Cohort effects are important factors in determining the evolution of human mortality for certain countries. Extensions of dynamic mortality models with cohort features have been proposed in the literature to account for these factors under the generalised linear modelling framework. In this paper we approach the proble…
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48 results for “cohort studies”
Study identifies 1,012 persistent wallet cohorts on Solana pump.fun, showing coordinated buying behavior.
problem Understanding coordinated buying behavior on Solana pump.fun.
method Two-stage detection pipeline: first-buyer-window extraction followed by persistent-cohort surfacing via graph co-occurrence.
result 1,012 persistent wallet cohorts identified, showing systematic co-buying across multiple launches.
Deep neural networks improve sleep stage classification across diverse datasets.
problem Manual sleep scoring is subjective and lacks reliability; automatic systems generalize poorly.
method Developed a deep neural network using 15,684 polysomnography studies from five cohorts.
result Classification accuracy improved with more training data and multiple data sources.
ODVICE augments EHR cohorts using ontology to improve analysis robustness.
problem Limited records in cohorts for rare diseases hamper robust analysis.
method Ontology-driven Monte-Carlo graph spanning algorithm for data augmentation.
result ODVICE augmented cohorts show ~30% improvement in AUC over non-augmented datasets.
We introduce a variable importance measure to quantify the impact of individual input variables to a black box function. Our measure is based on the Shapley value from cooperative game theory. Many measures of variable importance operate by changing some predictor values with others held fixed, potentially creating unl…
Treatment recommendations within Clinical Practice Guidelines (CPGs) are largely based on findings from clinical trials and case studies, referred to here as research studies, that are often based on highly selective clinical populations, referred to here as study cohorts. When medical practitioners apply CPG recommend…
CAT framework improves AI medical screening fairness and reliability.
problem Imbalanced data, varying performance across cohorts, and patient-level inconsistencies in traditional metrics.
method CAT framework introduces patient-level assessment, entropy-based distribution weighting, and cohort-weighted sensitivity and specificity.
result Enhanced predictive reliability, fairness, and interpretability of AI-driven medical screening models.
Cohort analysis speeds up Bitcoin blockchain data queries.
problem Efficiently querying Bitcoin blockchain data for economic insights.
method Cohort analysis applied to Bitcoin transaction data.
result Creation of datasets and visualizations for key Bitcoin transaction indicators.
The Lee Carter modelling framework is widely used because of its simplicity and robustness despite its inability to model specific cohort effects. A large number of extensions have been proposed that model cohort effects but there is no consensus. It is difficult to simultaneously account for cohort effects and age-adj…
Research aims to ensure fair classification across explicit and implicit sensitive features.
problem Ensuring fairness in machine learning models when sensitive features are not explicitly provided.
method Defined explicit and implicit cohorts, used clustering of embeddings, modified loss function.
result Improved classification parity across explicit and implicit sensitive features.
COHORTNEY groups web users based on activity patterns.
problem Lack of academic discussion on cohort analysis for user behavior.
method Unsupervised non-parametric machine learning approach.
result COHORTNEY outperforms traditional methods in cohort analysis.
Proposes a new model for mortality forecasting considering age groups and cohort effects.
problem Longevity risk due to ageing population.
method Mixed-effects time-series approach with age groups dependency and random cohort effects.
result Remarkable improvements in forecast accuracy compared to the CBD model.
Transformers simplify modeling of small longitudinal cohort data by reducing parameters and incorporating attention mechanisms.
problem Challenges in modeling longitudinal cohort data due to complex temporal dependencies and large dataset requirements.
method Simplified transformer architecture with attention mechanism, autoregressive model, and kernel-based temporal decay.
result The approach recovers contextual dependencies even with small datasets, identifying temporal patterns in stress and mental health.
Mean-field approximations simplify insurance liability calculations.
problem High-dimensional system of equations makes insurance liability calculation infeasible.
method Use mean-field model to replace high-dimensional system with a low-dimensional non-linear system.
result Insurance liability converges to mean-field approximation as cohort size increases.
