guaranteed coverage when relaxing linear assumption with neural networks.
method Two-stage conformal inference algorithm with non-conformity score.
result T-SCI provides guaranteed coverage under milder assumptions.
Defines a new process for financial modeling.
problem Developing a new stochastic process for financial applications.
method Introduces a fractional Cox-Ingersoll-Ross process and proves its properties.
result The process has unique solutions and is strictly positive for certain Hurst parameters.
Study uses machine learning and survival analysis to predict CKD progression.
problem Early detection and management of CKD to reduce ESRD risk.
method Combines machine learning and classical statistical models to identify novel CKD progression predictors.
result Deep learning models outperform other methods in predicting CKD progression.