This work aims to create a large-scale model for critical care time series data.
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Progress of machine learning in critical care has been difficult to track, in part due to absence of public benchmarks. Other fields of research (such as computer vision and natural language processing) have established various competitions and public benchmarks. Recent availability of large clinical datasets has enabl…
Acute kidney injury (AKI) in critically ill patients is associated with significant morbidity and mortality. Development of novel methods to identify patients with AKI earlier will allow for testing of novel strategies to prevent or reduce the complications of AKI. We developed data-driven prediction models to estimate…
New method evaluates personalized treatment in critical care, robust to death.
We study the problem of prescribing the Paneitz curvature on higher dimensional spheres. Particular attention is paid to the blow-up points, i.e. the critical points at infinity of the corresponding variational problem. Using topological tools and a careful analysis of the gradient flow lines in the neighborhood of suc…
Viewing the trajectory of a patient as a dynamical system, a recurrent neural network was developed to learn the course of patient encounters in the Pediatric Intensive Care Unit (PICU) of a major tertiary care center. Data extracted from Electronic Medical Records (EMR) of about 12000 patients who were admitted to the…
New model predicts ICU patients' stay duration efficiently.
Timely prediction of clinically critical events in Intensive Care Unit (ICU) is important for improving care and survival rate. Most of the existing approaches are based on the application of various classification methods on explicitly extracted statistical features from vital signals. In this work, we propose to elim…
LHIEM model predicts health, income, and employment over years.
Clinical decision making is challenging because of pathological complexity, as well as large amounts of heterogeneous data generated as part of routine clinical care. In recent years, machine learning tools have been developed to aid this process. Intensive care unit (ICU) admissions represent the most data dense and t…
We present a careful analysis of possible issues on the application of the self-excited Hawkes process to high-frequency financial data. We carefully analyze a set of effects leading to significant biases in the estimation of the "criticality index" n that quantifies the degree of endogeneity of how much past events tr…
We determine the critical batch size for large language models and find it scales with data size, not model size.
Over the past decades, both critical care and cancer care have improved substantially. Due to increased cancer-specific survival, we hypothesized that both the number of cancer patients admitted to the ICU and overall survival have increased since the millennium change. MIMIC-III, a freely accessible critical care data…
New model predicts ICU patient stays more accurately.
Model predicts wound and episode-level readmission risk and time to re-admit.
Waveform physiological data is important in the treatment of critically ill patients in the intensive care unit. Such recordings are susceptible to artefacts, which must be removed before the data can be re-used for alerting or reprocessed for other clinical or research purposes. Accurate removal of artefacts reduces b…
Study finds racial bias in pulse oximeter readings has minimal impact on ICU ventilation rates.
Develops a risk score to assist ECMO planning for critically ill patients with viral or unspecified pneumonia.
Traditional methods for assessing illness severity and predicting in-hospital mortality among critically ill patients require time-consuming, error-prone calculations using static variable thresholds. These methods do not capitalize on the emerging availability of streaming electronic health record data or capture time…
When training clinical prediction models from electronic health records (EHRs), a key concern should be a model's ability to sustain performance over time when deployed, even as care practices, database systems, and population demographics evolve. Due to de-identification requirements, however, current experimental pra…
Neural system optimizes glucose levels in diabetics.
In critical care, intensivists are required to continuously monitor high dimensional vital signs and lab measurements to detect and diagnose acute patient conditions. This has always been a challenging task. In this study, we propose a novel self-correcting deep learning prediction approach to address this challenge. W…
A new method uses deep Gaussian processes to handle missing values in irregularly sampled healthcare data.
New AI model optimizes personalized care for elderly residents.
After admission to emergency department (ED), patients with critical illnesses are transferred to intensive care unit (ICU) due to unexpected clinical deterioration occurrence. Identifying such unplanned ICU transfers is urgently needed for medical physicians to achieve two-fold goals: improving critical care quality a…
Paper proposes a hierarchical approach for early anomaly detection in time series data for critical health events.