Advances in molecular "omics'" technologies have motivated new methodology for the integration of multiple sources of high-content biomedical data. However, most statistical methods for integrating multiple data matrices only consider data shared vertically (one cohort on multiple platforms) or horizontally (different …
The reliability of a deep learning model in clinical out-of-distribution MRI data: a multicohort studyphysics.med-ph
Deep learning (DL) methods have in recent years yielded impressive results in medical imaging, with the potential to function as clinical aid to radiologists. However, DL models in medical imaging are often trained on public research cohorts with images acquired with a single scanner or with strict protocol harmonizati…
Brain imaging analysis on clinically acquired computed tomography (CT) is essential for the diagnosis, risk prediction of progression, and treatment of the structural phenotypes of traumatic brain injury (TBI). However, in real clinical imaging scenarios, entire body CT images (e.g., neck, abdomen, chest, pelvis) are t…
A new method for variable importance measures without impossible data.
problem Using impossible data for variable importance measures in black box models.
method Cohort Shapley, a method grounded in economic game theory using only observed data.
result Cohort Shapley provides a more trustworthy explanation of black box models' decisions.
Develops a GP framework for age and year-specific mortality surfaces.
problem Learning the covariance structure of age and year-specific mortality surfaces.
method Genetic programming algorithm to search for the most expressive GP kernel.
result Reveals the presence/absence of cohort effects in different populations.
Develops a new method to model overlapping asymmetric datasets effectively.
problem Handling overlapping asymmetric datasets in data science.
method Twice penalized P-Spline approximation method.
result Improves model fit by over 65% in a real-life dataset.
Enhancing spectral embedding for low-dimensional embeddings in rare disease cohorts
problem Representing clinical concepts and patients in electronic health records
method Spectral-based unsupervised learning with flexible knowledge transfer
result Outperforms competing approaches in challenging scenarios
At this moment, databanks worldwide contain brain images of previously unimaginable numbers. Combined with developments in data science, these massive data provide the potential to better understand the genetic underpinnings of brain diseases. However, different datasets, which are stored at different institutions, can…
The paper compares two methods for handling missing data in causal discovery.
problem Handling missing data in causal discovery algorithms.
method Test-wise deletion and multiple imputation.
result Multiple imputation is more challenging for causal discovery than for estimation.
Paper develops NN models for diabetes screening using NHANES data.
problem Developing accurate predictive models for diabetes in diverse populations.
method Proposes a neural network framework with survey weights, uncertainty quantification.
result Robust risk score models for diabetes in US population.
Typical cohorts in brain imaging studies are not large enough for systematic testing of all the information contained in the images. To build testable working hypotheses, investigators thus rely on analysis of previous work, sometimes formalized in a so-called meta-analysis. In brain imaging, this approach underlies th…
In systems biomedicine, an experimenter encounters different potential sources of variation in data such as individual samples, multiple experimental conditions, and multi-variable network-level responses. In multiparametric cytometry, which is often used for analyzing patient samples, such issues are critical. While c…
Randomized Controlled Trials (RCTs) are the gold standard for comparing the effectiveness of a new treatment to the current one (the control). Most RCTs allocate the patients to the treatment group and the control group by uniform randomization. We show that this procedure can be highly sub-optimal (in terms of learnin…
Background: Despite recent significant progress in the development of automatic sleep staging methods, building a good model still remains a big challenge for sleep studies with a small cohort due to the data-variability and data-inefficiency issues. This work presents a deep transfer learning approach to overcome thes…
Compact formulas for evaluating insurance policies' risks.
problem Quantifying demographic risk in insurance portfolios.
method Cohort-based approach with market-consistent valuation.
result Formal closed formula for idiosyncratic risk (accidental mortality).
New algorithm improves causal discovery in biomedical data.
problem Stability and accuracy issues in causal discovery algorithms.
method Exploits temporal structure and tiered background knowledge.
result Increases accuracy in finite samples for causal structure estimation.
Predicting response to neoadjuvant therapy is a vexing challenge in breast cancer. In this study, we evaluate the ability of deep learning to predict response to HER2-targeted neo-adjuvant chemotherapy (NAC) from pre-treatment dynamic contrast-enhanced (DCE) MRI acquired prior to treatment. In a retrospective study enc…
The paper presents a systematic review of state-of-the-art approaches to identify patient cohorts using electronic health records. It gives a comprehensive overview of the most commonly de-tected phenotypes and its underlying data sets. Special attention is given to preprocessing of in-put data and the different modeli…
A new model-free variable importance method (IGCS) is introduced for high-dimensional data.
problem Model-free variable importance for high-dimensional data, especially when prediction functions are proprietary or expensive.
method Integrated Gradient (IG) version of Cohort Shapley (CS) method with cost.
result IGCS closely matches Cohort Shapley (CS) in performance, especially for binary predictors.
Study compares neural and statistical models for Parkinson's disease progression from voice data.
problem Difficult statistical analysis of longitudinal voice biomarkers due to subject correlation, small cohorts, and varied disease trajectories.
method Evaluated Neural Mixed Effects (NME), Generalized Neural Network Mixed Models (GNMMs), and semi-parametric Generalized Additive Mixed Models (GAMMs).
result GAMMs achieve stronger predictive performance and retain interpretable smooth effects and subject-level structure.
Deep neural networks are a family of computational models that have led to a dramatical improvement of the state of the art in several domains such as image, voice or text analysis. These methods provide a framework to model complex, non-linear interactions in large datasets, and are naturally suited to the analysis of…
Many sleep studies suffer from the problem of insufficient data to fully utilize deep neural networks as different labs use different recordings set ups, leading to the need of training automated algorithms on rather small databases, whereas large annotated databases are around but cannot be directly included into thes…
Donor-aware scRNA-seq benchmarks improve classification accuracy in inflammatory bowel disease.
problem Influenza disease classification from scRNA-seq data is prone to donor-level confounding.
method Developed and evaluated three feature representations across two IBD cohorts.
result Compartment-stratified CLR composition and GatedStructuralCFN embeddings outperform linear models in classification accuracy.
Statistical approach uses ODEs for modeling individual health trajectories.
problem Challenges in applying ODEs to longitudinal cohort data, especially noise and parameter sensitivity.
method Combines ODEs with neural networks to model individual health trajectories using each observation as initial value.
result Demonstrates improved modeling of individual health trajectories compared to global regression.
Meta Fusion integrates various multimodal data fusion strategies into a unified framework.
problem Improving predictive power of machine learning methods across diverse applications.
method Meta Fusion constructs a cohort of models based on latent representations across modalities, sharing soft information to boost performance.
result Meta Fusion consistently outperforms conventional fusion strategies in simulation and real-world applications.
There is growing interest in the design of pension annuities that insure against idiosyncratic longevity risk while pooling and sharing systematic risk. This is partially motivated by the desire to reduce capital and reserve requirements while retaining the value of mortality credits; see for example Piggott, Valdez an…
A Convolutional Neural Network was used to predict kidney function in patients with chronic kidney disease from high-resolution digital pathology scans of their kidney biopsies. Kidney biopsies were taken from participants of the NEPTUNE study, a longitudinal cohort study whose goal is to set up infrastructure for obse…
Causal Analysis of the TOPCAT Trial: Spironolactone for Preserved Cardiac Function Heart Failurestat.ML
Causal analysis reveals regional discrepancies in TOPCAT trial results.
problem Inconclusive results in TOPCAT trial for heart failure treatment.
method Causal discovery methods with domain knowledge integration.
result Significant causal effects shown for some subgroups globally.
The exploitation of large-scale population data has the potential to improve healthcare by discovering and understanding patterns and trends within this data. To enable high throughput analysis of cardiac imaging data automatically, a pipeline should comprise quality monitoring of the input images, segmentation of the …
Paper uses RNN to predict SaaS user lifetime value.
problem Predicting user lifetime value in SaaS applications.
method Recurrent Neural Network with multi-cell architecture, accounting for cohort, age-in-system, and contemporaneous information.
result Significantly improved prediction accuracy compared to existing models.
Stein-Encoder isolates genetic signals in multi-modal biomedical data.
problem Integration of high-dimensional genomic data with clinical data obscures genetic predictive impact.
method White-box supervised framework using Stein's method and residualization.
result Stein-Encoder improves predictive accuracy and reveals specific biological mechanisms.
Motivation: How do we integratively analyze large-scale multi-platform genomic data that are high dimensional and sparse? Furthermore, how can we incorporate prior knowledge, such as the association between genes, in the analysis systematically? Method: To solve this problem, we propose a Scalable Network Constrained T…
Improves treatment effect estimation by reducing sample size needed.
problem Estimating causal treatment effects from observational data requires many covariates, increasing sample size.
method Proposes a nonconvex joint sparsity regularization objective function to recover a sparse subset of covariates.
result Improves sample complexity to scale with the size of the sparse subset and log of the total covariates.
Procedure removes training data dependency from deep networks, improving generalization.
problem Removing dependency on training data in deep networks for better generalization.
method Deterministic and stochastic parts to ensure forgetting, leveraging activation and weight dynamics.
result New bound on information extraction from black-box networks, ensuring forgetting in activations.