We study biminimal immersions, that is immersions which are critical points of the bienergy for normal variations with fixed energy. We give a geometrical description of the Euler-Lagrange equation associated to biminimal immersions for: i) biminimal curves in a Riemannian manifold, with particular care to the case of …
Study curves evolving on hypersurfaces with free boundaries, preserving length.
Bayesian model detects internal bleeding in ICU patients.
Translating machine learning (ML) models effectively to clinical practice requires establishing clinicians' trust. Explainability, or the ability of an ML model to justify its outcomes and assist clinicians in rationalizing the model prediction, has been generally understood to be critical to establishing trust. Howeve…
Gradient-based methods find saddle points, not critical points, in neural networks.
Study automates detection of visitation disruptions in ICU patients.
Literary critics often attempt to uncover meaning in a single work of literature through careful reading and analysis. Applying natural language processing methods to aid in such literary analyses remains a challenge in digital humanities. While most previous work focuses on "distant reading" by algorithmically discove…
We define Discrete Quasi-Einstein metrics (DQE-metrics) as the critical points of discrete total curvature functional on triangulated 3-manifolds. We study DQE-metrics by introducing some combinatorial curvature flows. We prove that these flows produce solutions which converge to discrete quasi-Einstein metrics when th…
Many in-hospital mortality risk prediction scores dichotomize predictive variables to simplify the score calculation. However, hard thresholding in these additive stepwise scores of the form "add x points if variable v is above/below threshold t" may lead to critical failures. In this paper, we seek to develop risk pre…
We answer affirmatively a question of Aviles posed in 1983, concerning the construction of singular solutions of semilinear equations without using phase-plane analysis. Fully exploiting the semilinearity and the stability of the linearized operator in any dimension, our techniques involve a careful gluing in weighted …
Predictive models identify patients at risk of severe COVID-19.
Ability for accurate hospital case cost modelling and prediction is critical for efficient health care financial management and budgetary planning. A variety of regression machine learning algorithms are known to be effective for health care cost predictions. The purpose of this experiment was to build an Azure Machine…
Blood lactate concentration is a strong indicator of mortality risk in critically ill patients. While frequent lactate measurements are necessary to assess patient's health state, the measurement is an invasive procedure that can increase risk of hospital-acquired infections. For this reason we formally define the prob…
Patients in the intensive care unit (ICU) require constant and close supervision. To assist clinical staff in this task, hospitals use monitoring systems that trigger audiovisual alarms if their algorithms indicate that a patient's condition may be worsening. However, current monitoring systems are extremely sensitive …
Alzheimer's disease (AD) is a degenerative brain disease impairing a person's ability to perform day to day activities. The clinical manifestations of Alzheimer's disease are characterized by heterogeneity in age, disease span, progression rate, impairment of memory and cognitive abilities. Due to these variabilities, …
A framework identifies worst-case decision points in safety-critical scenarios, improving risk assessment by 10 hours.
Model predicts COVID-19 growth in Senegal, highlighting health care capacity importance.
CTRNNs improve blood glucose forecasting in ICU, outperforming traditional models.
The health outcomes of high-need patients can be substantially influenced by the degree of patient engagement in their own care. The role of care managers includes that of enrolling patients into care programs and keeping them sufficiently engaged in the program, so that patients can attain various goals. The attainmen…
Collaborative filtering is widely used in modern recommender systems. Recent research shows that variational autoencoders (VAEs) yield state-of-the-art performance by integrating flexible representations from deep neural networks into latent variable models, mitigating limitations of traditional linear factor models. V…
Deep generative models can learn to generate realistic-looking images, but many of the most effective methods are adversarial and involve a saddlepoint optimization, which requires a careful balancing of training between a generator network and a critic network. Maximum mean discrepancy networks (MMD-nets) avoid this i…
Clinical decision support systems (CDSS) will play an in-creasing role in improving the quality of medical care for critically ill patients. However, due to limitations in current informatics infrastructure, CDSS do not always have com-plete information on state of supporting physiologic monitor-ing devices, which can …